[go: up one dir, main page]

 
 
Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (25,234)

Search Parameters:
Keywords = physical activity

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
13 pages, 4655 KiB  
Article
Analysis of Penalty Kick Performance in the Spanish Football League: A Longitudinal Study
by Iván Prieto-Lage, Juan Carlos Argibay-González, Pedro Bezerra, Pablo Cidre-Fuentes, Xoana Reguera-López-de-la-Osa and Alfonso Gutiérrez-Santiago
Appl. Sci. 2024, 14(16), 7046; https://doi.org/10.3390/app14167046 (registering DOI) - 11 Aug 2024
Abstract
(1) Background: the penalty kick is an action in football that decides many matches. The aim of this research was to establish the success rate of penalty kicks in Spain between the seasons 2012/2013 and 2019/2020 considering different key performance variables. (2) Methods: [...] Read more.
(1) Background: the penalty kick is an action in football that decides many matches. The aim of this research was to establish the success rate of penalty kicks in Spain between the seasons 2012/2013 and 2019/2020 considering different key performance variables. (2) Methods: A total of 941 penalty kicks were analysed from eight seasons of the first division of the Spanish men’s football league (La Liga). An observational methodology was used and, in order to obtain the results, different analytical techniques were employed: descriptive and chi square with a significance level of p < 0.05. (3) Results: The effectiveness of penalty kicks was 76.7%. Most of the penalties were taken by the home team (60.9%), with a tie on the scoreboard (44.2%) and within the last 30 min of the match (41.9%). The highest success rate was observed for balls kicked to the upper side of the goal (100%), even though the highest number of penalties were taken low, to one of the two sides of the goal (57.0%). Up to 5.6% of the penalties were not kicked inside the goal. (4) Conclusions: Effectiveness does not depend on home–visitor status, player laterality, score or remaining match time, studied independently. A loss of effectiveness is observed when the match scores of both teams are close and in critical moments of the match. Full article
(This article belongs to the Special Issue Advances in Sports, Exercise and Health)
Show Figures

Figure 1

Figure 1
<p>Goal areas according to direction-goal and direction-laterality criteria.</p>
Full article ">Figure 2
<p>Effectiveness according to the direction-goal and direction-laterality criteria.</p>
Full article ">Figure 3
<p>Effectiveness according to the result criteria (direction-goal and direction-laterality).</p>
Full article ">Figure 4
<p>Effectiveness according to the stadium and laterality criteria (direction-goal and direction-laterality).</p>
Full article ">Figure 5
<p>Effectiveness in critical moments during the match (direction-goal and direction-laterality).</p>
Full article ">
25 pages, 6275 KiB  
Article
Understanding Multi-Hazard Interactions and Impacts on Small-Island Communities: Insights from the Active Volcano Island of Ternate, Indonesia
by Mohammad Ridwan Lessy, Jonatan Lassa and Kerstin K. Zander
Sustainability 2024, 16(16), 6894; https://doi.org/10.3390/su16166894 (registering DOI) - 11 Aug 2024
Abstract
Drawing on a case study from Ternate Island, a densely populated volcanic island in Eastern Indonesia, this research illustrates how multi-hazards and extreme weather events are likely to compound and cascade, with serious consequences for sustainable development in small island context. At the [...] Read more.
Drawing on a case study from Ternate Island, a densely populated volcanic island in Eastern Indonesia, this research illustrates how multi-hazards and extreme weather events are likely to compound and cascade, with serious consequences for sustainable development in small island context. At the heart of Ternate Island sits the active Gamalama volcano, posing a constant eruption threat. Its location within the Ring of Fire further exposes the island to the risks of tsunamis and earthquakes. Additionally, the island’s physical features make it highly susceptible to flooding, landslides, and windstorms. Rapid urbanization has led to significant coastal alterations, increasing exposure to hazards. Ternate’s small-island characteristics include limited resources, few evacuation options, vulnerable infrastructure, and inadequate resilience planning. Combining GIS multi-hazard mapping with a structured survey in 60 villages in Ternate, this case study investigates the multi-hazard exposure faced by the local population and land coverage. The findings suggest significant gaps between village chiefs’ perceptions of the types of hazards and the multi-hazard assessment in each village. Out of 60 village chiefs surveyed, 42 (70%) are aware of earthquake risks, 17 (28%) recognize tsunami threats, and 39 see volcanoes as a danger. GIS assessments show that earthquakes could impact all villages, tsunamis could affect 46 villages (77%), and volcanoes could threaten 39 villages. The hazard map indicates that 32 villages are at risk of flash floods and 37 are at risk of landslides, and extreme weather could affect all villages. Additionally, 42 coastal villages on Ternate Island face potential extreme wave and abrasion disasters, but only 18 chiefs acknowledge extreme weather as a threat. The paper argues that addressing the cognitive biases reflected in the perceptions of community leaders requires transdisciplinary dialogue and engagement. Full article
Show Figures

