Tumour biomarkers articles from across Nature Portfolio

In this Tools of the Trade article, Jordan Lee describes the development and use of the Tumor Molecular Pathology (TMP) toolkit, a cancer subtyping tool that can assign TCGA molecular subtypes to new, independent non-TCGA datasets.

Patients with lung-metastatic pancreatic ductal adenocarcinoma survive longer than those with liver metastases. A study now leverages real-world data to identify distinct molecular and immune profiles that can explain differences in tumor aggressiveness and clinical outcomes.

Nuclear speckles are dynamic structures enriched in RNA and RNA regulators, with varying compositions. A study now reports two distinct signatures of nuclear speckles that are linked to the prognosis of clear cell renal cell carcinoma. The signatures influence the expression of genes regulated by the transcription factor HIF2α.