NEET Molecular Biology Questions
NEET Molecular Biology Questions
2. Purines found both in DNA and RNA are           6. Which one of the following does not follow the
(NEET 20M9)                                        central dogma of molecular biology?
(a) cytosine and thymine                           (2010)
(b) adenine and thymine                            (a) Pea
(c) adenine and guanine                            (b) Mucor
(d) guanine and cytosine.                          (c) Chlamydomonas
                                                   (d) HIV
3. The association of histone H1with a
nucleosome                                         7. The 3'.5' phosphodiester linkages inside a
indicates that                                     polynucdeotide chain serve to join
(NEET 2017)                                        (Main 2010)
(a) DNA replication is occurring                   (a) one DNA strand with the other DNA strand
(b) the DNA is condensed into a chromatin fibre   (b) one nucleoside with another nucleoside
(c) the DNA double helix is exposed               (c) one nucleotide with another nucleotide
(d) transcription is occurring.                   (d) one nitrogenous base with pentose sugar.
4. In sea urchin DNA, which is double stranded,   8. Which one of the following statements about
                                                  the
17% of the bases were shown to be cytosine.
 The                                              particular entity is true ?
                                                  (Main 2010)
 percentages of the other three bases expected
 to be                                            (a) Centromere is found in animal cels, which
 present in this DNA are                          produces aster during cell division.
 (2015 Cancelled)                                 (b) The gene for producing insulin is present in
 (a) G 17%, A 33%, T 33%                          every body cell.
 (b) G 8.5%, A 50%, T 24.5%                       (c) Nucleosome is formed of nucleotides.
 (c) G 34%, A 24.5%, T 24.5%                      (d) DNA consists of core of eight histones.
 (d) G 17%, A 16.5%,T 32.5%.
9. In the DNA molecule,
                                                   (a) one strand turns clockwise
(2008)
                                                   (b) one strand turns anti-clockwise
(a) the proportion of adenine in relation to
thymine                                            (c) the phosphate groups of two DNA
varies with the organism                           strands, at heir ends, share the same
(b) there are two strands which run                position
antiparallel-one in 5' +3 direction and other      (d) the phosphate groups at the start of two
in                                                 DNA strands are in opposite position (pole).
3+5'
(c) the total amount of purine nucleotides
                                                  13. Which one of the following makes use of RNA
and
                                                  template to synthesise DNA?
pyrimidine nucleotides is not always equal        (2005)
() there are two strands which run parallel       (a) DNA polymerase
in the
5'+3' direction.                                  (b) RNA polymerase
                                                  (c) Reverse transcriptase
                                                  (d) DNA dependant RNA polymerase
10. Which one of the following pairs of
nitrogenous
bases of nucleic acids, is wrongly matched       14. Which one of the following hydrolyses internal
with the                                         phosphodiester bonds in a polynucleotide chain?
category mentioned against it?                   (2005)
(2008)                                           (a) Lipase
(a) Guanine, Adenine- Purines                    (b) Protease
(b) Adenine, Thymine- Purines                    (c) Endonuclease
(c) Thymine, Uracil - Pyrimidines                (d) Exonuclease
(c) Uracil, Cytosine- Pyrimidines
                                                15. In a DNA percentage of thymine is 20% then what
11. One turn of the helix in a B-form DNA is    will be percentage of guanine?
approximately                                   (2002)
(2006)                                          (a) 20%
(a) 2 nm                                        (b) 40%
(b) 20 nm                                       (c) 30%
                                                (d) 60%
(c) 0.34 nm
(d) 3.4 nm.
                                                16. Length of one loop of B-DNA
12.Antiparallel strands of a DNA molecule       (2000)
means that                                      (a) 3.4 nm
(2006)                                          (b) 0.34 nm
                                                (c) 20 nm
                                                (d) 10 nm.
                                                         (b) it should be able to generate its replica
17. The experimental proof for semi-conservative         (c) it should be unstable structurally and
replication of DNA was first shown in a                  chemically
(NEET 2018)                                              (d) it should provide the scope for slow changes
(a) fungus                                               that are required for evolution.
(b) bacterium
(c) plant                                                22. Transformation was discovered by
() virus.)                                               (a) Meselson and Stahl (b) Hershey and Chase
                                                         (c) Griffith
18. Select the correct match.
                                                         (d) Watson and Crick.
