p53-dependent down-regulation of telomerase is mediated by p21waf1. (Q40515208)

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1 January 2020

title

p53-dependent down-regulation of telomerase is mediated by p21waf1 (English)

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1 January 2020

Varda Rotter

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1 January 2020

Igor Shats

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1 January 2020

Doron Ginsberg

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1 January 2020

Ira Kogan

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1 January 2020

Perry Stambolsky

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Xiaohu Tang

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1 January 2020

Ilana Braunstein

series ordinal

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1 January 2020

Maty Tzukerman

series ordinal

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language of work or name

English

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publication date

15 September 2004

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Journal of Biological Chemistry

1 January 2020

published in

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volume

279

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issue

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page(s)

50976-50985

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Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1 January 2020

cites work

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The RNA component of human telomerase

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A survey of telomerase activity in human cancer

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Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy?

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Decision making by p53: life, death and cancer

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The 1995 Walter Hubert Lecture--molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour-suppressor gene

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Regulation and function of the p53 tumor suppressor protein

21 January 2018

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c-Myc-mediated regulation of telomerase activity is disabled in immortalized cells

21 January 2018

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Telomerase activity in relation to p53 status and clinico-pathological parameters in breast cancer

21 January 2018

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Multiple tumor suppressor pathways negatively regulate telomerase

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

21 January 2018

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Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains

21 January 2018

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Identification of a novel transcription factor binding element involved in the regulation by differentiation of the human telomerase (hTERT) promoter

21 January 2018

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The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

21 January 2018

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A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

21 January 2018

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SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity

21 January 2018

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Lack of cell cycle regulation of telomerase activity in human cells

21 January 2018

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The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

21 January 2018

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

21 January 2018

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Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells

21 January 2018

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The regulation of E2F by pRB-family proteins

21 January 2018

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Pathways governing G1/S transition and their response to DNA damage

21 January 2018

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Histone acetylation and transcriptional regulatory mechanisms

21 January 2018

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Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle Inhibition

21 January 2018

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The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

21 January 2018

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Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

21 January 2018

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DNA microarrays identification of primary and secondary target genes regulated by p53.

21 January 2018

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Definition of a consensus binding site for p53

21 January 2018

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Transcriptional repression mediated by the p53 tumour suppressor

21 January 2018

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p130/E2F4 binds to and represses the cdc2 promoter in response to p53.

21 January 2018

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p53 down-regulates CHK1 through p21 and the retinoblastoma protein

21 January 2018

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Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway

21 January 2018

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Telomerase, Cell Immortality, and Cancer

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Transformation of normal human cells in the absence of telomerase activation.

21 January 2018

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Telomerase maintains telomere structure in normal human cells.

21 January 2018

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Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells

21 January 2018

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Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor

21 January 2018

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Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1

21 January 2018

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Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

21 January 2018

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p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor

21 January 2018

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Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

21 January 2018

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Wild-type p53 negatively regulates the expression of a microtubule-associated protein

21 January 2018

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The tumour suppressor protein p53 can repress transcription of cyclin B.

21 January 2018

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p21/CDKN1A mediates negative regulation of transcription by p53.

21 January 2018

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Activated p53 suppresses the histone methyltransferase EZH2 gene

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M402502200

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release_dkzhvlunp5a4tfu6ebgr6ld3k4

1 January 2020

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mapped directly with Wikidata item

24 November 2022

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