Март 2016

General Pharmacology

1. A patient with angina pectoris was helping himself with

nitroglycerin. One day the patient used nitroglycerin several times because of
frequent episodes of pain. So as the last sublingual administration of
nitroglycerin did not relieve pain, the patient addressed his doctor. Doctor
advised him to withdraw nitroglycerin for 8 hours and prescribed another drug.
After 8 hours the effect of nitroglycerin was restored. Which phenomenon did
take place in this case?
A. Increase in nitroglycerin metabolism
B. Increase in protein binding
C. Decrease of absorption
D. Drug dependence
E. Tolerance*.

2. Metabolism can render pharmacological activity to some initially

inert substances (pro-drug). Point out the substance, which is pro-drug, used for
treatment of hypertension.
A. Enalapril*
B. Salbutamol
C. Verapamil
D. Reserpine
E. Propranolol.

3. A patient who has been treated with diazepam on account of

neurosis complains of toothache. Doctor administered him an analgetic, but its
dose was lower than average therapeutic dose. What phenomenon did the doctor
take into account while prescribing the patient an underdose?
A. Summation
B. Potentiation*
C. Cumulation
D. Tolerance
E. Drug dependence.

4. A patient with frequent attacks of stenocardia was prescribed

sustak-forte to be taken one tablet twice a day. At first the effect was positive
but on the second day stenocardia attacks resumed. What can explain
inefficiency of the prescribed drug?
A. Tachyphylaxis*
B. Sensibilization
C. Dependence
D. Cumulation
E. Idiosyncrasy.
 5. A man who has been taking a drug for a long time cannot withhold
it because this causes impairment of psychic, somatic and vegetative functions.
Name the syndrome of different disturbances caused by drug discontinuation:
A. Idiosyncrasy
B. Sensibilization
C. Tachyphylaxis
D. Abstinence*
E. Cumulation.

6. What is the mechanism of absorption of drug which is lipophilic

and unionized?
A. Active transport
B. Passive diffusion*
C. Filtration
D. Pinocytosis
E. Binding to protein.

7. Which route of administration results in 100% bioavailability of

drug?
A. Oral
B. Subcutaneous
C. Inhalational
D. Intravenous*
E. Intramuscular.

8. Chloramphenicol is highly toxic in newborn. What is the cause of

such toxicity?
A. Intensive binding to protein
B. Deficiency of metabolizing enzymes in liver*
C. Penetration into the cell
D. Inhibition of protein synthesis
E. Inhibition of nucleic acid synthesis.

9. What is the result of tubular reabsorption of drug?

A. Increase in duration of action*
B. Increase in excretion
C. Increase in distribution
D. Decrease in duration of action
E. Loss of pharmacologic activity.

10. Anticoagulant drug warfarin is bounding to plasma albumin. How

its effect can be changed in case of hypoalbuminemia?
A. Effect unchanged
B. Increased*
C. Decrease
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 D. Significant delayed onset of effect
E. Abolishing of effect .

11. Passive reabsorption from tubular urine (pH of 5) of a drug

administered IV would be reduced if the drug were
A. A weak base*
B. A weak acid
C. Water soluble
D. Protein bound
E. None of the above.

12. Patient suffering from angina pectoris was helping himself by

sublingual usage of nitroglycerin. One day he used the drug several times. The
last use did not relieve his pain. What phenomenon does occur?
A. Antagonism
B. Tachyphylaxis*
C. Hypersensitivity
D. Cumulation
E. Binding to protein.

13. Point out the kind of drug interaction that permits to use one of
them in lower dose.
A. Antagonism
B. Cumulation
C. Potentiation*
D. Tolerance
E. Additive synergism.

14. Patient with infection of GIT was treated with antibiotic. Which
type of therapy is it?
A. Symptomatic
B. Pathogenetic
C. Ethiotropic*
D. Replacement
E. Stimulating.

15. Alongside with therapeutic effect drugs can cause side effects. In
which dose they can occur?
A. In overdose
B. In therapeutic dose*
C. In threshold dose
D. In subthreshold dose
E. At any dose.

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 16. Patient suffering from gastric peptic ulcer was treated with M-
cholinoblocker. What is the mechanism of this drug action?
A. Enzymatic
B. Receptor*
C. Direct chemical
D. Physicochemical
E. Action on ion channels of membrane.

17. A patient with chronic cardiac insufficiency was prescribed digoxin

in average therapeutic dose. After 2 weeks of treatment the symptoms of
intoxication (bradycardia, extrasystole, nausea) were developed. Point out the
phenomenon responsible for intoxication.
A. Tachyphilaxis
B. Material cumulation*
C. Idiosyncrasy
D. Functional cumulation
E. Tolerance.

18. The patient with heart failure was using digitoxin. His condition
initially improved, but with time the manifestations of heart failure have
increased again, and symptoms of glycoside intoxication apeared. What is the
cause of patient's condition worsening?
A. Potentiation
B. Cumulation*
C. Tachyphylaxis
D. Sensitization
E. Idiosyncrazy.

19. Analgesic effect of methamizole(analgin) in the dental pain

develops in 0.5 hour and lasts for 1.5-2 hours. Tablets "Piraminal" in the same
situation are faster and longer acting. What is the phenomenon responsible for
difference in the action of these drugs?
A. Chemical antagonism
B. Functional antagonism
C. Undirectional antagonism
D. Potentiation
E. Summation*.

20. In the elderly patient with symptoms of senile atonic constipation

long-term treatment with drug buckthorn has led to a weaking effect. What is
this phenomenon?
A. Tolerance*
B. Cumulation
C. Sensibilization
D. Desensitization
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 E. Tachyphylaxis.

21. During the barbituric anesthesia in a patient respiratory depression

occurred. After intravenous injection of 10 ml 0.5% solution of bemegride the
patient's condition improved, the volume of pulmonary ventilation inceased.
Point out the phenomenon responsible for curative effect of bemegride in this
case
A. Direct synergisnm
B. Undirectional antagonism
C. Direct antagonism*
D. Indirect antagonism
E. Indirect synergism.

22. A child of 2 years admitted to the infectious deseases hospital with

a diagnosis of bacillary dysentery. What a way of enteral administration of
antimicrobial agent polymyxin is the most rational, if child has uncontrollable
vomiting?
A. Subcutaneous
B. Intravenous
C. Oral
D. Rectal*
E. Inhaled.

23. In a patient with traumatic brain injury there are such symptoms:
the obscured consciousness, inpaired respiration, filiform pulse, absence of
reflexes. Which route of drug administration for urgent aid is the most
appropriate in this case?
A. Rectal
B. Intravenous*
C. Subcutaneous
D. Oral
E. Inhaled.

24. In poisoning with mushrooms containing muscarine atropine is used

as an antidote. Which of the following mechanisms, typical for atropine, leads to
the neutralization of the poison mushroom - muscarine?
A. Antimetabolic
B. Physical and chemical
C. Antienzymatic
D. Receptor*
E. Enzymatic.

25. Prolonged use of certain drugs before pregnancy can disrupt fetal
development. What is the name of this action?
A. Fetotoxic
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 B. Embriotoxic
C. Teratogenic
D. Mutagenic*
E. Carcinogenic.

26. With long-term treatment by antipsychotic drugs at therapeutic

doses in patient, along with the restoration of the psychic function, some
undesired effects such as tension in the skeletal muscles, stiffness of gait, and
some autonomic disorders occurred. What the type of drug’s effects should
include these?
A. Aftereffect
B. Overdose
C. The main therapeutic effect
D. Intoxication
E. Side effects*.

27. After clinical and laboratory examination of a patient with diabetes

mellitus insulin was appointed for treatment.What is the type of this therapy?
A. Etiotropic
B. Replacement*
C. Pathogenetic
D. Symptomatic
E. Functional.

28. In order to reduce toothache a patient was recommended to take

methamisol (analgin). What the type of pharmacotherapy was used?
A. Functional
B. Pathogenetic
C. Causal
D. Substitution
E. Symptomatic*.

29. In 18 years old patient with shoulder phlegmon intramuscular

injection of penicillin was made, after which he developed tachycardia, filiform
pulse, fall of blood pressure to 80/60 mm Hg. What type of pathological
response was originated?
A. Potentiation
B. Anaphylaxis*
C. Tolerance
D. Antagonism
E. Tachyphylaxis.

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 Local anesthetics

30. To lance abscess doctor performed local anesthesia with therapeutic

dose of anesthetic, but it was not sufficient. What was the cause of decrease in
anesthetic effect?
A. Quick absorption of drug
B. Quick metabolism of anesthetic
C. Alkaline medium
D. Acidic pH of tissues*
E. Neutral medium.

31. Surgeon is going to perform the operation under local anaesthesia.

The probable duration of operation is more than 2 hours. In past patient was
complaining for ventricular extrasystole. Which anaesthetic is reasonable to
chose for local anaesthesia?
A. Tetracaine(decaine)
B. Procaine(novocaine)
C. Benzocaine(anaesthesine)
D. Trimecaine*
E. Cocaine.

32. Dentist revealed that his patient is suffering from hypersensitivity to

procaine. Which of the following agents may be used for local anaesthesia?
A. Benzocaine(anaesthesine)
B. Piromecaine
C. Dicaine(tetracaine)
D. Lidocaine*
E. Cocaine.

33. Which of the listed drugs is usually added to local anaesthetic to

prolong its action and to decrease toxicity?
A. Noradrenaline
B. Ephedrine
C. Adrenaline*
D. Reserpine
E. Atropine.

34. A 25-year-old woman with red and itchy eczematoid dermatitis

visits your office, She had a dental procedure one day earlier with administration
of a local anesthetic. There were no other findings, although she indicated that
she had a history of allergic reactions. Which of the following drugs is most
likely involved?
A. Procaine*
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 B. Etidocaine
C. Bupivacaine
D. Cocaine
E. Lidocaine.

35. For the patient with gastroenteritis doctor prescribed preparation of

tannin derivative with anti-inflammatory effect on the basis of the astringent
mechanism. Which of the following drugs was prescribed?
A. Bismuth subnitrat
B. Tannin
C. Xeroform
D. Tanalbin*
E. De-nol.

36. Patient 75 years old suffers from chronic constipation. What the
drug of a group of emollients can be assigned to this patient?
A. Senna leaf*
B. Phenolphtalein
C. Neostigmine
D. Magnesium sulfate (enterally)
E. Camphor spirit.

37. Bed sores appeared in patient on strict bed regiment. What the
irritating drug was prescribed by physician to improve blood circulation in the
area of bed sores
A. Camphor spirit*
B. Vishnevsky’s ointment
C. Wilkinson's ointment
D. A solution of potassium permanganate
E. Talc.

38. A child with acute poisoning with datura seeds doctor prescribed
oral usage of activated charcoal. Specify the mechanism of its action.
A. Adsorptions alkaloids on the surface*
B. Insoluble salts formation
C. Block of sensory receptors of the stomach
D. Precipitation of proteins on the surface of gastric mucous
membrane
E. Formation of protective layer of the colloid on the mucous
membranes.

39. The drug from the group covering agents with antacid effect was
prescribed to patients with gastric ulcer. Which of the following medications
was prescribed?
A. Tannin
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 B. Decoction of oak bark
C. Almagel*
D. Infusion of sage leaves
E. Bismuth subnitrate.

40. Athlete has a sharp muscular pain in the back after training. What
the irritating drug is helpful in this case?
A. The turpentine oil*
B. A solution of menthol
C. Ammonia
D. Validol
E. Chloroform.

41. Gastric lavage with a solution of tannin was performed to the

patient with alkaloid poisoning. What the concentration of tannin solution
should be used for this purpose?
A. 0.5%*
B. 0.1%
C. 0,01
D. 0,05
E. 0,1.

42. The patient suffers from hemorrhoids. For pain relief doctor
prescribed rectal suppositories with local anesthetic. Point out anesthetic used in
this dosage form.
A. Cocaine
B. Tetracaine
C. Novocaine
D. Trimekaine
E. Benzocaine (Anestesin)*.

43. Doctor applied paste with benzocaine to reduce the itching of the
forearm skin. Due to which of the following properties of benzocaine it is used
in soft dosage form?
A. Good absorption
B. Poor solubility*
C. The high degree of distribution
D. The good solubility
E. Inadequate absorption.

44. The patient will have surgery on the limbs of more than 2 hours
duration, which anesthetist plans to hold under local anesthesia. Which of the
following drugs should be selected for long-term conduction anesthesia?
A. Novocaine
B. Cocaine
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 C. Tetracaine
D. Benzocaine
E. Lidocaine*.

Cholinomimetics

45. Patient with complaints of dryness in the mouth, photophobia and

disturbances of vision was admitted to the reception-room. Skin is hyperemic
and dry, pupils are dilated, tachycardia. Poisoning with belladonna alkaloids was
diagnosed on further examination. What medicine should be prescribed as
antidote?
A. Diazepam
B. Prozerin (Neostigmine)*
C. Atropine
D. Pilocarpine
E. Dipyroxim.

46. Patient with pin-point pupils, sweating, salivation, abdominal

cramps, disturbances in respiration was admitted to the emergency room.
Poisoning with what substance is the most likely occurred?
A. Non-narcotic analgesics
B. Sedatives
C. Narcotic analgesics
D. М-cholinergic antagonists
E. Muscarine*.

47. In the patient, after the stroke, paralysis of hand and leg appeared.
To restore the movements of paralyzed extremities patient was treated with
physical exercises and cholinomimetics. Which of listed drugs was used for this
purpose?
A. Aceclidine
B. Pilocarpine
C. Physostigmine
D. Ambenonium chloride (oxazyl)*
E. Lobeline.

48. A known patient of myasthenia gravis came to you with his disease
well controlled by neostigmine; but he asked you to give him drug that needs
more rare usage. Choose the necessary drug.
A. Physostigmine
B. Atropine
C. Ambenonium chloride*
D. Armin
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 E. Pralidoxime.

49. A49-year old frequent business traveler presents to his physician

requesting medication to help him with nausea and dizziness that he gets during
turbulent flights. A scolopamine patch is prescribed for his motion sickness.
Which of the following is the most likely side effects from this patch?
A. Bradycardia
B. Diaphoresis
C. Diarrhea
D. Salivation
E. Urinary retention*.

50. In complex treatment of a child, suffering from cerebral palsy, a

doctor decided to include anticholinesterase drug moderately improving mental
development. Choose this drug.
A. Physostigmine
B. Neostigmine (Proserinum)
C. Galanthamine*
D. Pilocarpine
E. Lobeline.

51. Analeptical remedy of reflective type from the N-cholinomimetics

group was given to the patient for restoration of breathing after poisoning with
carbon monoxide, What medicine was prescribed to the patient?
A. Adrenalin hydrochloride
B. Atropine sulphate
C. Mesaton
D. Pentamin
E. Lobeline hydrochloride*.

52. A patient with complaints of dryness in the mouth, photophobia and

vision impairment was admitted in the reception-room. Skin is hyperemic, dry,
pupils, are dilated, tachycardia. Poisoning with belladonna alkaloids was
diagnosed on further examination. What medicine should be prescribed?
A. Armine
B. Dipiroxim
C. Pilocarpine
D. Diazepam
E. Prozerin*.

53. On the 2-3rd day after stomach resection intestinal peristalsis wasn't
restored. What is to be administered for stimulation of gastrointestinal tract?
A. Atropine sulfate
B. Prasosin
C. Acetylcholine
11
 D. Proserin(Neostigmine)*
E. Cyclodole.

54. The patient developed postoperative intestinal atony. After injection

of M-cholinomimetic the patient's condition was improved. Point out the drug
that was used in this cvase
A. Arminum
B. Aceclidine*
C. Ambenonium chloride (Oxazylum)
D. Atropine
E. Platyphylline.

55. After completion of abdominal surgery conducted with the use of

nondepolarizing myoreolaxant, the patient did not restored spontaneous
breathing. What kind of drug is able to restore breathing in this case?
A. Scopolamine
B. Aceclidine
C. Pilocarpine
D. Neostigmine*
E. Izonitrozinum.

56. A child poisoned by mushrooms containing muscarine was brought

to the toxicological department Which drug should be used for emergency
assistance in the first place?
A. Papaverine
B. Sodium thiosulfate
C. Atropine*
D. Unitiol
E. Dipiroxim.

57. A patient with signs of poisoning by organophosphorus insecticides

was delivered to the hospital emergency department What medication should be
applied as a first-aid?
A. Atropine*
B. Unitiol
C. Panangin
D. Chlorpromazine
E. Glucose.

58. The patient was taken to the emergency department with complaints
of dryness in the mouth, photophobia and blurred vision. On examination
hyperemic dry skin, dilated pupils, tachycardia were revealed, and poisoning
with belladonna alkaloids was diagnosed. Which of the drugs is advisable to
apply?
A. Neostigmine*
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 B. Pilocarpine
C. Dipiroxim
D. Diazepam
E. Arminum.

59. The patient in the postoperative period to stimulate intestinal

motility and tone of the bladder has been appointed agent of a group of
anticholinesterase. Identify it among the following products:
A. Propranolol (Anaprilin)
B. Mannitol
C. Reserpine
D. Dichlotiazid
E. Neostigmine*.

60. The patient poisoned with carbon monoxide to restore breathing

was treated with analeptic of a reflex type from group of N-cholinomimetics.
Which drug was assigned to the patient?
A. Adrenalin hydrochloride
B. Pentamin
C. Lobeline hydrochloride*
D. Mezaton
E. Atropine sulfate.

61. Specify the M-cholinomimetic used for treatment of glaucoma:

A. Neostigmine methylsulfate
B. Pilocarpine*
C. Adrenaline
D. Norepinephrine
E. Phenylephrine (Mesatonum).

62. Which of the following medicines is anticholinesterase agent:

A. Clonidine
B. Atropine
C. Adrenaline
D. Acetylcholine
E. Neostigmine*.

63. Which group is pilocarpine?

A. M-cholinomimetics*
B. Anticholinesterase
C. Adrenomimetics
D. Adrenoblockers
E. Cholinoblockers.

64. Enter the N-cholinomimetic, which stimulates the reflex of breath:

13
 A. Neostigmine
B. Pilocarpine
C. Lobeline*
D. Atropine
E. Adrenaline.

Cholinoblockers

65. Teenager with fracture of hand was presented to the emergency

room. To perform reposition of fractured bones it was necessary to relax skeletal
muscle. For this purpose myorelaxant causing sustained depolarization of the
post junctional membrane was administered. Which of the following agents was
used?
A. Pancuronium
B. Atracurium
C. D-tubocurarine
D. Succinylcholine*
E. Millectine.

66. Patient suffering from gastric peptic ulcer was treated with
cholinotropic drug selectively blocking M1 cholinoceptors of parietal gastric
glands. Point out this drug?
A. Atropine
B. Plathyphylline
C. Metacine
D. Pirenzepine*
E. Hyoscine (scopolamine).

67. Young boy with burns is brought to emergency ward. There is

history of death of one of his family members due to succinylcholine induction.
So we will avoid succinylcholine because it
A. Causes hyperkalemia
B. Cause hepatotoxicity
C. Causes muscle pains
D. Can trigger malignant hyperthermia*
E. Can cause spasm of masseter muscle.

68. A patient given succinylcholine for skeletal muscle relaxation

during an operation, is not recovered for the last 1 hour. What must be used to
restore spontaneous respiration?
A. Carbogen
B. Lobelin
C. Neostigmine
14
 D. Blood transfusion*
E. Caffeine.

69. A 59 year old man develops excessive salivation and sweating,

diarrhea, and bradycardia while being treated with neostigmine for myasthenia
gravis. Which of the following is the most appropriate therapy for these
symptoms and signs?
A. Atropine*
B. Carbachol
C. Edrophonium
D. Epinephrine
E. Pralidoxime.

70. A patient with symptoms of phosphorganic poisoning was taken to

emergency department. Which of the following drugs mast be used as a drug of
first aid?
A. Unithyolum
B. Potassium chloride
C. Atropine*
D. Chlorpromazine (Aminazine)
E. Glucose.

71. After abdominal surgery performed under general anaesthesia with

non- depolarizing myorelaxant spontaneous respiration was not restored. Which
of the following drugs is to be used as an antidote of non-depolarizing
myorelaxant?
A. Aceclidinum
B. Pilocarpin
C. Neostigmine (Proserin)*
D. Hyascine
E. Isonitrosine.

72. A 5 years old child was taken to toxicological department with

Belladonna poisoning. Alongside with peripheral manifestations the CNS
symptoms were displayed. Which of the following agents has to be administered
as an antidote?
A. Aceclidin
B. Pilocarpin
C. Neostigmine (Proserin)
D. Adrenaline
E. Galanthamine hydrobromide*.

73. For testing refraction of eye atropine was instilled into conjunctival
sac. On completion of the procedure another cholinergic drug was used to
counteract mydriasis and cycloplegia, caused by atropine. Point this drug.
15
 A. Pilocarpine*
B. Lobeline
C. Hyoscine (Scopolamine)
D. Phenylephrine (Mesatonum)
E. Pirenzepine.

74. Administration of pirenzepine in patients with gastric peptic ulcer

is not accompanied by numerous side effects characteristic for atropine and
other M-cholinoblckers due to
A. Inability to penetrate through blood brain barrier
B. Selective inhibition of M1 –cholinoceptors*
C. Inhibition of all types of M –cholinoceptors
D. Inhibition of cholinesterase
E. Significant protein binding.

75. It is known that administration of tubocurarine during surgery can

enhance the development of postoperative paralytic ileus. What is the
mechanism of this side effect of tubocurarine?
A. Inhibition of M –cholinoceptors
B. Inhibition of cholinesterase
C. Ganglion blocking activity*
D. Stimulation of M –cholinoceptors
E. Stimulation of both M – and N-cholinoceptors.

76. Which of the following conditions is alleviated by centrally acting

anti-cholinergic drugs?
A. Depression
B. Multiple sclerosis
C. Mania
D. Parkinsonism*
E. Psychosis.

77. A 50-year-old male farm worker has been brought to the emergency
room. He was found confused in the orchard and since then has remained
unconscious. His heart rate is 45 and his blood pressure is 80/40 mm Hg. He is
sweating and salivating profusely. Which of the following should be prescribed?
A. Pentamine
B. Norepinephrine
C. Physostigmine
D. Atropine*
E. Proserine.

78. Introduction of a pharmaceutical substance to an experimental

animal resulted in reduction of salivation, pupil mydriasis. Next intravenous

16
introduction of acetylcholine didn't lead to any significant changes of heart rate.
Name this substance:
A. Proserin
B. Atropine*
C. Propranolol
D. Adrenaline
E. Salbutamol.

79. A patient had to go through an operation. Doctors introduced him

dithylinum (listenone) and performed intubation. After the end of operation and
cessation of anesthesia the independent respiration wasn't restored. Which
enzyme deficit prolongs the action of muscle relaxant?
A. Pseudocholinesterase*
B. K-Na-adenosine triphosphatase
C. N - acetyltransferase
D. Succinate dehydrogenase
E. Carbanhydrase.

80. A patient with fracture of his lower jaw was admitted to the
maxillofacial department. It was decided to fix his bones surgically under
anaesthetic. After intravenous introduction of muscle relaxant there arose short
fibrillar contractions of the patient's facial muscles. What muscle relaxant was
applied?
A. Dithylinum*
B. Pipecuronium bromide
C. Diazepam
D. Melictine
E. Tubocurarin chloride.

81. If a man has an attack of bronchiospasm it is necessary to reduce

the effect of vagus on smooth muscles of bronchi. What membrane
cytoreceptors should be blocked for this purpose?
A. M-cholinoreceptors*
B. beta-adrenoreceptors
C. alfa- and beta-adrenoreceptors
D. alfa-adrenoreceptors
E. N-cholinoreceptors.

82. The patient with bronchial asthma uses inhaled form M -

holinoblocker. In this case, as a rule, characteristic side effects such as blurred,
constipation tachycardia do not appear. Point out the drug that patient uses.
A. Platifillin
B. Atropine
C. Metacin
D. Ipratropium Bromide*
17
 E. Pirenzepine.

83. For the treatment of patients with essential hypertension doctor

prescribed the drug from the group M – cholinoblocker. Enter the drug.
A. Platyphylline*
B. Atropine
C. Scopolamine
D. Metacin
E. Gastrotsepin.

84. The drug selectively blocking M1 - cholinergic receptors was

assigned to patient suffering from gastric peptic ulcer. What this drug is?
A. Pirenzepine*
B. Atropine
C. Platyphylline
D. Methacinum
E. Scopolamine.

85. A patient with a fracture of the mandible was delivered to the

Maxillofacial department. It was decided to connect the bones surgically under
general anesthesia. After intravenous injection of muscle relaxant transient
fibrillar contractions of facial muscles were observed. What kind of muscle
relaxant was used?
A. Dithylinum*
B. Tubocurarine chloride
C. Pipecuroniub bromide
D. Mellictinum
E. Diazepam.

86. Dentist in order to reduce salivation during the filling of the tooth
prescribed the drug to the patient. What the medicine was prescribed?
A. Adrenalin hydrochloride
B. Phenylephrine (Mezaton)
C. Neostigmine
D. Pilocarpine hydrochloride
E. Atropine sulfate*.