Figure 1

Figure 1
<p>North Maluku and Ternate Island.</p>
Full article ">Figure 2
<p>Multi-hazard risk assessment flowchart.</p>
Full article ">Figure 3
<p>Hydro-meteorological hazard maps of Ternate Island: (<b>a</b>) flash flood; (<b>b</b>) landslide; (<b>c</b>) extreme weather; and (<b>d</b>) extreme wave and abrasion.</p>
Full article ">Figure 4
<p>Geological hazard maps of Ternate Island: (<b>a</b>) earthquake; (<b>b</b>) tsunami; (<b>c</b>) volcano eruption.</p>
Full article ">Figure 5
<p>Integrated hazard map of Ternate Island.</p>
Full article ">Figure 6
<p>Population density (<b>a</b>) and land use (<b>b</b>) maps of Ternate Island.</p>
Full article ">Figure 7
<p>The vulnerability map (<b>a</b>) and multi-hazard risk map (<b>b</b>) of Ternate Island.</p>
Full article ">Figure 8
<p>Identification of hazard interactions.</p>
Full article ">Figure 9
<p>Knowledge of village officials about disaster threats (N = 60).</p>
Full article ">
14 pages, 1488 KiB  
Article
Basic Psychological Needs in the Face of Achievement Vulnerability: A Study in Young Team Athletes
by Mirella Triguero Martín, David Manzano-Sánchez, Manuel Gómez-López and Juan González-Hernández
Behav. Sci. 2024, 14(8), 697; https://doi.org/10.3390/bs14080697 (registering DOI) - 11 Aug 2024
Abstract
The susceptibility of athletes to experience of emotional and psychological difficulties arising from the pressure and expectations associated with achieving and maintaining high performance can become a vulnerability in the desire to achieve success in sport. This study aims to investigate the protective [...] Read more.
The susceptibility of athletes to experience of emotional and psychological difficulties arising from the pressure and expectations associated with achieving and maintaining high performance can become a vulnerability in the desire to achieve success in sport. This study aims to investigate the protective value in the perception of satisfaction in basic psychological needs against the vulnerability that perfectionism generates in the appearance of reactivity linked to fear of failure. A cross-sectional, relational, and semi-randomized research design was used, applying perfectionism, fear of failure, and basic psychological needs measures adapted to both the competitive sports context and the Spanish language in a sample of 372 young Spanish athletes, under descriptive analyses and predictive models. The results showed that as the age of the participants increased, the indicators of perfectionism and fear of failure decreased, with no gender differences. The results offer and confirm the positive relationships between the dimensions of perfectionism and fear of making mistakes (where processes such as self-devaluation and fear of failing the people that participants deemed as important to them are intertwined). The perception of satisfaction of the basic psychological needs of autonomy, social relationships, and competence emerges as protective factors that mediate the perfectionism–fear of failure relationship. On the other hand, discrepancies are shown between the perfectionist dimensions concerning the relationships with the BPNs, describing certain sources of vulnerability, although there are adjustments of mental effort and discomfort in the young athletes. The conclusions offer the opportunity to investigate the aspects that facilitate the emergence of fear of failure in young athletes, mainly the performance of coaches connected to the emergence of patterns in pursuit of perfection. Full article
Show Figures

Figure 1

Figure 1
<p>Hypothetical model.</p>
Full article ">Figure 2
<p>Model Standardized by Striving for Perfection.</p>
Full article ">Figure 3
<p>Model Standardized by Negative Reactions to Imperfection.</p>
Full article ">
20 pages, 6832 KiB  
Article
Health-Oriented Evaluation and Optimization of Urban Square Space Elderly Suitability: A Case Study of Yiyang City Center
by Yuhua Li and Hui Tang
Buildings 2024, 14(8), 2482; https://doi.org/10.3390/buildings14082482 (registering DOI) - 11 Aug 2024
Abstract
Urban squares are the main place for older adults’ daily activities. The spatial layout of the urban square is not only related to the construction of a healthy city and the equitable distribution of public resources, but also of great significance in enhancing [...] Read more.
Urban squares are the main place for older adults’ daily activities. The spatial layout of the urban square is not only related to the construction of a healthy city and the equitable distribution of public resources, but also of great significance in enhancing the sense of gain, security, and happiness of older adults. This essay takes “health needs of older adults” as the perspective, and constructs a multi-dimensional evaluation index system of urban square space for elderly suitability in terms of physiological, psychological, and social health. It also takes six urban squares in Yiyang city center as an example and analyzes and evaluates them using GIS network analysis and the entropy weight method. The results of the study show that (1) Yiyang city center squares show the distribution characteristics of “dense in the middle and scattered around”, and the spatial distribution is not balanced, which leads to a small service area. (2) The overall intervention value of urban square space is mainly distributed between 0.291 and 0.710, with an average value of 0.481, and the overall intervention effect of the square is good. The reasons for differences in health interventions for older adults in urban square spaces centered on six aspects: the quality of the square space, the variety and convenience of travel lines, the tidiness of the environment, physical activities, safety, and social interaction. Based on this, this essay proposes three optimization strategies for the renewal of urban squares, the construction of characteristic squares, and the reconstruction of the urban square space system. The aim is to provide a reference for the future design and renewal of the elderly suitability of urban squares, so as to promote the construction of a healthy city. Full article
(This article belongs to the Special Issue Advances of Healthy Environment Design in Urban Development)
Show Figures

