PLACENTAL CIRCULATION
Prepared by
Mrs. Adline leena,
Clinical Instructor,
Nehru Nursing College, Vallioor
PLACENTAL
CIRCULATION
UTEROPLACENTA FETOPLACENTAL
L CIRCULATION CIRCULATION
UTEROPLACENTAL CIRCULATION
It is concerned with the circulation of maternal blood through the
intervillous space.
Divided in 3 parts
1. Arterial circulation
2. Venous drainage
3. Circulation in intervillous space
• Blood in the intervillous space is
temporarily outside maternal circulatory
system.
• These vessels discharge into the
intervillous space through gaps in the
cytotrophoblastic shell.
• Blood flowing from spiral arteries is
pulsatile and is propelled in jet-like
fountains by the maternal blood
pressure.
• Welfare of the embryo and fetus chiefly
depends on adequate bathing of branch
villi with maternal blood.
• Reduction in utero-placental circulation
result in fetal hypoxia and IUGR.
SPIRAL ARTERY REMODELLING
• There is cytotrophoblastic invasion into the spiral arteries upto the intradecidual portion within
12weeks of pregnancy.
• Endothelial and musculo elastic media is destroyed and replaced by fibrinoid material
• There is secondary invasion of trophoblast between 12-16 weeks.
• It extends upto the radial arteries within the myometrium.
• SPIRAL ARTERIES are remodelled into large bore UTEROPLACENTAL ARTERIES.
• During uterine contraction the veins are occuluded but the arterial blood is forced into the intervillous
space.
• Uterine relaxation facilitates venous drainge.
• Thus during contraction, larger volume of blood is available for the exchange even though the rate of flow is
decreased.
During uterine contraction the veins are occuluded but the arterial
blood is forced into the intervillous space.
Uterine relaxation facilitates venous drainge.
Thus during contraction, larger volume of blood is available for the
exchange even though the rate of flow is decreased.
INTERVILLOUS HEMODYNAMICS
Volume of blood in mature placenta 500ml
Volume of blood in intervillous space 150ml
Blood flow in intervillous space 150ml
Pressure in intervillous space
1) During uterine contraction 30-50mm Hg
2)During uterine relaxation 10-15mm Hg
Pressure in supplying uterine artery 70-80mm Hg
Pressure in draning uterine vein 8mm Hg
FETOPLACENTAL CIRCULATION
Two umbilical arteries enter the chorionic plate underneath the amnion, each
supplying one half of placenta.
The arteries breakup into small branches which enter the stems of chorionic villi.
Each in turn divides the primary, secondary and tertiary vessels of the
corresponding villi.
Poorly oxygenated blood leaves fetus and passes through umbilical arteries to the
placenta.
At the site of attachment of cord to placenta, these arteries divide into number of
radially disposed chorionic arteries that branch freely in chorionic plate before
entering chorionic villi.
Blood vessels form extensive arterio-capillary-venous system within chorionic villi,
brings fetal blood extremely close to maternal blood.
This system provides a very large area for exchange of metabolic and gaseous products
between maternal and fetal blood streams.
Well-oxygenated fetal blood in fetal capillaries passes into thin walled veins.
This follow chorionic arteries to site of attachment of the umbilical cord, where they
converge to form umbilical vein.
This large vessel carries oxygen-rich blood to the fetus.
FETAL HEMODYNAMICS
Fetal blood flow through placenta 400ml/min
Pressure in umblical artery 60mmHg
Pressure in umblical vein 10mmHg
Fetal capillary pressure in villi 20-40mmHG
PLACENTAL BARRIER
Partition between fetal & maternal circulation.
Not a perfect barrier.
Thickness- ~0.025mm
In early pregnancy it consists of--
1. Syncytiotrophoblast
2. Cytotrophoblast
3. Basement membrane
4. Stromal tissue
5. Endothelium of the fetal capillary wall with its basement
membrane.