Prostaglandin E receptor 4 (Q21120422)

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mammalian protein found in Homo sapiens

PGE2 receptor EP4 subtype
PTGER4
prostaglandin E receptor 4 (subtype EP4)
prostaglandin E2 receptor EP4 subtype
PGE receptor, EP4 subtype
prostanoid EP4 receptor

Language	Label	Description	Also known as
English	Prostaglandin E receptor 4	mammalian protein found in Homo sapiens	PGE2 receptor EP4 subtype PTGER4 prostaglandin E receptor 4 (subtype EP4) prostaglandin E2 receptor EP4 subtype PGE receptor, EP4 subtype prostanoid EP4 receptor

Statements

1 reference

13 November 2019

UniProt protein ID

Prostanoid EP4 receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35408

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

prostaglandin receptor activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

signal transducer activity

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35408&geneProductId=UniProtKB:P35408

determination method or standard

protein binding

determination method or standard

1 reference

9 May 2019

A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

prostaglandin E receptor activity

determination method or standard

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

9 May 2019

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

integral component of membrane

determination method or standard

3 references

9 May 2019

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35408&geneProductId=UniProtKB:P35408

determination method or standard

plasma membrane

determination method or standard

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

biological process

negative regulation of integrin activation

determination method or standard

1 reference

9 May 2019

Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

determination method or standard

1 reference

9 May 2019

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

ERK1 and ERK2 cascade

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

response to mechanical stimulus

determination method or standard

1 reference

9 May 2019

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

negative regulation of eosinophil extravasation

determination method or standard

1 reference

9 May 2019

Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

immune response

determination method or standard

1 reference

9 May 2019

Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

regulation of ossification

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

bone development

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

signal transduction

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

cellular response to prostaglandin E stimulus

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

inflammatory response

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

positive regulation of cytosolic calcium ion concentration

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

negative regulation of inflammatory response

determination method or standard

3 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

9 May 2019

A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35408

determination method or standard

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

prostaglandin D2

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

prostaglandin E2

2 references

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

prostaglandin F2α

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3039498

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL303960

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35408

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000302846

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000302846

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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