Emotion articles from across Nature Portfolio

Early life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promoting stress resilience in adolescent mice.

The sleep data from acute stress models indicate that CeA somatostatin neurons are a key neural substrate for modulating stress-induced sleep-onset insomnia, without influencing physiological sleep.

Inhibition of CaMKII blocks short-term memory but not long-term memory of inhibitory avoidance in mice.

Mice react differently to others’ stress depending on their own past experience of the same (but not different) stress. Corticotropin-releasing factor (CRF) neuron activity in the medial prefrontal cortex (mPFC) specifically modulates the influence of affective past experience on emotional reactions to others, which was estrus-dependent in females and dominance-dependent in males.

Mice that witness a cage mate’s distress become resilient to future adverse events as a result of altered serotonin release in the lateral habenula.