Supplementary Figure 4: Testosterone‑dependence of the efficacy of minocycline in reversing CFA-induced allodynia. | Nature Neuroscience

Supplementary Figure 4: Testosterone‑dependence of the efficacy of minocycline in reversing CFA-induced allodynia.

From: Different immune cells mediate mechanical pain hypersensitivity in male and female mice

Supplementary Figure 4

ANOVA revealed a significant sex x hormonal condition interaction (F3,24 = 3.9, p=0.02). Minocycline (50 μg) was ineffective in castrated male mice (male GDX) and young (4 week-old) mice of both sexes; its efficacy was reinstated in gonadectomized (GDX; castrated or ovariectomized) mice of both sexes given testosterone proprionate replacement (GDX + TP). Bars represent mean ± SEM percentage anti-allodynia (n=4 mice/sex/hormonal condition).

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