(NEET 2018)
                                                         (2014)
(a) Ribozyme
                                                         23. The unequivocal proof of DNA as the genetic
- Nucleic acid                                           material
(b) F2 * Recessive parent- Diybrid cross                 came from the studies on a
(c) T.H. Morgan                                          (a) bacterium
 Transduction
                                                         (b) fungus
() G. Mendel                                             (c) viroid
- Transformation
                                                         (d) bacterial virus.
                                                         (Main 2011)
19. The final proof for DNA as the genetic material      24. Semi-conservative replication of DNA was first
came from the experiments of                             demonstrated in
(NEET2017)
                                                         (a) Escherichia coli
(a) Hershey and Chase
(b) Avery, MacLeod and McCarty                           (b) Streptococcus pneumoniae
                                                         (c) Salmonella typhimurium
(c) Hargobind Khorana
                                                         (d) Drosophila melanogaster.
() Griffith.
                                                         (2009)
                                                         25. Transformation experiment was first performed
20.Taylor conducted the experiments to prove             on
semiconservative mode of chromosome                      which bacteria?
replication on                                           (a) E. coli
(NEET-II 2016)
(a) Vinca rosea                                          (b) Diplococcus pneumoniae
                                                          (c) Salmonella
(b) Vicia faba
(c) Drosophila melanogaster                               (d) Pasteurella pestis
() E. coli.                                              26. DNA synthesis can be specifically measured by
                                                         estimating the incorporation of radio-labelled
21. A molecule that can act as a genetic material        (a) thymidine
must                                                     (b) deoxyribose sugar
fulfill the traits given below, except                   (c) uracil
(NEET-I| 2016)                                           () adenine.
(a) it should be able to express itself in the form of   (1997)
'Mendelian characters'
                                                        31. Name the enzyme that facilitates opening of
                                                        DNA
27. Which one of the following is not applicable to     helix during transcription.
RNA?
                                                        (NEET 2020)
(2015)
(a) Heterocyclic nitrogenous bases                      (a) DNA ligase
                                                        (b) DNA helicase
(b) Chargaff 's rule
(c) Complementary base paiing                           (c) DNA polymerase
(d) 5' phosphoryl and 3' hydroxyl ends                   () RNA polymerase
28.Similarity in DNA and RNA is that                    32. What will be the sequence of mRNA
(2000)                                                  produced by
                                                        the following stretch of DNA?
(a) both are polymer of nucleotides
(b) both have similar pyrimidine                        (Odisha NEET 2019)
                                                        3ATGCATGCATGCATG5TEMPLATE STRAND
(c) both have similar sugar
(d) both are genetic material.                          5' TACGTACGTACGTAC3' CODING STRAND
                                                        (a) 3'AUGCAUGCAUGCAUGS'
                                                        (b) 5'UACGUACGUACGUAC 3
29. During DNA replication, Okazaki fragments are       (c) 3' UACGUACGUACGUAC 5'
used to elongate                                        (d) 5' AUGCAUGCAUGCAUG 3'
(NEET 2017)                                             33. Select the correct statement.
(a) the lagging strand towards replication fork         (NEET 2018)
(b) the leading strand away from replication fork       (a) Franklin Stahl coined the term "linkage".
(c) the lagging strand away from the replication fork   (b) Punnett square was developed by a British
                                                        scientist.
(d) the leading strand towards replication fork.
                                                        (c) Spliceosomes take part in translation.
30. During replication of a bacterial chromosome        (d) Transduction was discovered by S. Altman.
DNA
synthesis starts from a replication origin site and     34. AGGTATCGCAT is a sequence from the coding
(2004)                                                  strand of a gene. What will be the corresponding
(a) RNA primers are involved                            sequence of the transcribed mRNA?
(b) is facilitated by telomerase                        (NEET 2018)
(c) moves in one direction of the site                  (a) AGGUAUCGCAU (b) UGGTUTCGCAT
(d) moves in bidirectional way.                         (c) ACCUAUGCGAU(d) UCCAUAGCGUA
78. Out of 64 codons, 61 codons code for 20 types    83.A complex of ribosomes attached to a single
                                                     strand
amino acid. It is called                             of RNA is known as
(2002)
(a) degeneracy of genetic code                        (NEET-I 2016)
(b) overlapping of gene                              (a) polypeptide
(c) wobbling of codon                                (b) Okazaki fragment
(d) universility of codons.                           (c) polysome
                                                      (d) polymer.
