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Hou, Chen et al. show that aged bone marrow macrophages propagate senescence to multiple tissues in vivo, through extracellular vesicles containing PPARĪ±-targeted microRNAs. They demonstrate the therapeutic potential of intervening in this process using the PPARĪ± agonist fenofibrate.
Cervical lymphatic vessels drain cerebrospinal fluid from the brain. A recent study reveals an aging-related disruption in the pumping action of lymphatic vessels that hampers lymph flow, which may prevent efficient brain clearance of potentially toxic proteins linked to neurodegenerative disease.
Oocyte quality declines during aging. Here the authors show that oocytes from aged mice cultured within follicles from young mice have improved developmental potential. Aged oocytes cultured within young follicles have enhanced interaction with somatic cells, improved mitochondrial function and better meiotic chromosome segregation.
Meguro et al. show an accumulation of p16high senescent fibroblasts in the aging bladder that serves as a cancer-permissive niche and promotes tumor growth by secreting CXCL12. Inhibition of senescence or CXCL12 signaling suppresses bladder tumor growth.
A study from Ru, Deng, Chen, Zhang and colleagues investigates how mutations in the mitochondrial genes Nd1 and Nd5 are inherited in mice. The authors report that increased maternal age strengthens purifying selection during postnatal oocyte development, probably through an increase in oocyte protein synthesis.
We quantified age-related changes in gene regulatory relationships across eight human tissues. Our results reveal that the geneāgene relationships that become stronger with age affect mostly genes that operate on the same cellular processes, whereas relationships that become weaker affect genes involved in different processes.
Age-related loss of gene expression coordination may contribute to impaired cellular function. In this study, the authors analyzed age-related trends in geneāgene relationships. They found that expression control often remains intact among genes involved in shared cellular functions while the coordination between functions tends to decline.
Income is a modifying factor in the association between increased adherence to the planetary health diet and slower cognitive decline observed in a sample of 11,737 Brazilian civil servants who were followed for 8 years. Thus, addressing the barriers posed by low income is vital when promoting healthy eating patterns.
We developed āimaging-based chromatin and epigenetic ageā (ImAge), a technique that captures intrinsic age-related trajectories of the spatial organization of chromatin and epigenetic marks in single nuclei. We propose that ImAge represents a first-in-class imaging-based biomarker of aging with single-cell resolution.
Inhibition of S6 kinase 1 (S6K1) extends lifespan in mice, but the underlying mechanisms are not fully understood. Here Gallage et al. show that reduction of S6K signaling diminishes inflammation in the aged mouse liver via suppression of the senescence-associated secretory phenotype.
Alvarez-Kuglen, Ninomiya, Qin, Rodriguez et al. demonstrate that the spatial organization of chromatin and epigenetic marks in individual nuclei follows age-related trajectories that can be captured by an imaging-based biomarker of aging (ImAge).
The identification of senescent cells is a long-standing unresolved challenge, owing to their intrinsic heterogeneity and the lack of universal markers. In this Comment, we discuss the recent advent of machine-learning-based approaches to identifying senescent cells by using unbiased, multiparameter morphological assessments, and how these tools can assist future senescence research.
Research suggests that exercise has a beneficial effect on brain health during aging but more information is needed. Here, the authors show, using UK Biobank data, that the āweekend warriorā physical activity pattern, with concentrated exercise over 1ā2ādays, is similarly linked to lower risk of brain disorders compared to regular exercise.
Using high-throughput proteomics in a prospective population-based study of older adults, Frick et al. identified over 300 proteins linked to incident late-onset Alzheimerās disease, including associations dependent on or independent of APOE-Īµ4 status.
Cervical lymphatics drain cerebrospinal fluid and clear metabolic waste from the brain. Du et al. show using 2P-OPTIC that these are disrupted in aging due to reduced pumping. Restoring cervical lymphatic function with prostaglandin F2Ī± rescues brain clearance.