87. Iintroduction of the drug in experimental animals decreases

salivation, dilates pupils, and on the subsequent intravenous injection of
acetylcholine heart rate did not change significantly. Specify the name of the
substance:
A. Propranolol (Anaprilin)
B. Neostigmine methylsulfate
C. Adrenaline
D. Salbutamol
18
 E. Atropine*.

88. Dithylinum was injected to the patient before surgery and

intubation was performed. After the operation, and termination of anesthesia
spontaneous breathing was not restored. Deficiency of which enzyme is
responsible for prolongation of this muscle relaxant action?
A. Carbonic anhydrase
B. Pseudocholinesterase*
C. Succinate dehydrogenase
D. K-Na-ATPase
E. N-acetyltransferase.

89. The preparation of the depolarizing neuromuscular blocking agents

should be assign to the patient with a broken limb for short-lasting surgical
procedure. Choose the drug.
A. Atropine sulfate
B. Pentamin
C. Dithylinum*
D. Cytitonum
E. Tubocurarine chloride.

90. In a patient with myasthenia after the treatment with neostigmine

nausea, diarrhea, and hypersalivation appeared. Point out the drug to eliminate
these side effects.
A. Atropine Sulfate*
B. Phenylephrine (Mezaton)
C. Physostigmine
D. Isoprenaline
E. Pyridostigmine bromide.

91. In poisoned patient dryness of mucous membranes of the mouth and

dilated pupils were observed. What is the mechanism of these symptoms
development?
A. Stimulation of N-cholinergic receptors
B. Stimulation of the M-cholinergic receptors
C. Adrenoceptor blockade
D. M-cholinergic receptor blockade*
E. Stimulation of adrenergic receptors.

92. In the patient with a forearm injury during the bone repositioning
Dithylinum was used for muscle relaxation. Full recovery of muscle tone and
function took more than an hour. What can be the cause of significant
lengthening of the drug’s action?
A. Genetic deficiency of monoamine oxidase
B. Genetic deficiency of butyrylcholinesterase*
19
 C. Inhibition of microsomal oxidation
D. Genetic deficiency of hydroxylase
E. Formation of the active metabolite.

Adrenomimetics and sympathomimetics

93. A patient with bronchial asthma is administered inhalation of 0,5

percent isadrine solution. Bronchospasm was relieved but the patient began
complaining of pain in the heart region and palpitation. It is connected with the
stimulation of :
A. alpha one – adrenoreceptros
B. Beta two – adrenoreceptros
C. Beta one – adrenoreceptros*
D. Acetylchloline synthesis
E. M-chlolinoceptors.

94. Patient with bronchial asthma was taking tablets, which caused
insomnia, headache, increased blood pressure. What medicine can cause such
complications?
A. Chromolin sodium
B. Adrenaline
C. Euphyline
D. Ephedrine*
E. Izadrine.

95. Spasm of smooth muscle of bronchi developed in the patient. Usage

of activators of what membrane cytoreceptors is physiologically valid to
decrease attack?
A. alpha-аdrenoreceptors
B. beta-adrenoreceptors*
C. alpha-and- beta-аdrenoreceptors
D. N-cholinoreceptors
E. М-cholinoreceptors.

96. In the treatment of patient suffering from congestive heart failure

resistant to digitalis adrenomimetic was used as inotropic agent. Point out which
of the following drugs was administered.
A. Phenylephrine
B. Partusisten
C. Dobutamine*
D. Xylometazoline
E. Naphazoline.

20
 97. 63 years patient with symptoms of collapse was admitted into
emergency department. Doctor has chosen noradrenaline to overcome collapse.
What mechanism is responsible for therapeutic effect of this drug?
A. Activation of alfa1 receptors*
B. Activation of beta adrenoceptors
C. Activation of dopaminergic receptors
D. Blockade of M –cholinoceptors
E. Activation of serotonin receptors..

98. Dopamine increases urine production in a shocked patient because

it:
A. Increase cardiac output
B. Decreases aldosterone release
C. Decreases ADH release
D. Causes peripheral vasodilation
E. Causes renal arterial dilation*.

99. To perform fundoscopy ophthalmologist instilled in the eye an

agent capable of causing mydriasis without cycloplegia. Point out this agent.
A. Phenylephrine (Mesatonum)*
B. Noradrenaline
C. Atropine
D. Pilocarpine
E. Isoprenaline (Isadrinum).

100. A patient with bronchial asthma addresses his doctor with

complaints about unpleasant palpitations that occur after usage of inhalation
form of isoprenaline (isadrinum).What is the cause of this side effect?
A. stimulation of alfa1– adrenoceptros
B. stimulation of alfa2– adrenoceptros
C. stimulation of beta1– adrenoceptros*
D. stimulation of beta2– adrenoceptros
E. inhibition of M-chlolinoceptors.

101. A patient with moderate hypertension was treated with the drug that
realizes its effect by decrease in noradrenaline release from sympathetic nerve
endings. While treatment patient experienced drowsiness. What the drug was
used?
A. Prazosin
B. Reserpin*
C. Drotaverine
D. Atenolol
E. Dichlorothiazide.

21
 102. Surgical treatment of benign tumor of prostate in 67- year patient
was postponed instead pharmacotherapy with adrenergic drag was started. Point
out which of the drugs was most probably used.
A. Adrenaline
B. Ephedrine
C. Prazosine*
D. Propranolol (Anaprilinum)
E. Atenolol .

103. A patient has got a spasm of smooth muscles of bronchi. Blockers

of what membrane cytoreceptors are physiologically reasoned to stop an attack?
A. beta-adrenoreceptors
B. M-cholinoreccptors*
C. alpha- and beta-adrenoreceptors
D. H-cholinoreceptors
E. alpha -adrenoreceptors.

104. A patient ill with bronchial asthma didn't inform his doctor that he
had attacks of stenocardia. Doctor administered him a medication, which taking
resulted in less frequent attacks of bronchial asthma. but stenocardia attacks
became more frequent. What medication was administered?
A. Cromolyn sodium
B. Salbutamol
C. Aminophylline
D. Phenotherol
E. Isadrin*.

105. An ophthalmologist used a 1% mesaton solution for the diagnostic

purpose (pupil dilation for eve-ground examination). What is the cause of
mydriasis induced by the drug?
A. Activation of alfa1 adrenoreceptors*
B. Activation of beta1 adrenoreceptors
C. Activation of M-cholinoreceptors
D. Block of alfa1 adrenoreceptors
E. Activation of alfa2 adrenoreceptors.

106. At the doctor's the dentist- surgeon injected 1% - procaine for

conduction anesthesia. It caused the change in patient’s condition: the skin was
covered with sticky and cold sweat, the pulse became almost impalpable,
breathing became rare and weak. Realizing that anaphylactic shock is originated,
a doctor immediately introduced intravenously drug that promptly improved the
patient's condition. Which of the following drugs can be used for first aid in
severe allergic reactions?
A. Ipratropium bromide
B. Labetalol
22
 C. Fenoterol
D. Adrenaline*
E. Dobutamine.

107. A patient with heart failure, resistant to cardiac glycosides was

admitted to hospital. A doctor appointed adrenomimetic as inotropic
(cardiotonic) drug. Which of these adrenomimetic has inotropic (cardiotonic)
action?
A. Dobutamine*
B. Phenylephrine (Mezaton)
C. Naphazoline
D. Fenoterol
E. Halazolin.

108. In the maternity ward there is a pregnant woman with the danger of
miscarriage. Which of the following agents can be used to save the pregnancy?
A. Reserpine
B. Isoprenalin
C. Nicergoline
D. Ephedrine
E. Fenoterol (Partusisten)*.

109. The patient went to the doctor for medical examination. In the
queue while waiting an attack of asthma originated. Which group of drugs is
advisable to use to provide first aid?
A. N - cholinomimetics
B. Sympathomimetics
C. Beta-adrenomimetics*
D. Beta-adrenoblockers
E. M - cholinomimetics.

110. In anesthetic practice adrenaline is usually added to the local

anesthetics to prolong analgesia and reduce side effects. What the effect of
adrenaline contributes to this?
A. Reducing the sensitivity of pain receptors
B. Constriction of blood vessels*
C. Increase in peripheral resistance
D. Stimulation of the antinociceptive system
E. CNS depression.

111. In the course of therapy of a patient a number of complications such

as mydriasis, tachycardia, and increased blood pressure have occurred. Which of
the listed drugs can cause such side effects?
A. Propranolol (Anaprilin)
B. Adrenaline*
23
 C. Phentolamine
D. Isoprenaline
E. Norepinephrine.

112. A patient made an inhalation of medication to relieve an attack of

asthma it quickly improved patient condition but caused tachycardia. Which of
the following agents can lead to such a complication?
A. Fenoterol
B. Atenolol
C. Metoprolol
D. Isoprenaline*
E. Salbutamol.

113. A pregnant woman with a danger of abortion is admitted to

obstetric department. Which of these drugs should be applied to save the
pregnancy?
A. Salbutamol*
B. Oxytocin
C. Neostigmine methylsulfate
D. Dinoproston
E. Quinine.

114. An ambulance was called to women 28 years old in connection with

an attack of asthma. After intramuscular injection of ephedrine her condition
was improved. However, after 49 minutes the attack was repeated, ephedrine
injected once more acted weaker, in the third attack of bronchospasm that
occurred in half an hour, ephedrine did not cause any effect.What is the name of
this phenomenon?
A. Addiction
B. Biotransformation
C. Elimination
D. Adsorption
E. Tachyphylaxis*.

115. In a patient during a visit to the dentist an acute hypotension

occurred. Which of the drugs that stimulate adrenergic structures should be used
to normalize blood pressure?
A. Naphazoline
B. Xylometazoline
C. Phenylephrine (Mezaton)*
D. Ergotamine
E. Doxozasin.

24
 116. In the experimental modeling of mechanism of inotropic effect of
adrenaline activation of one of listed receptors was revealed. Point out these
receptors.
A. M-Cholinergic receptors
B. Beta-1 - adrenoceptors*
C. Beta 2 - adrenergic receptors
D. Alpha 2 - adrenergic receptors
E. Alpha 1 - adrenergic receptors.

117. A patient with acute rhinitis was often applying intranasally 5%

solution of ephedrine hydrochloride. The effectiveness of the drug was declining
with each usage and on the third day disappeared entirely? What is the cause of
rapid decrease in drug’s efficacy (tachyphylaxis)?
A. The progressive decrease in noradrenaline storage in sympathetic
nerve endings*
B. Violation of the synthesis of norepinephrine in the sympathetic
nerve endings
C. The increase in the reuptake of neurotransmitter
D. Adrenoceptor blockade
E. Violation of the process of neurotransmitter release from the depot.

Antiadrenergic drugs sympatholytics

118. The patient with a history of asthma have developed atrial

fibrillation, that requires agent appointment. Which of the listed
antiarrhythmic drug is contraindicated in this case?
A. Nifedipine
B. Verapamil
C. Propranolol (Anaprilin)*
D. Procainainamide
E. Ajmaline.

119. A patient with fibrillation, who has had bronchial asthma in his
anamnesis, should be administered antiarrhythmic drug. Which preparation from
the suggested group is contraindicated for this patient?
A. Ajimaline
B. Verapamil
C. Novocainamide
D. Nifedipine
E. Propranolol (Anapriline )*.

120. 72-year woman suffering from angina pectoris was treated by

propranolol (anaprilinium). On the background of the treatment the cough with
25
bronchospastic components was developed. Doctor replaced propanolol by
atenolol. It results in abolishing of respiratory disturbances. What is the reason
of beneficial effect of atenolol ?
A. Block of M-cholinoreceptors
B. Absence of action upon beta2- adrenoceptors*
C. Stimulating of M-cholonoreceptorsd
D. Inhibition of m-cholinireceptors
E. Absence of action on alfa- adrenoceptors.

121. Doctor prescribed selective alfa1-adrenoceptor blocker for

treatment of hypertensive patient. Which of the following drugs belongs to this
group?
A. Metoprolol
B. Phentolamine
C. Cordarone
D. Tropaphan
E. Doxazosine*.

122. Patient with angina pectoris was treated with drug decreasing
oxygen demands of myocardium. While treatment, patient starts to complain of
extremities coldness especially fingers. Which of the drug was used?
A. Atenolol
B. Propanol (anaprilin)*
C. Reserpine
D. Prazosin
E. Labetalol.

123. Patient with Raynaud disease was treated with phentolamine. What
is the mechanism of action of this drug?
A. Blockade of B-adrenoceptors
B. Blockade of alpha adrenoceptors*
C. Decrease in neurotransmitter amount
D. D Stimulation of central alpha2 adrenoceptors
E. Blockade of central M-cholinoceptors.

124. Patient with initial form of hypertension complains of pain in heart

and tachycardia. Which of the following drugs has to be used in the treatment of
this patient
A. Phentolamine
B. Dihydroergotamine
C. Propranolol (Anaprilin)*
D. Prazosin
E. Guanethidine(Octadinum).

26
 125. Patient having in the past episodes of bronchial asthma addressed
doctor with angina pectoris. Doctor decided to treat patient with B-
adrenoblocker. Which of B-adrenoblocker is not contraindicated in this case?
A. Anapriline(Propranolol)
B. Atenolol*
C. Oxprenolol
D. Pindolol
E. Nadolol.

126. Middle aged woman addressed doctor complaining on the attack of

periodical headache. On examination migraine was diagnosed. Doctor
prescribed anti-adrenergic drug. Point out the most suitable drug.
A. Phentolamine
B. Dihydoergotamine*
C. Atenolol
D. Dopamine
E. Reserpine.

127. For treatment of hypertensive patient doctor prescribed

antiadrenergic drug, first administration of which in therapeutic dose caused
“first dose syncope”. Which drug was most probably used?
A. Metoprolol
B. Atenolol
C. Prazosin*
D. Reserpin
E. Propranolol.

128. A 43 year-old male patient is suffering from hypertension. His

blood pressure was successfully controlled by monotherapy with adrenoblocker.
With time treatment was complicated with diarrhoea and impotence. The patient
addressed his doctor and the drug was changed for another adrenoblocker.
Which of adrenoblockers can cause above listed side effects?
A. Metoprolol
B. Salbutamol
C. Propranolol
D. Dobutamine
E. Prazosin*.

129. In the presence of a beta-blocker, administration of adrenaline is

most likely to cause:
A. Hypoglycemia
B. Hypokalemia
C. Hypertension*
D. Hyperglycemia
E. Hypotension..
27
 130. Doctor prescribed selective alfa1-adrenoceptor blocker for
treatment of hypertensive patient. Which of the following drugs belongs to this
group?
A. Metoprolol
B. Phentolamine
C. Cordarone
D. Tropaphan
E. Prazosin*.

131. A 62-year-old patient, prone to bronchoconstriction, addressed his

doctor with complaints of tachyarrhythmia troubling him several times a day.
The doctor prescribed anaprilin (propranolol). Administration of drug provoked
severe attack of bronchospasm. What is the mechanism of this side effect?
A. Stimulation of M1- cholinoceptors
B. Inhibition of alfa-adrenoceptors
C. Inhibition of beta2 - adrenoceptors*
D. Increase in n. vagus tone
E. Stimulation of leukotriene release.

132. A young woman with 6 months pregnancy visited her doctor

complaining of periodical slight contractions of uterus. To prevent premature
labour doctor prescribed partusisten (fenoterol). What is the mechanism of
action of this drug?
A. Stimulation of beta2 - adrenoceptors*
B. Inhibition of beta2 - adrenoceptors
C. Stimulation of alfa1 - adrenoceptors
D. Inhibition of alfa1 - adrenoceptors
E. Stimulation of M-cholinoceptors.

133. The patient with the initial form of hypertension complains of pain
in the heart and tachycardia. Which of the following drugs should be used in the
treatment of this patient?
A. Prazosin
B. Phentolamine
C. Dihydroergotamine
D. Propranolol (Anaprilin)*
E. Reserpine.

134. A doctor prescribed the drug to the patient with hypertension. The
drug is acting by selective block of alpha 1 - adrenergic receptors. What the drug
was prescribed?
A. Metoprolol
B. Doxazosin*
C. Phentolamine
28
 D. Propranolol (Anaprilin)
E. Reserpine.

135. The patient in case of angina chest pain regularly takes

nitroglycerin, however, recently angina pectoris complicated by extrasystoles
and episodes of bronchospasm. Which of beta - blockers better to appoint for
such a patient?
A. Timolol
B. Propranolol (Anaprilin)
C. Oxprenolol
D. Atenolol*
E. Nadolol.

136. Patients with essential hypertension (stage II) used one of

antihypertensive drugs. After a while blood pressure decreased, but the patient
began to complain of fatigue, sleepiness, apathy. Later on, a pain in the stomach
occurred, and gastric peptic ulcer was diagnosed. What the drug was used?
A. Reserpine*
B. Verapamil
C. Captopril
D. Dibazol
E. Furosemide.

137. A patient with ischemic heart disease was admitted to cardiology

department. To prevent attacks of angina pains drug of beta-1adrenoblockers
was assigned. Name this drug:
A. Metoprolol*
B. Morphine hydrochloride
C. Furosemide
D. Oxytocin
E. Atropine sulfate.

138. Hypertensive patients is taking sympatholytic. Enter the drug.

A. Propranolol (Anaprilin)
B. Reserpine*
C. Adrenaline
D. Atropine
E. Phenylephrine (Mesatonum).

139. Note the non-selective beta-blocker.

A. Mezatonum
B. Atenolol
C. Adrenaline
D. Salbutamol
E. Propranolol (Anaprilin)*.
29
 140. The patient with hypertension was appointed cardioselective beta-
blocker. Which drug is assigned to the patient?
A. Reserpine
B. Propranolol (Anaprilin)
C. Metoprolol*
D. Atropine
E. Adrenaline.

141. To patient with a tachyarrhythmia doctor prescribed a beta-blocker.

Enter the drug.
A. Adrenaline
B. Propranolol (Anaprilin)*
C. Atropine
D. Isoprenaline
E. Salbutamol.

142. The patient suffering from angina takes a selective beta-

adrenoblocker. Enter the drug.
A. Metoprolol*
B. Prazosin
C. Atropine
D. Pilocarpine
E. Propranolol (Anaprilin).

143. Non selective alpha-adrenoblocker is prescribed for diagnostic

purposes to a woman with a suspected pheochromocytoma. Point out this drug
A. Fentolamin*
B. Propranolol (Anaprilin)
C. Salbutamol
D. Phenylephrine (Mesatonum)
E. Clonidine.

The drugs for general anaesthesia

144. To anaesthetize the manipulation connected with burn surface

treatment, a patient was intravenously injected a medication for short-acting
narcosis.1 minute later the patient being under anesthesia had elevated blood
pressure, tachycardia, increased tone of skeletal muscles; the reflex were
reversed. After awakening the patient had disorientation and the visual
hallucination. What medicine was injected to the patient?
A. Sombrevin
B. Thiopental sodium
30
 C. Nitrous oxide
D. Ketamine*
E. Diethyl ether.

145. The anaesthetic used along with halothane to give excellent

analgesia and rapid induction is
A. Nitrous oxide*
B. Thiopental
C. Desflurane
D. Propofol
E. Choroform.

146. To anaesthetize the manipulation related to burn surface treatment,

a patient was intravenously injected a medication for short-acting narcosis. 1
minute later the patient being under anaesthesia had increased blood pressure,
tachycardia, increased tone of sceletal muscles reflexes remained. After
awakening the patient had desorientation and visual hallucinations. What
medication was the patient injected?
A. Nitrous oxide
B. Thiopental sodium
C. Ketamine*
D. Diethyl ether
E. Sombrevin.

147. Dental surgeon made tooth extraction in a patient under general

anesthesia. Which of the following medications can be used in this case for
short-term noninhalation general anesthesia?
A. Ketamine*
B. Predion
C. Thiopental sodium
D. Halothane
E. Nitrogen oxide.

148. To make the treatment of burn surface painless intravenous general

anesthetic for short-term anesthesia was injected to patient. Anesthesia
developed in 1 minute during anesthesia increase in blood pressure, tachycardia,
increase in tone of skeletal muscles have occurred. On the recovery from
anesthesia patient experienced disorientation and visual hallucinations. What is
the drug entered the patient?
A. Ether for anesthesia
B. Sombrevin
C. Ketamine*
D. Thiopental sodium
E. Nitrous oxide.

31
 149. To do a biopsy of breast tumors in 35 years old woman analgesia is
required. What type anesthesia should be used?
A. Potentiated anesthesia with muscle relaxants
B. Combined mixed anesthesia
C. Neurolept-analgesia*
D. Basic anesthesia (Na-hydroxybutyrate)
E. Inhalation anesthesia.

150. A 28 years old woman addressed the dentist about dental

prosthetics. Because she is allergic to local anesthetics, dental treatment was
necessary to carry out under general anesthesia. Which general anesthetic drug
should be used for this purpose, taking into consideration short duration of
manipulation?
A. Sodium hydroxybutyrate
B. Ketamine*
C. Thiopental
D. Halothane
E. Hexobarbital (Hexenalum).

151. To anesthetize the procedure of taking a biopsy in patient a drug

that causes a fast anesthesia lasting about 5 minutes was injected intravenously.
During anesthesia there were involuntary movements, slight decrease in blood
pressure, short-term respiratory arrest, which was quickly restored. What kind of
drug was used?
A. Halothane
B. Ketamine
C. Predion
D. Propanidid*
E. Sodium hydroxybutyrate.

152. Generalized tonic-clonic seizures with loss of consciousness were

periodically occurring in a patient after an injury; these seizures were followed
by a general depression of central nervous system. What the drug should be
assign to prevent seizures?
A. Trihexyphenidyl (Cyclodolum)
B. Midantan
C. Levodopa
D. Disilfiram (Teturam)
E. Phenobarbital*.

153. Identify the drug that has sedative, hypnotic, anesthetic, anti-
hypoxic, myorelaxant actions and it is used as general anesthetic and hypnotic.
A. Sodium hydroxybutyrate*
B. Hexobarbital
C. Chloral hydrate
32
 D. Diazepam
E. Thiopental sodium.

154. The patient takes disulfiram (teturam). What is the indication for
use of this drug?
A. Psychosis
B. Preparation for surgery
C. Fear and anxiety
D. Neurosis
E. Alcoholism*.

Hypnotic, antiepileptic and antiparkinsonian drugs

155. A 5 years old child from time to time have seizures with loss of
consciousness. The doctor diagnosed epilepsy (large seizures). Which drug is
advisable to appoint a patient?
A. Phenobarbital*
B. Benactizin(Amizulum)
C. Trihexyphenidyl (Cyclodolum)
D. Ethosuximide
E. Levodopa.

156. A man aged 68 with trembling hands and incoordination diagnosed

with Parkinson's disease. Which drug is advisable to appoint a patient?
A. Phenytoin
B. Finlepsin
C. Ethosuximide
D. Phenobarbital
E. Trihexyphenidyl (Cyclodolum)*.

157. 40 years woman addressed doctor with complaints of psychic

disturbances appeared with long-term usage of phenobarbital as a hypnotic.
What the drug should be used instead of phenobarbital?
A. Sodium hydroxybutyrate
B. Bromizoval
C. Chloral hydrate
D. Nitrazepam*
E. Noxiron.

158. Due to emotional stress a man permanently is in a state of nervous

tension and has poor sleep. The doctor gave him a diazepam. Which of the
following effects of diazepam is the base for its clinical application in this case?
A. Hypotensive
33
 B. Anxiolytic (Tranquilizing)*
C. Analgesic
D. Anticonvulsant
E. Antidepressant.

159. A patient suffering from insomnia addressed his doctor. The main
problem was in the difficulties with sleep onset. Doctor prescribed zolpidem.
Which of the following characteristics is true for this agent?
A. It belongs to benzodiazepine derivatives
B. It belongs to barbiturates
C. It has the ability to cause quick onset of sleep*
D. It’s poorly absorbed from GIT
E. It’s poorly bind to protein.

160. A 46- year-old patient with a history of epilepsy (grand mal)

developed status epilepticus. Choose the drug to arrest convulsions.
A. Sodium valproate
B. Diazepam*
C. Levodopa
D. Chlorpromazine
E. Droperidol.

161. An antiepileptic drug, which prevents metabolism of GABA, was

included in complex therapy of patient with epilepsy (grand mal). Point out this
drug
A. Phenytoin
B. Phenobarbitone
C. Carbamazepine
D. Ethosuximide
E. Sodium valproate*.

162. Patient with phenobarbital poisoning was presented to emergency

department. To promote kidney excretion of poison sodium bicarbonate was
administered intravenously. What mechanism is responsible for an increase in
barbiturate excretion?
A. Increase in polarity of barbiturate*
B. Increase in fat solubility of barbiturate
C. Increase in barbiturate reabsorption
D. Increase in rate of glomerular filtration
E. Decrease in protein binding.

163. Deficiency in dopamine production by neurons of strio-pallidal

system is considered to be one of the main causes of Parkinson’s disease. Point
out the drug used for replacement therapy of this disease
A. Atropine
34
 B. Dopamine
C. Levodopa*
D. Carbidopa
E. Amantadine.

164. The patient was taken the mixture prescribed by neuropathologist

for neurasthenia for 2 weeks. Patient felt better but developed coryza,
conjunctivitis, rash, inertia, decrease of memory. Bromizm was diagnosed.
What should be prescribed to decrease symptoms?
A. Glucose solution 5%
B. Calcium chloride
C. Natrium chloride*
D. Polyglucin
E. Asparcam.