Figure 1

Figure 1
<p>Map of relationship between urban square space and health interventions for older adults.</p>
Full article ">Figure 2
<p>Study area.</p>
Full article ">Figure 3
<p>Analysis of urban square space (<b>a</b>) Kernel density results, (<b>b</b>) Accessibility results.</p>
Full article ">Figure 4
<p>Mechanisms of spatial elderly suitability in health-oriented urban squares.</p>
Full article ">Figure 5
<p>Renovation and renewal of urban square space.</p>
Full article ">Figure 6
<p>(<b>a</b>) Featured urban square creation; (<b>b</b>) construction of urban square space system.</p>
Full article ">
33 pages, 1479 KiB  
Review
Effect of Environmental and Operating Conditions on Partial Discharge Activity in Electrical Machine Insulation: A Comprehensive Review
by Yatai Ji, Paolo Giangrande and Weiduo Zhao
Energies 2024, 17(16), 3980; https://doi.org/10.3390/en17163980 (registering DOI) - 11 Aug 2024
Abstract
: Electrical machines for transportation applications are subjected to harsh environmental conditions during their operations. Partial discharge (PD), which is one of the main reasons for insulation failure, is greatly affected by ambient conditions (i.e., temperature, pressure, and humidity). Countless efforts are made [...] Read more.
: Electrical machines for transportation applications are subjected to harsh environmental conditions during their operations. Partial discharge (PD), which is one of the main reasons for insulation failure, is greatly affected by ambient conditions (i.e., temperature, pressure, and humidity). Countless efforts are made for a comprehensive understanding of the physics of PD under variable environmental factors. This paper aims to review recent works addressing temperature, pressure, and humidity impact on PD activity. The main content of the paper is organized into three sections dealing with each environmental factor. In every section, relevant publications are reviewed considering the type of samples tested, voltage waveform applied, mutual effects, and the most common PD modeling strategies used. The applicability of the PD measurements for PD risk assessment is also discussed. Based on the review, the current progress in understanding the environmental effects on the PD inception mechanism and PD characteristics is presented and discussed in detail, and future research trends in this field are outlined. Full article
(This article belongs to the Section F: Electrical Engineering)
18 pages, 515 KiB  
Article
What Determinants Are Related to Milk and Dairy Product Consumption Frequency among Children Aged 10–12 Years in Poland? Nationwide Cross-Sectional Study
by Jadwiga Hamulka, Ewa Czarniecka-Skubina, Magdalena Górnicka, Jerzy Gębski, Teresa Leszczyńska and Krystyna Gutkowska
Nutrients 2024, 16(16), 2654; https://doi.org/10.3390/nu16162654 (registering DOI) - 11 Aug 2024
Abstract
Due to their high nutritional value, milk and dairy products should be a permanent element of a properly balanced diet for children and adolescents. The study aimed to identify (i) the frequency of milk and dairy product consumption by children aged 10–12 years [...] Read more.
Due to their high nutritional value, milk and dairy products should be a permanent element of a properly balanced diet for children and adolescents. The study aimed to identify (i) the frequency of milk and dairy product consumption by children aged 10–12 years in the opinion of children and their parents and (ii) the determinants related to the consumption of these products (including lifestyle, nutrition knowledge, and the nutritional status of children’s as well as parents’ nutrition knowledge). A cross-sectional study was conducted with 12,643 primary school students aged 10–12 and 7363 parents. Dietary data were collected using the Food Frequency Consumption and Nutritional Knowledge Questionnaire (SF-FFQ4PolishChildren® and KomPAN®). Anthropometric measurements were taken and body mass index (BMI) and waist/height ratios (WHtR) were calculated. A logistic regression model was used to assess the likelihood of the frequent consumption of dairy products in the opinion of both the children and their parents, and the quality of the obtained models was assessed using model fit statistics and the Hosmer and Lemeshow test. The frequency of consuming milk and milk products (every day and more) was low in the opinion of children aged 10–12 years (29.6%). According to their parents, the frequency of the consumption of dairy products was slightly higher (44.8%). Six factors associated with the frequency of milk and dairy product consumption were identified independently. These included schoolchildren and their parents’ nutrition knowledge, physical activity, sleep, gender, and place of residence. More of these products were consumed by children with greater nutrition knowledge—both their own and their parents’—higher physical activity, longer sleep duration, males, and those living in the city. Family eating habits, particularly eating meals together, also played an important role in the consumption of milk and dairy products. According to the parents, the children in older grades were less likely to consume dairy products more frequently. The obtained results suggest an insufficient consumption of milk and dairy products. The identification of modifiable factors, such as nutrition knowledge, physical activity, sleep duration, and eating meals with the family, suggests the need to improve the existing strategies, including activities encouraging nutritional education for both schoolchildren and their parents. Full article
(This article belongs to the Special Issue 2024 Collection: Dietary, Lifestyle and Children Health)
Show Figures

