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Talaromycosis: Symptoms and Treatment

1) Talaromyces marneffei was formerly known as Penicillium marneffei but was reclassified in 2011 based on new genetic evidence. It causes the disease talaromycosis, formerly known as penicilliosis. 2) Talaromycosis is caused by the fungus Talaromyces marneffei and mainly affects immunocompromised individuals like those with HIV/AIDS. It is endemic in Southeast Asia, East Asia, and parts of India. 3) The fungus is transmitted through inhalation of spores from soil and then spreads through the bloodstream to organs. Rainfall increases fungal growth and transmission risk.

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Alleah Akmad
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253 views6 pages

Talaromycosis: Symptoms and Treatment

1) Talaromyces marneffei was formerly known as Penicillium marneffei but was reclassified in 2011 based on new genetic evidence. It causes the disease talaromycosis, formerly known as penicilliosis. 2) Talaromycosis is caused by the fungus Talaromyces marneffei and mainly affects immunocompromised individuals like those with HIV/AIDS. It is endemic in Southeast Asia, East Asia, and parts of India. 3) The fungus is transmitted through inhalation of spores from soil and then spreads through the bloodstream to organs. Rainfall increases fungal growth and transmission risk.

Uploaded by

Alleah Akmad
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

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TALAROMYCOSIS

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Talaromyces title style
marneffei

Talaromyces marneffei was formerly classified


under the Penicillium subgenus Biverticillium
based on morphological characteristics. In
2011, the subgenus Biverticillium was found to
form a monophyletic group with Talaromyces
that is distinct from Penicillium, and was
taxonomically unified with the Talaromyces
genus. Hence, Penicillium marneffei was
changed to Talaromyces marneffei, and the
disease penicilliosis is now called
talaromycosis. Morphology of Talaromyces marneffei

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Epidemiology title style
of Talaromycosis

Talaromycosis is an invasive fungal infection


caused by the dimorphic fungus
Talaromyces marneffei (formerly Penicillium
marneffei). It mainly affects immunodeficient
individuals such as those infected with HIV-
AIDS. which is endemic in Southeast Asia
(in northern Thailand, Vietnam, and
Myanmar), East Asia (in southern China,
Hong Kong, and Taiwan), and South Asia (in
northeastern India).

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Talaromycosis title style
Transmission

The etiological fungus of


talaromycosis is transmitted to
human through inhalation of
spores from soil. It then spreads to
the reticuloendothelial system
(RES), skin and other organ
system through the hematogenous
route. Talaromycosis in Thailand is
most prevalent in rainy seasons;
rain may lead to fungal growth in
the environment.

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Symptoms
When talaromycosis affect does people with HIV
Bumps on the skins are a common symptom. These its more likely to spread through the blood and
bumps are usually small and painless. This may affect the whole body. When it comes to people
appear on the face and neck but can also appear in who do not have HIV it will commonly affect the
other places on the body. Other symptoms you will lungs, liver, and mouth. In people with HIV skin
encounter are the following: bumps due to talaromycosis usually have a small
• Fever dent in the center. In people who do not have
• Weight loss
HIV, these bumps are more likely to appear
smooth.
• Cough
• Difficulty breathing
• Diarrhea
• Abdominal pain

Person without HIV


Person with HIV

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Treatment Master title style
Talaromycosis

Talaromycosis must be treated with


prescription antifungal medicine. The
most common treatment is
amphotericin B, given through a vein
for two weeks, followed by
itraconazole, given by mouth for 10
weeks. Other antifungal medicines that
can be used include itraconazole by
itself or voriconazole.
Antifungal

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