165. The antiepileptic drug which causes nystagmus, ataxia and gum
hypertrophy is
A. Phenytoin*
B. Phenobarbitone
C. Carbamazepine
D. Ethosuximide
E. Valproic acid.

166. A 16 years boy is a known as patient suffering from epilepsy.

Following several years of a drug therapy, gingival hyperplasia developed. For
which drug this side effect is characteristic?
A. Alprazolam
B. Carbamazepine
C. Valproic acid
D. Ethosuximide
E. Phenytoin*.

167. A woman, which is on phenytoin, wants to conceive. What advice

you can give to her about drug?
A. Increase the dose of phenytoin
B. Change to valproic acid
C. Addition of valproic acid
D. Change to phenobarbitone*
E. Decrease the dose of phenobarbitone.

168. An old epileptic patient on phenytoin is having status eplilepticus.

What will you give to this patient in emergency?
A. Phenytoin
B. Carbamazepine
C. Diazepam*
35
 D. Valproic acid
E. Primidone.

169. Disulfiram is widely used in medical practice to prevent

alcocholism. It inhibits aldehyde dehydrogenase. Increased level of what
metabolite causes aversion to alcochol?
A. Propionic aldehyde
B. Methanol
C. Ethanol
D. Acetaldehyde*
E. Malonyc aldehyde.

Pharmacology of opioid analgesics

170. Very painful uterine contractions have been occurring in a pregnant

woman at normal term. To relieve the woman’s condition during labour, a
doctor decided to use opioid (narcotic) analgesic. Which of the listed drugs can
be used in this case?
A. Trimeperidine (Promedolum)*
B. Morphine
C. Metamizole (Analginum)
D. Papaverine
E. Codeine.

171. A 60-year-old male is brought to emergency room. He is comatose

and his pupils are constricted. Physician suspects opium overdose. What is the
best drug to be administered?
A. Flumazanil
B. Calcium carbonate
C. Sodium bicarbonate
D. Naloxone*
E. Atropine.

172. A young man was taken to emergency department with numerous

traumas of chest and head. Anesthesiologist proposed to inject morphine to
relieve patient’s condition, but traumatologist rejected proposition of his
colleague. Why morphine is contraindicated in this case?
A. It increases intracranial pressure*
B. It stimulates vagal center
C. It decreases intraocular pressure
D. It causes miosis
E. It depresses center of cough reflex.

36
 173. It is known that morphine can cause a shift of blood from
pulmonary to systemic circuit. It results in lowering of resistance in pulmonary
vascular bed. In which case in may be used?
A. Bronchitis
B. Pneumonia
C. Pulmonary oedema*
D. Bronchiectatic disease
E. Emphysema.

174. Patient in unconscious state was admitted to the emergency room.

Skin is cold, pupils are pinpoint like, breathing is heavy, with cycles of the
Cheyne- Stokes type, blood pressure is decreased, urinary bladder is overloaded.
Poisoning with what substance is the most likely?
A. Neosigmin (Proserinum)
B. Sedatives
C. M-cholinergic antagonists
D. Nor-narcotic analgesics
E. Narcotic analgesics*.

175. Examination of a patient revealed extremely myotic pupils,

sleepiness, infrequent Chain-Stoke's respiration. urinary retention, slowing-
down of heart rate, enhancement of spinal reflexes. What substance caused the
poisoning?
A. Atropine
B. Phosphacole
C. Caffeine
D. Morphine*
E. Barbital.

176. A patient with acute morphine poisoning was delivered to a

hospital. What specific narcotic antagonist should be chosen in this case?
A. Unithiol
B. Paracetamol
C. Digoxin
D. Methacin
E. Naloxone*.

177. A young man with an addiction to opioid drugs denies drug

dependence. Introduction of one of these drugs will help to prove drug
dependence. Point out this drug.
A. Morphine
B. Codeine
C. Trimeperidine (Promedol)
D. Fentanyl
E. Pentazocine*.
37
 178. A 30 years old patient was delivered to emergency department with
a fractured thigh bone after a car accident. The patient had dramatically reduced
blood pressure to 70/40 mm Hg, weak pulse, enhanced pain response to touch to
damaged area. What should be used for prevention of traumatic shock in
patient?
A. Metamizol (Analgin)
B. Papaverine
C. Morphine*
D. Paracetamol
E. Pentazocine.

179. The patient with inoperative lung cancer metastasizing in the spine
was suffering from severe pain. To relieve patient's condition analgesic is
required. Which drug should be administered?
A. Analgine
B. Codeine
C. Paracetamol
D. Morphine*
E. Papaverine.

180. On arrival of ambulance a 25 years old patient was unconscious and

15 vials of morphine solution were found near him patient had periodic
breathing, slowed heart rate, suppressed reflexes except for the knee, and
narrowed pupils he was taken to the emergency department. What measure
should be applied in the first place?
A. Gastric lavage*
B. Diuretic
C. Antiarrhythmic drug
D. Enema
E. Induction of vomiting.

181. A child of 4 years is hospitalized to the orthopedic department with

a fractured ankle with displacement. The reposition of bone fragments required
analgesia. What medication should be used?
A. Analgin
B. Promedol*
C. Morphine hydrochloride
D. Panadol
E. Omnopon.

182. Choose a specific antagonist of narcotic analgesics.

A. Caffeine-sodium benzoate
B. Ethimizol
C. Bemegride
38
 D. Strychnine
E. Naloxone*.

183. A patient with symptoms of renal colic is admitted to the urology

department. Which of these drugs should be advised to provide him first aid?
A. Morphine
B. Trimeperidine (Promedol)*
C. Pentazocine
D. Fentanyl
E. Tramadol.

184. A patient with dislocation of shoulder was admitted to

traumatologic department. The reduction of dislocation should be performed
under neuroleptanalgesia. Chose the opioid analgesic used for this purpose.
A. Naloxone
B. Cordiamin
C. Morphine
D. Ethimizol
E. Fentanyl*.

Pharmacology of nonopioid analgesics

185. A 67 year-old male patient suffering from arthritis was treating

himself with acetyl salicylic acid (aspirin). In 2 weeks patient addressed doctor
complaining of pain in epigastric area. On examination of the patient doctor
prescribed anti-inflammatory agent, selectively inhibiting COX–2. Point out this
drug.
A. Paracetamole
B. Diclophenac-sodium
C. Celecoxib*
D. Metamisole (Analginum)
E. Indomethacine.

186. In complex treatment of a patient with angina pectoris non- narcotic

analgesic exerting antiplatelet activity was included. Point out this agent.
A. Meperidine
B. Morphine
C. Tramadol
D. Metamizole
E. Aspirin*.

187. Due to inhibition of COX aspirin exerts all the following effects
except
39
 A. Anti-inflammatory
B. Antiplatelet
C. Increase in warfarin efficacy*
D. Antipyretic
E. Analgesic.

188. A patient with toothache was relieving his pain with help of
metamizole (analginum). Point out another useful effect of this drug that
contributes to the improvement of patient’s condition
A. Sedative effect
B. Anti-inflammatory effect*
C. AntIplatelet effect
D. Antioxidative effect
E. Antimicrobial effect.

189. The usage of acetylsalicylic acid resulted in occurrence of

epigastric pain in patient. On examination of the patient gastric ulcer was
revealed. What the mechanism is responsible for ulcerogenity of this drug?
A. Stimulation of pepsin secretion
B. Inhibition of prostaglandin synthesis*
C. Increase in bile production and its reflux
D. Spasm of vessels
E. Spasm of gastric smooth muscles.

190. Doctor visited a 5-year-old child with fever and complaints of

headache. Doctor suspected the onset of viral infection. To relieve patient’s
condition doctor prescribed non-opioid analgesic, which additionally exerts
antipyretic effect but lacks anti-inflammatory action. Point out the prescribed
drug
A. Metamizole (Analginum)
B. Celecoxib
C. Aspirin
D. Acetaminophen (Paracetamol)*
E. Diclophenac-sodium.

191. After the usage of acetylsalicylic acid a patient developed epigastric

pain because of exacerbation of his ulcer. What is the mechanism of this drug
ulcerogenity?
A. Stimulation of pepsin secretion
B. Antiprostagladinic effect*
C. Cholagogic effect
D. Spasm of vessels
E. Immunodepressive effect.

192. Point out non- narcotic analgesic, which exerts antiplatelet activity.
40
 A. Meperidine
B. Morphine
C. Tramadol
D. Metamizole
E. Aspirin*.

193. A 2-year-old child is often catching a cold with fever. Which

antipyretic drug is safer at this age than acetylsalicylic acid?
A. Analgin
B. Indomethacin
C. Paracetamol*
D. Phenylbutazone
E. Phenylbutasone.

194. A 7 year child have caught cold, he was shivering, fever up to 39,2
° C, his respiratory rate - 45 per minute, pulse - 105 beats per minute. The doctor
diagnosed an acute viral infection, and appointed a baby aspirin. By means of
what mechanism the drug realized its antipyretic effect in this case?
A. The overall calming effect
B. Slowing down heartbeat
C. Increase in heat output*
D. Slowing of the respiratory rhythm
E. Reduction of heat production.

Neuroleptics, antianxiety, and sedative agents

195. A patient was treated for psychosis for 2 weeks. The psychic
patient's condition improved but rigidity, tremor, and hypokinesia developed.
Which of the drugs can cause such complications?
A. Diazepam
B. Chlorpromazine (Aminazine)*
C. Amytriptiline
D. Piracetam
E. Chlordiazepoxide.

196. A 60 years old woman addressed her doctor complaining of side

effects which appeared while treatment with chlorpromazine (aminazinum). She
was troubled with tremor and disturbances of movements. What is the
mechanism of this side effect?
A. Activation of hyppocampus
B. Inhibition of reticular formation (alfa1 - adrenoceptors)
C. Inhibition of neostriatum (D2 receptors)*
D. Inhibition of hypothalamus
41
 E. Inhibition of hyppocampus.

197. A 50 years old patient with chronic alcoholism became aggressive.

To abolish aggression, chlorpromazine was administered intramuscularly. The
patient’s attempt to rise soon after an injection resulted in loss of consciousness.
What is the probable cause of such complication?
A. Blockade of reticular formation
B. Disturbance of coronary blood circulation
C. Blockade of alfa- adrenoceptors*
D. Inhibition of hypothamus
E. Blockade of M- cholinoceptors.

198. After emotional stress, patient was permanently in a condition of

nervous tension and had poor sleep. Doctor prescribed him diazepam. Which
of the listed effects of this drug is responsible for its clinical use?
A. Hypotensive effect
B. Analgesic effect
C. Anticonvulsant
D. Tranquilizing*
E. Anti psychotic.

199. Point out the neuroleptic that is most commonly used in

neuroleptanalgesia.
A. Chlorpromazine
B. Droperidol*
C. Diazepam
D. Chlorprotixene
E. Sulpiride.

200. A patient on a particular psychotropic medication complains of

severe dizziness. His blood pressure in a supine position is 115/80 mm hg on
standing it drops to 82/50 mm hg. Which of the following drugs is most likely
responsible for these symptoms?
A. Carbamazepine
B. Chlorprozamine*
C. Chlordiazepoxide
D. Cortisone
E. Ibuprofen.

201. A patient has been taking a mixture prescribed by neuropathologist

for neurasthenia for two weeks. The patient feels better but has developed
coryza, conjunctivitis, rash, inertia, decrease of memory. She is diagnosed with
bromizm. What should be prescribed to decrease the
A. Glucose solution 5%
B. Polyglucin
42
 C. Asparcam
D. Natrium chloride*
E. Kalium chloride.

202. A patient who has been treated in a neural clinic and has been
taking a sedative for a long time got the following complication: cough, rhinitis,
epiphora. What drug caused these disturbances?
A. Sodium bromide*
B. Valerian
C. Phenazepam
D. Reserpine
E. Diazepam.

203. Select the most appropriate drug for the systematic treatment of a
patient with severe productive psychotic symptoms (delirium and
hallucinations).
A. Trifluoperazine (Triftazin)*
B. Clozapine
C. Medazepam
D. Amitriptyline
E. Buspirone.

204. Neuroleptics have the properties of eliviating delusions,

hallucinations, reducing of aggression and psychomotor agitation. This action is
called:
A. Antipsychotic*
B. Hypodynamic
C. Antihysteric
D. Anxiolytic
E. Antineurotic.

205. A 40 years patient delivered to psychiatric clinic in a state of

agitation, aggression, delusions. What medication should be administered?
A. Sodium bromide
B. Chlorpromazine*
C. Reserpine
D. Tincture of valerian
E. Amitriptyline.

206. The patient with schizophrenia was appointed chlorpromazine.

What the pharmacological effect is the basis for assigning it to the patient?
A. Hypothermic
B. Hypotensive
C. Antipsychotic*
D. Antiemetic
43
 E. Myorelaxant.

207. A patient addressed a doctor complaining of anxiety, fear,

uneasiness, inner tension. Which drug should be assigned?
A. Tincture of valerian
B. Pavlov Medicine
C. Diazepam*
D. Tincture of leonuri
E. Etaminal sodium.

208. On examination of the patient, unstable blood pressure, irritability,

emotional imbalance, poor sleep were revealed, and doctor has prescribed
chlordiazepoxide (elenium). Which of the following statements is ground for
prescription elenium in this case?
A. Psychosis
B. Cardiopathy
C. Hypertention
D. Coronary artery disease
E. Neurosis*.

209. The presence of which syndrome is the basis for the appointment of
diazepam?
A. Lingering paralysis
B. Inadequate perceptions (hallucinations)
C. Euphoric state of pathological origin
D. Anxiety*
E. Pathological thought disorder.

210. Patient 38 years old suffering from schizophrenia for a long time is
on the psychotropic drugs. He addressed the doctor with complaints of
disturbances of motor coordination, hand tremor, drowsiness. Which group of
drugs can cause such a condition?
A. Antipsychotics*
B. Antidepressants
C. Analgesics
D. Adaptogens
E. Psychomotor stimulants.

211. A single parenteral administration of the drug in the patient with

schizophrenia caused severe hypotension. To which of these groups does drug
belong?
A. Nootropics
B. Antipsychotics*
C. Tranquilizers
D. Antidepressants
44
 E. CNS stimulants.

212. A patient with acute myocardial infarction experienced persistent

chest pain. The ineffectiveness of drugs previously designated gave the grounds
for doctor to use neuroleptanalgesia. Which antipsychotic agent is used for this
type of anesthesia?
A. Chlorpromazine
B. Triftazinum
C. Metaperazine
D. Droperidol*
E. Thioridazine.

213. A patient with schizophrenia is taking typical neuroleptic. Which of

the effects is the basis for its application in schizophrenia?
A. Antipsychotic*
B. Antiemetic
C. Hypothermic
D. Myorelaxant
E. Hypotensive.

214. A patient addressed the doctor with complaints of poor health,

depression, skin rashes. An interview revealed that the patient within three
weeks was taking sedative medicine, prescribed by a neurologist. With the
admission of which drugs complaints of patient were associated?
A. Bromides*
B. Lithium
C. Tranquilizers
D. Antipsychotics
E. Preparations of valerianae.

Psychotropic stimulating agents. Antidepressants.

Psychomotostimulants. Analeptics. Nootropic drugs

215. A patient with poisoning caused by carbon monoxide was

administered directly acting analeptic drug. What medicine was used?
A. Codeine
B. Ephedrine
C. Caffeine*
D. Atropine sulfate
E. Lobeline.

45
 216. A premature newborn was apnoic. Directly acting analeptic drug
was given to restore breathing. What medicine was most probably administered
to the patient?
A. Ethymisolum*
B. Phenylephrine (Mesatonum)
C. Adrenaline hydrochloride
D. Atropine sulfate
E. Lobeline hydrochloride.

217. A psychiatrist was invited to a patient who made an attempt to

commit suicide. Doctor diagnosed endogenous depression. Choose the most
suitable drug for treatment of this patient.
A. Nootropil (piracetam)
B. Amytriptyline*
C. Sydnocarbum
D. Ethymisolum
E. Caffeine.

218. A patient had a stroke. Which of the listed drugs is necessary to

include in the complex therapy in order to improve mental performance?
A. Caffeine
B. Piracetam*
C. Diazepam
D. Phenazepam
E. Amitryptiline.

219. What is the main mechanism by which amitriptyline increases

amount of catecholamines in CNS synapses?
A. Increase in catecholamines release from presynaptic membrane
B. Increase in catecholamines synthesis in presynaptic membrane
C. Prevention of catecholamines degradation in the synapse
D. Inhibition of neuronal re uptake of catecholamines*
E. Inhibition of MAO.

220. Analeptical directly acting drug was given to the patient for
restoration of breathing after poisoning with carbon monoxide. What medicine
was prescribed to the patient?
A. Pentamin
B. Mesaton
C. Caffeine*
D. Atropine sulphate
E. Lobeline hydrochloride.

221. Which of the following characteristics of amphetamines is most

likely to be responsible for increasing blood pressure?
46
 A. Indirect release of endogenous catecholamines*
B. Inhibition of catecholamines metabolism
C. Metabolism to false neuro-chemical transmitters
D. Potent alpha1 adrenergic transmitters
E. Potent beta-2 adrenergic agonist.

222. The CNS stimulation produced by methylxanthines, such as

caffeine, is most likely due to the antagonism of one of the following recertors:
A. Glycine receptors
B. Adenosine receptors*
C. Glutamate receptors
D. GABA receptors
E. Cholinergic muscarinic receptors.

223. A patient who has been treated with diazepam on account of

neurosis complains of toothache. Doctor administered him an analgetic, but its
dose was lower then average therapeutic dose. What phenomenon did the doctor
take into account while prescribing the patient an underdose?
A. Drug dependence
B. Cumulation
C. Tolerance
D. Summation
E. Potentation*.

224. Pharmacological effects of antidepressants are connected with

inhibitionof an enzyme catalyzing biogenic amines noradrenaline and serotonine
in the mitochondrions of cerebral neurons. What enzyme participates in this
process?
A. Lyase
B. Monoamine oxidase*
C. Transaminase
D. Peptidase
E. Decarboxylase.

225. A psychiatrist was called for the woman who tried to commit
suicide on examination the state of endogenous depression was diagnosed.
Which drug is most efficient for treatment of this patient?
A. Piracetam (Nootropil)
B. Amitriptyline*
C. Sydnokarb
D. Aethimizolum
E. Caffeine.

226. Which agent will you choose for increase in mental performance
and decrease of tiredness?
47
 A. Buspirone
B. Nialamide
C. Sidnokarb
D. Imipramine
E. Caffeine*.

227. Doctor recommended taking caffeine the patient with pathological

sleepiness.Which of the following mechanisms of action provides its therapeutic
effect in this disease?
A. The concentration and increased inhibition in the cerebral cortex
B. Increased synthesis of dopamine
C. Enhancement the processes of excitation in the brain*
D. Inhibition of the midbrain reticular formation
E. The weakening of the excitation in the brain.

228. Point out preferable analeptic in acute barbiturate poisoning

A. Cordiaminum
B. Caffeine
C. Camphor
D. Bemegride*
E. Aethimizolum.

229. The patient had a stroke. Which of the following drugs should be
included in the combined therapy to improve the metabolism of the brain?
A. Piracetam*
B. Caffeine
C. Diazepam
D. Phenazepam
E. Amitriptyline.

230. Which the drug from the group of psychomotor stimulants can
cause the development of drug addiction?
A. Amphetamin (Phenaminum)*
B. Meridil
C. Sidnokarb
D. Bemithylum
E. Caffeine.

231. Which of the following effects of piracetam is used for chronic

vascular disorders of the brain?
A. Anticonvulsant activity
B. Improvement of mental performance*
C. Antiwithdrawal effect
D. Improvement of physical activity
E. Antipsychotic effect.
48
 232. The patient complains of fatigue, general weakness, decrease in
visual acuty, low blood pressure. Which drug is helpful in this case?
A. Liquid extract of Eleutherococcus*
B. Phenibut
C. Piracetam
D. Dry extract of Valeriana
E. Amitriptyline.

233. The primary goal of medical aid in vascular collapse is an increase

in blood pressure. Which of the following medications can be used for this
purpose?
A. Aethimizolum
B. Diphenhydramine
C. Bemegride
D. Caffeine-sodium benzoate*
E. Ketotifen.

234. A patient admitted to the neurological department complains of

memory loss and cognitive disability after trauma of the head. What kind of
medication is needed to improve the metabolism of the brain?
A. Caffeine
B. Metamizole (Analginum)
C. Piracetam (nootropil)*
D. Sidnokarb
E. Meridil.

235. A psychiatrist was called for the woman who tried to commit
suicide on examination the state of endogenous depression was diagnosed.
Which drug is most efficient for treatment of this patient?
A. Piracetam (Nootropil)
B. Amitriptyline*
C. Sydnokarbum
D. Aethimizolum
E. Caffeine.

236. Which agent will you choose for increase in mental performance
and decrease of tiredness?
A. Nialamide
B. Diazepam
C. Imipramine
D. Buspirone
E. Caffeine*.

49
 237. When should you expect for a specific therapeutic effect of
pantocrinum in its systematic application?
A. After 9-15 days*
B. After 30-60 minutes
C. 1-3 days
D. After 30-45 days
E. After 3-6 hours.

238. Doctor recommended taking caffeine the patient with pathological

sleepiness. Which of the following mechanisms of action provides its
therapeutic effect in this disease?
A. Enhancement the processes of excitation in the brain*
B. Increased synthesis of dopamine
C. The concentration and increased inhibition in the cerebral cortex
D. Inhibition of the midbrain reticular formation
E. The weakening of the excitation in the brain.

239. Point out preferable analeptic in acute barbiturate poisoning

A. Caffeine
B. Bemegride*
C. Camphor
D. Cordiaminum
E. Aethimizolum.

240. The patient had a stroke. Which of the following drugs should be
included in the combined therapy to improve the metabolism of the brain?
A. Caffeine
B. Diazepam
C. Piracetam*
D. Phenazepam
E. Amitriptyline.

241. The primary goal of medical aid in vascular collapse is an increase

in blood pressure. Which of the following medications can be used for this
purpose?
A. Diphenhydramine
B. Bemegride
C. Caffeine-sodium benzoate*
D. Aethimizolum
E. Ketotifen.

242. A patient admitted to the neurological department complains of

memory loss and cognitive disability after trauma of the head. What kind of
medication is needed to improve the metabolism of the brain?
A. Piracetam (nootropil)*
50
 B. Metamizole (Analginum)
C. Caffeine
D. Sydnokarbum
E. Meridil.

243. Which of the following tonics is derived from animal products?

A. Tincture ginseng
B. Pantocrine*
C. Saparalum
D. Ecdistenum
E. Securininum.

244. Among the antidepressant drugs there are those that inhibit
neuronal norepinephrine reuptake. Point out such drug.
A. Fluoxetine
B. Nialamide
C. Chlorprothixene
D. Chlorpromazine
E. Maprotilime*.

245. Mark pharmacological effect, limiting the use of strychnine as

analeptic.
A. Stiffness in skeletal muscle, convulsions*
B. Hypercatharsis
C. Increased metabolism
D. Strengthening of sight and hearing
E. Impact on hematopoiesis.

246. What drug from the group of analeptics is preferable to use in

newborn asphyxia?
A. Caffeine
B. Aethimizolum*
C. Camphor
D. Cordiaminum
E. Corazolum.

247. A 19 years old boy addressed doctor complaining of discomfort in

the heart area. Doctor asked him about smoking and other bad habits. Patient
denied all of mentioned bad habits, and sad he likes coffee and uses up to 8
glasses of strong drink a day. Why coffee containing caffeine can worsen heart
function?
A. It causes tachycardia, increases in oxygen demand of the heart*
B. It slows impulse conduction in the heart
C. It weakens the force of heart contractions
D. It causes a narrowing of the coronary vessels
51
 E. It decreases automaticity of the heart.

248. What is the mechanism of action of antidepressant pirlindol

(pirazidol)?
A. The reversible inhibition of MAO*
B. Irreversible inhibition of MAO
C. Selective inhibition of neuronal capture of catecholamines
D. Non-selective inhibition of neuronal capture catecholamines
E. Inhibitor of vesicular capture catecholamines.

249. A patient with symptoms of mental depression in the drug treatment

did not keep the doctor recommended a diet that caused the rise in blood
pressure. Which group of antidepressants requires compliance in this condition?
A. Tricyclic antidepressant
B. Nonselective MAO inhibitors*
C. Selective inhibitors of catecholamines reuptake
D. Lithium preparations
E. Nonselective inhibitors of neuronal reuptake of catecholamine

52
Drugs acting on respiratory system

250. Analeptic remedy of reflective type from the N-cholinomemetics

group was given to the patient for restoration of breathing after poisoning
with carbon monoxide. What medicine was prescribed to the patient?
A. Adrenalin hydrochloride
B. Lobeline hydrochloride*
C. Mesaton
D. Pentamin
E. Atropine sulfate.

251. In complex therapy of bronchial asthma myotropic spasmolytic

drug was added. Soon after its usage, nervousness and sleep disturbances
occurred. Which of the following drugs can cause above-mentioned side
effect?
A. Papaverine
B. Platyphilline
C. Aminophylline *
D. Drotaverine
E. Ephedrine .

