Extended Data Figure 7: Allele-specific Hi-C analysis of wild-type and boundary-mutant ΔFT NPCs.
From: Structural organization of the inactive X chromosome in the mouse
a, Hi-C data, insulation scores, and the difference in insulation scores are shown to compare the wild-type Xi chromosome (NPC 129) and the ΔFT Xi chromosome (NPC 129). Top, the Cast allele (Xa chromosome) for both samples. Bottom, the 129 allele (Xi chromosome) for both samples. Large dips in the insulation vector are indicative of TAD boundaries. Peaks in the insulation vector are found towards the centre of each TAD. The insulation difference plot highlights areas of differential TAD structure between the wild-type and ΔFT NPCs. b, Cumulative plots of TAD strength at the wild-type expressed versus the wild-type silenced genes on Cast and 129 chromosomes, for ES cells, wild-type and ΔFT NPCs. Escapee genes on the Xi chromosome (NPC 129, ΔFT NPC 129) show higher insulation scores as compared to silenced genes.