79. Change in sequence of nucleotide in DNA is
called
(2002)
 84.Amino acid sequence, in protein synthesis is
                                                   87. Match the following genes of the Lac operon with
 decided
                                                       their respective products.
 by the sequence of                                   (A) i gene                    (i) B-galactosidase
 (2006)                                               (B) Zgene                     (ii) Permease
 (a) rRNA                                             (C) a gene                   (ii) Repressor
 (b) tRNA                                             (D) y gene                    (iv) Transacetylase
 (c) mRNA                                             Select the correct option.
 (d) cDNA.                                                    (A)   (B) (C) (D)
                                                       (a) (iüi) (iv) (i) (ii)
                                                       (b) () (iüi) (ii) (iv)
85. Using imprints from a plate with complete          (c) (iii) (i) (ii) (iv)
medium                                                                                              (NEET 2019)
                                                       (d) (iüi) (i)    (iv) (i)
and carrying bacterial colonies, you can select
streptomycin resistant mutants and prove that        88.All of the following are part of an operon
such
                                                     except
mutations do not originate as adaptation.            (NEET 2018)
These
                                                     (a) an operator
imprints need to be used                             (b) structural genes
(2005)                                               (c) an enhancer
(a) on plates with and without streptomycin          (d) a promoter.
(b) on plates with minimal medium
(c) only on plates with streptomycin                 89. Which of the following is required as
() only on plates without streptomycin.              inducer(s) for
                                                     the expression of Lac operon?
86.Protein synthesis in an animal cell occurs        (NEET-1 2016)
(2005)                                               (a) Lactose
(a) only on the ribosomes present in cytosol         (b) Lactose and galactose
(b) only on ribosome attached to the nucdear         (c) Glucose
envelope and endoplasmic reticulum                   (d) Galactose
(c) on ribosome present in the nucleolus as
well as
                                                     90.Gene regulation governing lactose operon of
in cytoplasm                                         E.coli
() on ribosomes present in cytoplasm as well         that involves the lac I gene product is
as in
                                                     (2015 Cancelled)
 mitochondria.                                       (a) negative and repressible because repressor
                                                     protein prevents transcription
                                                     (b) feedback inhibition because excess of
                                                     B-galactosidase can switch off transcription
                                                       94.The lac operon consists of
(c) positive and inducible because it can be induced   (Main 2010)
by lactose                                             (a) four regulatory genes only
(d) negative and inducible because repressor           (b) one regulatory gene and three structural
protein prevents transcription.                        genes
                                                       (c) two regulatory genes and two structural
                                                       genes
91. Which one of the following is wrongly matched?     (d) three regulatory genes and three structural
(a) Transcription - Writing information from DNA       genes.
to tRNA.
(b) Translatio                                         95.Expressed Sequence Tags (ESTs) refers to
(2014)n- Using information in mRNA to                  (a) novel DNA sequences
make protein.                                          (NEET 2019)
(c) Repressor protein - Binds to operator to stop      (b) genes expressed as RNA
enzyme synthesis.
                                                       (c) polypeptide expression
(d) Operon - Structural genes, operator and            () DNA polymorphism.
 promoter.
                                                       96.ldentify the correct order of organisation of
92.Which enzyme will be produced in a cell if there    genetic
is a                                                   material from largest to smallest.
nonsense mutation in the lacY gene?                    (2015)
(NEET 2013)                                            (a) Genome, chromosome, gene, nucleotide
(a) Transacetylase                                     (b) Chromosome, genome, nucleotide, gene
(b) Lactose permease and transacetylase                (c) Chromosome, gene, genome, nucleotide
(c) B-galactosidase                                    (d) Genome, chromosome, nucleotide, gene
(d) Lactose permease
                                                       97. Satelite DNA is important because it
93.In an inducible operon, the genes are               (2015)
(Karnataka NEET 2013)                                  (a) does not code for proteins and is same in
                                                       all
(a) usually not expressed unless a signal turns
them"on".                                              members of the population
(b) usually expressed unless a signal turns them       (b) codes for enzymes needed for DNA
"off.                                                  replication
(c) never expressed                                    (c) codes for proteins needed in cell cycle
(d) always expresser.                                  (d) shows high degree of polymorphism in
                                                       population
                                                       and also the same degree of polymorphism in
                                                       an
106.The lac operon is an example of                  E. coli and proposed operon concept. Operon
                                                     concept
(1995)
                                                     is applicable for
(a) repressible operon
 (b) overlapping genes                               (2002)
(c) arabinose operon                                 (a) all prokaryotes
(d) inducible operon.                                (b) all prokaryotes and some eukaryotes
                                                     (c) all prokaryotes and all eukaryotes
107.An environmental agent, which triggers           (d) all prokaryotes and some protozoans.
