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Cell Cycle Regulation
1. What are the different restriction points of the cell cycle? Describe each.
G1 (Restriction) Checkpoint * End of G1, just before onset of the S phase (DNA replication) *
Yeast start ; other eukaryotes restriction point * The options for the cell at this point: * divide,
delay division, or exit the cell cycle * Cells can exit the cell cycle at this point into an arrested stage
(G0) * When this checkpoint is passed, cdk4 and cyclin D interact. This interaction results in
phosphorylation of the retinoblastoma protein, which in turn allows activation of the transcription
factor E2F. Active E2F promotes expression of the cyclin E gene. Cyclin E (protein) and cdk 2
interact to ... Show more content on Helpwriting.net ...
Therefore, mutations in tumor suppressor genes are recessive at the level of an individual cell. As
we will see, the inactivation of tumor suppressor genes plays a major role in cancer.
3. In a tabulated form, present the different proteins and genes involved in the regulation of the
cell cycle. Include their functions and their classifications as oncogene and tumor suppressor
gene. Protein/Gene| Function| Classification| Retinoblastoma (RB) protein| * located on
chromosome 17p13.1, is the single most common target for genetic alteration in human tumors *
tumor suppression protein that is dysfunctional in many types of cancer. One highly studied
function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell
is ready to divide. It is also a recruiter of several chromatin remodelling enzymes such as
methylases and acetylases.| Tumor Suppressor Gene| Cdk inhibitors| * drives the cell cycle by
unregulated activation of cyclins and CDKs| Tumor Suppressor Gene| P16| * is a common target
of deletion or mutational inactivation in human tumors * an inhibitor of Cdk4 cyclin D complexes;
* The loss of p16 leads to increased Cdk4 cyclin D activity| Tumor Suppressor Gene| P53| * located
on chromosome 17p13.1, is the single most common target for genetic alteration in human tumors|
Tumor Suppressor Gene| BRCA1 and BRCA2| * located on
Dna Tells Tale Of How Cats Conquered The World Summary
Julianna Baker
Benjamin Wheeler
Biology 101
27 July 2017
Title
Domesticated cats are currently spread wide and far across the world, posing as the cute creatures
we know them as today, but how did they get there? What exactly did they domesticate from, and in
what ways were they transported around the world? In her article, DNA Tells Tale of How Cats
Conquered the World, Tina Hesman Saey examines and analyzes these questions, using the research
and findings from Eva Maria Geigl, Thierry Grange, and Carlos Driscoll.
Using the DNA from today s cats, scientists have found out that modern house cats have been
domesticated from African wildcats. However, the big question still remained: how did they make it
all the way around the world? Geigl ... Show more content on Helpwriting.net ...
Being natural predators, they would hunt rodents, which encouraged Middle Eastern farmers to keep
them around. Grange explains that this set up could be dubbed as mutually profitable for both sides
(qtd. in Saey). Also, as many cat owners know, cats typically mark their territory and stay in one
place. Using this knowledge, scientists have drawn conclusions that cats were transported to
Europe; they didn t migrate there themselves. This idea is backed up with evidence from
mitotypes. European wildcats carried one mitotype. It s called clade I. A 6,400 year old
Bulgarian cat and a 5,200 year old Romanian cat had a different type of mitochondrial DNA. They
both had mitotype IV A (Saey). These mitotypes are relative to location, so when cats in Africa
were found with mitotypes previously only found in Egypt, it suggested that cats were being
transported by people. Saey also brings up a valid point, Thirty two of 70 cats from Southwest Asia
also had that mitotype. That rapid spread may indicate that sailors traveled with cats, some of which
could have jumped ship to find a new
Reproductive Rights Of Women In The United States
The ability for women from all walks of life to have access to affordable and safe healthcare
including abortion is something I m passionate about. It is appalling to me as both a woman and
as a citizen of the United States that women have had their reproductive choices made for them or
extremely limited by legislatures, especially when these decisions seem to come from a place of
ignorance. It s been incredibly disheartening to watch the reproductive rights of women within the
United States be chipped away and restricted over the past decade by state and federal legislatures.
