Quetiapine Fumarate (Seroquel) is an atypical antipsychotic prescribed to manage psychotic disorders and agitation/dementia. It comes as 25, 100, and 200 mg tablets taken by mouth up to twice or three times daily, with a maximum daily dose of 800 mg for psychosis or 200 mg for agitation/dementia. Major side effects include dizziness, headache, somnolence, and weight gain. The drug interacts with several other medications and herbal supplements like St. John's Wort, so patients should be monitored and cautioned about safety risks.
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Quetiapine Fumarate (Seroquel) is an atypical antipsychotic prescribed to manage psychotic disorders and agitation/dementia. It comes as 25, 100, and 200 mg tablets taken by mouth up to twice or three times daily, with a maximum daily dose of 800 mg for psychosis or 200 mg for agitation/dementia. Major side effects include dizziness, headache, somnolence, and weight gain. The drug interacts with several other medications and herbal supplements like St. John's Wort, so patients should be monitored and cautioned about safety risks.
Quetiapine Fumarate (Seroquel) is an atypical antipsychotic prescribed to manage psychotic disorders and agitation/dementia. It comes as 25, 100, and 200 mg tablets taken by mouth up to twice or three times daily, with a maximum daily dose of 800 mg for psychosis or 200 mg for agitation/dementia. Major side effects include dizziness, headache, somnolence, and weight gain. The drug interacts with several other medications and herbal supplements like St. John's Wort, so patients should be monitored and cautioned about safety risks.
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Quetiapine Fumarate (Seroquel) is an atypical antipsychotic prescribed to manage psychotic disorders and agitation/dementia. It comes as 25, 100, and 200 mg tablets taken by mouth up to twice or three times daily, with a maximum daily dose of 800 mg for psychosis or 200 mg for agitation/dementia. Major side effects include dizziness, headache, somnolence, and weight gain. The drug interacts with several other medications and herbal supplements like St. John's Wort, so patients should be monitored and cautioned about safety risks.
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2. Dose range and routes for adult & geriatric client.
PREPARATIONS: PO – (25, 100, 200) mg tablets
DOSING: Psychosis – initiate with 25 mg bid, may increase by 25 – 50 mg bid to tid on the second or third day as tolerated to a target dose of 300 – 400 mg/d divided by bid to tid, may adjust dose by 25 – 50 mg bid qd as needed (max. 800 mg/d) Agitation/Dementia – initiate with 25 mg bid, may increase by 25 – 50 mg bid, q 2-7 if needed, (max 200 mg/d)
3. Purpose prescribed. Underline reason your client is prescribed drug.
THERAPEUTIC EFFECTS: indicated by a reduction in psychotic behaviour
USES: management of psychotic disorders, management of agitation and dementia
4. Major side effects & drug interactions.
DRUG INTERACTIONS: Barbiturates, carbamazepine, phenytoin, rifampin, thioridazine may increase clearance of seroquel. • Seroquel may potentiate the cognitive and motor effects of alcohold, enhance the effect of antihypertensive agents, antagonize the effects of levodopa and dopamine agonists. • Ketoconazole, itraconazole, fluconazole, erythromycin may decrease clearance of seroquel
HERBAL INTERACTIONS: St. John’s Wort may cause serotonin syndrome
SIDE EFFECTS: dizziness, headache, somnolence, asthenia, fever, hypertonia, dysarthria, flu syndrome, weight gain, peripheral edema 5. Nursing Implications & teaching.
IMPLICATIONS: • Reassess need for continued Tx periodically • Withhold med and immediately report S & S of tardive dyskinesia or neuroleptic malignant syndrome • Lab tests – periodically monitor liver function, lipid profile, thyroid function, blood glucose, CBC with differential • Monitor ECG periodically, especially in those with known cardio vascular disease • Perform baseline cataract exam when therapy is started and at 6-mo intervals thereafter • Monitor pts with a history of seizures for lowering of the seizure threshold
TEACHING: • Exercise caution with potentially dangerous activities requiring alertness, especially during the first week of drug therapy or during dose increments • Make position changes slowly, especially when changing from lying or sitting to standing to avoid dizziness, palpitations, and fainting • Avoid alcohol consumption and activities that may cause overheating and dehydration • Inform Dr immediately if you become pregnant
(the Maudsley Prescribing Guidelines) Mark Horowitz, David M. Taylor - The Maudsley Deprescribing Guidelines_ Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs (the Maudsley Prescribing Gui
