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Pain is an unpleasant sensory and emotional experience. Acute nociceptive pain is induced by noxious stimuli, and is often a result of an intense or potentially damaging stimulus.
Chronic pain remains a major clinical challenge with unclear causes and a need for new treatment. Using the single-cell transcriptomics atlas iPain, here the authors show that nociceptor senescence may drive chronic pain and present senolytics as a potential therapeutic approach.
Meijs et al. perform an electrophysiological investigation of cortical responses in a pig nerve injury model, showing the role of layer III–VI neurons in altered primary somatosensory cortex excitability after nerve injury.
A randomized trial shows that a low-cost, accessible, walking-based intervention reduced low-back-pain recurrence, and could offer a scalable approach to tackling this common condition.
The voltage-gated sodium channel Nav1.7 is expressed on chondrocytes, regulates chondrocyte biology and osteoarthritis progression, and is a promising dual target for modifying disease while providing pain relief in osteoarthritis.
A focus on maternal mortality reduction and time-restricted follow-ups after childbirth has led to neglect of long-term labor and birth complications experienced by women.
VX-548 selectively inhibits peripheral sodium channels to reduce acute pain, with potentially fewer safety concerns than for existing, nonselective blockers.