transcription
from an operon, isa                                  111.in E. coli, during lactose metabolism repressor
                                                     binds to
(1995)
(a) depressor                                        (2002)
(b) controlling element                              (a) regulator gene
(c) regulator                                        (b) operator gene
(d) inducer.                                         (c) structural gene
                                                     (d) promoter gene.
108. Lac operon' in E. coli, is induced by
(1994)                                               112.In negative operon,
(a) "' gene                                          (2001)
(b) promnoter gene                                   (a) co-repressor binds with repressor
(c) B-galactosidase                                  (b) co-repressor does not bind with repressor
(d) lactose.                                          (c) co-repressor binds with inducer
                                                      (d) CAMP have negative effect on lac operon.
                                                  116.The codons causing chain termination are
113.Khorana first deciphered the triplet codons   (1997)
of
                                                  (a) AGT, TAG, UGA
(1992)
(a) serine and isoleucine                          (b) UAG, UGA, UAA
                                                  (c) TAG, TAA, TGA
(b) cysteine and valine
                                                  (d) GAT, AAT, AGT.
(c) tyrosine and tryptophan
(d) phenylalanine and methinonine.
                                                  117.Which of the following serves as a terminal
                                                  codon?
114.In the genetic dictionary, there are 64
                                                  (1996)
codons as
                                                  (a) UAG
(1990)                                            (b) AGA
(a) 64 amino acids are to be coded
                                                  (c) AUG
(b) 64 types of tRNAS are present
                                                  (d) GCG
(c) there are 44 nonsense codons and 20 sense
 codons                                           118.If the DNA codons are ATG ATG ATG and a
 (d) genetic code is triplet.                     cytosine
                                                  base is inserted at the beginning, then which of
 115.Genetic code consists of
                                                  the
 (1988)                                           following will result?
 (a) adenine and guanine                          (1995)
 (b) cytosine and uracil                          (a) CAT GAT GAT G (b) A non-sense mutation
 (c) cytosine and guanine                         (c) CATGATG ATG (d) CA TGA TGA TG
 (d) all of these.
                                                  119.Anticodon is an unpaired triplet of bases in
                                                  an
                                                  exposed position of
                                                  (1995)
                                                  (a) tRNA
                                                  (b) mRNA
                                                  (c) rRNA
                                                  (d) both (b) and (c).
                                                  120.Initiation codon of protein synthesis (in
                                                  eukaryotes)
                                                  is
                                                   (1993)
                                                   (a) GUA
                                                   (b) GCA
                                                   (c) CCA
                                                   (d) AUG.
1.A    31.D   61.D   91.A.D
2.C    32.B   62.C    92.C
3.B    33.B   63.A    93.A
4.A    34.A   64.D    94.B
5.C    35.D   65.B   95.B
6.D    36.C   66.C   96.A
7.C    37.B   67.B   97.D
8.B    38.C   68.B   98.D
9.B    39.A   69.D   99.A
10.B   40.D   70.D   100.D
11.D   41.B   71.D   101.A
12.D   42.A   72.A   102.B
13.C   43.A   73.C   103.C
14.C   44.A   74.A   104.C
15.C   45.D   75.C   105.C
16.A   46.B   76.D   106.D
17.B   47.A   77.C   107.D
18.A   48.C   78.A   108.C
19.A   49.B   79.B   109.A
20.C   50.D   80.C   110.C
21.C   51.C   81.C   111.B
22.C   52.A   82.A   112.A
23.D   53.C   83.C   113.B
24.A   54.A   84.C   114.D
25.B   55.A   85.C   115.D
26.A   56.C   86.D   116.B
27.B   57.C   87.D   117.A
28.A   58.A   88.C   118.A
29.C   59.A   89.A   119.A
30.D   60.D   90.D   120.D