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Breathing and Exchange of Gases Lec1

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BREATHING AND EXCHANGE OF GASES

BREATHING
BREATHING EXCHANGE OF GASES

Glucose CO2
Intake of food Amino Acid H2O
Fatty Acid Energy

Digestion Indirect Oxidation


BREATHING EXCHANGE OF GASES

INTRODUCTION
•Oxygen (O2) is utilised by the organisms to
indirectly break down simple molecules like glucose,
amino acids, fatty acids, etc., to derive energy to
perform various activities.

•Carbon dioxide(CO2) which is harmful is also


released during the above catabolic reactions.
BREATHING EXCHANGE OF GASES

•It is, therefore, evident that O2 has to be


continuously provided to the cells and CO2 produced
by the cells have to be released out.

•This process of exchange of O2 from the


atmosphere with CO2 produced by the cells is called
breathing , commonly known as respiration.
BREATHING EXCHANGE OF GASES
Steps of respiration Breathing or pulmonary ventilation by which
atmospheric air is drawn in and CO2 rich
alveolar air is released out.

Diffusion of gases (O2 and CO2)


across alveolar membrane.

Transport of gases by blood.

Diffusion of O2 and CO2 between


blood and tissues.
Utilisation of O2 by the cells for catabolic
reactions and resultant release of CO
BREATHING EXCHANGE OF GASES

Organs and types of respiration


ORGAN RESPIRATION

• Gills • Gill respiration(branchial)


• Skin • Cutaneous respiration
• Lungs • Pulmonary respiration
• Trachea • Tracheal respiration
• Buccal cavity • Buccopharyngeal
respiration
BREATHING EXCHANGE OF GASES
S.no. Name of Organism Respiratory organ
1 Protozoa

2 Porifera
Respiratory organs are absent but
3 Coelentrata respiration takes place by general
body surface
4 Ctenophora

5 Platyhelminthes

6 Aschelminthes

7 Annelida Moist cuticle


BREATHING EXCHANGE OF GASES

8 Insects(cockroach, Trachea
silkworm)

9 Prawn Gills

10 Arachnida (spider) Book lungs

11 Mollusca Gills(Ctenidia)

12 Echinodermata Body surface called dermal branchaiae in most,


Genital bursae in Brittle star and tube feet in all.
BREATHING EXCHANGE OF GASES

13 Fishes Gills

14 Tadpole Gills

15 Frog Lungs/skin/bucco-pharyngeal cavity

16 Reptiles Lungs

17 Birds Lungs

18 Mammals Lungs
BREATHING EXCHANGE OF GASES

Respiratory organ Examples


General body surface Sponges, Coelenterates, Flatworms

Moist cuticle (skin) Earthworms, Frogs

Tracheal tubes Insects

Gills Aquatic arthropods, Molluscs ,


Fishes

Lungs Reptiles, Birds, Mammals


BREATHING EXCHANGE OF GASES
Human respiratory system

Respiratory passage Respiratory organ


1. Nose and Nasal chamber 1. Lungs
2. Pharynx
3. Larynx
4. Trachea
5. Bronchial & Respiratory Tree
6. Alveoli
RESPIRATORY PASSAGE
1. Vestibular zone
Skin, Hair, sebaceous gland
2. Olfactory zone
Schneiderian membrane,
Bowman’s gland, PSCCGE

3. Respiratory zone
Conchae/turbinal
RESPIRATORY PASSAGE

•One pair of external nostrils (dirhynous


condition) opening out above the upper lips.

•External nostrils lead to nasal chamber


through the nasal passage.

•Both the nasal chambers are separated from


each other by hyaline cartilage.
RESPIRATORY PASSAGE

•The anterior part of each nasal chamber is called


nasal vestibule ,which is formed by invagination
of skin during embryonic development, so this
part contains hair and sebaceous glands. In this
manner dust particles can not enter in.

•The posterior part of the nasal chamber is


occupied by three bones or conchae.
RESPIRATORY PASSAGE

•At several places in the nasal passage these


bones form outgrowths called turbinals. Due to
these outgrowths the nasal passage is long and
spiral.