Figure 1

Figure 1
<p>Flowchart of the study design and population.</p>
Full article ">
23 pages, 324 KiB  
Article
The Impact of Thyroid Hormones on Cardiometabolic Risk in Children and Adolescents with Obesity, Overweight and Normal Body Mass Index (BMI): A One-Year Intervention Study
by Eleni Ramouzi, Konstantina Sveroni, Maria Manou, Christos Papagiannopoulos, Sofia-Maria Genitsaridi, Athanasia Tragomalou, Aikaterini Vourdoumpa, Diamanto Koutaki, George Paltoglou, Penio Kassari and Evangelia Charmandari
Nutrients 2024, 16(16), 2650; https://doi.org/10.3390/nu16162650 (registering DOI) - 11 Aug 2024
Viewed by 133
Abstract
Thyroid hormones regulate metabolism and have a major impact in maintaining cardiovascular homeostasis. The purpose of our study was to examine the relation of thyrotropin (TSH) and thyroid hormones with cardiometabolic parameters in children and adolescents with obesity, overweight, and normal body mass [...] Read more.
Thyroid hormones regulate metabolism and have a major impact in maintaining cardiovascular homeostasis. The purpose of our study was to examine the relation of thyrotropin (TSH) and thyroid hormones with cardiometabolic parameters in children and adolescents with obesity, overweight, and normal body mass index (BMI) before and after the implementation of a comprehensive, multidisciplinary, personalized, lifestyle intervention program for 1 year. One thousand three hundred and eleven (n = 1311) children and adolescents aged 2 to 18 years (mean age ± SD: 10.10 ± 2.92 years) were studied prospectively. Patients were categorized as having obesity (n = 727, 55.45%), overweight (n = 384, 29.29%) or normal BMI (n = 200, 15.26%) according to the International Obesity Task Force (IOTF) cutoff points. All patients received personalized guidance on diet, sleep, and physical activity at regular intervals throughout the 1-year period. Detailed clinical evaluation and hematologic, biochemical and endocrinologic investigations were performed at the beginning and the end of the study. Subjects with obesity had a more adverse cardiometabolic risk profile than subjects with overweight and normal BMI on both assessments. At initial evaluation, total T3 concentrations were positively associated with uric acid and HbA1C, and free T4 concentrations were negatively associated with insulin concentrations, while there was no association between TSH concentrations and cardiometabolic risk parameters. Following the 1 year of the multidisciplinary, lifestyle intervention program, the concentrations of lipids, HbA1C, ALT, and γGT improved significantly in all subjects. Changes in TSH concentrations were positively associated with changes in systolic blood pressure (SBP), glucose, triglycerides, and cholesterol concentrations. Changes in free T4 concentrations were negatively associated with changes in cholesterol and insulin concentrations. Furthermore, changes in T3 concentrations were positively associated with changes in HbA1C, glucose, uric acid, and triglyceride concentrations. These findings indicate that in children and adolescents with overweight and obesity, thyroid hormones are associated with indices conferring cardiometabolic risk. Full article
(This article belongs to the Section Pediatric Nutrition)
25 pages, 565 KiB  
Article
Cross-Sectional Assessment of Nutritional Status, Dietary Intake, and Physical Activity Levels in Children (6–9 Years) in Valencia (Spain) Using Nutrimetry
by María Morales-Suárez-Varela, Isabel Peraita-Costa, Agustín Llopis-Morales and Agustín Llopis-González
Nutrients 2024, 16(16), 2649; https://doi.org/10.3390/nu16162649 (registering DOI) - 10 Aug 2024
Viewed by 407
Abstract
The aims of this research were to evaluate the current nutritional status, dietary intake, and level of physical activity and assess the need for intervention. This was a cross-sectional study with 2724 participating children aged 6–9 years old. Nutritional status was assessed using [...] Read more.
The aims of this research were to evaluate the current nutritional status, dietary intake, and level of physical activity and assess the need for intervention. This was a cross-sectional study with 2724 participating children aged 6–9 years old. Nutritional status was assessed using nutrimetry, dietary intake with a 3-day food-recall questionnaire and physical activity with an ad hoc questionnaire. The nutricode with the highest prevalence was healthy weight/normal stature, with 51.3% of the sample. For the BMI for age Z-score, those in the overweight/obesity category represented 37.5% of the sample, while the thinness category included 7.6%. Intake of calories, proteins, sugar, lipids, SFA, MUFA, and cholesterol were significantly higher than recommended. The thinness groups consumed a significantly higher amount of excess calories while the overweight/obesity groups had the lowest mean excess calorie intake. Children in the thinness category presented the highest rates at both ends of the spectrum for sedentary activities. This study showed the high prevalence of malnutrition in schoolchildren. The results for the risk of thinness and overweight/obesity according to individual nutrient intake should be carefully interpreted. Lifestyle is a fundamental aspect to consider when combating malnutrition, especially at the level of dietary and physical activity habits, to combine various methods of intervention to improve nutritional status. Full article
(This article belongs to the Section Pediatric Nutrition)
Show Figures

