Extended Data Fig. 7: Youden’s index by baseline IL-8 cutoff (in pg/ml) from OS ROC curve analyses. | Nature Medicine

Extended Data Fig. 7: Youden’s index by baseline IL-8 cutoff (in pg/ml) from OS ROC curve analyses.

From: Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

Extended Data Fig. 7

Determination of optimal IL-8 cutoff value for the Nivo-containing arm of CheckMate 067 (n = 589) (a), nivolumab arm of CheckMate 025 (n = 392) (b), nivolumab arm of CheckMate 017 (n = 108) (c), nivolumab arm of CheckMate 057 (n = 255) (d), and all studies pooled (N = 1,344) (e). Red dotted lines indicate 23 pg/ml. IL, interleukin; Nivo, nivolumab; OS, overall survival; ROC, receiver operating characteristic.

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