252. A 5 year-old –child was suffering from bronchitis, accompanied

with a productive cough with thick sputum. In addition to antimicrobial
treatment a mucolytic drug was prescribed. This drug was especially
beneficial for the child due to its ability to stimulate production of
surfactant. Point out this drug
A. Codeine
B. Ambroxolum*
C. Oxeladine
D. Ethylmorphine
E. Potassium iodide.

253. Severe attack of bronchospasm and cough occurred in a patient with

bronchial asthma. Choose the best drug for quick relief of the patient
condition.
A. Ipratropium bromide
B. Orciprenaline sulfate
C. Atropine
D. Adrenaline*
E. Noradrenaline.

254. A patient with bronchial asthma had been taking tablets which
caused insomnia, headache, increased blood pressure. What medecine can
cause such complications?
A. Ephedrine*
B. Chromolin sodium
 C. Euphyline
D. Adrenaline
E. Izadrine.

255. A 13-year-old girl with history of asthma complained of cough,

dyspnea and wheezing. Her symptoms became so severe that her parents
brought her to the emergency room. Physical examination revealed
diaphoresis, dyspnea, tachycardia and tachypnea. Her respiratory rate was
42/min. pulse rate was 110 beats per minute, and blood pressure was
l30/70 mm Hg. Choose from the following list the most appropriate drug
to reverse the bronchoconstriction rapidly:
A. Methylprednidsolone
B. Salbutamol*
C. Beclomethasone
D. Cromolyn
E. Ipratropium.

256. Apnoic newborn was resuscitated by administration of respiratory

stimulant.Which agent is the drug of first choice in this case?
A. Bemegridum
B. Aethimisolum*
C. Lobeline
D. Codeine
E. Camphor.

257. In complex treatment of patient with bronchial asthma cromolyn-

sodium was included as antiallergic agent. What is the mechanism of this
drug action?
A. Inhibition of histaminic H1 receptors
B. Inhibition of histaminic H2 receptors
C. Prevention of mast cell degranulation*
D. Inhibition of antigen-antibody interaction
E. Blockade of D2 receptors.

258. Severe attack of bronchospasm and cough occur in patient with

bronchial asthma. Choose the best drug for quick relieve of patient
condition.
A. Ipratropium bromide
B. Orciprenaline sulfate
C. Atropine
D. Adrenaline*
E. Noradrenaline.

54
259. Patient with bronchial asthma was taking tablets, which caused
insomnia, headache, increased blood pressure. What medicine can cause
such complications?
A. Izadrine
B. Adrenaline
C. Chromolin sodium
D. Euphyline
E. Ephedrine*.

260. In complex therapy of bronchial asthma myotropic spasmolytic

drug was included. Soon after its usage nervousness and sleep
disturbances occurred. Which of the following drugs can cause above-
mentioned side effect?
A. Papaverine
B. Platyphilline
C. Aminophylline*
D. Drotaverine
E. Ephedrine.

261. A patient suffering from chronic bronchitis takes a synthetic

mucolytic drug that facilitates the sputum thinning. What drug is it?
A. Acetylcysteine*
B. Diazepam
C. Heparin
D. Furosemide
E. Enalapril.

262. A patient suffering from bronchial asthma didn't inform his doctor
that he had attacks of angina pectoris(stenocardia). Doctor administered
him a drug, which usage resulted in less frequent attacks of bronchial
asthma, but stenocardia (anginal) attacks became more frequent. What
medication was administered?
A. Isadrin (Isoprenalin)*
B. Salbutamol
C. Aminophylline
D. Cromolyn sodium
E. Phenotherol.

263. A 70-year-old man, who suffered from chronic bronchitis, was

prescribed medicine for the cough - codeine. What is the mechanism of
antitussive effect?
A. Central*
B. Reflex
C. Competitive
D. Local effect
55
 E. Peripheral effect.

264. In long lusting usage of fenoterol in bronchial asthma its

bronchodilating effect is gradually decreasing. What is probable cause of
tolerance development?
A. Worsening of absorption
B. Decrease in numbers of beta-adrenoceptors*
C. Enhancement of binding with plasma albumin
D. Enhancement of elimination
E. Decrease in numbers of Gs-proteins.

265. To terminate an attack of asthma patients used inhalation of the

drug that is used by inhalation as bronchodilators, and in injections it is
used in obstetric practice to prevent miscarriages. What drug was used by
patient?
A. Fenoterol*
B. Atenolol
C. Adrenaline
D. Ephedrine
E. Euphylline.

266. In patient with bronchial asthma attacks usually occur at night, they
are accompanied by bradycardia, spasmodic pains in the intestines,
diarrhea. Preparation of which group can eliminate these symptoms?
A. H2-histaminoblockers
B. N-cholinoblockers
C. M cholinoblockers*
D. Alpha-blockers
E. Beta-blockers.

267. A patient with respiratory depression was admitted to hospital.

Drugs of which pharmacological group stimulate breathing in such case?
A. Antidepressants
B. Tranquilizers
C. Antipsychotics
D. Analeptics*
E. Analgesics.

268. Asthmatic patient was assigned to inhalation of 0.5% solution

(isoprenalin) isadrinum. Bronchospasm was relieved, but the patient
began to complain of pain in the heart and heartbeat. This is due to the
stimulation of:
A. Beta2-adrenergic
B. Alpha1-adrenoceptor
C. M-cholinergic
56
 D. Beta1-adrenergic*
E. Synthesis of acetylcholine.

269. Patient suffering from bronchitis with poorly separated sputum

started taking acetylcysteine. Name the mechanism of mucolytic action of
the drug.
A. Reflex stimulates the secretion of bronchial glands
B. Stimulates the cough center
C. Increases the secretion of bronchial mucus
D. Depolymerizes sputum*
E. Increases bronchial contraction.

270. A patient with severe attacks of asthma that was not stopped by
earlier effective beta-adrenoceptor agonists was admitted to the intensive
care unit Diagnosis: asthma, asthmatic status. What drug should be
administered the patient in the first place?
A. Adrenaline*
B. Acyclovir
C. Prednisone
D. Famotidine
E. Fenoterol.

271. A 25 y.o. patient in the dental office suddenly developed an attack

of asthma. The doctor gave the patient salbutamol to inhale. What is the
mechanism of action of this drug?
A. Stimulates the alpha-adrenergic
B. Blocks histamine H1 receptors
C. Blocks M-cholinergic
D. Stimulates beta2-adrenergic receptors*
E. Blocks phosphodiesterase.

272. For patient suffering of pneumonia and cough with thick poorly
separated sputum doctor prescribed expectorant drug that activates the
synthesis of surfactant in the lungs. What the drug was prescribed?
A. Acetylcysteine
B. Infusion of herb Thermopsis
C. Glaucin
D. Trypsin
E. Lasolvan (Ambroxol)*.

273. To suppress dry cough in patient with chronic bronchitis doctor

prescribed antitussive - glaucine hydrochloride. What is the mechanism of
action of this drug?
A. Resorptive central*
B. M-cholinergic blockade
57
 C. Reflex
D. Antienzymatic
E. Peripheral.

274. Exhausting cough with fetid odor appeared in patient with lobar
pneumonia. Which of the following agents should be used in this case?
A. Famotidine
B. Mesaton
C. Fenoterol
D. Acyclovir
E. Trypsin*.

Cardiac glycosides and other inotropic drugs. Antiarrhythmic drugs.

275. Which of the following drugs is most likely to produce positive

inotropic and negative chronotropic effects?
A. Nitroglycerin
B. Furosemide
C. Diltiazem
D. Procainamide
E. Digoxin.*.

276. Choose the inotropic drug for treatment of patient suffering from
congestive heart failure, not responding to digitalis.
A. Phenylephrine
B. Dobutamine*
C. Clonidine
D. Noradrenaline
E. Salbutamol.

277. A patient who has been suffering from cardiac insufficiency for
several months has been taking digoxin on an outpatient basis. At a
certain stage of treatment there appeared symptoms of drug overdose.
What phenomenon underlies the development of this complication?
A. Functional cumulation
B. Tachyphylaxis
C. Habituation
D. Sensibilization
E. Material cumulation*.

278. A 50 y.o. patient with chronic cardiac insufficiency and

tachyarrythmia was prescribed cardiotonic drug. What drug was
prescribed?
58
 A. Dobutamine
B. Mildronate
C. Amyodarone
D. Digoxin*
E. Dopamine.

279. A patient suffering from chronic cardiac insufficiency was

recommended to undergo a prophylactic course of treatment with a
cardiological drug from the group of cardiac glycosides that is to be taken
enterally. What drug was recommended?
A. Corglycon
B. Cordiamin
C. Strophanthine
D. Cordarone
E. Digoxin*.

280. A patient that entered the admission office had the following signs
of acute cardiac insuffiency: paleness, acrocyanosis, frequent shallow
respiration. What drug is indicated in this case?
A. Corglycon*
B. Adrenaline hydrochloride
C. Nitroglycerine
D. Cordiamin
E. Digitoxin.

281. To maintain normal sinus rhythm in patient with atrial fibrillation

the doctor prescribed an antiarrhythmic drug. After laboratory testing of
thyroid function administration of this drug was withdrawn. What drug
was initially prescribed?
A. Verapamil
B. Amiodarone*
C. Quinidine
D. Procainamide
E. Lidocaine.

282. Patient suffering from tachyarrhythmia was treated with calcium

channel blocker. What drug was used?
A. Niphedipine
B. Verapamil*
C. Labetolol
D. Alprenolol
E. Nicardipine.

283. A 52 year old patient with supraventricular tachyarrhythmia was

using antiarrhythmic drug of class III. For a long period it maintained the
59
 normal cardiac rhythm, but with time dispnoe started to occur while going
upstairs. Patient addressed doctor. The examination revealed pulmonary
sclerosis. Which of the antiarrhythmic drug can cause such side effect?
A. Verapamil
B. Amiodarone*
C. Bretylium
D. Lidocaine
E. Procainamide.

284. Digoxin in tablets was prescribed to patient with chronic congestive

heart failure. After 1 month of treatment decrease in heart rate was noted
doctor advised the patient to continue treatment with lower dose of
digoxin. In spite of this the bradycardia was soon transformed into A-V-
block. Choose the necessary drug for abolishing of this manifestation of
glycoside toxicity.
A. Potassium chloride
B. Phenytoin
C. Atropine*
D. Lidocaine
E. Propranolol.

285. A pregnant woman addressed her doctor complying of frequent

heartbeats. Which of antiarrhythmic agents is contraindicated in this
case?
A. Atenolol
B. Propranolol*
C. Metoprolol
D. Verapamil
E. Diltiazem.

286. Patient with chronic congestive heart developed tachyarrhythmia.

Which of the listed drugs is contraindicated in this case?
A. Quinidine*
B. Lidocaine
C. Timecaine
D. Phenytoin
E. Ajmaline.

287. In the treatment of patient suffering from congestive heart failure

resistant to digitalis adrenomimetic was used as inotropic agent. Point out
which of the following drugs was administered.
A. Phenylephrine
B. Partusisten
C. Dobutamine*
D. Xylometazoline
60
 E. Naphazoline

288. A 62-year-old patient, prone to bronchoconstriction, addressed his

doctor with complaints of tachyarrhythmia troubling him several times a
day. The doctor prescribed anaprilin (propranolol). Administration of
drug provoked severe attack of bronchospasm. What is the mechanism of
this side effect?
A. Stimulation of M1- cholinoceptors
B. Inhibition of α-adrenoceptors
C. Inhibition of β2 - adrenoceptors*
D. Increase in n. vagus tone
E. Stimulation of leukotriene release

289. A patient with fibrillation, who has had bronchial asthma in his
anamnesis, should be administered antiarrhythmic drug. Which
preparation from the suggested drugs is contraindicated for this patient?
A. Ajimaline
B. Verapamil
C. Novocainamide
D. Nifedipine
E. Anapriline (Propranolol)*

290. A 55-year-old patient with persisting ventricular arrhythmia was

admitted to the hospital. The patient is taking Timolol drops for
glaucoma, daily insulin injections for diabetes mellitus, and an ACE
inhibitor for hypertension. You have decided to use phenytoin instead of
procainamide. What is the reason?
A. The total anesthetic effect of procaninamide would aggravate the
hypertension
B. The anticholinergic effect of procainamide would aggravate
glaucoma*
C. The local aneathetic effect of procainamaide would potentiate
diabetes
D. The hypertensive effects of procainamide would aggravate the
hypertension
E. The cholinergic effects of procainamide would aggravate the diabetes

291. A patient with chronic cardiac insufficiency has been treated with
cardiotonic drugs and a thiazide diuretic, but in spite of it there are still
edemata and risk of ascites. What medication should be prescribed to
amplify diuretic effect of the applied drugs?
A. Furosemide
B. Spironolactone*
C. Amyloride
D. Clopamide
61
 E. Mannitol

292. A patient takes digoxin for treatment of cardiac insufficiency. What

diuretic may increase digoxin toxicity due to the intensified excretion of
K+ ions?
A. Spironolactone
B. Hydrochlorothiazide*
C. Panangine
D. Siliborum
E. Lisinopril

293. A patient suffers from chronic left-ventricular insufficiency. What

medication should be administered?
A. Digoxin*
B. Bemegride
C. Aethimizolum
D. Vinpocetine
E. Pyracetam

294. Patient suffering from acute cardiac failure was treated with
nonglycoside inotropic drug inhibiting phosphodiesterase III. Which drug
was used?
A. Mildronate
B. Dopamine
C. Dobutamine
D. Amyodarone
E. Amrinone*

295. Patient complains of weakness, dyspnea, low extremities oedema.

Diagnosis: chronic cardiac insufficiency. What medicine should be
prescribed first of all?
A. Caffeine
B. Digitoxin*
C. Papaverine
D. Propranolol
E. Raunatin

Diuretics.

296. Point out antihypertensive agent that increases salts and H2O
excretion and can causes hyperglycemia and uric acid retention?
A. Nifedipine
B. Propranolol
62
 C. Prazosin
D. Hydrochlorothiazide*
E. Acetazoleamide (Diacarbum).

297. A 67- year-old man treated with hydrochlorothiazide for control of

mild hypertension visited his doctor complaining of pains in joints. Which
of the listed side effects is the most probable cause of patient’s
complains?
A. Hyperglycemia
B. Hyperuricemia*
C. Drug hypersensitivity
D. Hyperkalemia
E. Hypokalemia.

298. A patient suffering from hypertension was treated with

hydrochlorothiazide. With time he addressed doctor complaining of
worsening of his condition. On examination of the patient hypokalemia
was diagnosed. Choose the drug, which has to be added aiming at
enhancement of diuretic effect and abolishing of hypokalemia.
A. Acetazolamide
B. Furosemide
C. Ethacrynic acid
D. Spironolactone*
E. Chlorothiazide.

299. A patient with acute poisoning was admitted to emergency

department. It was established that poisonous substance was excreted by
kidney. Choose the best diuretic for forced diuresis.
A. Acetazolamide
B. Amiloride
C. Spironolactone
D. Furosemide*
E. Hydrochlorothiazide.

300. A 42-year-old man suffering from gout has increased level of

urinary acid in blood. Allopurinol was prescribed to decrease the level of
urinary acid. Competitive inhibitor of what enzyme is allopurinol?
A. Xanthine oxidase*
B. Guanine deaminase
C. Adenosine deaminase
D. Hypoxanthine phosphoribosiltransferase
E. Adenine phosphoribosiltransferase.

63
301. A doctor administered Allopurinol to a 26-year-old young man with
the symptoms of gout. What pharmacological action of Allopurinol
ensures therapeutical effect?
A. By inhibiting leucocyte migration into the joint
B. By general analgetic effect
C. By increasing uric acid excretion
D. By general anti-inflammatory effect
E. By inhibiting uric acid synthesis*.

302. The alternate usage or dichlotiazide, etacrin acid and lasex did not
influence diuretically upon the patient with marked peripheral edemata.
The aldosterone rate in the blood is increased. Indicate which medicine
should be prescribed:
A. Urea
B. Amilorid
C. Clopamid
D. Spironolacton*
E. Mannit.

303. A patient with chronic cardiac insufficiency has been treated with
cardiotonic drugs and a thiazide diuretic, but in spite of it there are still
edemata and risk of ascites. What medication should be prescribed to
amplify diuretic effect of the applied drugs?
A. Spironolactone*
B. Furosemide
C. Manitole
D. Clopamide
E. Amyloride.

304. A patient takes digoxin for treatment of cardiac insufficiency. What

diuretic may increase digoxin toxicity due to the intensified excretion of
K+ ions?
A. Lisinopril
B. Panangine
C. Siliborum
D. Spironolactone
E. Hydrochlorothiazide*

305. Highly potent diuretic drug was prescribed to the patient with
pulmonary edema in the course of complex treatment. In a few days signs
of hypokaliemia were developed. What drug could cause such
complications?
A. Furosemide (Lasix)*
B. Spironolactone
C. Acetazolamide
64
 D. Triamterene
E. Enalapril

306. For treatment of hypertensive patient doctor prescribed diuretic

agent. It resulted in sufficient control of BP, but soon patient addressed
doctor, complaining of pain in joints. Which diuretic was used?
A. Spironolactone
B. Hydrochlorothiazide*
C. Clonidine
D. Triamterene
E. Enalapril

307. A patient with chronic cardiac insufficiency has been treated with
cardiotonic drugs and a thiazide diuretic, but in spite of it there are still
edema and risk of ascite. What medication should be prescribed to
amplify diuretic effect of the applied drugs?
A. Spironolactone*
B. Furosemide
C. Amyloride
D. Clopamide
E. Mannitol

308. Diuretic drug was prescribed to the patient with hypertension in the
course of complex treatment. In a few days BP decreased but signs of
hypokaliemia developed. What drug could cause such complications?
A. Spironolactone
B. Clophelin
C. Lasix (Furosemide)*
D. Triamterene
E. Enalapril

309. A 65 year old female patient suffers from chronic renal

insufficiency accompanied by evident edemata caused by chronic
glomerulonephritis. What diuretic should be administered for forced
diuresis?
A. Furosemide*
B. Hydrochlorothiazide
C. Chlorthalidone
D. Cyclometazide
E. Acetazolamide

65
 Antihypertensive drugs. Antihyperlilpidemic agents

310. A hypertensive patient was treated with the drug suppressing the
formation of angiotensin II and preventing degradation of bradykinine.
Point out the drug realizing antihypertensive effect by these mechanisms.
A. Nifedipine
B. Guanethidine
C. Clonidine
D. Enalapril*
E. Propranolol.

311. A hypertensive patient was fond of meat dishes and did not keep
proper diet. In the course of complex antihypertensive treatment an acute
attack of gout developed. Which of the following agents is responsible for
worsening of patient condition?
A. Hydrochlorothiazide*
B. Prazosin
C. Allopurinol
D. Acetazolamide
E. Propranolol.

312. The blood pressure of hypertensive patient is successfully

controlled by administration of enalapril. Which mechanism is
responsible for antihypertensive effect of this drug?
A. Inhibition of peripheral alpha1 - adrenoceptors
B. Blockade of angiotensin II receptors
C. Inhibition of renin release
D. Inhibition of kallikrein – kinin system
E. ACE inhibition and stimulation of kalliкrein – kinin system*.

313. Metabolism can render pharmacological activity to some initially

inert substances (pro-drug). Point out the substance, which is pro-drug,
used for treatment of hypertension.
A. Levodopa
B. Enalapril*
C. Verapamil
D. Reserpine
E. Propranolol.

314. Hypertensive patient was treated with the drug that decreases
vascular tone. His treatment was complicated by persistent dry cough.
Which drug most probably was used?
A. Papaverine
B. Phentolamine
66
 C. Lisinopril*
D. Prazosin
E. Clonidine.

315. For treatment of hypertensive patient doctor prescribed captopril,

but soon patient addressed doctor, complaining of dry cough and rashes.
Doctor substituted captopril for losartan. What is the mechanism of the
last drug action?
A. Inhibition of renin release
B. Inhibition of ACE
C. Inhibition of angiotensinogen conversion to angiotensin I
D. Blockade of angiotensin II receptors*
E. Increase in bradykinin level.

316. A patient with II stage hypertension has been taking one of

hypotensive medications for the purpose of treatment. After a time arterial
pressure decreased, but the patient started complaining of flaccidity,
sleepiness, indifference. A bit later he felt stomach pain. He was
diagnosed with ulcer. What hypotensive medication has the patient been
taking?
A. Captopril
B. Dibazoie
C. Reserpine*
D. Furosemide
E. Verapamil.

317. A patient taking clonidine for essential hypertension treatment was

using alcohol that caused intense inhibition of central nervous system.
What may it be connected with?
A. Intoxication
B. Idiosyncrasy
C. Cumulation
D. Effect potentiating*
E. Effect summation.

318. A patient with hypertensic crisis was admitted to the cardiological

department, he was injected intravenously with an antihypertensive drug -
salt of an alkaline-earth metal. What drug was injected?
A. Benzohexamethonium
B. Potassium chloride
C. C Sodium hydrocarbonate
D. Magnesium sulfate*
E. Caleium lactate.

67
319. For treatment of hypertensive patient doctor prescribed
antiadrenergic drug, first administration of which in therapeutic dose
caused “first dose syncope”. Which drug was most probably used?
A. Metoprolol
B. Atenolol
C. Prazosin*
D. Reserpin
E. Propranolol

320. A 43 year-old male patient is suffering from hypertension. His

blood pressure was successfully controlled by monotherapy with
adrenoblocker. With time treatment was complicated with diarrhea and
impotence. The patient addressed his doctor and the drug was changed for
another adrenoblocker. Which of adrenoblockers can cause above listed
side effects?
A. Metoprolol
B. Salbutamol
C. Propranolol
D. Dobutamine
E. Prazosin*

321. Which of the following antiadrenergic drugs used in the treatment

of hypertension is contraindicated in patients prone to bronchospasm?
A. Prazosin
B. Metoprolol
C. Reserpine
D. Atenolol
E. Propranolol (Anaprilinum)*

322. Point out antihypertensive agent that increases salts and H2O
excretion and can cause hyperglycemia and uric acid retention?
A. Nifedipine
B. Propranolol
C. Prazosin
D. Hydrochlorothiazide*
E. Acetazoleamide (Diacarbum)

323. A patient suffering from hypertension was treated with

hydrochlorothiazide. With time he addressed doctor complaining of
worsening of his condition. On examination of the patient hypokalemia
was diagnosed. Choose the drug, which has to be added aiming at
enhancement of diuretic effect and abolishing of hypokalemia.
A. Acetazolamide
B. Furosemide
C. Ethacrynic acid
68
 D. Spironolactone*
E. Chlorothiazide

324. A patient with moderate hypertension was treated with the drug that
realizes its effect by decrease in noradrenaline release from sympathetic
nerve endings. While treatment patient experienced drowsiness. What the
drug was used?
A. Prazosin
B. Reserpin*
C. Drotaverine
D. Atenolol
E. Dichlorothiazide

325. Phenofibrate was prescribed for a patient with a history of angina

pectoris and high plasma cholesterol level. What is the mechanism of
action of this drug?
A. Activation of lipoprotein lipolysis*
B. Inhibition of lipoprotein lipase
C. Inhibition of hydroxymethyl glutaryl coenzyme A
D. Inhibition of DL oxidation
E. Bile acid sequestration

326. In complex treatment of hypertensive patient antiatherogenic agent

that decreases synthesis of cholesterol was included. Point out this agent.
A. Cholestyramine
B. Colestipol
C. Fenofibrate
D. Simvastatin*
E. Probucol

327. Point out the most atherogenic lipoproteins

A. Chylomicrons (Chy)
B. Low density lipoproteins (LDL)*
C. Very low-density lipoproteins (VLDL)
D. High-density lipoproteins (HDL)
E. Intermediate density lipoproteins (IDL)

328. A 64 –year-old patient addressed doctor complaining of vertigo and

ringing in ears. On examination the disturbance of brain blood circulation
was diagnosed. Doctor prescribed the drug that is vinca alkaloid
derivative. Which drug was prescribed?
A. Cinnarizine
B. alfa-Tokopherol
C. Vinpocetine*
D. Xantinol nicotinate
69
 E. Parmidin

329. Point out the class of lipoprotein that facilitates the removal of
cholesterol from tissues
A. Chylomicrons (Chy)
B. Low density lipoproteins (LDL)
C. Very low-density lipoproteins (VLDL)
D. High-density lipoproteins (HDL)*
E. Intermediate density lipoproteins (IDL)

330. A 60 year-old patient with angina pectoris visited her doctor for
routine examination. Blood sampling revealed elevated level of
cholesterol in the plasma. Due to this antisclerotic drug was added to
antianginal therapy. The effect of prescribed drug is based upon the
inhibition of cholesterol synthesis by suppression of HMG-CoA reductase
activity. What the drug was prescribed?
A. Nicotinic acid
B. Probucol
C. Lovastatin*
D. Clofibrate
E. Colestipol

331. Patient with moderate hypertension was treated with the drug,
decreasing heat work and renin release, and causing coldness of hands as
a side effect. What the drug was used?
A. Prazosin
B. Propranolol*
C. Spironolacton
D. Atenolol
E. Dichlorothiazide

332. Blood pressure of hypertensive patient is successfully controlled by

administration of enalapril. Which mechanism is responsible for
antihypertensive effect of this drug?
A. Inhibition of peripheral alpha –1 adrenoceptors
B. Blockade of angiotensin II receptors
C. Inhibition of renin release
D. Inhibition of kallikrein – kinin system
E. ACE inhibition and enhancement of kalliкrein – kinin system*

333. A 60 year-old patient suffering from hypertension was prescribe

drug inhibiting RAS that inhibits rennin directly. Point out this drug.
A. Enalapril
B. Verapamil
C. Reserpine
70
 D. Propranolol
E. Aliskiren*

334. A 66 year old female patient got intravenous injection of

magnesium sulfate solution for the purpose of elimination of hypertensive
crisis. But arterial pressure didn't go down and after repeated
introduction of the same preparation there appered sluggishness, slow
response, inhibition of consciousness and respiration. What preparation
is antagonist of magnesium sulfate and can eliminate symptoms of its
overdose?
A. Calcium chloride*
B. Potassium chloride
C. Sodium chloride
D. Activated carbon
E. Potassium permanganate
Antianginal drugs

335. A patient with angina pectoris was helping himself with

nitroglycerin. One day the patient used nitroglycerin several times
because of frequent episodes of pain. So as the last sublingual
administration of nitroglycerin did not relieve pain, the patient addressed
his doctor. Doctor advised him to withdraw nitroglycerin for 8 hours and
prescribed another drug. After 8 hours the effect of nitroglycerin was
restored. Which phenomenon did take place in this case?
A. Increase in nitroglycerin metabolism
B. Increase in protein binding
C. Decrease of absorption
D. Drug dependence
E. Tolerance *.