Figure 1

Figure 1
<p>Participants’ flow diagram.</p>
Full article ">
16 pages, 2243 KiB  
Article
Construction and Application of the Phaeozem Health Evaluation System in Liaoning Province, China
by Ying-Ying Jiang, Zhong-Xiu Sun, Shan Liu and Jia-Qing Wang
Agronomy 2024, 14(8), 1754; https://doi.org/10.3390/agronomy14081754 (registering DOI) - 10 Aug 2024
Viewed by 266
Abstract
Soil degradation has led to a continuous decline in the quality of phaeozem, which is seriously threatening the foundation of national food security. Therefore, precisely evaluating the health status of phaeozem resources and their spatial and temporal variations are crucial for ensuring the [...] Read more.
Soil degradation has led to a continuous decline in the quality of phaeozem, which is seriously threatening the foundation of national food security. Therefore, precisely evaluating the health status of phaeozem resources and their spatial and temporal variations are crucial for ensuring the effective implementation of soil degradation prevention and control strategies. In this study, soil data from 140 sites were collected, and eight physical and chemical indices (sand content, silt content, pedon thickness, organic matter, total potassium, total nitrogen, total phosphorus, and pH) were utilized to assess the soil health status of phaeozem in Liaoning Province. The results showed the following: (1) The minimum data set is aligned with previous research findings and effectively mirrors the soil’s health condition. (2) The substantial coefficients of variation observed for pedon thickness, sand content, and silt content across regions suggest notable differences, likely influenced by climatic variations, parent material differences, and anthropogenic activities. (3) The study area’s average soil pH of 6.39 indicates an overall acidic nature, potentially attributed to intense soil weathering and suboptimal fertilization practices. (4) The soil health index (SHI) ranged from 0.33 to 0.91, with an average of 0.62, which indicates that the majority of the phaeozem in Liaoning Province are in a sub-healthy state (SHI < 0.6 = unhealthy, SHI 0.6–0.8 = sub-healthy, SHI ≥ 0.8 = healthy). These sub-healthy areas are primarily located in hills, mountains, and the Liaohe Plain, and are significantly impacted by rainfall and wind erosion. Meanwhile, unhealthy areas are concentrated in the south and center of the province, characterized by fragile ecological environments and challenging agricultural conditions. Full article
(This article belongs to the Section Soil and Plant Nutrition)
Show Figures

Figure 1

Figure 1
<p>Soil sampling sites. The map was digitized from the 1:1 million Soil Map of the People’s Republic of China compiled and published by the National Soil Survey Office in 1995, using Arc GIS 10.7.</p>
Full article ">Figure 2
<p>Frequency of soil physical indices selected in the literature.</p>
Full article ">Figure 3
<p>Frequency of soil chemical indices selected in the literature.</p>
Full article ">Figure 4
<p>Linear regression analysis of SHI−TDS and SHI−MDS.</p>
Full article ">Figure 5
<p>Health grade distribution map of phaeozem in Liaoning Province.</p>
Full article ">
30 pages, 10268 KiB  
Article
Musculoskeletal Disorder (MSD) Health Data Collection, Personalized Management and Exchange Using Fast Healthcare Interoperability Resources (FHIR)
by Fabio A. Seixas-Lopes, Carlos Lopes, Maria Marques, Carlos Agostinho and Ricardo Jardim-Goncalves
Sensors 2024, 24(16), 5175; https://doi.org/10.3390/s24165175 (registering DOI) - 10 Aug 2024
Viewed by 418
Abstract
With the proliferation and growing complexity of healthcare systems emerges the challenge of implementing scalable and interoperable solutions to seamlessly integrate heterogenous data from sources such as wearables, electronic health records, and patient reports that can provide a comprehensive and personalized view of [...] Read more.
With the proliferation and growing complexity of healthcare systems emerges the challenge of implementing scalable and interoperable solutions to seamlessly integrate heterogenous data from sources such as wearables, electronic health records, and patient reports that can provide a comprehensive and personalized view of the patient’s health. Lack of standardization hinders the coordination between systems and stakeholders, impacting continuity of care and patient outcomes. Common musculoskeletal conditions affect people of all ages and can have a significant impact on quality of life. With physical activity and rehabilitation, these conditions can be mitigated, promoting recovery and preventing recurrence. Proper management of patient data allows for clinical decision support, facilitating personalized interventions and a patient-centered approach. Fast Healthcare Interoperability Resources (FHIR) is a widely adopted standard that defines healthcare concepts with the objective of easing information exchange and enabling interoperability throughout the healthcare sector, reducing implementation complexity without losing information integrity. This article explores the literature that reviews the contemporary role of FHIR, approaching its functioning, benefits, and challenges, and presents a methodology for structuring several types of health and wellbeing data, that can be routinely collected as observations and then encapsulated in FHIR resources, to ensure interoperability across systems. These were developed considering health industry standard guidelines, technological specifications, and using the experience gained from the implementation in various study cases, within European health-related research projects, to assess its effectiveness in the exchange of patient data in existing healthcare systems towards improving musculoskeletal disorders (MSDs). Full article
(This article belongs to the Section Wearables)
Show Figures

