Health care articles from across Nature Portfolio

Heat-related deaths are estimated to increase more rapidly than cold-related deaths are estimated to decrease under future climate change scenarios across European cities. An unrealistic degree of adaptation to heat would be required to revert this trend, indicating the need for strong policies to reduce greenhouse gases emissions.

Generalist AI systems in healthcare can handle multiple complex clinical tasks, unlike narrow AI tools that perform isolated functions. However, current payment systems struggle to capture the value of these integrated capabilities. We examine potential solutions, including value-based and tiered structures, balancing innovation, equitable access, continuous performance evaluation, and cost-effectiveness to realize generalist AI’s transformative potential.

In a recently reported study, a novel engineered oncolytic Newcastle disease virus encoding porcine α1,3-galactosyltransferase was evaluated in monkeys with CRISPR-induced primary hepatocellular carcinoma and in a phase I clinical trial. The virus induced hyperacute tumour rejection and an objective response rate of 35% in 20 evaluable patients. This approach highlights the promises and challenges of oncolytic virus drug development.

Federal policy action to improve the healthiness of food environments in the United States has been limited. This Perspective calls for the involvement of researchers and advocates in food policymaking at the state and local levels and shows how this can be achieved at each stage of the policy process.

Haque et al. report a case of chronic alcohol use disorder that had early remission following a traumatic brain injury with left orbitofrontal cortex intracerebral hemorrhage. Mapping of this lesion converges on recently described addictive behavior network maps, but with inverse connectivity.

After 150,000 articles and 17 million genome sequences, what has science taught us about SARS-CoV-2?

The Lancet Global Health Commission on medical oxygen security highlights catastrophic failures of governments and other stakeholders to provide equitable access to this lifesaving resource, and sets out recommendations to close the gap.