Republic of the Philippines

UNIVERSITY OF EASTERN PHILIPPINES

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS

Name of the Patient: Guy, Klein Ivy

Generic Name: IV, IM:  Cefuroxime Respiratory Tract Hypersensitivity to SIDE EFFECTS: BASELINE ASSESSMENT:
Cefuroxime binds to one or Infections: Cefuroxime is Cephalosporins:
ADULTS, ELDERLY: more of the commonly used to treat Frequent: Discomfort Obtain CBC, renal function test.
penicillin- respiratory Cefuroxime is with IM administration, Question for history of
750 mg–1.5 g q8h contraindicated in allergies, particularly
Brand Name: binding tractinfections, oral candidiasis
individuals with a
Ceftin, Cefuroxi up to 1.5 g q6h for proteins including: (thrush), mild diarrhea, cephalosporin’s, penicillin’s.
known hypersensitivity
me, Zinacef severe infections. (PBPs) which or allergy to mild abdominal
inhibits the  Community- cephalosporin cramping, vaginal
INFANTS, final acquired antibiotics. candidiasis.
CHILDREN, INTERVENTION/EVALUATION
Classification: transpeptidati pneumonia
Pharmacothera ADOLESCENTS:  Acute Cross-reactivity with Occasional: Nausea,
on step of Assess oral cavity for white
peutic: Second- penicillins may also serum sickness–like
peptidoglycan bronchitis patches on mucous
Mild to moderate occur in some cases.
generation synthesis in  Acute reaction (fever, joint membranes, tongue (thrush).
cephalosporin. infection: 75–100 exacerbations pain; usually occurs
bacterial cell History of Severe Monitor daily pattern of bowel
mg/kg/day divided of chronic after second course of
wall, thus Allergic Reactions: activity, stool consistency. Mild
Clinical: q8h. bronchitis therapy and resolves
inhibiting GI effects may be tolerable
Antibiotic. biosynthesis  Pharyngitis and Individuals with a after drug is (increasing severity may
Maximum: 1,500 history of severe allergic discontinued).
and arresting tonsillitis indicate onset of antibiotic-
mg/dose. reactions, including
cell wall anaphylaxis, to any associated colitis). Monitor
assembly Urinary Tract Infections: Rare: Allergic reaction
Severe infection: cephalosporin or I&O, renal function tests for
resulting in Cefuroxime is effective (rash, pruritus,
100–200mg/kg/day penicillin should not use nephrotoxicity. Be alert for
bacterial cell against urinary tract cefuroxime. urticaria),
divided into 3–4 superinfection: fever,
death. infections caused by thrombophlebitis (pain,
doses. vomiting, diarrhea
susceptible bacteria. It is Clostridium difficile- redness,swelling at
aanal/genital pruritus, oral
Absorption: commonly used or Associated Disease: injection site).
Mximum: 1,500 mucosal changes (ulceration,
uncomplicated urinary pain, erythema).
mg/dose. Cefuroxime, like other
Absorbed from the GI tract infections.
antibiotics, may
NEONATES: 50 tract with peak plasma
Skin and Soft Tissue contribute to the ADVERSE
mg/kg/dose q8– concentrations after 2-
Infections: Cefuroxime is overgrowth of EFFECTS/TOXIC PATIENT/FAMILY TEACHING
12h. 3 hr (oral); may be
used to treat skin and Clostridium difficile, REACTIONS:
enhanced by the
soft tissue infections, leading to  Discomfort may occur
PO: ADULTS, presence of food.
such as cellulitis and pseudomembranous Antibiotic-associated with IM injection.
ELDERLY: 250–500 colitis. It is generally colitis, other  Doses should be
mg twice daily Distribution: Pleural impetigo.
and synovial fluid, contraindicated in superinfections evenly spaced.
INFANTS, patients with a history (abdominal cramps,  Continue antibiotic
sputum, bone and Bone and Joint
aqueous fluids; CSF Infections: Cefuroxime of this condition. severe watery diarrhea, therapy for full length
CHILDREN,
(therapeutic may be prescribed for fever) may result from of treatment. May
ADOLESCENTS: 20– Renal Impairment (In
concentrations). the treatment of bone altered bacterial balance cause GI upset (may
30 mg/kg/day in 2 Some Cases):
Crosses the placenta and joint infections, in GI tract. take with food, milk).
divided doses.
and enters breast milk. including osteomyelitis Nephrotoxicity may
 Drug Name Dosage/ Mechanism of action Indication Contraindication Side /Adserve Effect Nursing Responsibility
Frequency/ Route

