Drug Mechanism of Action Indications Side Effects Nursing Responsibility

Generic Name: Leuprolide A synthetic analogue of luteinizing Advanced prostate cancer in The most common side effects of Examination and Evaluation:
hormone–releasing hormone patients who are unable to tolerate
Brand Name: Lupron (LHRH). Initially causes a transient orchiectomy or estrogen therapy LUPRON DEPOT include hot Assess pulmonary function
increase in testosterone; however, (may be used in combination with flashes/sweats; injection site periodically by measuring lung
Classification: LHRH Agonist with continuous administration, flutamide or bicalutamide): volumes, breath sounds, and
reaction/pain; general pain;
testosterone levels are decreased. Management of central precocious respiratory rate. Notify physician
Dosage/Route/Frequency: Reduces gonadotropins, puberty (CPP). 3.75-mg depot only: swelling; testicular shrinkage; immediately if patient experiences
Prostate cancer: 1 mg/d testosterone, and estradiol.. Endometriosis: Uterine fibroids signs of pulmonary fibrosis (dry
difficulty urinating;
subcutaneously or various depot (with iron therapy).
fatigue/weakness; headache; and cough, dyspnea, shortness of
preparations
breath, cyanosis) or pulmonary
joint, gastrointestinal, and embolism (sudden shortness of
Endometriosis: 3.75 mg IM once a
month Precocious puberty: 45 mg respiratory problems. breath, chest pain, cough, bloody
subcutaneously every 6 mo or sputum).
various depot preparations Contraindication/s Adverse Reaction/s Assess heart rate, ECG, and heart
sounds, especially during exercise
People who have experienced any Asthma was reported in women
type of allergic reaction to LUPRON with a history of asthma, sinusitis, (See Appendices G, H). Report any
DEPOT or similar drugs should not and environmental or drug rhythm disturbances or symptoms
take LUPRON DEPOT or LUPRON allergies. of increased arrhythmias, including
DEPOT-PED. palpitations, chest discomfort,
Females who are or may be Rare cases of delayed serious skin shortness of breath.
References: pregnant or have undiagnosed reactions that included a rash See immediate medical assistance if
https://my.clevelandclinic.org/ uterine bleeding should not receive containing blisters with and without symptoms of MI develop, including
health/drugs/18166-leuprolide- LUPRON DEPOT or LUPRON DEPOT- peeling have been reported in sudden chest pain, pain radiating
injection020578s037lbl.pdf PED. patients receiving leuprolide- into the arm or jaw, shortness of
https://www.lupron.com/ containing therapy. breath, dizziness, sweating, anxiety,
and nausea.
Depression may occur or worsen
while taking LUPRON DEPOT,
especially in patients who have a
history of depression.