The solutions I would propose lie primarily in education as it is education that combats ignorance
and misinformation. In this particular case, it would be better sex
Revolutionary War Incredibly Revolutionary
The Revolutionary war was incredibly revolutionary because it was the transformation from the
colonies to the United States of America, they escaped the deathly tax and escaped from the
Proclamation of 1763, and now they transformed from a horrible Parliament to a democracy and a
change to a more moderate class. The revolution now sparked a beginning of an America without
being under the rule of King George the third and Britain (Declaration of Independance and the
tearing down of the Statue Royale in New York). They had a majestic change from the colonies to
the United Statesof America. They fought to escape the deathly taxes from the British.. America has
transformed from being an afterthought of the British to the United States of
Essay on How Ekg Works
Essay on EKG Replacement for missing work By Mohammad Chenchar
http://www.webmd.com/heart disease/electrocardiogram http://www.nobelprize.org/nobel_prizes
/medicine/laureates/1924/einthoven bio.html http://www.ecglibrary.com/ecghist.html
EKG is an electrocardiogram, a machine used to check on problems with your electrical activity with
your heart. An electrocardiogram machine translates the heart s electrical pattern into lines that
specific professionals can read it. The first EKG was made by Willem Einthoven, a Dutch Java
island (now called Indonesia) born citizen. Willem was born the 21st day of May 1860. His father,
Jacob Einthoven, was born and educated in Groningen (Netherlands). His father was also ... Show
more content on Helpwriting.net ...
At the latter end of the p q interval, atrial contraction occurs forcing additional blood into the
ventricles. At the beginning of the QRS interval on an ECG reading, the mitral valve closes and
the ventricles are at EDV (135ml). During the QRS interval, ventricular contraction occurs
increasing the pressure in the ventricle and the aorta. When the pressure continues in the ventricle
exceeds the pressure in the arteries, the aortic valve opens and blood is ejected. The increased
pressure continues through the t peak. The ventricles are now in ESV (65ml) and the aortic valve
is closed. Now the ventricles are relaxed causing pressure to fall and the cardiac cycle starts over
again. This ECG reading was from a normal tracing. Keep in mind that an ECV is easy to obtain,
but there are some subtleties that are very complex.
Exercise increases heart rate by a process of sympathetic autonomic stimulation. Sympathetic
(adrenergic) nerves increase the excitability of the sino atrial node and reduce the P R interval .As
exercise continues, the physiological changes in the body are continuously monitored by a number
of physiological systems and the balance of activity of the sympathetic system (speeding up) and the
parasympathetic system (slowing down) is constantly adjusted. When exercise is over, the heart rate
does not drop immediately as the body has to undergo a period of re adaption to return to the resting
state.
Public Long Term Care Insurance Of Germany, Japan, And The...
Introduction The U.S. Census has reported that by 2050, the United States population of
Americans aged 65 and over is predicted to be 83.7 million, which is almost double its estimated
population of 43.1 million in 2012 (Ortman, Velkoff, Hogan, 2014). The baby boomer generation is
largely responsible for this increase in the population of aging Americans. By 2050, the surviving
baby boomers will be over the age of 85 (Ortman, Velkoff, Hogan, 2014). This projected growth of
the older population in the United Stateswill present challenges for the healthcare system. Campbell,
Ikegami, and Gibson (2009) provided an analysis of the healthcare systems in Germany, Japan, and
the United States in their article Lessons From Public Long Term Care Insurance in Germany and
Japan (Campbell, Ikegami, Gibson, 2009). Germany and Japan reportedly experienced similar
growth with their aging populations and took proactive measures to introduce comprehensive long
term healthcare insurance due to inadequacies in funding within their standard universal healthcare
system programs (Campbell, Ikegami, Gibson, 2009). Germany and Japan have based their
healthcare systems on the Bismarck model which was founded by Otto von Bismarck who
introduced it to Germany nearly 125 years ago (Wallace, 2013). Bismarck viewed the concept of
universal health insuranceas an effective strategy in his scheme for German unification. This model
utilizes an insurance system which is usually funded jointly by
Chlorophyll Synthesis
2a. The pigment bacteriorhodopsin is used to generate the absorption spectrum in graph 1. An
organism that contains bacteriorhodopsin appears purple because the pigment absorbs light in the
green light spectrum and transmits or reflects the light from the violet/red/blue light spectrum.
