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Fungal pathogenesis is the process by which fungi infect and cause disease in a host. Not all fungi are pathogens and have the ability for pathogenesis, also known as virulence.
Genetic engineering of Metarhizium robertsii with a silkworm antibacterial gene substantially boosts fungal potency against different insects. Both the cuticle and gut microbiomes can be disrupted to accelerate insect death after fungal infection.
Nematode-trapping fungi are able to overcome the cuticle of Caenorhabditis elegans to colonize the nematode body. Here, Emser et al. characterise a nematode induced protein that induces blister formation in the nematode epidermis to facilitate fungal entry.
Through transcriptional and phenotypic profiling, authors show that ribose catabolism by the fungus Candida albicans shapes the metabolic landscape of the intra-abdominal cavity to derepress agr signaling in the bacterium Staphylococcus aureus, driving α-toxin release and synergistic lethality during co-infection.
This study shows that hyphae formation is critical for Candida albicans gut colonization in the presence of commensal bacteria owing to the production of a hyphal-associated factor.
In this study, Liu et al. explore the interplay between a fungal effector and a plant cysteine protease and design a small-molecule compound aimed at targeting this effector to combat rice blast disease.
This study reports the identification of the novel Candida auris-specific adhesin Scf1, which, together with the adhesin Iff4109, is a key mediator of surface association, infection and long-term colonization.