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BioInformatics Quiz1 Week1

This document provides an introduction to bioinformatics including a brief history. It discusses key topics such as the size of the human genome, the percentage of bases that encode proteins, databases commonly used in bioinformatics like Genbank and SRA, differences between next generation sequencing and Sanger sequencing, and common processes involved in bioinformatics analysis of data including data mining, management, computation, and modeling. It also provides brief details on the establishment of Sanger sequencing in 1965, the initiation of the Human Genome Project in 1988 and publication of the draft sequence in 2001, the development of the PAM score matrix for amino acid substitution, and the development of dynamic programming based sequence alignment algorithms in 1970.

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1K views6 pages

BioInformatics Quiz1 Week1

This document provides an introduction to bioinformatics including a brief history. It discusses key topics such as the size of the human genome, the percentage of bases that encode proteins, databases commonly used in bioinformatics like Genbank and SRA, differences between next generation sequencing and Sanger sequencing, and common processes involved in bioinformatics analysis of data including data mining, management, computation, and modeling. It also provides brief details on the establishment of Sanger sequencing in 1965, the initiation of the Human Genome Project in 1988 and publication of the draft sequence in 2001, the development of the PAM score matrix for amino acid substitution, and the development of dynamic programming based sequence alignment algorithms in 1970.

Uploaded by

chahoub
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Bioinformatics: Introduction and Methods 生物信息学: 导论与方法 Week 1

Introduction and History of Bioinformatics

Introduction and History of Bioinformatics


Submit your assignment
Due DateOct 26, 7:59 AM CET
Attempts3 every 8 hours
Receive grade
To Pass80% or higher
Grade
—
Introduction and History of Bioinformatics
Graded Quiz • 30 min

Due Oct 26, 7:59 AM CET

Introduction and History of Bioinformatics

Total points 10
1.
Question 1

人基因组大小约为:

The size of human genome is:

1 point

3.1*10^10 bp

3.1*10^7 bp

3.1*10^9 bp

3.1*10^8 bp

2.
Question 2

人基因组大约有多少是编码蛋白的基因区间:
How many percent of the human genome is composed of the bases encoding proteins?

1 point

90%

不足 5%

less than 5%

10%

30%

3.
Question 3

Genbank 数据库存储的数据是什么

Genbank is a database for:

1 point

核酸序列

nucleotide sequences

蛋白序列

protein sequences

蛋白结构

protein structures
核酸结构

nucleotide structures

4.
Question 4

SRA 数据库存储的数据是什么

SRA is a database for:

1 point

存储 Sanger 测序数据

Sanger sequencing data

存储新一代测序技术的数据

next-generation-sequencing data

存储基因芯片的数据

Microarray data

5.
Question 5

高通量测序错误率和传统 Sanger 测序相比

Compared with the error rate of Sanger sequencing, the error rate of next-generation
sequencing is

1 point

差不多

more or less the same


低

lower

higher

6.
Question 6

生物信息学对数据的处理一般是一个什么样的过程

How are the data processed in a bioinformatics way?

1 point

数据挖掘-数据管理-数据计算-建立模型/进行预测

Data mining –data management–data computation - modeling/simulation

数据管理-数据计算-数据挖掘-建立模型/进行预测

Data management-data computation –data mining –modeling/simulation

数据挖掘-数据管理-建立模型/进行预测-数据计算

Data mining –data management–modeling/simulation -data computation

建立模型/进行预测-数据挖掘-数据管理-数据计算

Modeling/simulation-Data mining –data management–data computation

7.
Question 7

Sanger 测序哪年发表
Sanger sequencing was established in：

1 point

1965

2002

1970

1977

8.
Question 8

人基因组计划哪年启动?哪一年发表草图?

The Human Genome Project was initiated in _ and the draft sequence was published
in _.

1 point

1988 2004

1977 2004

1988 2001

1977 2001

9.
Question 9
PAM 打分矩阵是为什么设计的

PAM score matrix was designed for

1 point

氨基酸替换

amino acid substitution

核苷酸替换

nucleotide substitution

10.
Question 10

基于动态规划的序列匹配算法哪年出现：

Sequence alignment algorithm based on dynamic programming was developed in：

1 point

1991

1970

1977

1988

Honor Code Agreement


I, MOHAMED CHIHEB BEN CHAABANE, understand that submitting work that
isn’t my own may result in permanent failure of this course or deactivation of my
Coursera account. 

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