zeta chain of T cell receptor associated protein kinase 70 (Q1998562)

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mammalian protein found in Homo sapiens
  • 70 kDa zeta-associated protein
  • zeta-chain associated protein kinase, 70kD
  • ZAP-70
  • ZAP70
  • zeta-chain (TCR) associated protein kinase 70kDa
  • syk-related tyrosine kinase
  • tyrosine-protein kinase ZAP-70
  • 70 kDa zeta-chain associated protein
  • zeta chain of T cell receptor associated protein kinase 70kDa
edit
Language Label Description Also known as
English
zeta chain of T cell receptor associated protein kinase 70
mammalian protein found in Homo sapiens
  • 70 kDa zeta-associated protein
  • zeta-chain associated protein kinase, 70kD
  • ZAP-70
  • ZAP70
  • zeta-chain (TCR) associated protein kinase 70kDa
  • syk-related tyrosine kinase
  • tyrosine-protein kinase ZAP-70
  • 70 kDa zeta-chain associated protein
  • zeta chain of T cell receptor associated protein kinase 70kDa

Statements

molecular function
protein binding
determination method or standard
IPI
25 references
retrieved
8 April 2019
stated in
A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mechanism of activation for Zap-70 catalytic activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Alternative modes of binding of proteins with tandem SH2 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Peptide microarrays for the detection of molecular interactions in cellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of substrates of human protein-tyrosine phosphatase PTPN22
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IPI
protein tyrosine kinase activity
determination method or standard
NAS
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
TAS
retrieved
8 April 2019
stated in
ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
NAS
retrieved
8 April 2019
stated in
A mutation in zap-70 protein tyrosine kinase results in a selective immunodeficiency
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IEA
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of VHR phosphatase by ZAP-70
GOA
curator
UniProt
UniProt protein ID
P43403
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43403
determination method or standard
IDA
cell component
biological process
Gene Atlas image
PBB GE ZAP70 214032 at fs.png
732 × 530; 9 KB
0 references

Identifiers

MeSH descriptor ID
D051746
subject named as
ZAP-70 Protein-Tyrosine Kinase
0 references
PDB structure ID
 
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