DRUG INTERACTION – MCQs
Date – 04.04.2023
1.________________ causes pharmacodynamic drug interaction.
a) Gastric motility changes.
b) Stimulation of metabolism.
c) Alteration of pH of GIT.
d)Interactions at receptor site.
2.Mechanism by which adrenaline can prolong the duration of local anesthesia
a) Decreased permeability of the vascular endothelium
b) Precipitation of lidocaine
c) Changing the pH of the solution
d) Local Vasoconstriction
3.Why should care be taken when prescribing warfarin and amiodarone in combination?
a) Amiodarone and warfarin both have an anticoagulant effect.
b) Amiodarone may reverse the anticoagulant effect of warfarin.
c) Amiodarone may increase the anticoagulant effect of warfarin.
d) Warfarin may reverse the antiarrhythmic effect of amiodarone.
4. Absorption of Griseofulvin increases with -----------diet.
a) Carbohydrate
b) Fatty
c) protein
d) vitamin
5. When tetracycline is given with antacids the absorption of tetracycline -----
a) Increases
b) Decreases
c) Minimally altered
d) Not altered at all
6.Which of the following would you classify as a pharmacodynamics interaction?
a) ACE inhibitors with potassium-sparing diuretics cause life-threatening hyperkalaemia
b) Antacids reduce the absorption of fluoroquinolones
c) Increased bleeding due to cimetidine and warfarin
d) Probenecid increases half-life of penicillin
7.The renal clearance of a drug bound to plasma protein is increased after displacement with
another drug.
a) True
b) False
8.Antibiotics which interacts with calcium ions
a) Amoxicillin
b) Erythromycin
c) Streptomycin
d) Tetracycline
9. A person taking organic nitrate has to avoid one of the following drugs as it can cause severe
hypotension
a) Aspirin
b) Cholestyramine
c) Warfarin
d) Sildenafil
10. Which of the following drugs is interact with grapefruit juice?
a) Cyclosporin
b) Atorvastatin
c) Cisapride
d) Paroxetine
