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Induced pluripotent stem cells (iPSCs) are pluripotent stem cells generated from adult cells by reprogramming. iPSCs have the same properties as embryonic stem cells, and therefore self-renew and can differentiate into all cell types of the body except for cells in extra-embryonic tissues such as the placenta.
PSC can be differentiated into blood cells in vitro. In this report, Sun and Motazedian et al describe a differentiation method that generates blood-forming endothelial cells that push newly emerging blood cells to become lymphocytes.
The interplay between blood vessel (BV) and epithelial tissue is crucial for organogenesis. Here, the authors co-culture hiPSC-derived liver progenitors on artificial BV to establish functional human bile ducts for modeling congenital biliary disease.
Early-career scientists shared some of their plans, hopes and dreams about being a principal investigator at the 2024 annual meeting of the International Society for Stem Cell Research.