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9/17/2020 Discovery Service for Universiti Kebangsaan Malaysia

Record: 1
Title: Applying a New Indicator Based on the ATC/DDD System for
Evaluating the Appropriateness of Clinical Application: Coxibs and
Traditional Nonsteroidal Anti- Inflammatory Drugs for Postoperative
Orthopaedics Pain Control.
Authors: Bakrin, Faizah Safina1
Bakry, Mohd Makmor2
Wan Hazmy Che Hon3
Faizal, Shafeeq Mohd3
Long Chiau Ming4
Manan, Mohamed Mansor5
Source: Current Trends in Biotechnology & Pharmacy. Apr2020 Suppl, p141-
142. 2p.
Document Type: Article
Subject Terms: *MEDICAL records
*DRUG utilization
*POSTOPERATIVE pain
*DRUGS
*ANTI-inflammatory agents
*TEACHING hospitals
*DDT (Insecticide)
Author-Supplied Keywords: Coxibs
NSAIDs
orthopedics
Company/Entity: WORLD Health Organization
NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing
325190 Other basic organic chemical manufacturing
325410 Pharmaceutical and medicine manufacturing
424210 Drugs and Druggists' Sundries Merchant Wholesalers
414510 Pharmaceuticals and pharmacy supplies merchant
wholesalers
Abstract: A recent drug utilization study on antibiotics established a new
indicator for evaluating appropriateness of clinical application. The
calculation is based on the World Health Organization (WHO)
anatomical therapeutic chemical classification system with defined
daily doses (ATC/DDD) system. It combines two main indicators for
drug i.e. dose and duration of treatment. The aim of current study
was to describe the appropriateness of clinical application of coxibs
and traditional nonsteroidal anti-inflammatory drugs (tNSAIDs) that
indicated for postoperative orthopaedics pain control.A drug
utilization review of coxibs and tNSAIDs of an inpatient orthopaedics
department of a private teaching hospital in the city of Seremban,
Malaysia was conducted. The NSAIDs were classified and
calculated according to the WHO ATC/DDD system. The formula for
measuring the appropriateness of clinical application is by
calculating the ratio of use density to use rate (UD/UR). A total of
195 patient records who received NSAIDs were randomly selected
eds.a.ebscohost.com/eds/delivery?sid=846005f5-43e5-4270-a1b5-bbd8187c2b6d%40sdc-v-sessmgr01&vid=1&ReturnUrl=http%3a%2f%2feds.a.… 1/2
9/17/2020 Discovery Service for Universiti Kebangsaan Malaysia

among 1169 cases. The tNSAIDs were dexketoprofen injection,


diclofenac sodium tablet; and the coxibs were celecoxib capsule,
etoricoxib tablet and parecoxib injection. The UD/UR for all NSAIDs
were less than 100 except for etoricoxib tablet (105.75) and
parecoxib injection (108.00). The UD/UR value more than 100,
indicating a high possibility of irrational medication and may require
of enhanced monitoring. The findings of this DUR study may suggest
of applying new indicator for evaluating the appropriateness of
clinical application of NSAIDs for postoperative orthopaedics pain
control. [ABSTRACT FROM AUTHOR]
Copyright of Current Trends in Biotechnology & Pharmacy is the
property of Association of Biotechnology & Pharmacy and its content
may not be copied or emailed to multiple sites or posted to a listserv
without the copyright holder's express written permission. However,
users may print, download, or email articles for individual use. This
abstract may be abridged. No warranty is given about the accuracy
of the copy. Users should refer to the original published version of
the material for the full abstract. (Copyright applies to all Abstracts.)
1
Author Affiliations: School of Pharmacy, KPJ Healthcare University College, Nilai,
Negeri Sembilan, Malaysia
2
Faculty of Pharmacy, Universiti Kebangsaaan Malaysia, Kuala
Lumpur, Malaysia
3
KPJ Seremban Specialist Hospital, Seremban, Negeri Sembilan,
Malaysia
4PAPRSB Institute of Health Sciences, Universiti Brunei

Darussalam, Bandar Seri Begawan, Brunei


5
Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam,
Selangor, Malaysia
ISSN: 0973-8916
Accession Number: 145466037
Database: Academic Search Complete

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