336. A patient with Raynaud disease was treated with niphedipine.

What is the mechanism of action of this drug?
A. Blockade of B-adrenoceptors
B. Blockade of alpha adrenoceptors
C. Decrease in neurotransmitter amount
D. Calcium channels’ blockade*
E. Blockade of central M-cholinoceptors.

337. To prevent the onset of myocardial infarction in a patient with

angina pectoris aspirin was used. Due to which of listed effects aspirin is
beneficial in this case?
A. Antiinflammatory
B. Antiplatelet*
C. Analgesic
71
 D. Antipyretic
E. Ulcerogenic.

338. After a tooth extraction a patient felt persistent pain behind his
breast bone. After sublingual intake of an antianginal drug the pain behind
the breast bone disappeared, but the patient complained of headache and
dizziness. What drug are these properties typical for?
A. Validol
B. Verapamil
C. Nitroglycerin*
D. Metoprolol
E. Propranolol.

339. In complex treatment of a patient with angina pectoris non- narcotic

analgesic exerting antiplatelet activity was included. Point out this agent.
A. Meperidine
B. Morphine
C. Tramadol
D. Metamizole
E. Aspirin*

340. A 72-year woman suffering from angina pectoris was treated by

propranolol (anaprilinium). On the background of the treatment cough
with bronchospastic components was developed. Doctor replaced
propanolol with metoprolol. This resulted in abolishing of respiratory
disturbances. What is the reason for the beneficial effect of metoprolol?
A. Block of M-cholinoceptors
B. Absence of action upon β2- adrenoceptors*
C. Stimulating of M-cholinoceptors
D. Inhibition of m-cholinireceptors
E. Absence of action on α- adrenoceptors

341. A patient with myocardial infarction was treated with

intravenous infusion of heparin. What is the goal of this drug
administration?
A. To cause the lysis of thrombus directly
B. To transform plasminogen into plasmin
C. To prevent further thrombosis*
D. To prevent platelets activation
E. To decrease the area of necrosis

342. It is necessary to prevent the onset of myocardial infarction in

patient with angina pectoris. Choose the drug with antiplatelet and
vasodilating effects.
A. Ticlopidine
72
 B. Dipiridamole*
C. Aspirin
D. Nifedipine
E. Verapamil

343. Patient complains of weakness, dyspnea, low extremities

oedema. Diagnosis: chronic cardiac insufficiency. What medicine
should be prescribed first of all?
A. Digitoxin*
B. Caffeine
C. Papaverine
D. Propranolol
E. Raunatin

344. Myocardial infarction patient was treated with streptokinase. What

is the mechanism of thrombolytic action of this drug?
A. Formation of active complex with proactivator of plasminogen*
B. Direct activation of plasminogen
C. Prevention of prothrombin conversion to thrombin
D. Prevention of fibrin formation
E. Direct lysis of thrombus

345. 72-year-old patient with angina pectoris was prescribed

dipyridamole. Administration of drug resulted in worsening of patient
condition and doctor substituted dipyridamole by long acting organic
nitrate. What was the most probable cause of worsening?
A. Lack of coronary vessels dilation
B. Increase in oxygen demand
C. “Coronary steal phenomenon”*
D. Decrease in arterial pressure
E. Decrease in venous pressure

346. A patient who had myocardial infarction was prescribed 75 mg of

acetylsalicylic acid a day. What is the purpose of this administration?
A. Reduction of platelet (thrombocyte) aggregation *
B. Inflammation reduction
C. Pain relief
D. Temperature reduction
E. Coronary vessel dilatation

347. Anapriline (Propranolol) therapy caused positive effect in the

dynamic of the disease of a 44-year-old woman suffering from
stenocardia (angina pectoris). What is the main mechanism of the effect
of this medicine?
A. Blockade of β-adrenoreceptors and decrease myocardial requirements

73
 to the oxygen.*
B. Decrease of oxidative exchange in myocardium due to enzyme
blockade of Krebs' cycle
C. Decreased power inputs of myocardium due to reduced loading
D. Increased oxygen supply to the myocardium
E. Decreased need in increasing of oxygen supply to the myocardium

348. A patient suffering from coronary artery disease had taken a certain
drug many times a day in order to arrest stenocardia attacks. Overdose of
this drug finally caused intoxication. Objectively: cyanotic skin and
mucous membranes, dramatic fall in the arterial pressure, tachycardia,
respiration inhibition. Blood has increased concentration of
methemoglobin. The drug the patient had taken relates to the following
group:
A. Organic nitrates*
B. Alpha-adrenoceptor blockers
C. Calcium channel blockers
D. Adenosine drugs
E. Myotropic spamolytics

349. A patient suffers from stenocardia and takes isosorbide

mononitrate. He was prescribed a complementary drug with
disaggregating effect. What drug is it?
A. Acetylsalicylic acid*
B. Nitroglycerine
C. Propranolol
D. Nifedipine
E. Validol

350. A patient with coronary artery disease was admitted to the

cardiological department. For stenocardia (angina pectoris) prevention a
drug from the group of beta-adrenoceptor blockers was administered.
What drug is it?
A. Metoprolol*
B. Atropine sulfate
C. Morphine hydrochloride
D. Oxytocin
E. Furosemide

351. A patient with frequent attacks of stenocardia was prescribed

sustak-forte to be taken one tablet twice a day. At first the effect was
positive but on the second day stenocardia attacks resumed. What can
explain inefficiency of the prescribed drug?
A. Tachyphylaxis*
B. Cumulation
74
 C. Sensibilization
D. Idiosyncrasy
E. Dependence

Drugs affecting GIT

352. Patient with gastric peptic ulcer addressed his doctor. After
examination doctor prescribed famotidine aiming at inhibition of gastric
acid secretion. What is the mechanism of this drag action?
A. Inhibition of proton pump
B. Neutralization of gastric acid
C. Prevention of histamine release
D. Blockade of H1 histamine receptors
E. Blockade of H2 histamine receptors*.

353. A young woman with breast cancer after surgery was treated with a
chemotherapeutic complex. At the very beginning of treatment the patient
experienced much distressing nausea and vomiting. Choose the best agent
to relieve patient’s condition
A. Hyoscine (Aeronum)
B. Diphenhydramine (Dimedrolum)
C. Validolum
D. Chlorpromazine (Aminazinum)
E. Metoclopramide*.

354. Patient with gastric peptic ulcer was treated with omeprazole. This
agent is capable of decreasing in HCl production because it
A. Neutralizes gastric acid
B. Blocks H2 –histamine receptors
C. Inhibits the H+, K+-ATPase proton pump*
D. Coats gastric mucosa
E. Blocks muscarinic receptors.

355. A 45-year-old woman presents to the emergency room with severe

epigastric pain. On the base of patient examination and laboratory
findings an acute pancreatitis is diagnosed. Which of the drugs is to be
administered in this case?
A. Pancreatin
B. Mezym forte
C. Contrycal*
D. Morphine
E. Fentanyl.

75
356. A patient addressed doctor with complaints of heartburn often
troubling him. On examination ulcerative esophagitis was diagnosed and
inhibitor of proton pomp was prescribed. Which of the following drugs
was prescribed?
A. Cimetidine
B. Ranitidine
C. Omeprazole*
D. Misoprostol
E. Metronidazole.

357. A 37-year-old man was admitted to the surgical department with the
symptoms of acute pancreatitis: vomiting, diarrhea, bradycardia,
hypotention, weakness, dehydration of the organism. What medicine
should be used first of all?
A. Ephedrine
B. Platyphylline
C. No-spa
D. Etaperazine
E. Contrycal*.

358. A liquidator of a breakdown at a nuclear power plant who was

irradiated complained about vomiting that occurs all of a sudden. What
medication should be prescribed?
A. Metoclopramide*
B. Aeron
C. Reserpine
D. De-Nol
E. Atropine.

359. Examination of a 35 year old patient revealed high acidity of gastric

juice. What receptors should be blocked in order to reduce it?
A. alpha 1-adrenoreceptors
B. beta2-adrenoreceptors
C. beta1 -adrenoreceptors
D. alpha2-adrenoreceptors
E. Histamine*.

360. For treatment of biliary tract dyskinesia ( hypokinetic type) doctor

prescribed cholagogue, referring to the group holekinetics. Indicate the
drug
A. Magnesium sulfate (gavage)*
B. Alloholum
C. Cholenzymum
D. Oxafenamid
E. Cholosasum.
76
361. Aged patient is suffering from constipation for a long time. Which
synthetic laxatives should be proposed in this case?
A. Atropine
B. Bisacodyl*
C. Castor oil
D. Liquid paraffin
E. Magnesium sulfate.

362. A patient suffering from gastric ulcer with hyperacidic syndrome

was admitted to hospital. The drug of which group should be used in the
treatment of the patient?
A. Nonsteroidal anti-inflammatory drugs
B. Calcium channel blockers
C. Steroidal anti-inflammatory drugs
D. Blockers H1 histamine receptor
E. H2 histamine receptors lockers*.

363. For patients with peptic ulcer the drug inhibiting the growth and
reproduction of H.pylori was prescribed as a causal treatment. Name the
drug:
A. Corglyconum
B. Glauvent
C. Metronidazole*
D. Furosemide
E. Prazosin.

364. A 46 years old patient was complained of stomach pain, heartburn.

During examination increased gastric acidity was revealed. What should
be assigned to neutralize the acidity of gastric juice?
A. Papaverine
B. Atropine Sulfate
C. Almagel*
D. Neostigmine
E. Benzohexonium.

365. Patients with peptic ulcer of the duodenum uses famotidine. What is
the group of this drug?
A. Beta-agonists
B. Alpha-adrenergic agonists
C. Antiholinesterase
D. H2-blockers of histamine receptors*
E. Irritant.

77
366. A patient with exacerbation of duodenal peptic ulcer was admitted
to hospital The analysis showed an increased gastric secretion and acid-
forming function of the stomach. Choose a product that will reduce the
secretory function of the stomach by blocking histamine H2-receptor?
A. Famotidine*
B. Atropine Sulfate
C. Plathyphylline
D. Dry extract of belladonna
E. Metacin.

367. A pregnant woman is suffering from heartburn. Which agent is the

best?
A. Ranitidine
B. Sodium bicarbonate
C. Omeprazole
D. Almagel*
E. Bismuth sulfate.

368. The doctor prescribed bisacodyl for patient suffering from chronic
constipation. What pharmaceutical group is the drug?
A. Narcotic analgesics
B. Laxatives*
C. Antihypertensives
D. Blockers H2-histamine receptor
E. Diuretics.

369. A 45 –year-old women is suffering from chronic pancreatitis.

Doctor prescribed her complex preparation containing pancreatic enzymes
and dried bile. Point out prescribed drug.
A. Allocholum
B. Pancreatin
C. Aprotinin
D. Festal*
E. Cholenzymum.

370. A patient with cholecystitis relieves periodical attacks of pain with

myotropic spasmolytic drug. Which of listed agents is used?
A. Drotaverine(No-spa)*
B. Ephedrine
C. Pancreatin
D. Aprotinin
E. Atropine.

371. Patient addressed doctor complaining of periodically occurring

dyspepsia. Laboratory tests did not reveal pathogens that can be
78
 responsible for diarrhoea. Choose the drug the most beneficial in this
case.
A. Atropine
B. Platyphylline
C. Papaverine
D. Bisacodyl
E. Loperamide*.

372. Patient with chronic hepatitis was prescribed complex preparation

with hepatoprotecting properties. Preparation contains essential
phospholipids and vitamins. Point out this preparation
A. Legalon
B. Essentiale*
C. Liv-52
D. Siliborum
E. Papaverine.

373. 25 year-old man was hospitalized to gastroenterology department

with complaints of "hungry" pain, a feeling of heaviness in the stomach,
heartburn. Doctor prescribed gastrocepin (pirenzepine). What effect of
gastrocepin (pirenzepine) was the base for choice of a physician?
A. Relaxation of biliary tract muscle
B. Relaxation of smooth muscles of the stomach
C. Reduction of gastric acid secretion and gastrin*
D. Destruction of Helycobacter pylori
E. Reduction of trypsin secretion .

374. Usage of sodium bicarbonate in peptic ulcer with high acidity gives
temporary relief. What is the cause of short lasting effect of drug in this
case?
A. The formation of carbon dioxide stimulating a secondary
hypersecretion*
B. Neutralization of hydrochloric acid
C. Stimulation of histamine H2-receptors
D. Stimulation of the gastric M-cholinergic receptors
E. Accumulation of histamine.

375. The patient has hyperacidic gastritis. Specify the drug with the
mechanism realized by blocking of proton pump (H +-K +-ATPase) used
in the combined therapy.
A. Gastrocepin (pirenzepine)
B. Omeprazole*
C. Misoprostol
D. Atropine sulfate
E. Almagel.
79
376. A patient with chronic hyperacidic gastritis to relieve heartburn is
using antacid, it gives prompt effect, but it is accompanied by unpleasant
feeling of fullness in the stomach. Which of the drugs can cause this side
effect?
A. Magnesium trisilicate
B. Aluminum hydroxide
C. Pepsin
D. Magnesium oxide
E. Sodium bicarbonate*.

377. A complex treatment of gastric peptic ulcers includes famotidine.

What is the mechanism of this drug action?
A. M-cholinergic blockade
B. The blockade of proton pump (H +, K +-ATPase)
C. Blockade of H2 histamine receptors*
D. Antacid effect
E. Local anesthetic effect on the mucous membrane of the stomach..

378. A patient has complex treatment of gastric peptic ulcers;

concomitant disease is glaucoma. Drugs of which group in this connection
should not be included in antiulcer therapy?
A. Myotropic antispasmodics
B. Blockers H2-histamine receptor
C. Antacid
D. Cholinoblockers*
E. Gastroprotectors.

379. Almagel was prescribed for patient with gastric ulcer. What is the
mechanism of drug action?
A. The neutralization of hydrochloric acid*
B. Local anesthetic action
C. The blockade of the H2 histamine receptor
D. M-cholinergic blockade
E. Adsorption of alkaline foods.

Drugs acting on haemopoises and haemostasis

380. The patient was using levomycetin for a long time without control,
his examination revealed a decrease in leukocyte count in the blood.
Which drug should be used for stimulation leukopoiesis?
A. Methotrexate
B. Prednisolone
80
 C. Pentoxyluv*
D. Mercaptopurine
E. Cyanocobalamin.

381. Severe anemia occurred in patients after gastric resection on

account of ulceration. What medicine has to be assigned along with
improvement of nutrition?
A. Ferroceronum
B. Cyanocobalamin*
C. Methyluracilum
D. Iron sulfate
E. Coamidum.

382. Blood test revealed anemia in the patient with megaloblastic forms
of red cells, due to this cyanocobalamin was assigned for treatment. At
what type of anemia this vitamin preparation is indicated?
A. Hyperchromic anemia*
B. Hypoplastic
C. Hemolytic
D. Aplastic anemia
E. Hypochromic anemia.

383. Hypochromic anemia appeared in patient due to internal bleeding.

Which of these drugs can provide rapid recovery of red blood cells?
A. Cobamamid
B. Heparin
C. Sirepar
D. Furosemide
E. Ferum-Lek*.

384. After radiation therapy the myelo depressive reaction in the form of
leukopenia appeared in patient. Which of the following drugs should be
applied to stimulate leukopoiesis?
A. Vitogepat
B. Ferropleks
C. Hemostimulin
D. Sodium nucleinat*
E. Nicotinic acid.

385. In the patient that had long history of stomach disease

hyperchromic anemia was found. Which of the following agents is to be
prescribed for this disease?
A. Ascorbic acid
B. Cyanocobalamin*
C. Unithiolum
81
 D. Ferum-Lek
E. Oxyferriscorbone sodium.

386. Iron deficiency anemia is very common among pregnant women,

complicating pregnancy, childbirth, adversely affects the fetus and
newborn. Propose for the treatment such anemia preparation of ferrous
iron for oral administration.
A. Ferkoven
B. Ferrum-lek
C. Hemostimulin
D. Koamidum
E. Iron ferrous lactate*.

387. Patients suffering from angina and receiving isosorbide

mononitrate, was appointed an additional drug with antiplatelet effect.
Identify the drug:
A. Validolum
B. Nitroglycerine
C. Nifedipine
D. Aspirin*
E. Inderal.

388. The child emerged bleeding from the nose. Which of the following
drugs can stop it?
A. Thrombin*
B. Fibrinolysin
C. Vicasolum (Menadione)
D. Potassium chloride
E. Ethamzylatum.

389. Massive bleeding began in woman after separation of the placenta.

Which of the drug you need to help in this case?
A. Thrombin
B. Fibrinolysin
C. Aminocapronic acid*
D. Fepromaronum
E. Vicasolum (Menadion).

390. Gastric bleeding appeared in the patient. Which of these drugs can
stop it?
A. Folic acid
B. Thrombin
C. Sodium citrate
D. Sodium oxalate
E. Fibrinogen*.
82
391. Anticoagulant therapy with heparin was performed in patient with
myocardial infarction. What preparation should be used to continue
treatment after withdrawal of heparin to prevent recurrence of
thrombosis?
A. Neodikumarinum*
B. Calcium chloride
C. Furosemide
D. Fibrinolysin
E. Sodium hydrocitrate.

392. Analysis of the patient's blood showed an increased number of red

blood cells and hemoglobin that is characteristic of polycythemia. Which
of these drugs should be prescribed for a patient?
A. Kobamamid
B. Contrycal
C. Vitogepatum
D. Imiphosum*
E. Pentoxylum.

393. To stop heavy uterine bleeding ergot alkaloid that increases

myometrium tone was selected. Which of listed agents is of this group?
A. Oxytocin
B. Ergometrine*
C. Neostigmin
D. Aminocapronic acid
E. Fenoterol.

394. Direct acting anticoagulant was prescribed for patients prone to

thrombosis. Point out the drug:
A. Aminocaproic acid
B. Vicasolum (Menadione)
C. Neodikumarin
D. Sinkumar
E. Heparin*.

395. Before tooth extraction a patient was advised to take a certain drug
for hemorrhage prevention. What drug was advised?
A. Heparin
B. Vicasolum (Menadione)*
C. Asparcam
D. Magnesium sulfate
E. Dimedrolum.

83
396. A patient with essential hypertension was recommended a drug that
prevents thrombosis. This drug exerts antiplatelet and coronary dilating
effects. What drug is it?
A. Heparin
B. Dipiridamole*
C. Protamine sulfate
D. Neodicumarin
E. Syncumar.

397. In acute thrombosis intravenous heparin rlieves the patient's

condition. Which of these mechanisms is responsible for effect of
heparin?
A. Dissolution of fresh thrombus
B. Inhibition of the transformation of prothrombin to thrombin in the
blood*
C. Inhibition of the synthesis of prothrombin in the liver
D. Reduction of the number of calcium ions in the blood
E. Influence on the retraction of the clot.

398. In the laboratory experimental studies in vitro and in vivo

antagonist of direct anticoagulant was selected for the clinical use. What
could be the preparation of these?
A. Protamine sulfate*
B. Sodium citrate
C. Contrycal
D. Menadione
E. Calcium chloride.

399. Massive uterine bleeding in woman was stopped by introducing

aminocaproic acid. Which of listed mechanisms contributed to hemostatic
effect of this drug?
A. Inhibition of fibrinolysis*
B. Activation of fibrinolysis
C. Increased prothrombin in the blood
D. Increasing calcium in the blood
E. Increased synthesis of prothrombin in the liver.

400. 8 year-old child is preparing for tonsillectomy. Blood analysis

showed clotting time increased to 7 minutes. What medication should be
included in a complex of drugs for preparation period of 5 days before
surgery in the first place?
A. Etamsylate
B. Vicasolum*
C. Calcium chloride
D. Fibrinogen
84
 E. Aminocapronic acid.

401. For the prevention of myocardial infarction doctor prescribed

nonsteroidal anti inflammatory drug with antiplatelet effect - aspirin.
Choose the dose and regimen at which the drug will exert antiplatelet
effect.
A. 0.1 three times a day
B. 0.25 three times a day
C. 1.0 three or four times a day
D. 0.5 three times a day
E. 0.1-0.2 once a day for a long time*.

402. For the treatment of hypochromic anemia patient takes iron ferrous
sulfate. Specify one of the side effects of this drug.
A. The darkening of the teeth*
B. Dyspepsia
C. Allergy
D. Itching
E. Dizziness.

403. Vicasolum (Menadione) has been prescribed for patient a week

before tonsillectomy to prevent bleeding. Specify the mechanism of
action of this drug.
A. Inhibits fibrinolysis
B. Activates fibrinolysis
C. Increases the synthesis of clotting factors in the liver*
D. Inhibits ACE
E. Causes vasoconstriction.

404. Indirect acting anticoagulant warfarin was prescribed for patient to

prevent thrombosis. What is the mechanism of action of this drug?.
A. Inhibition of fibrinolysis
B. Activation of fibrinolysis
C. Decrease in the synthesis of clotting factors in the liver*
D. Inhibition of ACE
E. Inhibition of platelets aggregation.

405. On discontinuation of heparin treatment of patient with myocardial

infarction administration of warfarin was started. This drug exerts its
anticoagulant effect by
A. Blocking calcium binding to clotting factors
B. Forming a complex with clotting factors
C. Breaking down thrombin
D. Inhibiting of pro-clotting factor synthesis in the liver*
E. Depolymerization of fibrin.
85
406. A patient with myocardial infarction was treated with intravenous
infusion of heparin. What is the goal of this drug administration?
A. To cause the lysis of thrombus directly
B. To transform plasminogen into plasmin
C. To prevent further thrombosis*
D. To prevent platelets activation
E. To decrease the area of necrosis.

407. A patient with a history of angina pectoris and high plasma

cholesterol level was prescribed phenofibrate. What is the mechanism of
action of this drug?
A. Activation of lipoprotein lipase*
B. Inhibition of lipoprotein lipase
C. Inhibition of hydroxymethyl glutaryl coenzyme A
D. Inhibition of LDL oxidation
E. Bile acid sequestration.

408. Patient suffering from pernicious anemia is treated with folic acid.
Which agent is to be added to make effective the treatment of this
disease?
A. Retinoli acetas
B. Cyancobalamin*
C. Thiamine bromide
D. Retabolil
E. Insulin.

409. A patient ill with essential hypertension was recommended a drug

that prevents thrombosis. It is to be taken parenterally. What drug is it?
A. Protamine sulfate
B. Amben
C. Heparin*
D. Neodicumarin
E. Syncumar.

Drugs acting on myometrium. Antigout drugs.

410. Choose the hormonal drug for enhancement of uterine contraction

during labor
A. Dinoprost (PGF2)
B. Oxytocin*
C. Ergometrine
D. Salbutamol
86
 E. Partusisten

411. To stop postpartum bleeding doctor prescribed ergot alkaloid

derivative. Point out this drug
A. Oxytocin
B. Methylergometrine*
C. Neostigmin
D. Dinoprostone (PGE2)
E. Qinine

412. Pregnant woman developed rhythmic uterine contractions at the

physiological term of delivery. But contractions were not progressing in
force and frequency. Cervix of uterus was neither softening nor opening.
Chose the drug, which is the most beneficial in this case.
A. Oxytocin
B. Pituitrin
C. Ergometrine
D. Dinoprostone*
E. Partusisten

413. A pregnant woman developed rhythmic uterine contractions at the

physiological term of delivery. But contractions were not progressing in
force and frequency. Choose the drug for stimulation of uterine
contraction.
A. Oxytocin*
B. Ergometrine
C. Partusisten
D. Physostigmine
E. Castor oil.

414. Intake of oral contraceptives containing sex hormones inhibits

secretion of the hypophysiae hormones. Secretion of which of the
indicated hormones is inhibited while taking oral contraceptives with sex
hormones?
A. Somatotropic
B. Oxytocin
C. Vasopressin
D. Follicle-stimulating*
E. Thyrotropic.

