Interactions between Ras proteins and their effectors (Q41080800)

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scientific article published on August 1996

Language	Label	Description	Also known as
English	Interactions between Ras proteins and their effectors	scientific article published on August 1996

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

1 reference

Europe PubMed Central

Interactions between Ras proteins and their effectors (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

author name string

McCormick F

1

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Wittinghofer A

2

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

publication date

1 August 1996

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Current Opinion in Biotechnology

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Europe PubMed Central

PubMed publication ID

26 September 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

449-456

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Activators and effectors of ras p21 proteins

1 reference

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7 January 2021

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inferred from DOI database lookup

Ras‐effector interactions, the problem of specificity

1 reference

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7 January 2021

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Multiple Ras functions can contribute to mammalian cell transformation

1 reference

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7 January 2021

based on heuristic

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A role for Rho in Ras transformation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

An essential role for Rac in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

ralGDS family members interact with the effector loop of ras p21.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of AF-6 and canoe as putative targets for Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1).

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Chemical shift assignments and folding topology of the Ras-binding domain of human Raf-1 as determined by heteronuclear three-dimensional NMR spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Equilibrium and kinetic measurements reveal rapidly reversible binding of Ras to Raf.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The structure of Ras protein: a model for a universal molecular switch

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Two distinct Raf domains mediate interaction with Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The activation of phosphatidylinositol 3-kinase by Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential structural requirements for interaction of Ras protein with its distinct downstream effectors.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The differential effects of the Gly-60 to Ala mutation on the interaction of H-Ras p21 with different downstream targets

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Purification and characterization of REKS from Xenopus eggs. Identification of REKS as a Ras-dependent mitogen-activated protein kinase kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a putative target for Rho as the serine-threonine kinase protein kinase N

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A family of Ran binding proteins that includes nucleoporins

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A Ran-binding motif in nuclear pore proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase Byr2 is a target of Ras1 in the fission yeast Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions among proteins involved in bud-site selection and bud-site assembly in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cooperative interaction of S. pombe proteins required for mating and morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a mouse p21Cdc42/Rac activated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ras-related GTPase Rac1 binds tubulin

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to that of protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel partner for the GTP-bound forms of rho and rac

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Rho1p, a yeast protein at the interface between cell polarization and morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A giant nucleopore protein that binds Ran/TC4

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Purification of a Ran-interacting protein that is required for protein import into the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2896%2980123-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0958-1669(96)80123-6

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

release_pl4fu73s55f5vjxvyqvno4hsba

1 reference

https://api.fatcat.wiki/v0/release/pl4fu73s55f5vjxvyqvno4hsba

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

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