Stem-cell biotechnology articles from across Nature Portfolio

A differentiation method informed by developmental biology converts human pluripotent stem cells to engraftable hematopoietic stem and progenitor cells without the use of transgenes.

Creation of chimeric renal organoids using human iPSC technology with fetal pig kidneys demonstrates inter-species coexistence and codevelopment in early kidney development, paving the way for humanized xenogeneic kidney creation for clinical use.

In vitro modelling of the adipose tissue-liver axis can advance understanding and therapy of metabolic disease, including by distinguishing effects of obesity and inflammation. Here, authors develop such a system based on isogenic human iPSCs and interconnected microphysiological devices.

STRAIGHT-IN is a platform for rapidly generating panels of genetically modified human pluripotent stem cell lines through targeted integration of a DNA payload into a landing pad, which is achieved with minimal scarring.

Hamazaki, Yang et al. report that an early pulse of retinoic acid robustly induces human gastruloids with a neural tube, segmented somites and more advanced cell types than conventional gastruloids.

A differentiation method informed by developmental biology converts human pluripotent stem cells to engraftable hematopoietic stem and progenitor cells without the use of transgenes.

Satellite cells, the stem cells of skeletal muscle, are responsible for muscle development and regeneration. Although low in abundance, satellite cells can be isolated from muscle but cannot be propagated successfully in culture in numbers needed for therapeutic use. We developed a method to generate cells with satellite cell characteristics from skeletal muscle organoid cultures.

An article in Nature reports the generation of human chimeric brain organoids that integrate cells from multiple donors.

Although the clinical application of induced pluripotent stem cells is still in its infancy, the development of iPSC technologies reflected by an increasing number of patents provides hope that they will realize their therapeutic potential.

An article in Nature Communications reports the development of cultured meat with organoleptic properties by regulating the differentiation of stem cells to produce muscle and fat blocks.

A basket-like device records the electrical activity of neural organoids over months of maturation.