Anti-Inflammatory Foods

Nutrition Guidelines for People

with Rheumatic Diseases
By Sarah L. Patterson, M.D. & Sara K. Tedeschi, M.D.
 Nutrition Anti-Inflammatory Foods

INTRODUCTION
The Food & Inflammation Connection

There is no “one size fits all” diet, but

studies on nutrition and health show that
most people can improve their health by
eating a plant-based diet rich in a variety
of foods from plants, including vegetables,
fruits, whole grains, legumes, and nuts.
Food will not cure your condition or reverse
damage that has already occurred in your
body, but it may reduce active inflamma-
tion, improve your symptoms, and decrease
the risk of future disease flares.

The information presented here is based

on the best data available from biomed-
ical research. We have focused on the
relationship between diet and two specific
conditions—rheumatoid arthritis (RA) and
systemic lupus erythematosus (SLE)—but
a lot of the information presented will be
relevant for other rheumatic conditions. We
recognize that outside of biomedical re-
search there are many ways of understand-
ing the link between nutrition and health,
including other systems of medicine, heal-
ing traditions, and cultural/religious beliefs.

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 Anti-Inflammatory Foods Nutrition

Anti-Inflammatory Diets
There are many different definitions of
an anti-inflammatory diet, and most diets
that claim to be anti-inflammatory are not
actually proven to decrease inflammation.1,2
However, we know that certain food com-
ponents and ingredients can increase or
decrease inflammation by affecting blood
sugar, antioxidant levels, and the bacte-
ria that live in our gut. These helpful and
harmful food components are discussed in
the section called “General Nutrition Rec-
ommendations.” An example of a diet with
anti-inflammatory properties is the Mediter-
ranean diet, discussed in more detail below.
On the other end of the spectrum, the Stan-
dard American Diet (or SAD diet), which
contains large amounts of calorically-dense
processed foods, saturated fat, and added
sugar, is pro-inflammatory and associated
with increased risk of cardiovascular disease
and death.3-6

Mediterranean Diet
The Mediterranean diet is a pattern of eating
based on typical diets in countries near the
Mediterranean Sea, such as Greece, Italy, and
Spain. This diet contains lots of vegetables,
fruits, olive oil, whole grains, and beans, as
well as moderate amounts of fish, chicken,
low-fat dairy, and nuts. The Mediterranean
diet limits red meat, sugary drinks (including
fruit juices), salt, processed foods, and pro-
cessed meats. The American Heart Associa-
tion provides a helpful and relevant summary

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 Nutrition Anti-Inflammatory Foods

of this diet on their website: https://www.heart.org/en/healthy-liv-

ing/healthy-eating/eat-smart/nutrition-basics/mediterranean-diet

Two different randomized controlled trials have studied whether

the Mediterranean diet decreases joint inflammation in people
with RA. The first study found that the group eating a Mediter-
ranean diet had a significant improvement in RA disease activity
(reduced joint inflammation) after 12 weeks on the diet.7 The
amount of improvement in the Mediterranean diet group was
large for a diet intervention and was about one-third the size of
the benefit seen in trials of methotrexate for RA (the most com-
mon RA medication). This version of the Mediterranean diet
included olive oil, canola oil, green vegetables, root vegetables,
fish, fruit, low-fat yogurt, low-fat cheese, green tea, black tea,
poultry, and sparing amounts of red meat. Notably, RA patients
on the Mediterranean diet lost a significant amount of weight at
the end of 12 weeks—about seven pounds—so it’s possible that
some of the improvement in RA symptoms was due to weight
loss.

Another trial that tested a six-week Mediterranean-type diet for

RA patients found that the group eating the Mediterranean diet
had less pain and morning stiffness six months later, suggesting
that it provided a long-lasting benefit.8 The intervention included
weekly Mediterranean diet cooking classes and provided recipes,
written materials about the diet, and information about local ac-
cess to affordable ingredients. The Mediterranean-type diet was
high in fruit, vegetables, legumes (beans), and olive oil.

