Mediator of DNA damage checkpoint 1 (Q21106545)

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mammalian protein found in Homo sapiens
  • mediator of DNA damage checkpoint protein 1
  • nuclear factor with BRCT domains 1
  • MDC1
  • homologue to Drosophila photoreceptor protein calphotin
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Language Label Description Also known as
English
Mediator of DNA damage checkpoint 1
mammalian protein found in Homo sapiens
  • mediator of DNA damage checkpoint protein 1
  • nuclear factor with BRCT domains 1
  • MDC1
  • homologue to Drosophila photoreceptor protein calphotin

Statements

molecular function
protein binding
determination method or standard
IPI
17 references
retrieved
8 April 2019
stated in
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
GOA
curator
UniProt
UniProt protein ID
Q14676
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDC1 is a mediator of the mammalian DNA damage checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDC1 interacts with Rad51 and facilitates homologous recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14676
determination method or standard
IPI
cell component
biological process

Identifiers

Ensembl protein ID
 
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