Drug therapy articles from across Nature Portfolio

A randomized clinical trial showing the superiority of behavioral treatment plus phentermine to behavioral treatment plus placebo for weight loss in those that previously had not responded to behavioral treatment.

Eisinger-Mathason et al. examine how data linkage transforms healthcare research by integrating diverse datasets. They also discuss privacy-preserving methods and challenges related to data quality and privacy.

The mechanism of currently prescribed antidepressants is incompletely understood. Here, the study identifies associations between antidepressant use and DNA methylation, highlighting shared signals across datasets, and tissue enrichment in the amygdala.

In this Tools of the Trade article, Birch describes how extracellular vesicles can be engineered to deliver therapeutic microRNAs for the treatment of ischaemic stroke.