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 Anti-Inflammatory Foods Nutrition

General Nutrition Recommendations

Fruits & Vegetables
Cover at least half your plate with an abun-
dance of non-starchy vegetables and fruits
from the entire color spectrum.
• Vegetables and fruits have high concentra-
tions of polyphenols (antioxidants), carot-
enoids (antioxidants), and fiber.
• Examples of highly nutritious vegetables:
lightly cooked dark leafy greens (spinach,
collard greens, kale, and Swiss chard),
cruciferous vegetables (broccoli, cabbage,
Brussels sprouts, kale, bok choy, and
cauliflower), carrots, beets, onions, peas,
squash, sea vegetables, and washed raw
salad greens.
• Examples of highly nutritious fruits: rasp-
berries, blueberries, strawberries, peach-
es, nectarines, oranges, pink grapefruit,
plums, pomegranates, blackberries, cher-
ries, apples, and pears.

Whole Grain Carbohydrates

Choose low glycemic index carbohydrates
rather than high glycemic index foods, and
whole grains rather than refined grains.
• The glycemic index (GI) is a value assigned
to foods based on how quickly the body
turns them into glucose (blood sugar).
Foods low on the glycemic index scale
tend to release glucose slowly, which gives
your body steady energy. Foods high on
the glycemic index release glucose rapidly.
This website lists the glycemic index for
many common foods: https://www.health.
harvard.edu/diseases-and-conditions/
glycemic-index-and-glycemic-load-for-100-
foods

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 Nutrition Anti-Inflammatory Foods
• Eat whole grains—grains that are intact or
in a few large pieces—such as brown rice,
basmati rice, wild rice, quinoa, and steel-
cut oats.
• Limit products made from flour, especially
white bread and sugary desserts.

Choose Plant-Based Protein

and Limit Red Meat
• People who eat a mostly vegetarian diet
live longer. Furthermore, vegetarian diets
have been associated with less severe
symptoms in several inflammatory condi-
tions, including rheumatoid arthritis.9,10
• Examples of vegetarian protein include
beans, legumes, nuts, and whole soy
foods.
• Fish is also a healthy source of protein and
healthy fats (see above).

Healthy Fats
Eat healthy fats that are rich in
monounsaturated and/or omega-3
polyunsaturated fatty acids.
• Omega-3 fatty acids, commonly called
“omega-3s”, have a number of anti-inflam-
matory properties.11 Humans cannot make
omega-3 fatty acids in the body, so they
need to come from the diet. Fatty fish (for
example, sardines, salmon, herring, and
black cod), seeds (including hemp, chia,
flaxseed oil, and freshly ground flaxseed),
and nuts (especially walnuts) are important
sources of omega-3 fatty acids.
• Use extra virgin olive oil, which is rich in
monounsaturated fatty acids, for cooking
and making salad dressings.
• Other sources of healthy fat include avoca-
dos, omega-3 enriched eggs, and whole-
soy foods (e.g., tofu, tempeh, edamame).
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Anti-Inflammatory Foods Nutrition

Season Your Food with

Anti-Inflammatory Spices
• Turmeric (Curcuma longa) is a medicinal
plant with a long history of usage in indig-
enous South Asian cultures and Ayurve-
dic medicine. The rhizome (rootstock) of
turmeric contains curcumin, a bright yellow
chemical with anti-inflammatory proper-
ties.12-14 Turmeric is traditionally used as a
spice in food preparation, an ingredient in
topical applications, and as an extraction
made with water, milk, or ghee.
• Ginger root is another plant commonly
used in South Asian cooking that is known
to have anti-inflammatory and anti-ox-
idative effects.15,16 It has traditionally
been used as an herbal supplement for
the treatment of many chronic ailments,
including asthma and arthritis. A study that
looked at how ginger may be helpful for
people with lupus found that one of its
compounds—called 6-gingerol—helps to
decrease the release of inflammatory sub-
stances from neutrophils, a type of blood
cell.17

Foods to Limit and Avoid

• Avoid any food containing hydrogenated
or partially hydrogenated oils as
ingredients.
• Avoid processed flour, added sugar, foods
containing high fructose corn syrup, and
high-fructose juices.
• Avoid or minimize red meat. Avoid all pro-
cessed meat (e.g., hot dogs, pepperoni,
bacon, packaged lunch meat).