Vitamins

87
415. There is an inhibited coagulation in the patients with bile ducts
obstruction, bleeding due to the low level of absorbtion of a vitamin.
What vitamin is in deficiency?
A. Carotene
B. E
C. K*
D. A
E. D.

416. A patient suffers from vision impairment - hemeralopy (night

blindness). What vitaminpreparation should be administered the patient in
order to restore his vision?
A. Thiamine chloride
B. Tocopherol acetate
C. Retinol acetate*
D. Vicasol
E. Pyridoxine.
417. Patients after long-term complex treatment that included vitamin
drug began to complain of muscular weakness, loss of appetite, nausea,
and diarrhea. On examination tachycardia, hypertension, weakening of the
heart sounds were revealed. In the urine protein, red blood cells,
hypercalciuria were revealed, in the blood - increasing the concentration
of Ca and P was found. What phenomenon was observed in a patient?
A. Hypovitaminosis vit. C
B. Hypervitaminosis vit. A
C. Hypervitaminosis vit. D*
D. Hypovitaminosis vit. A
E. Hypervitaminosis vit. K.

418. The retardation of fontanelle closure and teeth appearance were

observed in child. The increase in activity of alkaline phosphatase and
decrease in the concentration of citrate in the blood were found. This
violation is related to deficiency of vitamin:
A. Vitamin D*
B. Vitamin A
C. Ascorbic acid
D. Vitamin E
E. Vitamin K.

419. The patient with myocardiodystrophy appointed vitamin

preparation with a potent antioxidant effect. Which of these drugs has
such action?
A. Rutin
B. Pyridoxine
C. Menadione
88
 D. Riboflavin
E. Tocopherol*.

420. The patient has dementia, diarrhea and dermatitis. Which of the
following drugs should be included in complex treatment of this patient?
A. Nicotinamide*
B. Cobalamin
C. Calcium pantothenate
D. Riboflavin
E. Thiamine nitrophosphate.

421. In order to accelerate healing of a radiation ulcer a vitamin drug

was administered. What drug was it?
A. Levamisole
B. Retabolil
C. Prednisolone
D. Retinol acetate*
E. Methyluracil .

Hormonal, enzymatic and antienzymatic drugs

422. A person has reduced diuresis, hypernatremia, hypokalemia.

Hypersecretion of what hormone can cause such changes?
A. Parathormone
B. Aldosterone*
C. Adrenalin
D. Vasopressin
E. Auricular sodiumuretic factor.

423. A patient with infectious mononucleosis had been taking

glucocorticoids for two weeks. He was brought into remission, but he fell
ill with acute attack of chronic tonsillitis. What action of glucocorticoids
caused this complication?
A. Antiallergic
B. Immunosuppressive*
C. Anti-inflammatory
D. Antishock
E. Antitoxic.

424. A patient had been taking glucocorticoids for a long time. When the
preparation was withdrawn he developed the symptoms of disease
aggravation, decreased blood pressure and weakness. What is the reason
of this condition?
89
 A. Appearance of adrenal insufficiency*
B. Hyperproduction of ACTH
C. Cumulation
D. Sensibilization
E. Habituation.

425. Examination of a 60 y.o. patient revealed hyperglycemia and

glucosuria. A doctor administered him a medication for internal use. What
medication is it?
A. Oxytocin
B. Corglycon
C. Furosemide
D. Pancreatine
E. Glibenclamid*.

426. A patient ill with collagenosis has been taking prednisolone for a
long time. Hypokaliemia development caused spastic pain of skeletal
muscles. What medication should be used in order to correct potassium
exchange?
A. Dithylinum
B. Panangin*
C. Thyrocalcitonin
D. Diazepam
E. Noshpa.

427. In course of histidine catabolism a biogenic amin is formed that has

powerful vasodilatating effect. Name it:
A. Histamine*
B. Dopamine
C. Dioxyphenylalanine
D. Noradrenalin
E. Serotonin.

428. Continious taking of a drug can result in osteoporosis. erosion of

stomach mucous membrane, hypokaliemia, retention of sodium and
water, reduced content of corticotrophin in blood. Name this drug:
A. Digoxin
B. Indometacin
C. Reserpine
D. Prednisolone*
E. Hydrochlorothiazide.

429. Examination of a 70 year old patient revealed non insulin-

dependent diabetes. What drug should be administered?
A. Glibenclamid*
90
 B. Parathyroidin
C. Insulin
D. Mercazolilum
E. Cortisone.

430. Examination of a 60 year old patient revealed hyperglycemia and

glucosuria. A doctor administered him a medication forinternal use. What
medication is it?
A. Pancreatine
B. Furosemide
C. Oxytocin
D. Glibenclamid*
E. Corglycon.

431. Doctor prescribed preparation of posterior pituitary for the woman

with the uterine inertia. Choose the preparation:
A. Dihydroergotamine
B. Vasopressin
C. Oxytocin*
D. Adrenocorticotropin
E. Dinoprost.

432. The levorotatory isomer of thyroid hormone was assigned to the

patient with diagnosed myxedema. What drug was assigned?
A. Levodopa
B. L-thyroxine*
C. L-asparaginase
D. L-carnitine
E. Parathyroid hormone.

433. Doctor prescribed the inhalation of drug with proteolytic action to

improve sputum discharge. Mark drug that has proteolytic effect.
A. Trypsin*
B. Lidaza
C. Pepsin
D. Streptokinase
E. Festal.

434. Choose the drug that is a hormone produced by alpha-cells of

Langerhan’s islets of the pancreas.
A. Insulin
B. Glucagon*
C. Somatostatin
D. Natriuretic hormone
E. Testosterone.
91
435. The patient complained of a acute girdle pain in area of pancreas
projection. Which of the following drugs should be selected to provide
emergency aid to him?
A. Potassium chloride
B. Contrykal (Aprotinin)*
C. Platyphylline hydrotartrate
D. Pancreatin
E. Bendazol.

436. The patient with severe chest pain was admitted to the infarction
department. On the ECG extensive myocardial infarction caused by
thrombosis of the left coronary artery was revealed, and therefore the
administration of thrombolytic agent was started immediately. What the
drug was used in the treatment of this patient?
A. Collagenase
B. Hyaluronidase
C. Trypsin
D. Streptokinase*
E. Ribonuclease.

437. The patient was diagnosed a myocardial infarction with thrombosis

of the left coronary artery. Which group of drugs is used to restore blood
flow?
A. Nonopioid аnalgesics
B. Fibrinolysis activators*
C. Beta-blockers
D. ACE inhibitors
E. Glucocorticoids.

438. Doctor prescribed enzymatic preparation to the patient with

hypoacidic gastritis. Which of these preparations will improve digestion
in the stomach?
A. Pepsin*
B. Pancreatin
C. Trypsin
D. Medaza
E. Contrykal (Aprotinin).

439. Replacement hormonal treatment was assigned for patient with

hypothyrosis. Which drug should be selected for treatment?
A. Merkazolil (Thiamazole)
B. Parathyreoidinum (Parathyreocrinum)
C. Dihydrotachysterol
D. Potassium perchlorate (Kalii perchloridi)
92
 E. Thyroidin*.

440. Patients aged 73 years has slovly healing fracture of the femoral
neck. What of hormones with anabolic effect can be assigned to him?
A. Parathyreoidin (Parathormon, Parathyreocrinum)
B. Prednisolone
C. Insulin
D. Retabolil (nandrolone)*
E. Thyroxine.

441. Blood pressure and blood glucose level were increased in female
patients with low blood pressure after parenteral administration of the
hormone. Which hormone was injected?
A. Folliculin (Estrone)
B. Adrenaline*
C. Glucagon
D. Progesterone
E. Insulin.

442. Hemostatic therapy that was assigned to a patient with a bleeding

gastric ulcer did not give desirable effect. The activation of the
fibrinolytic system was found in the patien’t blood. The administration of
what drug is beneficial in this case?
A. Aminocaproic acid*
B. Contrykal (Aprotinin)
C. Medical gelatin
D. Captopril
E. Fibrinogen.

443. To remove necrotic tissue of wound the surgeon made a wound

dressing with chymotrypsin. Explain the mechanism of drug action.
A. Inhibits protease
B. Depolymerization of nucleic acids
C. Depolymerization of hyaluronic acid
D. Breaks peptide bonds in proteins
E. Breaks bonds formed by aromatic residues and / acids*.

444. A woman addressed the pediatrician concerning illness of the 8

months child manifested by sweating, increased size of the crown,
retarded dentition (only 2 of the tooth), and anxiety. What medication
should be assigned at the first place?
A. Calcium pangamas
B. Folic acid
C. Cyanocobalamin
D. Thiamin
93
 E. Ergocalciferol*.

445. The woman had several spontaneous miscarriages. The lack of

which vitamin can cause this?
A. Thiamine bromide
B. Vitamin D
C. Vitamin K
D. Vitamin E*
E. Ascorbic acid.

446. The patient complains of increased vascular fragility (touch to the

skin are bruises), bleeding from the gums. Appointment of ascorbic acid
reduced these symptoms. Specify the mechanism of action of the drug on
vascular permeability.
A. Stimulates the synthesis of corticosteroids
B. Stabilizes the cell membrane
C. Improves oxidation-inflammatory processes
D. Increases collagen production*
E. Stimulates the conversion of folic acid to folinic.

447. The patient developed a hypersensitivity to common cold after

long-term use of one of the therapeutic agents. Which of these drugs
could reduce immunity?
A. Sustak forte (Nitroglycerin)
B. Prednisone*
C. Reserpine
D. Tincture Ginsengi
E. Clonidine.

448. 16 years old young man was suffering from diabetes mellitus for 10
years. He heard about the replacement of insulin by glibenclamide tablets.
However, the doctor refused to change insulin for glibenclamide tablets.
Why glibenclamide is not assigned in this case?
A. Rapidly degraded in the liver.
B. Deplete the function of beta cells of the pancreas.*
C. Causes hyperproduction of hydrocortisone.
D. Increased allocation of adrenaline.
E. Stimulates the alpha cells of the pancreas..

449. Dermatologist for topical treatment of eczema selected ointment

containing fluorinated glucocorticoid, which provides a more expressed
antiinflammatory effect. Which of the following dermatological ointments
was applied?
A. Hydrocortisone ointment
B. Prednizolone ointment
94
 C. Ointment "Sinaflan"*
D. Diclophenac ointment
E. Heparin ointment .

450. Patient was on glucocorticoids for a long time, discontinuation of

usage caused exacerbation of the illness, decreased BP, weakness. How
can you explain it?
A. Insufficiency of adrenal glands*
B. Adaptation to the medicine
C. Sensitization
D. Hyperproduction of ACTH
E. Cumulation.

451. Testosterone and it's analogs increase the mass of skeletal muscles
that allows to use them for treatment of dystrophy. Due to interaction of
the hormone with what cell substance is this action caused?
A. Proteins- activators of transcription
B. Membrane receptors
C. Ribosomes
D. Chromatin
E. Nuclear receptors*.

452. A patient ill with neurodermatitis has been taking prednisolone for a
long time. Examination revealed high level of sugar in his blood. This
complication is caused by the drug influence
A. Glycogenogenesis activation
B. Gluconeogenesis activation*
C. Intensification of glucose absorption in the bowels
D. Activation of insulin decomposition
E. Inhibition of glycogen synthesis.

453. Continious taking of a drug can result in osteoporosis, erosion of

stomach mucous membrane, hypokaliemia, retention of sodium and
water, reduced content of corticotropin in blood. Name this drug:
A. Digoxin
B. Hydrochlorothiazide
C. Prednisolone*
D. Indometacin
E. Reserpine .

454. A patient suffers from diabetes melitus. After the regular insulin
injection his condition grew worse: there appeared anxiety, cold sweat,
tremor of limbs, general weakness, dizziness. What preparation can
eliminate these symptoms?
A. Adrenaline hydrochloride*
95
 B. Butamide
C. Caffeine
D. Noradrenaline
E. Glibutide .

455. Examination of a 60 y.o. patient revealed hyperglycemia and

glucosuri A doctor administered him a medication for internal use. What
medication is it?
A. Corglycon
B. Furosemide
C. Oxytocin
D. Pancreatine
E. Glibenclamid*.

456. An elderly female patient suffers from the type 2 diabetes mellitus
accompanied by obesity,
A. Insulin
B. Glibenclamid*
C. Retabolil
D. Lovastatin
E. Amlodipine .

Anti-inflammatory and antiallergic drugs. Immunomodulators

457. A patient with continious bronchopneumonia was admitted to the

therapeutic department. Antibiotic therapy didn't give much effect. What
medication for improvement of immune state should be added to the
complex treatment of this patient?
A. Timaline*
B. Analgin
C. Sulfocamphocaine
D. Paracetamol
E. Benadryl.

458. A patient with rheumatoid arthritis who had been treated with
indometacin has got signs of gastropathy. What activity of the drug can
this complication be connected with?
A. Anticyclooxygenase*
B. Antiserotonin
C. Antihistamine
D. Locally irritating
E. Antikinine.

96
459. A 45-year-old woman suffers from seasonal allergic rhinitis caused
by the ambrosia blossoming. What medicine from the stabilizer of the
adipose cells group can be used for prevention of this disease?
A. Diazoline
B. Tavegyl
C. Phencarol
D. Dimedrol
E. Kromolin sodium*.

460. A doctor administered a patient with allergic dermatitis a H1

-histamine blocker as a part of complex treatment. Name this medication:
A. Prednisolone
B. Loratadine*
C. Cromolyn sodium
D. Hydrocortisone
E. Adrenaline.

461. A 12 year old child has intolerance to some foodstuffs. Their

consumption causes an allergic reaction in form of itching skin eruptions.
What antihistaminic drug should be admistered so that the child could
attend school?
A. Loratadine*
B. Dimedrol
C. Ephedrine
D. Aminophylline
E. Diclofenac.

462. Signs of gastropathy occurred in the patient with rheumatoid

arthritis who was treated with indometacin. With what activity of the drug
can this complication be connected?
A. Antikinine
B. Antiserotonin
C. Antihistamine
D. Anticyclooxygenase*
E. Local irritating.

463. A female patient consulted a doctor about pain and limited

movements in the knee joints. Which of the following nonsteroid anti-
inflammatory drugs should be administered taking into consideration that
the patient has a history of chronic gastroduodenitis?
A. Celecoxib*
B. Diclofenac sodium
C. Promedol
D. Acetylsalicilic acid
E. Butadiounum .
97
464. The patient suffering from arthritis was treated with prednisolone
for long period. Doctor decided to discontinue prednisolone
administration and change it for another drug. What is the right way of
this drug discontinuation?
A. It must be preceded by corticotropin administration*
B. It must be done in a vary short time
C. It must be preceded by administration of ADH
D. It must be performed on the background of mineralocortcoid
administration
E. It must be preceded by growth hormone administration.

465. A 45-year-old woman suffers from allergic seasonal coryza caused

by the ambrosia blossoming. What medicine from the stabilizer of the
mast cells group can be used for prevention of this disease?
A. Tavegyl
B. Diazoline
C. Phencarol
D. Ketotifen*
E. Dimedrolum.

466. Patient was on glucocorticoids for a long time, discontinuation of

usage caused exacerbation of the illness, decreased BP, weakness. How
can you explain it?
A. Sensitization
B. Adaptation to the medicine
C. Hyperproduction of ACTH
D. Insufficiency of adrenal glands*
E. Cumulation.

467. Patient suffering from rheumatoid arthritis was treated with potent
nonsteroidal anti-inflammatory drug. The treatment was complicated by
gastric bleeding. What drug was used?
A. Paracetamol
B. Indomethacin*
C. Analgin
D. Prednisolone
E. Dexametasone.

468. In complex treatment of patient with bronchial asthma cromolyn-

sodium was included as antiallergic agent. What is the mechanism of this
drug action?
A. Inhibition of histaminic H1 receptors
B. Inhibition of histaminic H2 receptors
C. Prevention of mast cell degranulation*
98
 D. Inhibition of antigen-antibody interaction
E. Blockade of D2 receptors.

469. A patient who had myocardial infarction was administrated 75 mg

of acetylsalicylic acid a day. What is the purpose of this administration?
A. Coronary vessels dilatation
B. Temperature reduction
C. Inflammation reduction
D. Pain relief
E. Redaction of thrombocyte aggregation*.

470. Continuous use of certain drug may cause osteoporosis, erosion of

gastric mucosa, hypokalemia, retention of sodium and water in the
organism, decreased concentration of corticotropin in blood. What drug is
it?
A. Reserpine
B. Digoxine
C. Hypothiazide
D. Prednisolone*
E. Indomethacin.

471. A 33 –year-old female patient, who long treated for chronic

polyarthritis, complains of high blood pressure, changes in distribution of
body fat, menstrual disorders. Admission of which drug is related to these
complaints?
A. Prednisolone*
B. Beclomethasone
C. Phenylbutazone
D. Sinaflan
E. Indomethacin.

472. Prolonged use of steroid and non-steroid anti-inflammatory drugs in

patients with rheumatoid arthritis has not given effect. The doctor
changed non-steroid anti-inflammatory drugs for the preparation of gold.
Find this preparation among the listed drugs.
A. Krizanol*
B. Hingamin
C. Prednisolone
D. Plaquenil
E. D-penicillamine.

473. What pharmacological property of dimedrolum (diphenhydramine)

is used in the hives treatment?
A. Interference with formation of the antigen-antibody complex
B. Elimination of histamine action on the cell*
99
 C. Sedative effect on the central nervous system
D. Violation of antibody synthesis
E. Inhibition of biologically active substances release by mast cell.

474. The patient who received steroid anti-inflammatory drugs had a

complication in the form of hypokalemia. Which of these drugs should be
used for correction of potassium level?
A. Sodium chloride
B. Magnesium sulfate
C. Panangin*
D. Calcium lactate
E. Calcium chloride.

475. Immune stimulant of animal origin was included in the complex

treatment of patients with severe bronchopneumonia. Which of these
drugs belong to this group of drugs?
A. Timalin*
B. Pirogenal
C. Prodigiozan
D. Levamisole
E. Sodium nucleinat.

476. Patient has got severe trauma in car accident due to this kidney
transplant was performed in emergency procedure. Which of the
following drugs should be included in the post-operative therapy for
successful engraftment of the transplanted organ?
A. Pirogenal
B. Levamisole
C. Timalin
D. Prodigiozan
E. Azathioprine*.

477. Anaphylactic shock developed in patient after administration of

lidocaine. Which of the following medications must choose a doctor to
bring the patient out of shock?
A. Acetylsalicylic acid
B. Corticotropin
C. Azathioprine
D. Adrenaline*
E. Aminopyrine.

478. A patient suffering from rheumatism was treated with prednisolone

for two months. After the abrupt discontinuation of the drug
administration patient’s blood pressure dropped dramatically, there was a

100
 severe weakness, tachycardia, reappeared joint pain. Which condition was
developed in patient due to prednisolone discontinuation?
A. Orthostatic collapse
B. Withdrawal*
C. Allergic reaction
D. Anaphylactic shock
E. Hyperglycemic coma.

479. A patient with rheumatoid arthritis was on non-steroidal anti-

inflammatory drug - diclofenac sodium. After some time worsening of
associated disease occurred in the patient that required withdrawal of
medication. What disease was associated with rheumatoid arthritis?
A. Coronary artery disease
B. Bronchial asthma
C. Gastric ulcer*
D. Diabetes mellitus
E. Hypertention.

480. A patient with rheumatoid arthritis was on diclofenac sodium. After

blood test the doctor canceled the drug administration. What the
abnormality in blood test was the base for diclofenac sodium
discontinuation?
A. Enhancement of hemocoagulation
B. Eosinophilia
C. Leukopenia
D. Leukocytosis
E. Decrease in blood coagulation*.

481. The 12-year-old child has intolerance of some food stuffs. Their use
causes an allergic reaction in the form of itchy skin rash. What
antihistamines should be appointed, not to interfere with school activities
of the child (not cause drowsiness)?
A. Loratadine*
B. Mezaton
C. Diclofenac sodium
D. Aminophylline
E. Diphenhydramine.

482. To prevent transplant rejection after organ transplantation

immunosuppressive hormone therapy is compulsory. What group of
hormones is used for this purpose?
A. Catecholamines
B. Thyroid
C. Glucocorticoids*
D. Mineralocorticoids
101
 E. Sex hormones.

483. Student addressed the doctor to appoint a drug for the treatment of
allergic rhinitis occurred in lime blossoming. Which drug can be used?
A. Loratadine*
B. Losartan
C. Noradrenaline gidrotartrat
D. Inderal
E. Ambroxol.

484. In the complex therapy of patient with allergic dermatitis doctor

prescribed H1-histamine blockers. Point out the drug.
A. Hydrocortisone
B. Prednisolone
C. Cromolyn sodium
D. Loratadine*
E. Adrenaline.

102
 Antiseptics and disinfectants

485. For the preparation of a patient`s burn skin surface a certain medication
was used. Its antiseptic action is provided by free oxygen that segregates in
presence of organic substances. Choose the right answer:
A. Potassium permanganate*
B. Chlorhexidine
C. Sodium bicarbonate
D. Boric acid
E. Furacilin.

486. Patient suffering from tonsillitis was recommended to gargle throat with
preparation of nitrofurans. What drug was recommended?
A. A solution of hydrogen peroxide,
B. Solution of furacilinum,*
C. Solution of silver nitrate,
D. Chlorhexidine
E. Alcoholic solution of iodine.

487. Burned skin surface was treated with antimicrobial preparation. Its
antiseptic properties are provided by atomic oxygen that is formed in presence
of organic substances. What preparation was applied?
A. Potassium permanganate*
B. Furacillin
C. Chlorhexidine bigluconate
D. Alcoholic iodine solution
E. Boric acid .

488. Patient with abscess of the cut wound applied to the traumatological
department. Doctor for the cleaning of the wound from the pus washed it with
3% hydrogen peroxide. Foam was absence. What is the cause of absence of
the drug activity?
A. Pus in the wound
B. Low concentration of H2O2
C. Inherited insufficiency phosphatdehydrogenase of erythrocyte
D. Shallow wound
E. Inherited insufficiency of catalase*.

489. A group of students were traveling by countryside collecting medicinal

plants. It was a hot day and the students spent the entire drinking water. The
team leader offered the water of the pond, using the chlorine containing tablet
for its disinfection. Point the drug.
A. Chloramine-B
B. Chlorhexidine
C. Halozan*
 D. Brilliant Green
E. Furacilinum.

490. A nurse washed the patient’s contaminated wound with 3% hydrogen

peroxide solution that causes formation a lot of foam. What is the mechanism
of antiseptic effect of this drug?
A. The formation of molecular oxygen*
B. The formation of atomic form of oxygen
C. The interaction of hydrogen peroxide with fibrinolysine
D. Aggressive action of hydrogen peroxide on tissues
E. Formation of albuminates.

491. Patient with burns was treated by application of antiseptic containing

halogen and polyvinyl pirrolidon. Point out this preparation.
A. Iodovidon*
B. Halozan
C. Chlorhexidine
D. Chloramine
E. Pantocide.

492. The patient was admitted to the infectious disease clinic with complaints
of vomiting, diarrhea, fever, after errors in diet. What antiseptic should be used
for gastric lavage (washing out)?
A. Ethanol
B. Hydrogen peroxide
C. Methylene blue
D. Activated char coal
E. Potassium permanganate*.

493. A patient has purulent wound with necrotic content. What medication
should be used to cleanse the wound?
A. Hydrogen peroxide*
B. Furacilinum (Nitrofurazone)
C. Sulfacyl sodium
D. Alcohol solution of iodine
E. Aetacridini lactas.

494. In the patient with syphilis treated by, bismuth preparations gray patches
on the mucous membrane of the mouth and symptoms of kidney disturbances
appeared. Which agent is advisable for the treatment of bismuth poisoning?
A. Naloxone
B. Unitiol*
C. Methylene blue
D. Nalorphine

104
 E. Bemegride.

495. Dentist handled herpetic lesions of 7 years old child with halogen
antiseptic that has antimicrobial, antifungal and antiviral properties. Name the
drug.
A. Alcohol solution of iodine*
B. Potassium permanganate
C. Formaldehyde
D. Silver nitrate
E. Brilliant Green.

496. The patient with gingivitis after using applications was assigned to rinse
oral cavity with antiseptic agent realizing its effect by atomic oxygen drug
exerts deodorant and astringent effects. Identify the drug.
A. Ethanol
B. Chlorhexidine bigluconate
C. Hydrogen peroxide
D. Sodium bicarbonate
E. Potassium permanganate*
F. Hydrogen peroxide.

497. To prepare the operative field surgeon used a solution of iodine in

alcohol. What is the chemical group of this antiseptic preparation?
A. Heavy metals
B. Halogen-containing compounds*
C. Alcohols
D. Detergents
E. Aliphatic substance.

498. For disinfecting of metallic instruments in the surgical department the

formaldehyde solution is used. What is the chemical group of this antiseptic
preparation?
A. Halogenated compounds
B. Aromatic substance
C. Detergents
D. Aliphatic agent*
E. Alcohols.