•This helps in making the temperature of air


equal to the body temperature before it reaches
the lungs and does not allow the unwanted
materials like dust to reach the lungs.
RESPIRATORY PASSAGE

•Some part of this outgrowth consist of


olfactory epithelium (Schneiderian membrane)
while some part is lined by pseudostratified
columnar ciliated glandular epithelium
(PSCCGE).
RESPIRATORY PASSAGE
2. Pharynx
• The nasal chamber opens into nasopharynx
through internal nostrils (choanae).

• The nasal chamber opens into nasopharynx,


which is a portion of pharynx, the common
passage for food and air.

• Nasopharynx opens through glottis of the larynx


region(oropharynx) into the trachea.
RESPIRATORY PASSAGE
3) Larynx
•Cartilaginous box, help in sound
production hence called sound box.

•During swallowing glottis can be


covered by a thin elastic cartilaginous
flap called epiglottis to prevent the
entry of food into the glottis.
RESPIRATORY PASSAGE
RESPIRATORY PASSAGE
On the On the Basis
On the Basis of shape
Basis of no. of origin
One THYROID (Largest cartilage of larynx / Ventrally Hyaline
broad / laterally narrow/dorsally incomplete/ cartilage
C shaped cartilage/In human males , ventral
surface of thyroid cartilage make a process
called as ADAMS APPLE
CRICOID Hyaline
One (Signet ring shape cartilage /dorsally broad cartilage
/laterally narrow/ventrally fibre like)
Two ARYTENOID (conical shaped cartilage) Hyaline
Two CARTILAGE OF SANTORINI(spherical cartilage on Elastic
Arytenoids cartilage/smallest cartilage of larynx)
Two CUNEIFORM cartilage Elastic
RESPIRATORY PASSAGE

Larynx is the sound producing


organ in which two types of
vocal cords are present-

(i) False vocal cords provide


moisture to the true vocal
cords.
(ii) True vocal cords are
helpful in phonation(sound
production).
RESPIRATORY PASSAGE
4) Trachea

C-1
C-2
C-3
C-4
C-5
T-1
T-2
T-3
T-4
T-5
RESPIRATORY PASSAGE

Visceral pleura
Parietal pleura
Pleural cavity
Right primary bronchus
Right secondary bronchus

Right tertiary bronchus


Right bronchiole

Right terminal bronchiole


Anterior view
RESPIRATORY PASSAGE
•A straight tube(diameter 2.5 cm) extending up to the
mid thoracic cavity, which divides at the level of 5th
thoracic vertebra into a right and left primary
bronchi.

•Each bronchi undergoes repeated divisions to forms


the secondary and tertiary bronchi and bronchioles
ending up in very thin terminal bronchioles.

•The trachea, primary ,secondary and tertiary, and


initial bronchioles are supported by incomplete
cartilaginous rings.
RESPIRATORY PASSAGE (Bronchial & Respiratory tree)
External Vestibule/Passage Nasal chamber Internal nares
nostrils
Nasopharynx

Alveoli Pharynx
Conducting Zone Larynx
Alveolar sac
Exchange zone Trachea
Atria (Respiratory tree)
Primary Bronchus
Alveolar duct
Bronchial tree Secondary Bronchus
Respiratory Terminal Total pulmonary Tertiary/segmental
Bronchioles Bronchioles Bronchioles Bronchus
RESPIRATORY PASSAGE
Terminal
bronchiole

Respiratory
bronchiole
Alveolar
ducts

Alveoli

Alveolar
sac
RESPIRATORY PASSAGE

 There are two zones in respiratory system-


conducting and respiratory zone.

• The part starting with the external nostrils up to


the terminal bronchioles constitute the conducting
zone /part.

• From respiratory bronchiole to alveoli form the


respiratory tree or exchange zone.
RESPIRATORY PASSAGE
•The conducting zone transports the atmospheric air
to the alveoli, clears it from the foreign particles,
humidifies and also brings the air to body
temperature.

•Exchange zone is the site of actual diffusion of O2


and CO2 between blood and atmospheric air.

•C-shaped cartilaginous rings are present from


trachea to initial bronchiole.
RESPIRATORY PASSAGE
6) ALVEOLI

•Structural and functional units of lungs.


