Telomere length is an important determinant of cellular aging and disease risk, but the genetics of telomere length control in humans is unclear. A genome-wide CRISPR screen has now identified a central role for thymidine nucleotide metabolism in the regulation of telomere length, which has implications for the diagnosis and treatment of disease.
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Bryan, T.M. Nucleotide metabolism regulates human telomere length via telomerase activation. Nat Genet 55, 532–533 (2023). https://doi.org/10.1038/s41588-023-01359-1
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DOI: https://doi.org/10.1038/s41588-023-01359-1