Preosteoclasts give rise to bone-resorbing osteoclasts, which are crucial for skeletal homeostasis. A study now shows that preosteoclasts also contribute to bone formation by releasing platelet-derived growth factor-BB, which promotes bone vascularization and osteogenesis.
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Kusumbe, A., Adams, R. Osteoclast progenitors promote bone vascularization and osteogenesis. Nat Med 20, 1238–1240 (2014). https://doi.org/10.1038/nm.3747
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DOI: https://doi.org/10.1038/nm.3747
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