Antibiotics articles from across Nature Portfolio

Gram-negative bacteria envelope controls drug accumulation via passive influx and active efflux mechanisms. This article discusses recent in cellulo, in vitro, and in silico methods highlighting key “drug-transporters” dialogues and proposes new perspectives to overcome drug resistance.

Class II bacteriocins in the Streptococcus salivarius pan-genome were bioinformatically identified based on conserved sequence properties. These diverse “salivaricins” show antibacterial activity against Gram-positive pathogens.

Synthetic indole derivative kills gram-positive bacteria by quenching the respiratory metabolism pathway.

Ahead of a United Nations meeting on the global challenge of drug-resistant infections, Nature asked health-care experts in emerging economies to describe what would address the issue in their country or region most effectively.

Ensuring that clinics in low- and middle-income countries are well-stocked with high-quality antibiotics could help physicians to treat millions of people each year and slow the spread of drug resistance.

By 2050, around 2 million people — the majority aged 70 and over — could die from drug-resistant infections each year.

Antibacterial drug resistance is a critical global health issue that affects countries across all economic levels, though it disproportionately affects populations in low- and middle-income countries. Infection and resistance rates vary considerably, necessitating tailored interventions to meet the specific demands of each area. This underscores the need for global solidarity and national accountability in effectively addressing antibacterial drug resistance.

Newfound compound is as effective at treating infected skin wounds as is the antibiotic of last resort.