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JURNAL Stroke Iskemik

Fatigue is a common complication after ischemic stroke, affecting about one-third of patients. This study investigated the prevalence of fatigue 6 months after stroke in patients who received acute revascularization therapy. The study found that 34% of patients reported fatigue, which was associated with worse quality of life, memory impairment, and executive dysfunction. Fatigue correlated with residual motor disability and may be linked to damage in neural networks important for attention and arousal. The high prevalence of fatigue underscores the need for further research into treatments targeting this debilitating symptom.

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Zuhra Meiliza Humam
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118 views20 pages

JURNAL Stroke Iskemik

Fatigue is a common complication after ischemic stroke, affecting about one-third of patients. This study investigated the prevalence of fatigue 6 months after stroke in patients who received acute revascularization therapy. The study found that 34% of patients reported fatigue, which was associated with worse quality of life, memory impairment, and executive dysfunction. Fatigue correlated with residual motor disability and may be linked to damage in neural networks important for attention and arousal. The high prevalence of fatigue underscores the need for further research into treatments targeting this debilitating symptom.

Uploaded by

Zuhra Meiliza Humam
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Association Between Fatigue and

Cognitive Impairment at 6 Months in


Patients With Ischemic Stroke
Treated With Acute Revascularization
Therapy
dr. Andi

Supervisor : Dr. dr. Suherman, Sp. S


TABLE OF CONTENTS

01 02
BACKGROUND METHODS

03 04
RESULTS DISCUSSION

OUR HEALTHCARE CENTER 3


01
BACKGROUND

BACKGROUND
Selama 20 tahun terakhir, fokus dan tujuan mayor terapi stroke
adalah survival dan outcome motorik saja.

Konsekuensinya, ada beberapa komplikasi stroke terabaikan,


padahal sangat mempengaruhi kualitas hidup pasien pasca
stroke.
OUR HEALTHCARE CENTER 4
01
BACKGROUND

29-77% Prevalence of
fatigue after
ischemic
stroke

OUR HEALTHCARE CENTER 5


01
BACKGROUND

Fatigue….
Subjective, multidimensional
experience, perceptual, Feeling of exhaustion,
motor, emotional and weakness, and
cognitive components aversion to effort

Decrease in performance
Impossible to perform
occurs during the repetition
routine activities
of a mental or physical
activity

OUR HEALTHCARE CENTER 6


- Investigate the prevalence of
fatigue 6 months after ischemic
Aims of this stroke
- Association with cognitive
study? performances in patients who
received acute revascularization
therapy
02
METHODS

Design Place
Prospective cohort At Stroke Unit of the
study University Hospital of
Dijon, France

OUR HEALTHCARE CENTER 8


02
METHODS

Inclusion Criterias

Received
a revascularization therapy
(intravenous thrombolysis
Patients ≥18 years, suffffered and/or mechanical
hemispheric acute thrombectomy)
ischemic stroke

Between August 2017 and


May 2018.

OUR HEALTHCARE CENTER 9


02
METHODS
Exclusion Criterias
Major co-morbidities prior
to ischemic stroke that may be previous dementia
responsible for signifificant or aphasia,
fatigue,
1 2
Modifified Rankin scale
5 4 3 Persistence of severe
score > 3
aphasia

Severe disability

OUR HEALTHCARE CENTER 10


02
METHODS

Data we collected…

Demographic Stroke severity Functional handicap Fatigue


The National Institutes of The modifified Rankin Score The Fatigue Severity
Health Stroke Scale (mRS) Scale (FSS)
(NIHSS) score.

OUR HEALTHCARE CENTER 11


02
METHODS

Data we collected…

Global pain and quality of life Sleep assessment Several cognitive domains
The
Pittsburgh Sleep Quality Index
(PSQI)

OUR HEALTHCARE CENTER 12


02

Steps of this study METHODS


03

Results
03
RESULTS
Prevalence of Fatigue and Patients
Characteristics

Prevalence of fatigue Quality of life Factors of fatigue


Patients with fatigue History of
Twenty four patients hypercholesterolemia, the
had worse quality
(34.3%) have fatigue presence of depressive
of life (47–67) vs (65–
(FSS score >4) symptoms on the HAD scale,
80),
. mRS score ≥2.
P = 0.0005
.

OUR HEALTHCARE CENTER 15


03
RESULTS
Neuropsychological Evaluation and
Fatigue at 6 Months

MoCA Score Memory aspect Executive dysfunction


Patients with fatigue Patients with fatigue had Impairment of either working
have a low score on the memory impairment (60 vs. memory, processing speed,
MoCA (score <26) 30.6%, p=0.035) fluency or mental flexibility (65
(79.2 vs. 47.8% p = vs. 30.8%, p= 0.014)
0.015)

OUR HEALTHCARE CENTER 16


04

Discussion
04
DISCUSSION
Correlation of fatigue and other neuropsycological
aspects

Fatigue is correlated with residual motor disability

Primary fatigue after stroke could be linked to damage in


neural networks, particularly reticular formation and
attention network

OUR HEALTHCARE CENTER 18


Fatigue after ischemic stroke
is a frequent symptom even
in patients treated with acute
revascularization
therapies

Conclusion Could be of interest in


developing further interventional
studies to define therapeutic
strategies
THANKS

OUR HEALTHCARE CENTER 20

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