Figure 1

Figure 1
<p>Example of a FHIR resource represented in JSON.</p>
Full article ">Figure 2
<p>Personalized MSD Health Data Collection and Management overview.</p>
Full article ">Figure 3
<p>Improving physical activity—healthcare cycle [<a href="#B72-sensors-24-05175" class="html-bibr">72</a>].</p>
Full article ">Figure 4
<p>Hardware used in the data collection: (<b>a</b>) MedX lumbar extension machine; (<b>b</b>) wearable devices.</p>
Full article ">Figure 5
<p>BLE device attributes’ structure example.</p>
Full article ">Figure 6
<p>Communication between the device and Citizen Hub [<a href="#B74-sensors-24-05175" class="html-bibr">74</a>].</p>
Full article ">Figure 7
<p>Observation definition in Citizen Hub: (<b>a</b>) observation resource example for a posture measurement; (<b>b</b>) observation resource specification.</p>
Full article ">Figure 8
<p>Citizen Hub IoT architecture.</p>
Full article ">Figure 9
<p>Continua end-to-end reference architecture [<a href="#B80-sensors-24-05175" class="html-bibr">80</a>].</p>
Full article ">Figure 10
<p>Implementation of CDG in Citizen Hub, based on the reference architecture.</p>
Full article ">Figure 11
<p>Resource for authorship of data.</p>
Full article ">Figure 12
<p>Wearable data profile [<a href="#B81-sensors-24-05175" class="html-bibr">81</a>].</p>
Full article ">Figure 13
<p>Heart rate observation resource.</p>
Full article ">Figure 14
<p>Activity observation resource.</p>
Full article ">Figure 15
<p>Posture observation resource.</p>
Full article ">Figure 15 Cont.
<p>Posture observation resource.</p>
Full article ">Figure 16
<p>Blood pressure observation resource.</p>
Full article ">Figure 17
<p>Lumbar extension training observation resource.</p>
Full article ">Figure 18
<p>Report resource.</p>
Full article ">Figure 19
<p>Device resource.</p>
Full article ">Figure 20
<p>Structure Definition data model.</p>
Full article ">Figure 21
<p>Citizen Hub data collection simplified architecture.</p>
Full article ">Figure 22
<p>Citizen Hub data collection simplified architecture [<a href="#B85-sensors-24-05175" class="html-bibr">85</a>].</p>
Full article ">Figure 23
<p>Comorbidities addressed in the PoP and technical overview for data sharing [<a href="#B86-sensors-24-05175" class="html-bibr">86</a>].</p>
Full article ">Figure 24
<p>ICU4Covid implementation of devices and sensors [<a href="#B27-sensors-24-05175" class="html-bibr">27</a>].</p>
Full article ">Figure 25
<p>Citizen Hub user interface.</p>
Full article ">
14 pages, 1804 KiB  
Article
ABCC1 Is a ΔNp63 Target Gene Overexpressed in Squamous Cell Carcinoma
by Veronica La Banca, Sara De Domenico, Sara Nicolai, Veronica Gatti, Stefano Scalera, Marcello Maugeri, Alessandro Mauriello, Manuela Montanaro, Jens Pahnke, Eleonora Candi, Silvia D’Amico and Angelo Peschiaroli
Int. J. Mol. Sci. 2024, 25(16), 8741; https://doi.org/10.3390/ijms25168741 (registering DOI) - 10 Aug 2024
Viewed by 159
Abstract
The transcription factor ΔNp63 plays a pivotal role in maintaining the integrity of stratified epithelial tissues by regulating the expression of distinct target genes involved in lineage specification, cell stemness, cell proliferation and differentiation. Here, we identified the ABC transporter subfamily member ABCC1 [...] Read more.
The transcription factor ΔNp63 plays a pivotal role in maintaining the integrity of stratified epithelial tissues by regulating the expression of distinct target genes involved in lineage specification, cell stemness, cell proliferation and differentiation. Here, we identified the ABC transporter subfamily member ABCC1 as a novel ΔNp63 target gene. We found that in immortalized human keratinocytes and in squamous cell carcinoma (SCC) cells, ∆Np63 induces the expression of ABCC1 by physically occupying a p63-binding site (p63 BS) located in the first intron of the ABCC1 gene locus. In cutaneous SCC and during the activation of the keratinocyte differentiation program, ∆Np63 and ABCC1 levels are positively correlated raising the possibility that ABCC1 might be involved in the regulation of the proliferative/differentiative capabilities of squamous tissue. However, we did not find any gross alteration in the structure and morphology of the epidermis in humanized hABCC1 knock-out mice. Conversely, we found that the genetic ablation of ABCC1 led to a marked reduction in inflammation-mediated proliferation of keratinocytes, suggesting that ABCC1 might be involved in the regulation of keratinocyte proliferation upon inflammatory/proliferative signals. In line with these observations, we found a significant increase in ABCC1 expression in squamous cell carcinomas (SCCs), a tumor type characterized by keratinocyte hyper-proliferation and a pro-inflammatory tumor microenvironment. Collectively, these data uncover ABCC1 as an additional ∆Np63 target gene potentially involved in those skin diseases characterized by dysregulation of proliferation/differentiation balance. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Skin Diseases)
Show Figures

