MutS homolog 2 (Q14911693)

From Wikidata
Jump to navigation Jump to search
mammalian protein found in Mus musculus
  • mutS protein homolog 2
  • DNA mismatch repair protein Msh2
  • Msh2
edit
Language Label Description Also known as
English
MutS homolog 2
mammalian protein found in Mus musculus
  • mutS protein homolog 2
  • DNA mismatch repair protein Msh2
  • Msh2

Statements

molecular function
cell component
nucleus
determination method or standard
IC
IDA
IEA
ISO
6 references
retrieved
10 September 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
ISO
retrieved
10 September 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P43247
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IEA
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IEA
retrieved
10 September 2018
stated in
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IDA
retrieved
10 September 2018
stated in
Mouse models for hereditary nonpolyposis colorectal cancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IDA
retrieved
10 September 2018
stated in
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IC
nucleus
determination method or standard
IBA
IC
IDA
IEA
ISO
7 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P43247
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IEA
retrieved
9 May 2019
stated in
Mouse models for hereditary nonpolyposis colorectal cancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IDA
retrieved
9 May 2019
stated in
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IDA
retrieved
9 May 2019
stated in
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IC
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IBA
biological process
somatic hypermutation of immunoglobulin genes
determination method or standard
IGI
IMP
6 references
retrieved
9 May 2019
stated in
Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IGI
somatic recombination of immunoglobulin gene segments
determination method or standard
IGI
IMP
5 references
retrieved
9 May 2019
stated in
The Sμ Tandem Repeat Region Is Critical for Ig Isotype Switching in the Absence of Msh2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IGI
DNA mismatch repair
determination method or standard
IDA
IGI
IEA
IMP
ISO
21 references
retrieved
24 April 2018
stated in
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
ISO
retrieved
24 April 2018
stated in
Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
ISO
retrieved
24 April 2018
stated in
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Female embryonic lethality in mice nullizygous for both Msh2 and p53
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
24 April 2018
stated in
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IGI
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IEA
retrieved
24 April 2018
stated in
Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IDA
retrieved
24 April 2018
stated in
In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247
determination method or standard
IDA
DNA mismatch repair
determination method or standard
IBA
IDA
IEA
IGI
IMP
ISO
22 references
retrieved
9 May 2019
stated in
Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
ISO
retrieved
9 May 2019
stated in
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
ISO
retrieved
9 May 2019
stated in
Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Female embryonic lethality in mice nullizygous for both Msh2 and p53
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IMP
retrieved
9 May 2019
stated in
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IGI
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IEA
retrieved
9 May 2019
stated in
Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IDA
retrieved
9 May 2019
stated in
In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247
determination method or standard
IBA

Identifiers

 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q14911693&oldid=2023073878"