Penile cancer is a rare malignancy, but one with uniquely profound consequences for sexual health, body image, and intimate relationships. While advances in surgical management have improved oncological and functional outcomes, many patients continue to struggle with sexual dysfunction and psychological distress. This special issue brings together multidisciplinary perspectives to explore the intersection of penile cancer and sexuality, addressing pre- and postoperative sexual problems, partner dynamics, psychosocial support, and opportunities for sexual rehabilitation. By integrating medical innovation, this collection aims to inspire care for men and their partners living with penile cancer.