Figure 1

Figure 1
<p>(<b>A</b>) RT-qPCR analysis (<b>left</b> panel) of ABCC1 mRNA levels in human primary keratinocytes (HEKn) transfected with siRNA oligos targeting p63 (sip63) or non-relevant mRNA. The mean of three (<span class="html-italic">n</span> = 3) independent biological replicates ± SD is shown. <span class="html-italic">p</span> value was calculated using two-tailed unpaired Student’s <span class="html-italic">t</span> test. In parallel, Western blotting analysis using antibodies to the indicated proteins (right panel) was performed utilizing protein lysates from transfected cells. (<b>B</b>) Human HNSCC A253 cell line was transfected and analyzed as described in (<b>A</b>). (<b>C</b>) RT-qPCR analysis (<b>left</b> panel) of ABCC1 mRNA levels in A253 transfected with siRNA targeting ΔNp63 isoform (siΔNp63#1) or non-relevant mRNA (scr). The mean of three (<span class="html-italic">n</span> = 3) independent biological replicates ± SD is shown. <span class="html-italic">p</span> value was calculated using two-tailed unpaired Student’s <span class="html-italic">t</span> test. In parallel, Western blotting analysis using antibodies to the indicated proteins (<b>right</b> panel) was performed utilizing protein lysates from transfected cells. (<b>D</b>) ChIP-qPCR analysis (<b>right</b> panel) of endogenous ΔNp63 binding to the <span class="html-italic">ABCC1</span> genomic locus. p63 binding region was determined by analyzing publicly available p63 ChIP-seq data obtained in HEKn cells (GSM1446927) (<b>left</b> panel: p63 binding sites in purple; <span class="html-italic">ABCC1</span> gene locus in blue). Average values from <span class="html-italic">n</span> = 2 biological replicates measured using three technical replicates are plotted. (<b>E</b>). Western blotting (<b>left</b> panel) or RT-qPCR analysis (<b>right</b> panel) was performed utilizing protein lysates or total RNA extracted from HEKn at different time points (0, 3, 6, 9 days) upon CaCl<sub>2</sub> treatment. The mean of two (<span class="html-italic">n</span> = 2) independent biological RT-qPCR replicates is shown. (<b>F</b>) Representative images of immunohistochemical analysis of p63 and ABCC1 expression in normal skin samples.</p>
Full article ">Figure 2
<p>(<b>A</b>) Representative images of Hematoxylin/eosin (H&amp;E) staining of newborn and adult epidermis of <span class="html-italic">hABCC1<sup>flx/flx</sup></span> and <span class="html-italic">hABCC1<sup>−/−</sup></span> mice. (<b>B</b>) Immunofluorescence staining of the differentiation marker KRT10 (green) and the basal marker p63 (red) in epidermis of <span class="html-italic">hABCC1<sup>flx/flx</sup></span> and <span class="html-italic">hABCC1<sup>−/−</sup></span> mice. DAPI staining (blue) was used to visualize the nuclei. (<b>C</b>) Immunoblot analysis of the indicated proteins in murine keratinocytes isolated from the epidermis of <span class="html-italic">hABCC1<sup>flx/flx</sup></span> and <span class="html-italic">hABCC1<sup>−/−</sup></span> mice. (<b>D</b>) TPA treatment as indicated in the left panel was performed in the dorsal skin of <span class="html-italic">hABCC1<sup>flx/flx</sup></span> and <span class="html-italic">hABCC1<sup>−/−</sup></span> mice. Representative images of the immunofluorescence analysis of epidermis isolated from the TPA-treated mice (central panel). Keratin 14 (KRT14) (red) is a marker of the basal layer, while Ki67 staining (green) is utilized to visualize proliferating cells. Quantification of Ki67 positive basal cells in <span class="html-italic">hABCC1<sup>flx/flx</sup></span> and <span class="html-italic">hABCC1<sup>−/−</sup></span> TPA-treated epidermis (right panel). Each dot represents the count of Ki67 positive basal cells over the DAPI positive cells in each microscopic field. We analyzed <span class="html-italic">n</span> = 6 microscopic fields (<span class="html-italic">n</span> = 6) for each mouse (<span class="html-italic">n</span> = 2). Data shown are the mean of <span class="html-italic">n</span> = 12 measurements ± SD for <span class="html-italic">hABCC1<sup>flx/flx</sup></span> and <span class="html-italic">hABCC1<sup>−/−</sup></span> TPA-treated epidermis. *** <span class="html-italic">p</span> value &lt; 0.001. <span class="html-italic">p</span> value was calculated using two-tailed unpaired Student’s <span class="html-italic">t</span> test.</p>