Making it appear purple.The pigment chlorophyll a is used to generate the absorption spectrum in
graph 2. An organism that contains chlorophyll a appears green because the pigment absorbs lightin
either the violet or red/blue light spectrum and either transmits or reflects the light from the green
light spectrum. This causes it to appear green.
2b. 650 nm , the first group, will have an intermediate rate of photosynthesis out of all the groups.
This is because a 650 nm wavelength is relative to a red color light which is absorbed by the
organisms containing the pigment from graph 2/ chlorophyll a, but only produces an intermediate
amount of energy for photosynthesis. 550 nm, the second group, will have the lowest rate of
photosynthesis out of all of the groups. This is because a 550 nm wavelength is relative to a green
color light. Green colored light is either transmitted or reflected by the pigment from graph 2
/ chlorophyll a. There is the least amount of energy for photosynthesis at this wavelength. 430 nm,
the third ... Show more content on Helpwriting.net ...
The key metabolic process depicted in step 1 is photosynthesis. In photosynthesis, step 1, carbon is
moved through the cycle when carbon fixation happens. This is when carbon dioxide is fixed into
organic molecules like glucose. To do this photosynthesis uses light energy in the form of ATP.
The key metabolic process depicted in step 2 is cellular respiration. In cellular respiration, step 2,
the reverse is performed in relation to photosynthesis. Organic molecules like glucose are
hydrolyzed back into carbon dioxide. Energy from cellular respiration is released when the organic
molecules are broken down, they then are used for other processes within the
Impact of Celebrity Endorsement on Overall Brand
Impact of Celebrity Endorsement on Overall Brand
By Muneeb Ahmed
Synopsis
The general belief among advertisers is that brand communication messages delivered by celebrities
and famous personalities generate a higher appeal, attention and recall than those executed by non
celebrities. The quick message reach and impact are all too essential in today s highly competitive
environment.
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The different models applied by brands to achieve the full potential of such endorsements, highlight
the need for a convergence between the theoretical and pragmatic approaches of brand building and
... Show more content on Helpwriting.net ...
Celebrities reflect the modern society, transfer their associated qualities to the brand and project a
living, breathing image to the product as opposed to a faceless entity. This triggers a chain of social
influence which allows the consumers to be in accord instantly with the communicated attitude.
As discussed by Kelman (1961), the basis for the effectiveness of celebrity endorsed advertising can
be linked to this process of identification and internalization of the desired behaviour. Price of fame
may be high for the celebrity endorsed brands but they have both what the markets and the everyday
common man want attention, power and star sizzle.
In the same breath, the theoretical model hierarchy of effects suggests that for a purchase to take
place, the consumer must be first aware of the product, then inculcate a liking towards it, and
finally develop an intention to acquire it. This ascension is catalysed by celebrity presence during
brand promotion. Be it Rajnikant making a demographic connection or the new avatar of Amitabh
Bachchan forging a psychological attachment, they carry a mass appeal and establish instant brand
credibility while adopting a subtle persuasive approach. It is presumed that a personality s dynamic
qualities of attractiveness, likeability and appeal are superimposed on the brand image and lead it to
acceptance by their fans and the general mass.
We can now safely look at the various roles played by the
The American Colonial Period
The American colonial period refers to the years 1600 1776, in which Great Britain sent colonists to
live on the east coast of North America. During this period the American people went from dutiful
British citizens to rebels who rose up against their mother country to gain their independence. This
period was formative in both our legislation and literature, setting a precedent and groundwork for
their contemporaries and descendants. In my opinion the core of colonial American literature can be
summed up in three themes: Morality, enlightenment, and transcendentalism. The founding fathers
had a vested interest in moral conditions and standards. Colonial America started with many
religious castaways, including Puritans and Quakers, notoriously conservative and strict in their
ideologies. These were the seeds that were sowed when these groups were isolated and began to self
govern. With the political upheaval, philosophers were... Show more content on Helpwriting.net ...
