Myofibroblast activation requires nuclear translocation of ATP citrate lyase (ACLY) that triggers chromatin remodeling and the induction of fibrosis-associated genes. ACLY inhibition prevents myofibroblast conversion and causes de-differentiation of myofibroblasts to fibroblasts, indicating a potential therapeutic approach for heart failure.
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Acknowledgements
N.G.F.’s laboratory is supported by National Institutes of Health (NIH) grants R01 HL76246, R01 HL85440 and R01 HL149407, and by US Department of Defense grant PR211352.
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Frangogiannis, N.G. Targeting metabolically activated fibroblasts in the failing heart. Nat Cardiovasc Res 3, 782–784 (2024). https://doi.org/10.1038/s44161-024-00500-5
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DOI: https://doi.org/10.1038/s44161-024-00500-5