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 Nutrition Anti-Inflammatory Foods

Anti-Inflammatory Food Pyramid

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 Anti-Inflammatory Foods Nutrition

Frequently Asked Questions

Should I eliminate gluten?

There is very little information on gluten, RA, and SLE from clin-
ical trials. In one study, RA patients assigned to a vegan, glu-
ten-free diet for one year had slightly better RA disease activity
(less joint inflammation) at the end of the trial compared to those
assigned to a non-vegan regular diet.9 However, we don’t know
if the benefit the treatment group experienced was from being
gluten-free, vegan, or both. The vegan, gluten-free diet included
vegetables, nuts, fruit, buckwheat, millet, corn, rice, sunflower
seeds, and sesame milk.

Another randomized trial tested a diet for RA patients with three

different phases: fasting for 7-10 days, followed by a vegan/glu-
ten-free diet for three months, and then nine months of a vege-
tarian diet.10 During the fasting phase, dietary intake consisted
of herbal teas, garlic, vegetable broth, a liquid extraction from
potatoes and parsley, and juice from carrots, beets, and celery.
No fruit juices were allowed. During the vegan/gluten-free phase,
the diet excluded gluten, meat, fish, eggs, dairy, refined sugar,
and citrus fruits. During the vegetarian phase, participants did
not eat meat and fish, but they could eat gluten and dairy. After
the first four weeks of the trial (which included the fasting phase
and the vegan/gluten-free phase), patients with RA in the spe-
cial diet group had fewer tender and swollen joints, lower pain
scores, and less systemic inflammation (measured by erythrocyte

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 Nutrition Anti-Inflammatory Foods

sedimentation rate and c-reactive protein) compared to the RA

patients who continued to eat their normal diet. The improve-
ment in RA symptoms lasted until the end of the trial, even after
participants were back to eating gluten, suggesting that being
vegetarian, as opposed to being gluten-free, was the main driver
of improvement.

Should I eliminate sugar?

Though the effect of sugar has not yet been
studied in clinical trials of people with RA
or SLE, there is a lot of research from the
general population showing that long-term
overconsumption of added sugars increases
the risk of a wide range of health problems.
Eating too much sugar is associated with
increased risk of diabetes, heart disease, liver
disease, certain cancers, and obesity. The
link between sugar and obesity is particularly
relevant for people with RA and SLE since
obesity was associated with worse RA and
SLE disease activity in several studies.18-20
Finally, eating less added sugars reduces
the risk of diabetes, which can be a problem
for people with rheumatic diseases who are
treated with high-dose or long-term predni-
sone.

Should I eliminate dairy?

Clinical trials have not studied whether dairy
can worsen RA or SLE symptoms. Vegan
diets–which eliminate all animal products,
including meat, fish, eggs, and dairy–have
shown possible benefits for RA. For example,
one trial found that RA patients improved
after one year of adhering to a vegan, glu-
ten-free diet9, as described under the FAQ for
gluten. Another trial found that patients re-
ported less joint pain and swelling after three
months of an uncooked vegan diet.21

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 Anti-Inflammatory Foods Nutrition

Should I eliminate meat?

Please see FAQs for “gluten” and “dairy”
for information about studies of vegan and
vegetarian diets.

Should I eliminate
nightshades?
Nightshade vegetables include tomatoes,
eggplants, bell peppers, and potatoes. These
foods contain an alkaloid molecule called
solanine (a glycoalkaloid), and some people
believe that solanine in nightshade vegeta-
bles can cause inflammation in the gut (in-
cluding increased intestinal permeability)22,
but no research has shown that solanine has a
direct effect on inflammation or arthritis pain.
Furthermore, since nightshades include foods
that are otherwise considered healthy (e.g.,
tomatoes), we do not recommend eliminating
nightshades unless you have a food intoler-
ance or food allergy to them.

Literature Cited

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