The invention of the printing press and the electric light let ideas spread more rapidly and lifestyles
change to accommodate the new knowledge. Rational thought and the scientific method from
Francis Bacon brought common sense and exponential advancement to the developing country. This
paved the way for modern secular thinking and scientific advancement, including disease control,
contraception, and ethical legal proceedings. These two values came together in a specific and
politically relevant way in the 1800 s. Transcendentalism was a literary movement often associated
with writers like Ralph Waldo Emerson and Henry David Thoreau and most popular in the late 1820
s and 1830 s. Transcendentalists tout the merits of individuality, connection with nature, and total
freedom. More than just a literary theme, transcendentalism is a worldview, an optimistic one. The
core belief is that human beings and nature are inherently good, and personal intuition is to be
Monitoring The Energy Consumption Mac Protocols
Data Transmission in Automatic Irrigation System Using WSN
Akshay U. Mankar
Department of Electronics and Telecommunication Engineering
R. M. D. Sinhgad School of Engineering and Technology
Pune, India akshaymankar3511@gmail.com Prof. Mrs. Snehal Bhosale
Assistance Professor, Department of Electronics and Telecommunication Engineering
R. M. D. Sinhgad School of Engineering and Technology
Pune, India snehalbhosale@sinhgad.edu Abstract Wireless Sensor Network broadly used for
observing the environmental constraint. An automated irrigation system is developed to improve
water use for agriculture yields. Energy conservation is a very critical issue in wireless sensor
networks. For monitoring the energy consumption MAC protocols plays a very major role. With
the help sensors and simple circuitry this work purposes low cost product, which can be bought
even by a poor farmer. The structure has a dispersed sensor nodes (SN) comprising of soil
moisture, humidity and temperature sensors located in the soil and base station (BS). BS will
gather data from SN. If the collected data in the BS is less than threshold value then BS will
perform a needed action for irrigation. In this project, a TDMA based algorithm and single hop
wireless communication are used to provide better energy efficiency. Network Simulator 3 (NS 3)
has been used for the exploration of the algorithm.
Keywords TDMA scheduling, Wireless sensor networks, Energy efficiency, Automatic irrigation
I. INTRODUCTION
The French Revolution And The Arab Spring
Throughout history many societies have, and will likely continue to have revolutions as we as
humans strive towards a utopian society. Each and every one of these revolution follows some
pattern, a pattern that most often includes a great number of civilian casualties. But what is it that
pushes such revolutions forward? Why have people risked and given their lives fighting against their
own leadership? Looking at both the French Revolutionand the Arab Spring can help uncover the
answer to these questions, as for people to willingly risk their lives, they must have been living in
destitute situations. Both of these societies did indeed have many social and economic problems,
as well as a poor quality of life, specifically for the bottom class, or in the case of the French
Revolution, the Third Estate. It is because of these issues that the people stood up to their leaders
and demanded a better life, overtaking the government in the process. Prior to the French
Revolution enlightenment thinkers such as Voltaire had been writing about equality and individual
freedoms. These ideas began to catch hold with the populous of France, who were almost all living
in very poor conditions. Perhaps the most important of these authors, in regards to the French
Revolution, was John Locke who talked about the idea of a decentralized government, a system
where the people represented the people; a democracy.1 The people of France began to make a push
for such equality, and in August of
Summary Of The Call Of Cthulhu
In the short story, The Call of Cthulhu by H.P. Love Craft, Cthulhu is described multiple times
throughout the story a giant, otherworldly, unimaginable monster with ancient origins. What if
Cthulhu is more than a giant evil monstrosity but is a representation of madness itself, and like the
narrator, the reader is doomed to a fate of madness and there s nothing we can do about it. The story
is split into three chapters that introduces us to Thurston and Angell who learned of Cthulhuand starts
researching about it, then in chapter two it gives us more detail about the fanatic cultand then in the
third chapter, we learn a horrible truth behind the monster and the cult. The story shows how anyone
who knows or anyone who even conceives the idea of Cthulhu becomes crazy or even dies. This fate
has happened to the great uncle Angell, the narrator Thurston, and even possibly us as the reader.
In chapter one, we re introduced to Thurston and we discover his great uncle, Angell, died from
mysterious circumstances and left several journals behind. Angell was a professor of Semitic
Languages at Brown University in Rhode Island. He was studying a strange statue of an
otherworldly creature on a pedestal with some hieroglyphics. Thurston describes it by saying My
somewhat extravagant imagination yielded simultaneous pictures of an octopus, a dragon, and a
human caricature.... A pulpy, tentacled head surmounted a grotesque and scaly body with
rudimentary wings . The statue was made by