499. After extirpation of the tooth in the patient bleeding from the hole
emerged. What drug from the group of antiseptics should be used in this case?
A. A solution of hydrogen peroxide*
B. Solution of epinephrine hydrochloride
C. Solution of brilliant green
D. Iodinol

105
 E. A solution of ethyl alcohol.

500. Nitrofurane antiseptic was prescribed for mouth wash to patient with
stomatitis. Point out this agent
A. Hexamethylen tetraminum
B. Aethonium
C. Furacilinum*
D. Boric acid
E. Aethacridini lactates.

501. Teenager addressed dermatologist complaining of acne. Doctor

prescribed him an antiseptic agent that gradually releases oxygen and is
traditionally used locally for treatment of acne. Point out prescribed drug.
A. Hydrogen peroxide
B. Potassium permanganate
C. Benzoyl peroxide*
D. Boric acid
E. Methylenum coeruleum.

502. To prevent pyodermia in 4-year-old girl with chickenpox mother was

recommended to apply a preparation of a group of dyes. Point out this
preparation.
A. Chlorhexidine
B. Alcoholic solution of iodine
C. Furacilinum
D. Alcoholic solution of of Brilliant Green*
E. Chloramine.

503. Before the operation surgeon used degmicidum for disinfecting his
hands. Point the group of this antimicrobial agent
A. Group of detergent*
B. Group of dyes
C. Halogen containing antiseptic
D. Oxidizing agent
E. Group of nitrofuranes .

504. Doctor prescribed oral rinse for patient with stomatitis. Which antiseptic
of oxidazinggroup is most suitable for this?
A. Boric acid
B. Potassium permanganate*
C. Alcoholic solution of iodine
D. Chloramine
E. Ethanol.

106
505. Gastric lavage with a solution of potassium permanganate was
performed in patient due to food poisoning. Which group of antiseptics does
this drug belong to?
A. Aromatic substances
B. Halogens
C. Acid
D. Oxidizing agents*
E. Detergents.

506. Solution of carbolic acid was used for disinfecting of instruments. To

which group does this antiseptic belong?
A. Oxidizing agents
B. Phenols*
C. Halogens
D. Acid
E. Detergents.

507. For disinfecting of hand before operation surgeon used chlorine

containing antiseptic, that also widely used in dentistry. Point out this agent.
A. Potassium permanganate
B. Boric acid
C. Alcoholic solution of iodine
D. Chlorhexidine*
E. Ethanol.

508. Surgeon was urgently summoned to the operating room. Choose the
antiseptic used for surgeon hands in emergency.
A. Boric acid
B. Ethyl alcohol 96%*
C. Ethacridine lactate
D. Hydrogen peroxide
E. Ethyl alcohol 70%.

Synthetic antimicrobial drugs. Fluoroquinolones. Sulfonamides.

509. A 7 vear old child is ill with bronchitis. It is necessary to administer him
an antibacterial drug. What drug of fluoroquinolone group is CONTRA-
INDICATED at this age?
A. Cyprofloxacin*
B. Sulfadimethoxine
C. Ampiox
D. Ampicillin

107
 E. Amoxicillin.

510. Patient with pneumonia has intolerance to antibiotics. Which of the

combined sulfanilamide medicines should be prescribed to the patient?
A. Sulfacyl sodium
B. Aethazol
C. Biseptol*
D. Streptocid
E. Sulfadimethoxine.

511. A patient consulted a stomatologist about purulent inflammation of his

gums. What drug will be the most effective if it is suspected that a causative
agent is an anaerobe?
A. Co-trimoxazole
B. Gentamicin
C. Oxacillin sodium
D. Metronidazole*
E. Nitroxoline .

512. A patient with pneumonia had a complex treatment that included

sulfonamide preparation. What should doctor recommend to prevent
cristaluria?
A. Decrease the dose of sulfonamide
B. Drinking of alkaline solution*
C. Administration of drugs before meal
D. Drinking of acidic solution
E. Use of vitamins.

513. Gonorrhoea was revealed in the patient on bacterioscopy of the smear

from urethra. Taking into account that medicines for gonorrhea are
fluorquinolones, patient should be prescribed:
A. Ciprofloxacin*
B. Furazolidone
C. Fluorouracil
D. Urosulfan
E. Cefazoline.

514. Patient with pneumonia has intolerance to antibiotics. Which of the

combined sulfanilamide medicine should be prescribed to the patient?
A. Trimethoprim
B. Aethazol
C. Natrium sulfacyl
D. Streptocid
E. Biseptol*.

108
515. A 30-year-old patient complains about having abdominal pain and
diarrhea for 5 days body temperature rise up to 37,5o C along with chills. The
day before patient had been in forest and drunk from open water reservoir.
Laboratory analysis enabled to make the diagnosis of amebic dysentery. What
is the drug of choice for its treatment?
A. Phthalazol
B. Furazolidonum
C. Emetine hydrochloride
D. Metronidazole*
E. Levomycetin.

516. What is the mechanism of antimicrobial effect of sulfonamide?

A. Inhibition of protein synthesis
B. Inhibition of bacterial cell wall synthesis
C. Competitive antagonism with para-aminobensoic acid*
D. Inhibition of cell membrane synthesis
E. Inhibition of nucleic acid synthesis.

517. Combined sulfonamide preparation with bactericidal effect was

prescribed for treatment of sore throat in 13 years old child. Point out this drug.
A. Biseptol*
B. Eneroceptol
C. Sulfalen
D. Aethasolum
E. Urosulfanum.

518. A HIV patient has bacterial dysentery. On the result of antimicrobial

sensitivity test doctor prescribed him cotrimoxazol (bactrim,biseptol). What
type of antibacterial action has this drug?
A. Virostatic
B. Bacteriostatic
C. Fungicidal
D. Fungistatic
E. Bactericidal*.

519. A Bactrim was prescribed for 35-years old patient with bronchitis. What
is the mechanism of action of this drug?
A. Sequential block of two stages of bacterial folate metabolism*
B. Inhibition of bacterial cell wall synthesis
C. Inhibition of protein synthesis
D. Inhibition of cell membrane synthesis
E. Inhibition of nucleic acid synthesis.

109
520. For treatment of typhoid fever ciprofloxacin was prescribed. What is
mechanism of this drug action?
A. Inhibition of bacterial cell wall synthesis
B. Inhibition of DNA gyrase*
C. Inhibition of protein synthesis
D. Competitive antagonism with paraaminobenzoic acid
E. Inhibition of nucleic acid synthesis.

521. Due to which side effect ciprofloxacin is contraindicated in children?

A. Hepatotoxicity
B. Glucosuria
C. Cartilage damage*
D. Nausea
E. Insomnia.

522. A doctor prescribed sulfonamide drug to patient with acute bronchitis.

After urinalyses he changed it for antibiotic of penicillin group. The possibility
of which side effect of sulfonamide was the base for changing it by other drug?
A. Mental confusion
B. Hyperglycemia
C. Allergic reaction
D. Crystalurea*
E. Glucosurea .

523. Urinalyses revealed crystaluria in patient who used synthetic

antimicrobial drug for treatment of bronchitis. Which group of antimicrobial
drug can cause such side effect?
A. Sulfonamides*
B. Fluorochinolons
C. Tetracyclines
D. Penicillins
E. Macrolydes.

524. Sulfonamides are the drugs of broad antimicrobial spectrum that includes
some protozoa. For complex treatment of which protozoal infection is it used?
A. Tuberculosis
B. Malaria*
C. Amebiasis
D. Otitis
E. Bronchitis.

525. Why procaine is not compatible with sulfonamides?

A. It binds with sulfonamide
B. It forms paraaminobenzoic acid when metabolized.*

110
 C. It inhibits bacterial cell wall synthesis
D. It interferes with sulfonamide absorption
E. It interfere with sulfonamide distribution.

526. Synthetic antimicrobial drug of quinolones with moderate activity

against mycobacteria tuberculosis was recently included in second-line
antitubercular drugs. Point this drug.
A. Furozalidone
B. Sulfadimetoxine
C. Biseptol
D. Isoniazid
E. Ciprofloxacin*.

Antibiotics I

527. A 60-year-old patient was admitted to the surgical department because of

infection caused by blue pus bacillus (Pseudomonas aeruginosa) which is
sensitive to penicillin antibiotics. Indicate which of the given penicillins has
marked activity to the Pseudomonas aeruginosa?
A. Methicillin
B. Phenoxymethylpenicillin
C. Carbenicillin disodium*
D. Oxacillin
E. Benzylpeniciilin.

528. A 50-year-old patient with typhoid fever was treated with Levomycetin,
next day his condition became worse, temperature rose to 39,6°C. What caused
the complication?
A. The effect of endotoxin agent*
B. Reinfection
C. Secondary infection addition
D. Irresponsiveness of an agent to the levomycetin
E. Allergic reaction.

529. A patient suffers from severe postoperative pseudomonadous infection.

What of the following antibiotics should be administered in this case?
A. Erythromycin
B. Doxycycline
C. Cephazolin
D. Benzylpenicillin
E. Amicacin sulfate*.

111
530. Car driver has got into accident and was admited to emergancy
department. Surgical invasion in abdominal cavity was successfuly performed,
but postoperative period was complicated by peritonitis. Bacterial analysis
revealed Pseudomonas aeruginosa. For treatment of patient you may propose
any antibiotic leasted below with axception
A. Azlocillin
B. Genamycine
C. Cefotaxim
D. Imipenem (Tienam)
E. Tetracycline*.

531. A 6-year boy was admitted to hospital with pneumonia. Treatment with
amoxycycline was not effective. Bacterial analysis revealed Micoplasma
pneumoniae. Choose the most suitable drug for treatment of this child.
A. Tetracycline
B. Azithromycine*
C. Bicillin 5
D. Nystatin
E. Oxacillin.

532. A 20 years old man with gonorrhea was treated with penicillin G in
combination with probenecid. His state was improved, but 1 week later the
patient was still complaining of a persistent urethral discharge and pain on
urination. Laboratory test reveals chlamidia in discharge. Which of the listed
drugs effective both in gonorrhea and chlamidial infection must be used for
further treatment
A. Amoxicillin
B. Doxycycline*
C. Oxacillincin
D. Gentamycin
E. Streptomycin.

533. Patient with tuberculosis was on the complex treatment including

antibiotics. At the end of first course doctor noticed significant decrease in
patient hearing. Which of the following drugs can cause such side effect?
A. Isoniazid
B. Rifampicin
C. Streptomycin*
D. Paraaminosalicylic acid
E. Pirazinamide .

534. Patient, with severe pneumonia was treated with the III generation
cephalosporin. Doctor warned him about the danger of alcohol usage while
treatment. What the drug was used for treatment of patient?

112
 A. Carbenicilin
B. Cefotaxim*
C. Cefalexin
D. Gentamycin
E. Doxycycline.

535. Patient was admitted to the infection unit with diagnosis of bacterial
dysentery. On laboratory studies it was revealed that causative element is
sensitive to the many antimicrobial medicines, but patient has anemia. What
medicine is contra-indicated to the patient?
A. Levomycetin*
B. Phthalazol
C. Enteroseptol
D. Furazolidone
E. Ampicillin.

536. Patient with pneumonia, prone to use alcohol, was treated with antibiotic
of wide spectrum. On the third day of treatment after alcohol usage severe
antabus-like reaction occurs. What was the group of antibiotic used for
treatment of patient?
A. Biosynthetic penicillin
B. Aminoglycoside
C. 3rd generation cephalosporin*
D. Penicilinse resistant penicillin
E. Tetracycline.

537. Patient condition after long term atimicrobial treatment was complicated
by pseudomembranous enterocolitis. For it treatment vancomycin was
prescribed. What is the mechanism of its antimicrobial effect?
A. Disturbances of structure and function of cell membrane
B. Inhibition of cell wall synthesis*
C. Inhibition of protein synthesis
D. Inhibition of nucleic acid synthesis
E. Inhibition of folic acid metabolism.

538. Patient was admitted to the infection unit with diagnosis of bacterial
dysentery. On laboratory studies it was revealed that causative element is
sensitive to the many antimicrobial medicines, but patient has anemia. What
antibiotic can be recommended for this patient?
A. Levomycetin
B. Amoxicillin*
C. Erythromycin
D. Cotrimoxazol
E. Oxacillin.

113
539. A 5-year-old child has been diagnosed with acute right distal pneumonia.
Sputum inoculation revealed that the causative agent is resistant to penicillin,
but it is senstive to macrolides. What drug should be prescribed?
A. Azithromycin*
B. Tetracycline
C. Gentamycin
D. Streptomycin
E. Ampicillin .

540. A 19 year old woman suffers from primary syphilis. Doctor administered
her complex therapy that includes benzylpenicillin sodium salt. What is the
mechanism of action of this drug?
A. It blocks RNA synthesis
B. It blocks synthesis of cytoplasm proteins
C. It blocks thiol enzymes
D. It blocks synthesis of peptidoglycan of microbal wall*
E. It blocks DNA synthesis .

541. A patient underwent appendectomy. In the postoperative period he has

been taking an antibiotic. The patient complains about hearing impairment and
vestibular disorders. What group of antibiotics has such side-effects?
A. Cephalosporins
B. Penicillins
C. Tetracyclines
D. Macrolides
E. Aminoglycosides*.

542. A patient with bacterial pneumonia was prescribed benzylpenicillin.

What is the mechanism of its antibacterial effect?
A. Abnormal permeability of cytoplasmic membrane
B. Inhibition of intracellular protein synthesis
C. Inhibition of synthesis of microbial cell wall*
D. Inhibition of SH-groups of microorganism enzymes
E. Antagonism with p-amino-benzoic acid .

543. A patient with gastric peptic ulcer was on complex treatment that
includes antibiotic of macrolide group. Point out this antibiotic.
A. Clarithromycin*
B. Tetracycline
C. Gentamycin
D. Streptomycin
E. Ampicillin .

114
544. Antibiotic used for the treatment of typhoid fever is:
A. Oxacillin
B. Erythromycin
C. Cephalexin
D. Benzylpenicillin
E. Levomicetin*.

545. Patient has primary syphilis. What is the most effective antibiotic in this
case?
A. Penicillin*
B. Nystatin
C. Amphotericin
D. Streptomycin
E. Kanamycin.

546. Why tetracycline is not recommended in pregnant women?

A. Due to ototoxicity
B. Due to the depressing effect on the respiration of the fruit
C. Due to the ability of the drug to increase uterine tone
D. Due to the teratogenic effect of the drug*
E. Due to the ability to cause anemia in pregnant.

547. In the patient, who has long used tetracycline, there was mucosal
candidiasis. What medication should be appointed to treat it?
A. Nystatin*
B. Nizoral
C. Griseofulvin
D. Furadonin
E. Nitrofungin.

548. Mother of 2 years old child addressed dentist with tooth abnormality in
her child. On child examination the destruction of the incisors, yellow enamel,
the brown rim on the necks of the teeth ware revealed. Mother informed doctor
that she had infection and used antibiotics. Which of the drugs has a strong
teratogenic effect, disrupting the development of teeth?
A. Polymyxin
B. Erythromycin
C. Tetracycline*
D. Cefrenol
E. Ampiox.

549. The patient of 42 years old for the treatment of bacterial pneumonia was
appointed ampicillin. Specify the mechanism of bactericidal action of the drug
A. Inhibition of intracellular protein synthesis

115
 B. Inhibition of the synthesis of the cell wall of the microorganism*
C. Violation of the permeability of the cytoplasmic membrane
D. Inhibition of SH - groups of enzymes of microorganisms
E. Antagonism with paraaminobenzoic acid.

550. Infectious patient is sensitized to benzylpenicillin. Which of the

following antibiotics would be the safest in this case?
A. Amoxicillin
B. Ampicillin
C. Erythromycin*
D. Oxacillin
E. Bicillin 1.

551. A 6 year child was admitted to the hospital with diagnosis of candidiasis
caused by Candida albicans, the mucous membrane of cheeks, palate and
tongue was cowered by fur of white and yellow color. Which of the drugs can
be used to treat the child?
A. Gentamicin
B. Ketoconazole*
C. Tetracycline
D. Cefran
E. Penicillin.

552. A patient with impaired hearing has severe bacillary infection. Which
group of antibiotics is contraindicated in this case?
A. Aminoglycosides*
B. Penicillins
C. Cephalosporins
D. Tetracyclines
E. Rifamycins.

553. A patient diagnosed with purulent pleurisy caused by penicillin resistant

staphylococcus. What preparation of penicillin resistant to beta-lactamase may
be used for the treatment of this patient?
A. Ampicillin
B. Benzylpenicillin
C. Phenoxymethylpenicillin
D. Augmentin*
E. Carbenicillin.

554. Use of which broad-spectrum antibiotic is contraindicated in liver

disease?
A. Polymyxin
B. Lincomycin

116
 C. Tetracycline*
D. Oxacillin
E. Penicillin G.

555. Patient with staphylococcal sepsis was treated with benzylpenicillin.

Therapy was ineffective. What preparation of penicillin group should be
prescribed for the patient to continue treatment?
A. Oxacillin*
B. Polymyxin
C. Erythromycin
D. Phtalazol
E. Aztreonam.

556. Child of 5 years with a staphylococcus infection was assigned penicillin

antibiotic without testing pathogen susceptibility to drugs of this group. Which
drug of penicillin group is resistant to beta-lactamase and effectively influences
on the penicillin-resistant staphylococci?
A. Carbenicillin
B. Ampicillin
C. Bicillin-5
D. Phenoxymethylpenicillin
E. Oxacillin*.

Antituberculous drugs, antiviral, antispirochetous drugs. Antimycotic

agents

557. A 35-year-old man under the treatment for pulmonary tuberculosis has
acute-onset of right big toe pain, swelling, and low-grade fever. The gouty
arthritis was diagnosed and high serum uric acid level was found. Which of the
following antituberculosis drugs are known for causing high uric acid levels?
A. Rifampicin
B. Aminosalicylic acid
C. Thiacetazone
D. Pyrazinamide*
E. Cycloserine.

558. A patient was diagnosed with active focal pulmonary tuberculosis. What
drug should be prescribed in the first place?
A. Ethionamide
B. Isoniazid*
C. Ethoxide
D. Sulfalen

117
 E. Cyclocerine.

559. A patient suffers from pulmonary tuberculosis. During treatment neuritis

of visual nerve occurred. What drug has caused this side effect?
A. Isoniazid
B. Ethambutol*
C. Kanamycin
D. Rifampicin
E. Streptomycin .

560. Patient suffering from tuberculosis was treated with isoniazid. In the
course of treatment peripheral neuritis was developed. What is the mechanism
of this side effect?
A. Direct toxic effect of drug on peripheral nerves
B. Inhibition of myoneural junctions
C. Interference with pyridoxine metabolism*
D. Interference with folic acid synthesis
E. Inhibition of sodium channels.

561. Patient with tuberculosis was on the complex treatment including

antibiotics. At the end of first course doctor noticed significant decrease in
patient hearing. Which of the following drugs can cause such side effect?
A. Isoniazid
B. Rifampicin
C. Streptomycin*
D. Paraaminosalicylic acid
E. Pirazinamide .

562. One of the problems in the treatment of tuberculosis is caused by

existence of metabolically dormant forms of mycobacterium (persister). Which
of the drugs is effective against all subpopulations of Mycobacteria
tuberculosis and causes sterilizing effect?
A. Streptomycin
B. Isoniazid
C. Kanamycin
D. Rifampicin*
E. Paraaminosalicylic acid.

563. The patient suffering from tuberculosis was treated with combination of
antituberculous drugs, including isoniazid. Which drug should be added to
prevent neurological side effects of isoniazid?
A. Streptomycin
B. PASA
C. Rifampicin

118
 D. Pyridoxine*
E. Ascorbic acid.

564. A patient has herpetic rash. What medication should be administered?

A. Acyclovir*
B. Gentamycin
C. Clotrimazole
D. Benzylpenicillin sodium salt
E. Biseptol.

565. Point out the antiviral agent used in influenza.

A. Oseltamivir.*
B. Streptomycine
C. Gentamycin
D. Clotrimazole
E. Pyridoxine.

566. A patient with lung tuberculosis is treated with a drug that has a wide
antimicrobial spectrum; mycobacteria of tuberculosis are highly sensitive to it.
Its effect is realized by depression of bacterial RNA synthesis. Drug is staining
body liquids (urine, sputum, tears) in red color. What the drug is used?
A. Streptomycin
B. Isoniazid
C. Ethambutol
D. Rifampicin*
E. Paraaminosalicylic acid.

567. Treatment of tuberculosis is realized by means of combination

chemotherapy, including agents with different mechanisms of action. Which of
the antituberculosis drugs inhibit the transcription of DNA into RNA of
mycobacteria?
A. Rifampicin*
B. Isoniazid
C. Streptomycin
D. Ethionamide
E. PAS.

568. The patient went to a doctor complaining of red staining of urine and
tear. From his case history it is known that he is treated on pulmonary
tuberculosis. Which of anti-TB drugs is responsible for this phenomenon?
A. Isoniazid
B. Ethionamide
C. Ethambutol
D. Rifampicin*

119
 E. Streptomycin .

569. How do you explain the fact that the in treatment of tuberculosis with
isoniazid dose is adjusted individually, with mandatory measurement of its
concentration in the urine after the first drug?
A. Genetically determined differences in rate of drug acetylating*
B. Occurrence of hyperglycemia as a side effect
C. The development of renal failure
D. Irritant action of the drug
E. Development of hemolytic anemia.

570. TB patient after prolonged treatment with effective anti-TB drug called
attention to breast enlargement. On this occasion he went to a doctor, who
confirmed gynecomastia. Identify the drug, which he used.
A. Cycloserine
B. Ethambutol
C. Isoniazid*
D. Rifampicin
E. Streptomycin sulfate .

571. As a result of prolonged use of broad spectrum antibiotics intestinal

candidamycosis was developed. What should be prescribed to treat it?
A. Interferon
B. Remantadin
C. Itraconazole*
D. Rifampicin
E. Gramicidin.

572. A patient with a diagnosis of AIDS was admitted to the infectious

disease hospital. To improve the immune status of patient, stabilizing body
weight and improwement of his condition, antiviral agent - an antagonist of
thymidine, which blocks the DNA polymerase of HIV was prescribed. Select
the designated agent.
A. Azidothymidine*
B. Acyclovir
C. Interferon
D. Rimantadine
E. Midantan.

573. Patients with herpes doctor prescribed an antiviral drug, which the main
mechanism of action is inhibition of viral DNA polymerase, and the ability to
be integrated instead of deoxyguanosine into viral DNA. Name the drug.
A. Interferon
B. Azidothymidine

120
 C. Acyclovir*
D. Midantan
E. Ethambutol.

574. A 20 years old patient with primary syphilis is receiving combined

therapy, which includes the sodium salt of benzylpenicillin. What is the
mechanism of action of this drug?
A. Blockade of DNA synthesis
B. RNA synthesis blockade
C. Blockade of the SH- groups of enzymes
D. Blockade of the synthesis murein of cell wall of microorganisms*
E. Blockade of protein synthesis in cytoplasm.

575. A patient addressed doctor with complaints on the damage of skin

between the fingers of foot, exudation and itching. Doctor prescribed paste
containing antifungal agent of wide spectrum. Point out this drug
A. Nystatin
B. Clotrimazole*
C. Streptomycin
D. Co-trimoxazol
E. Levorin.

576. This drug is used for treatment of tuberculosis, rate of its inactivation in
the liver is genetically determined and is different in different persons. Point
out this drug
A. Acyclovir
B. Azidothymidine
C. Ciprofloxacin
D. Isoniazid*
E. Rifampicin.

Antiprotozoal drugs

577. To prevent of 4-day malaria a 42-year-old patient was prescribed

primaquine. On the 3-rd day from the begin of treatment there appeared
stomach and heart pains, dyspepsia, general cyanosis, hemoglobinuria. What is
the cause of side effects of the preparation?
A. Drug potentiation by other preparations

121
 B. Cumulation of the preparation
C. Delayed urinary excretion of the preparation
D. Decreased activity of microsomal liver enzymes
E. Genetic insufficiency of glucose 6-phosphate dehydrogenase*.

578. A 52-year-old patient has the following diagnosis: systemic amebiasis

with involvement of intestines, liver, lungs. What drug should be prescribed?
A. Enteroseptol
B. Tetracycline
C. Quiniofone
D. Quingamine
E. Metronidasol*.

579. A patient consulted a doctor about bowels disfunction. The doctor

established symptoms of duodenitis and enteritis. Laboratory examination
helped to make the following diagnosis: lambliosis. What medication should
be administered?
A. Tetracycline
B. Monomycin
C. Metronidazole*
D. Erythromycin
E. Chingamin.

580. A patient consulted a stomatologist about purulent inflammation of his

gums. What drug will be the most effective if it is suspected that a causative
agent is an anaerobe?
A. Oxacillin sodium
B. Gentamicin
C. Nitroxoline
D. Co-trimoxazole
E. Metronidazole*.

581. A patient ill with amebiasis was prescribed a certain drug. The use of
alcohol together with this drug is contra-indicated because the drug inhibits
metabolism of ethyl alcohol. What drug is it?
A. Clonidine
B. Metronidazole*
C. Reserpine
D. Diazepam
E. Aminazine.

582. Before the doctor’s business trip to foreign country he was proposed
histoschizontocidal antimalarial drug for the personal prevention of malaria.
Which drug has got a specialist?