Generic Name: Oral or suppository: The analgesic and Analgesic- antipyretic in Hypersensitivity to
 10-15 mg/kg/per acetaminophen, severe SIDE EFFECTS BASELINE ASSESSMENT
Paracetamol dose orally/rectally. antipyretic effects of patients with aspirin hepatic impairment or
(acetaminophen paracetamol are allergy, hemostatic severe active liver Rare: Hypersensitivity If given for analgesia, assess
) Neonates: believed to be related disturbances, bleeding disease. reaction. onset, type, location, duration
Brand Name: For babies born at to the inhibition of diatheses, upper Gl of pain. Effect of medication is
28-31 weeks of Cautions: ADVERSE reduced if full pain response
Suppositories: prostaglandin disease, gouty arthriti
gestation: EFFECTS/TOXIC recurs prior to next dose.
Abenol (CAN), synthetase (a
Every 12 hours; Arthritis and rheumatic Sensitivity to REACTIONS Assess for fever. Assess LFT in
Acephen mechanism shared by
dose to not exceed disorders involving acetaminophen; severe pts with chronic usage or
ASA and related drugs). Early Signs of
Oral: Aceta, 40 mg/kg/day. musculoskeletal pain renal impairment; history of hepatic impairment,
It is postulated that the Acetaminophen
Apacet, Atasol (but lacks clinically alcohol dependency, alcohol abuse.
analgesic effect is Toxicity: Anorexia,
(CAN), For babies born at significant hepatic impairment, or
produced by elevation nausea, diaphoresis,
Genapap, 32-37 weeks of antirheumatic and anti- active hepatic disease; INTERVENTION/EVALUATION
of the pain threshold fatigue within first 12–
Genebs, gestation: inflammatory effects) chronic malnutrition
and the antipyretic 24 hrs. Assess for clinical
Liquiprin, Every 8 hours; dose and hypovolemia
effect Is produced Later Signs of Toxicity: improvement and relief of
Mapap, Panadol, to not exceed 60 Common cold, flu, other (Ofirmev); G6PD
through action on the Vomiting, right upper pain, fever. Therapeutic serum
Tapanol, mg/kg/day. viral and bacterial deficiency (hemolysis
hypothalamic heat- quadrant tenderness, level: 10-30 mcg/mL; toxic
Tempra, infections with pain and may occur). Limit dose
For term babies, 0-9 regulating centre. elevated LFTs within serum level: greater than 200
Tylenol fever to less than 4 g/day
days of life: Every 6- 48–72 hrs after mcg/mL. Do not exceed
8 hours; dose to not Unlabeled use: ingestion. maximum daily recommended
Classification:
exceed 60 Prophylactic for dose: 4 g/day.
mg/kg/day. Hematologic:
Pharmacothera children receiving DPT
PATIENT/FAMILY TEACHING
peutic: vaccination to reduce Methemoglobinemia
For term babies, 10-
Central incidence of fever and -cyanosis; hemolytic  Consult physician for
29 days of life:
analgesic. pain. anemia-hematuria, use in children
Every 4-8 hours;
dose to not exceed anuria; neutropenia, younger than 2 yrs,
Clinical: leukopenia,
90 mg/kg/day. oral use longer than 5
Nonnarcotic pancytopenia, days (children) or
analgesic, Infants: thrombocytopenia, longer than 10 days
antipyretic. Every 4-6 hours; hypoglycemia. (adults), or fever
dose to not exceed lasting longer than 3
75 mg/kg/day. days.
 Severe/recurrent pain
Children and
or high/continuous
 adolescents (<60
kg): fever may indicate
Every 4-6 hours; serious illness.
dose to not exceed 1  Do not take more than
g/dose or 75 4 g/day (3 g/day if
mg/kg/day. using OTC [over-the-
counter]). Actual OTC
>12 years: 325-650 dosing
mg every 4-6 hours; recommendations
dose to not exceed may vary by product
3.25-4 g/day. and/or manufacturer.
Many nonprescription
combination products
contain
acetaminophen. Avoid
alcohol.

Prepared by:
Cerse, Mercy O.
Cobrana, Felix Pablo P.

CI: Sir Joel Delorino,RN