Abstract
Fluid shear stress plays a key role in sculpting blood vessels during development, in adult vascular homeostasis and in vascular pathologies. During evolution, endothelial cells evolved several mechanosensors that convert physical forces into biochemical signals, a process termed mechanotransduction. This Review discusses our understanding of endothelial flow sensing and suggests important questions for future investigation.
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Acknowledgements
This work was supported, in part, by grants from the BHF The Wilson and Olegario Class of 2020 (to C.A.); Wellcome Trust (senior research fellowship to E.T.); BHF (PG/16/29/32128, PG/19/70/34630 and RG/F/20/110025 to E.T.); MRC (2109HS002/AM111); John Fell Fund (to E.T.); the BHF Centre of Excellence, Oxford (RE/13/1/30181); and the Wellcome Trust grant 203141/Z/16/Z supporting the Wellcome Centre for Human Genetics. M.A.S. was supported by USPHS grant R01 HL155543. We thank J. Reader for illuminating discussions.
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Aitken, C., Mehta, V., Schwartz, M.A. et al. Mechanisms of endothelial flow sensing. Nat Cardiovasc Res 2, 517–529 (2023). https://doi.org/10.1038/s44161-023-00276-0
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DOI: https://doi.org/10.1038/s44161-023-00276-0
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