•300 millions in both lungs.
•Having two types of cells called pneumocytes.
•On outer side yellow fibrous connective tissue
is present.
RESPIRATORY PASSAGE
Pneumocyte

Type I Pneumocyte Type II Pneumocyte


Numerous, Few,
smaller, help in larger,
Type I gaseous exchange
pneumocyte
secrete lecithin
Type II Dust cell
pneumocyte
Lecithin is phospholipid
surfactant, reduce surface
tension of alveoli and keep
alveoli always remain open for
efficient gaseous exchange
RESPIRATORY ORGAN
LUNGS
RESPIRATORY ORGAN
1) LUNGS-
• Main Respiratory Organ.
• Endodermal in origin.
• The branching network of bronchi, bronchioles and
alveoli comprise the lungs.
• Right lung have 3 lobes and weight 625 gm.
• Left lung have 2 lobes and weight 575 gm.
• Cardiac notch is present in left lung.
• Both the lungs are covered by pleural membranes.
• Both the lungs are situated in air tight thoracic
chamber.
RESPIRATORY ORGAN

Pleural cavity

Parietal pleura

Visceral pleura
RESPIRATORY ORGAN
Double layered pleura

Parietal pleura Visceral pleura


In close contact of In contact with
thoracic lining lung surface

•Pleural cavity contains pleural fluid.


•Pleural fluid reduces friction on the lung surfaces.
•Pleural fluid acts as a shock absorber.
RESPIRATORY ORGAN
• The lungs are situated in the thoracic chamber which
is anatomically an air tight chamber.
THORACIC CAGE
Coverings of thoracic cavity makes thoracic cage

Anterior surface Clavicle bones


Posterior surface Diaphragm
Dorsal surface Vertebral column, ribs
Ventral surface Sternum, ribs
Lateral surface Ribs
THORACIC CAGE

•The anatomical setup of the lungs in the thorax is


such that any change in the volume of the thoracic
cavity will be reflected in the lung (pulmonary)
cavity.

•Mammalian lungs are solid and spongy without


muscles so power of self contraction and self
relaxation is not present in mammalian lungs.

•Such an arrangement is essential for breathing ,as


we can not directly alter the pulmonary volume.
DIAPHRAGM
DIAPHRAGM
•It is muscular structure (radial muscle) which
separate thoracic cavity from abdominal cavity

•Word related with “diaphragm” is “phrenic”.

•Principal muscle of breathing and aid in ventilation.

•Phrenic nerve is present for diaphragm contraction.

•Diaphragm also helpful in parturition, micturition


and defaecation.
INTERCOSTAL MUSCLES

• Spaces between two pairs of ribs are called


intercostal spaces and muscles present in these
spaces are called intercostal muscles(ICM).

• ICM are of two types- External intercostal muscles


(EICM) and internal intercostal muscles (IICM).
INTERCOSTAL MUSCLES

Ribs

External intercostal
muscles

Internal intercostal muscles


INTERCOSTAL MUSCLES
EICM IICM
• Connect dorsal surface of • Connect ventral surface of
upper rib with ventral upper rib with dorsal
surface of lower rib. surface of lower rib.

• Contraction in EICM, at the • Contraction in IICM, at the


time of inspiration moves time of forceful expiration
sternum outwardly and ribs moves sternum inwardly
moves upwardly. and ribs moves downwardly.

• Increase volume of thoracic • Decrease volume of


cavity in dorso-ventral axis. thoracic cavity in dorso-
ventral axis.
MECHANISM OF RESPIRATION
Breathing ( 12-16/Min.)

Normal Inspiration Normal Expiration


 Inhale  Exhale
 Active process  Passive process
 2 Sec.  3 Sec.

Diaphragm ICM
BREATHING
•The movement of air into and out of the lungs is
carried out by creating a pressure gradient between
the lungs and the atmosphere.
BREATHING

• Inspiration can occur if the pressure within the lungs


(intra-pulmonary pressure) is less than atmospheric
pressure, i.e., there is a negative pressure in the lungs
with respect to atmospheric pressure.

• Expiration takes place when the intra-pulmonary


pressure is higher than the atmospheric pressure.
MECHANISM OF BREATHING
MECHANISM OF BREATHING

Inspiration Expiration
(atmospheric air is drawn in) (alveolar air is released out)
Intra-pulmonary Atmospheric Intra-pulmonary Atmospheric
pressure < pressure pressure > pressure
MECHANISM OF BREATHING
inspiration Contraction In

Diaphragm EICM

Increase in Increase in
Antero-posterior Dorso-posterior
axis axis

Pulmonary volume increase

Intra pulmonary pressure decrease

Forces air from outside to more


into the lungs (inspiration)

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