122
 A. Mefloquine
B. Chloroquine
C. Quinine
D. Doxycycline
E. Primaquine*.

583. The patient with lovered immunity was examined concerning

helminthiasis. Laboratory studies have found ascariasis. Which drug should be
prescribed?
A. Niclosamide
B. Piperazine
C. Furazolidone
D. Gentamicin
E. Levamisole*.

584. The patient addresed her gynecologist complaining of heavy vaginal

discharge with an unpleasant odor. After the smears bacterioscopy
trichomoniasis was diagnosed. What the drug is indicated in this case?
A. Sulfadimezin
B. Chloroquine
C. Pyrimethamine
D. Metronidazole*
E. Monomecinum.

585. The patient has a mixed helminthic invasion: intestinal ascariasis and
liver trematodes. What anthelminthic drugis the most advisable for the
treatment of this patient?
A. Mebendazole*
B. Pyrantel B.
C. Chloxylum
D. Piperazine adipate
E. Levamisole.

586. The drug has a devastating effect on the erythrocytic forms of malaria
parasites, dysenteric amoeba. It is used to treat and prevent malaria, the
treatment of amoebiasis and connective tissue diseases. Identify the drug.
A. Emetine hydrochloride
B. Chloroquine*
C. Tetracycline
D. Erythromycin
E. Quinine.

123
587. The patient addressed doctor complaining of epigastric discomfort,
nausea, loss of appetite. The study of duodenal content revealed Giardia
resistant to metronidazole. Which drug should be appointed?
A. Rifampicin
B. Chloroquine*
C. Metronidazole
D. Isoniazid
E. Acyclovir .

588. Antiprotozoal agent of wide spectrum was included in complex

treatment of patient with gastric peptic ulcer. Doctor warned patient about
prohibition of alcohol usage during treatment with this drug. What the drug
was used?
A. Chloramphenicol
B. Metronidazole*
C. Cotrimoxazole
D. Chloroquine
E. Praziquantel.

589. Patient suffering from severe malaria caused by plasmodium falciparum

resistant to chloroquine was treated with the oldest antimalarial drug, obtained
from the bark of cinchona tree. Point out this drug.
A. Primaquine
B. Proguanil
C. Pyrimethamine
D. Quinine*
E. Emetine.

590. Point out the drug of first choice for treatment of patient suffering from
kala-azar (visceral leishmaniasis)
A. Metronidazole
B. Sodium stibogluconate*
C. Tetracycline
D. Pyrimethamine
E. Nystatin.

591. For treatment of neck phlegmon caused by anaerobic infection

antimicrobial drug of imidasole group was included. Point out this drug
A. Norfloxacin
B. Clindamycin
C. Metronidazole*
D. Tetracycline
E. Ampicillin.

124
 592. A 30-year-old patient complains about having abdominal pain and
diarrhea for five days body temperature rise up to 37,5oC along with chills.
The day before a patient had been in a forest and drunk from an open water
reservoir. Laboratory analyses enabled to make the following diagnosis:
amebic dysentery. What is the drug of choice for its treatment?
A. Metronidazole*
B. Furazolidonum
C. Levomycetin
D. Phthalazol
E. Emetine hydrochloride .

593. Amebiasis of hepatic localization was diagnosed in patient. Choose the

drug for treatment of patient.
A. Norfloxacin
B. Clindamycin
C. Chloroquine*
D. Tetracycline
E. Ampicillin.

594. The drug with histoschizontocydal and gametocydal action was used for
causal prophylaxis of malaria. Point out this drug.
A. Metronidasole
B. Primaquine*
C. Chloroquine
D. Tetracycline
E. Emetine hydrochloride .

595. Point out the antimalarial drug that exert erythrocytic schizontocidal
effect by changing pH in parasitic vesicles and prevention of haeme
transformation to hemozoin.
A. Primaquine
B. Chloroquine*
C. Metronidazole
D. Sulfadoxine
E. Pyrimethamine.

Anticancer drugs. Preparations of acids, bases and salts. Basic principles

of acute poisoning treatment

596. A patient who was previously ill with mastectomy as a result of breast
cancer was prescribed radiation therapy. What vitamin preparation has marked
radioprotective action caused by antioxidant activity?

125
 A. Ergocalciferol
B. Tocopherol acetate*
C. Thiamine chloride
D. Ribof1avin
E. Folic acid.

597. In order to accelerate healing of a radiation ulcer a vitamin drug was

administered. What drug is it?
A. Methyluracil
B. Retinol acetate*
C. Levamisole
D. Prednisolone
E. Retabolil.

598. An oncological patient was prescribed methotrexate. With the lapse of

time target cells of the tumour lost susceptibility to this drug. There is change
of gene expression of the folowing enzyme:
A. Thiaminase
B. Deaminase
C. Dehydrofolate reductase*
D. Folate decarboxylase
E. Folate oxidase.

599. Patient after surgery for breast cancer chemotherapy with antiestrogen
agent was prescribed. Which of the following drugs belongs to antiestrogen
with anticancer activity?
A. Tamoxifen*
B. Cyclophosphamide
C. Chlorbutin
D. Cisplatin
E. Fosfestrol.

600. What is the basic mechanism of anticancer action of ethyleneimine

derivative?
A. Alkylation of RNA and DNA of tumor cells*
B. Inhibition of cell division in metaphase
C. Formation of stable complexes with DNA of tumor cells
D. Competitive inhibition of nucleic acid metabolism in tumors
E. Cytorecptors blockade on the cell membrane.

601. In the intensive care unit a child was enrolled with pronounced signs of
acidosis, to relieve his condition immediate drip of infusion was started. Which
of the following drugs should be used in acidosis?
A. Potassium Chloride

126
 B. Sodium Chloride
C. Sodium bicarbonate*
D. Glucose
E. Magnesium sulfate.

602. Patients with chronic heart failure was using digoxin. To increase the
result of treatment additional drug was included in patient therapy. It resulted
in the development of symptoms of intoxication. Which drug can cause
increase in cardiac glycoside toxicity?
A. Potassium chloride
B. Magnesium chloride
C. Asparkam
D. Glucose
E. Calcium chloride*.

603. A patient with acute poisoning was admitted to emergency department. It

was established that poisonous substance was excreted by kidney. Choose the
best diuretic for forced diuresis.
A. Acetazolamide
B. Amiloride
C. Spironolactone
D. Furosemide*
E. Hydrochlorothiazide.

604. Choose the most beneficial agent for stomach wash in patient poisoned
with alkaloid
A. Physiological solution
B. Chlorhexidine
C. Sodium bicarbonate
D. Potassium permanganate*
E. 5% solution of glucose.

605. Point out the antidote used in poisoning with salts of heavy metals
A. Penicillamine
B. Unithiolum*
C. Acetylcysteine
D. Magnesium sulfate
E. Atropine.

606. A patient in comatose state was admitted to emergency department. His

respiration was abnormal (Cheyn-Stoke’s respiration). Poisoning with opioid
analgesic was diagnosed. After intravenous administration of antidote
respiration was restored. What agent was used as antidote?
A. Pralidoxime

127
 B. Naloxone*
C. Ethanol
D. Acetazolamide
E. Unithiolum.
607. A patient with myocardium infarction was treated with heparin. On 6th
day of treatment nasal bleeding occurred. Overdose of heparin was diagnosed.
Point out the antidote of heparin
A. Acetylcysteine
B. Protamine sulfate*
C. Magnesium sulfate
D. Unithiolum
E. Deferoxamine.

608. Patient suffering from cancer of skin is treated with anticancer antibiotic.
Point out this drug
A. Neomycin
B. Danazol
C. Mercaptopurine
D. Phtoruracil
E. Bleomycin*.
609. Radio protector was given to a worker of a nuclear power station. What
mechanism is considered to be responsible for radioprotection?
A. Increasing of respiration
B. Inhibiton of free radicals formation*
C. Activation of oxidation reactions
D. Prevention of tissue's hypoxia
E. Increasing of tissue blood supply.
610. Patient suffering from acute leucosis was treated with agent that is
competitive antagonist of folic acid. Point out this agent
A. Phtoruracil
B. Methotrexate*
C. Mercaptopurine
D. Phtorafur
E. Cytarabine.

611. Patient with gastric cancer is treated with drug that interferes with
synthesis of nucleic acids due to its resemblance with pirimidine. Point out this
drug
A. Mercaptopurine
B. Methotrexate
C. Phluorouracil (Phtoruracil)*
D. Neomycin

128
 E. Bleomycin.

612. Highly dehydrated patient with cholera was admitted to specialized

department. Which agent is necessary to use to normalize the volume of
circulating blood?
A. Solution KCl 4%
B. Solution of calcium chloride 10%
C. Solution of glucose 40%
D. Solution calcium gluconate
E. Solution of NaCl 0,9%*.
613. A patient working at a chemical plant was admitted to the toxicological
department with mercury poisoning. What medicine should be used?
A. Isonitrozin
B. Naloxone
C. Enterosorbent
D. Unithiol*
E. Activated carbon.

129
 Дополнения базы тестов 2015-2016 гг.

614. After surgical removal of the thyroid gland for patients assigned L-
thyroxine. What type of pharmacotherapy achieved in such treatment?
A. Replacement*
B. Recovery
C. Etiological
D. Functional
E. Symptomatic

615. In the treatment of patients with antibiotics frequently occurs an allergy.

What is the mechanism lies at the basis of this complication?

A. Immune*
B. Enzyme
C. Metabolic
D. Physico-chemical
E. Receptor

616. Tobaco smoking - a consequence of nicotine addiction.

From what reaction begins its development?

A. Euphoria*
B. Passion
C. Addiction
D. Abstinence
E. Synergy

617. Emergency care in drugs overdose including primarily maintenance of

specific antidotes. What type of drug interaction provides their application?

A. Functional antagonism*
B. Summation
C. Incompatibility
D. Drug synergy
E. Compatibility

130
 618. Long-term use of chlorpromazine in patients with schizophrenia, along
with the restoration of mind, led to the development of Parkinson's disease
symptoms. For what type of drug action should be attributed these manifestations?

A. Complication*
B. Allergic reaction
C. The main medicinal effect
D. Sensitization
E. Addiction

619. The young scientist after working in the archive library there was allergic
to book dust. What H1 histaminoblokator without long-acting hypnotic effect should
apply?

A. Loratadine*
B. Depot medroxyprogesterone acetate
C. Metylmetyonynsulfonyya chloride
D. Enoxaparin calcium
E. Ropivakayin

620. For the treatment of arthritis celecoxib doctor has ordered. What group of
NSAIDs owned this vehicle?

A. Koksyby*
B. Adaptogens
C. Oxidizing
D.Trombolytic
E. Complexons

621. The 3-year old child with a fever over chickenpox. What antipyretic
medication is allowed in this case to avoid the development of Reye syndrome?

A. Paracetamol*
B. Menthol
C. Castor Oil
D. Ringer-Locke solution
E. Fish Oil

131
 622. In patients after long-term use of aspirin as antiplatelet agents was
dyspnea. How is this difficulty?

A. Apirin asthma*
B. Euphoria
C. Functional cumulation
D. Dysbacteriosis
E. Idiosyncrasy

623. After myocardial infarction, the doctor scheduled the patient anty-
atherosclerotic drug that blocks the synthesis of cholesterol in liver and reduces the
risk of ischemic complications. Define a drug?

A. Atorvastatin*
B. Lobeline
C. Clonidine
D. Reserpine
E. Xylometazoline

624. In the intensive care unit delivered a man with a diagnosis of cardiogenic
shock. The introduction of any drug would be appropriate in this situation

A. Dobutamine*
B. Novocaine
C. Lovastatin
D. Phenytoin
E. Ranitidine

625. Determine the drug that the doctor prescribed for the treatment of a patient
who has history of angina, tachycardia and asthma?

A. Metoprolol*
B. Haloperidol
C. Bromocriptine
D. Tannin
E. Metronidazole

626. Select the drug has a hypotensive effect, reduces blood volume and
displays ions of sodium, potassium and magnesium from the body.
A. Furosemide*
B. Caffeine-sodium benzoate
C. Bemegride
D. Pantotsid
E. Magnesium sulfate

132
 627. Elderly man suffering from bronchitis, was appointed drug with mucolytic
mucokinetic action. It is known that in addition to the drug expectorant action
promotes the synthesis of endogenous surfactant. What is this medicines?

A. Ambroxol*
B. Naphthyzinum
C. Omnoponum
D. Tubokurarіn
E. Rofecoxib

628. Patients with cystitis doctor appointed antimicrobial agent with broad-
spectrum fluoroquinolone group, mechanism of action is associated with blocking the
enzyme DNA gyrase? What kind of preparation we talking about?

A. Ciprofloxacinum*
B. Arbіdol
C. Furacillіnum
D. Holenzіmum
E. Tanalbіnum

629. The patient to complex treatment of hypertension was included long-

acting medicine (24 hour), mechanism of action is associated with the blocking an
enzyme that promotes the synthesis of angiotensin II. What is this drug?

A. Lizinopril*
B. Ergocalciferol
C. Mercaptopurine
D. Lavomax
E. Bromhexinum

630. After tooth extraction doctor prescribed to the patient for mouthwash
procedure an antiseptic drug from halogencontaining group. Determinate the drug?
А. Chlorhexidine *
B. Ampicillin
C. Fraxiparyn
D. Lobeline
E. Benzocaine

631. During stomatolodical procedure under conductive anesthesia in patient

with hypertension, blood pressure increased. Which of the following drugs should be
used to decrease blood pressure?
А. Magnesium sulfate *
B. Fizostihmin
133
 C. Nafazolin
D. Haloperidol
E. Tramadol

632. During the root canal filling it’s important to irrigate a canal from necrotic
residual dentin by antiseptic solution. Determine which of the following agents will
contribute to mechanical cleaning.
А. Hydrogen peroxide *
B. Festal
C. Prazosin
D. Amoxiclav
E. Almagel

633. Dentist decided to conduct short-term anesthesia (neuroleptanalgesia).

Which of the psychotropic drugs in it combination?
A. Droperidol *
B. Sulpiride
C. Trioxazyn
D. Reserpine
E. Neuleptil
634. Before stomatological treatment, patient has got the tranquilizer –
diazepam. Identify the mechanism of its anxiolytic action.
А. Benzodiazepine receptor agonist *
B. M-cholinergic receptors agonist
C. β-adrenoceptor blocker
D. Histamine receptor blocker
E. Stimulator of redox processes

635. Anaphylactic shock appeared in patient after injection of local anesthetic

in dental department. Determine the hormonal agent for emergency medical aid.
А. Prednisolone *
B. Cermion
C. Vancomycin
D. Ribavirin
E. Probucol

636. A patient complained to a doctor about an appearance on the oral mucosa

a gray spots. He suffers from syphilis and takes bismuth preparation which causes
intoxication symptoms. What is the antidote should be used in this case?
А. Unithiol *
B. Artykain
C. Fenoterol
D. Reserpine
E. Sulpiride

134
 637. During the tooth extraction preparation, doctor indicated for patient an
agent that prevents bleeding. Determine this drug.
А. Vikasol *
B. Diakarb
C. Ethonium
D. Analgin
E. Benzohexonium

638. Patient B. 45 years, previously was instal with amalgam seal. A month
later, she complained of unwell feeling and was diagnosed with acute mercury
poisoning. What is the antidote advisable to appoint in this case?
A. Unithiol *
B. Atenolol
C. Enalapril
D.Ceftriaxone
E. Zidovudine
639. For mandibular biopsy procedure doctor used a neuroleptanalgesia. What
is the opioid analgesic that should be used in combination with droperidol for this
goal?
А. Fentanyl *
B. Emetine hydrochloride
C. Depo-medroxyprogesterone acetate
D. Metylmetioninsulfonium chloride
E. Fish Oil

640. Lincosamide antibiotic have been prescribed to a patient with mandibular

osteomyelitis. Determine this agent.
А. Lincomycin *
B. Kanamycin
C. Byseptol
D. Fuzydin sodium
E. Vancomycin
 
641. Wide spectrum antibiotic have been prescribed by the dentist for
odontogenic sepsis prevention that well-penetrates into bone tissue. Determine this
drug.
A. Doxycycline *
B. Nystatin
C. Tubocurarinum
D. Ethambutol
E. Pyrazinamide
 

135
 642. Before the tooth extraction procedure dentist have done an anesthesia by
articaine and epinephrine combined agent. What did the dentist used?
А. Ultracaine *
B. Novocaine
C. Cocaine
D. Benzocaine
E. Codeine
 
643. Facial nerve paresis appeared in patient during a stomatological
procedure. Which of the anticholinestherase agents should be prescribed to the
patient?
A. Proserinum *
B. Fluoxamine
C. Sulmazole
D. Atenolole
E. Dipyridamole

644. For the xerostomia treatment have been prescribed a cholinestherase drug
that is widly use in ophtolmological practice in glaucoma. What is the drug above?
A. Pilocarpine hydrochloride *
B. Klopamid
C. Estrone
D. Bronhofit
E. Suprastin
645. A patient diagnosed with bacterial stomatitis, caused by anaerobic
microflora. What synthetic antimicrobial agent should be given?
А. Metronidazol *
B. Carbocholine
C. Terazosin
D. Cyklodole
E Amphetamine
646. During tooth extraction the patient developed collapse. What drug should
be used to increase blood pressure?
A. Phenylephrine *
B. Arduan
C. Halothane
D. Apisarthron
E. Enflurane

647. A patient developed acute bronchospasm during dental examination.

Which drug should be administered urgently?
A. Epinephrine *
136
 B. Chingaminum
C. Lovastatin
D. Procaine
E. Phenythoin

648. A patient was prescribed fluconazole after dental examination. What

disease in the oral cavity is an indication for use of fluconazole?
А. Candidomycose
В. Dental caries
С. Periodontitis
D. Bacterial inflammation
Е. Allergic gingivitis

649. The complex jaw joint tuberculosis therapy insludes isoniazid and vitamin
preparation which prevents its side effects (neuritis). What vitamin is used for this
purpose?
А. Pyridoxine*
В. Papaverine hydrochloride
С. Plathyphylline
D. Piracetam
Е. Trimeperidine

650. The examination of dental patient revealed stomatitis with bleeding gums
and pain during chewing. What vitamin preparations should be assigned to him in the
first place?
А. Ascorbic acid*
В. Aceclidine
С. Ambroxolum
D. Acetylsalicylic acid
Е. Аmitriptyline

651. After poliomyelitis a patient was appointed agent for recovery of skeletal muscle
tone. Determine the drug:
A. Neostigmine *
B. Nyzatidin
C. Sukralfat
D. Estrone
E. Hutalaks

652. A man who is working at the factory got the minor injuries of his hands.
What antiseptic drug from the halogens group should be used for disinfecting hands
scratches?
А. Solution of iodine*
B. Dibazol
137
 C. Kanamycin
D. Dipyridamole
E. Pirenzepine

653. For the treatment of hypertensive patient was appointed angiotensin II

receptor antagonist. Which of the following drugs was prescribed?
А. Losartan*
B. Nitrazepam
C. Cyclodolum
D. Erythromycin
E. Galantamine.

654. For the treatment stroke patient doctor prescribed nootropic agent. Point
out this drug.
А. Piracetam*
B. Askorutin
C. Sermion
D. Vecuronium
E. Itipromin

655. A patient has chronic fatigue due to hard physical and mental work. The
doctor appointed psychomotor stimulant. Select this agent.
А.Caffeine*
B. Nicergoline
C. Talinololum
D. Ipratropium bromide
E. Analginum

656. A patient with impaired heart rate for prevention of attack of angina
pectoris was prescribed Ca channel blockers. Determine this drug.
А. Amiodarone*
B. Nakom
C. Sodium bromide
D. Tavegil
E. Logest

657. A patient was diagnosed gastric peptic ulcer. Indicate which drug will
reduce the function of gastric glands by blockade of H2-histamine receptors?
A. Famotidine*
B. Syrepar
C. Trymetazyn
D. Analginum
E. Dyzopiramid

138
 658. Patient with peptic ulcer was treated with omeprazole. The acidity of
gastric juice decreased significantly. What is the mechanism of this drug action?
A. Inhibition of Н+К+-АTPase*
B. Blockade of beta- adrenoceptors
C. Blockade of cyclooxygenase
D. Blockade of monoamineoxidase
E. Activation of Н-cholinoceptors

659. Aged patient is suffering from chronic constipation. Prescribe the drug for
treatment this condition.
А. Bisacodil*
В. Isoflurane
С. Leykohen
Д. Butorphanol
Е. Probucol

660. Patient is suffering from diarrhea. Prescribe the drug which acted by
binding with opioid receptors of intestine.
А. Loperamide*
В. Reaferon
С. Dihydroergotamine
Д. Amylnitrite
Е. Bismoverol

661. After gastric resection the megaloblastic anemia developed in patient.

What drug should be applied in this case?
А. Cyanocobalamin*
В. Pentoxifylline
С. Euphylline
D. Primaquine
Е. Phenobarbital

662. A pregnant woman with low generic activities was admitted to the
hospital. What preparation will be the most beneficial for stimulating of labor activity
in this case?
А. Oxytocin*
В. Aetacridini lactatis
С. Bupivacaine
D. Ephedrine
Е. Miconazole

663. A woman was admitted to the hospital with biliary colic. Which drug
from group of opioid analgesics with spasmolytic activity should be used?
А. Promedol*

139
 B. Abciximab
C. Escitalopram
D. Oxandrolone
E. Zanamiviр

664. Patient after strok for prevention of thrombosis was treated with
antiplatelet agent from the group of nonselective cyclooxygenase inhibitors. Point out
this drug:
А. Acetylsalicylic acid *
B. Groprynozyn
C. Bupivacaine
D. Venlafaxine
E. Amfoglukamin

 
665. For the treatment of pregnant woman with tonsillitis doctor prescribed
antibiotic of narrow spectrum. Point out this antibiotic.
 
А. Penicillin sodium*
B. Laevomycetin
С. Тetracycline
D. Furacilinum
Е. Trimethoprim
 
666. A 5-year-old child was admitted to the hospital with pneumonia caused by
mycoplasma. Which antibiotic from macrolides group should be assigned for its
treatment?
А. Аzithromycin*
В. Tetracycline
С. Phthalazolum
D. Bactrim
E. Furacilinum

667. After applying eye drops in the patient with iris inflammation was mydriasis and
paralysis of accommodation. Which drug was prescribed by a doctor?
A. Аtropine *
B. Ferkoven
C. Аtenolol
D. Niridazol
E. Primaquine
668. A patient appealed to the doctor complaining of muscular rigidity, stiffness of
movement, permanent hand tremor. Diagnosis - Parkinson's disease. What preparation
is advisable to appoint a patient?
A. Levodopa *
B. Ferkoven
140
 C. Sinestrol
D. Ketoprofen
E. Neomycin

669. A patient with rheumatism was prescribed antimalarial drug. Determine

the drug:
А. Chingaminum *
В. Tubocurarine hydrochloride
С. L-cet
D. Ferrum-lek
Е. Infusum Valerianae

670. A patient with chronic heart failure takes cardiac glycoside. Determine the
drug:
А. Digoxin *
В. Phenobarbitone
С. Heptral
D. Clindamycin
Е. Levamisole

671. A doctor prescribed a patient with acute heart failure digoxin. To which
pharmacological group this drug belongs to?
А. Cardiac glycosides *
В. Neuroleptics
С. Adrenoblokers
D. Antiprotozoal agents
Е. Cholinomimetics

672. According to medical examination a patient with ischemic heart disease

was found hyperlipidemia. A doctor prescribed a patient the drug that violates the
synthesis of cholesterol. Determine the drug:
A. Atorvastatin *
B. Nystatin
C. Pirenzepine
D. Reserpine
E. Xylometazoline

673. A patient suffers from hypertension and angina pectoris. Which of β-

adrenoblockers should be prescribed?
A. Propranolol *
B. Haloperidol
C. Bromocriptin
D. Tanninum
141
 E. Levamisole

674. A man developed bronchospasm. What drug should be administered to

relieve bronchospasm?
A. Salbutamol *
B. Atenolol
C. Pindolol
D. Phetanolum
E. Timolol

675. A patient with acute pancreatitis was admitted to the surgical clinic.
Which drug should be administered urgently?
А. Contrycal *
В. Almagel
С. Pirenzepine
D. Norepinephrine
Е. Fraxiparine

676. A patient has impaired visual acuity, especially in the evening. What
vitamin preparation contribute to the restoration of vision?
А. Retinol *
В. Reserpine
С. Reparil
D. Retabolil
Е. Ranitidine

677. A child has bronchitis. The doctor appointed expectorant which stimulates
the synthesis of endogenous surfactant. Determine the drug:
А. Ambroxol *
B. Minizistone
C. Sitagliptin
D. Solutio Ringer-Locke
E. Nifuroxazide

678. A patient with rheumatoid arthritis was assigned non-steroidal anti-

inflammatory agent from selective cyclooxygenase-2 inhibitors. Determine the drug:
А. Celecoxib *
B. Fluticasone propionate
C. Castor oil
D. Enoxaparin
E. Rosiglitazone

679. A 3-year-old child was diagnosed mixed helminthosis. Which drug should
be prescribed?

142
А. Mebendazole *
В. Riboflavine
С. Fraxiparine
D. Papaverine hydrochloride
Е. Ranitidine

143