Full article ">Figure 3
<p>(<b>A</b>) Violin plot illustrating ABCC1 expression values in basal cell carcinomas (BCC, <span class="html-italic">n</span> = 15), cutaneous squamous cell carcinomas (cSCC, <span class="html-italic">n</span> = 11) and in the respective normal tissues (normal). <span class="html-italic">p</span> value was calculated using two-tailed unpaired Student’s <span class="html-italic">t</span> test. (<b>B</b>) Violin plot illustrating ABCC1 expression values in lung SCC (LUSC, <span class="html-italic">n</span> = 466), head and neck SCC (HNSC, <span class="html-italic">n</span> = 517), cervical SCC (CESC, <span class="html-italic">n</span> = 303) and the respective normal tissues. * indicates <span class="html-italic">p</span> value &lt; 0.05. (<b>C</b>) Co-expression analysis of TP63/ABCC1 in datasets of human cervical SCC (CESC) (TCGA, provisional) and human lung SCC (LUSC) (TCGA, provisional) was performed at cBioPortal for Cancer Genomics (<a href="http://www.cbioportal.org" target="_blank">http://www.cbioportal.org</a> accessed on 28 May 2024). Spearman correlation coefficient is reported. (<b>D</b>) Representative images of immunohistochemistry analysis of p63 and ABCC1 expression in cSCC (left panel). Red box indicates area of higher magnification image. Correlation plot of ABCC1 and p63 IHC-scores in 70 human cSCC tumor samples (right panel). <span class="html-italic">p</span> value (<span class="html-italic">p</span>) of the Pearson’s correlation coefficient (0.57) is reported.</p>
Full article ">Figure 4
<p>(<b>A</b>) Schematic representation of the ΔNp63-dependent regulation of ABCC1 expression during epidermal differentiation. (<b>B</b>) The genetic ablation of ABCC1 led to a marked reduction in inflammation-driven proliferation of basal keratinocytes (see text for details). The figure was drawn in part using and/or modifying images from Servier Medical Art. Servier Medical Art is licensed under CC BY 4.0 (<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a> accessed on 28 May 2024).</p>
Full article ">
23 pages, 785 KiB  
Article
A Physical-Layer Security Cooperative Framework for Mitigating Interference and Eavesdropping Attacks in Internet of Things Environments
by Abdallah Farraj and Eman Hammad
Sensors 2024, 24(16), 5171; https://doi.org/10.3390/s24165171 (registering DOI) - 10 Aug 2024
Viewed by 210
Abstract
Intentional electromagnetic interference attacks (e.g., jamming) against wireless connected devices such as the Internet of Things (IoT) remain a serious challenge, especially as such attacks evolve in complexity. Similarly, eavesdropping on wireless communication channels persists as an inherent vulnerability that is often exploited [...] Read more.
Intentional electromagnetic interference attacks (e.g., jamming) against wireless connected devices such as the Internet of Things (IoT) remain a serious challenge, especially as such attacks evolve in complexity. Similarly, eavesdropping on wireless communication channels persists as an inherent vulnerability that is often exploited by adversaries. This article investigates a novel approach to enhancing information security for IoT systems via collaborative strategies that can effectively mitigate attacks targeting availability via interference and confidentiality via eavesdropping. We examine the proposed approach for two use cases. First, we consider an IoT device that experiences an interference attack, causing wireless channel outages and hindering access to transmitted IoT data. A physical-layer-based security (PLS) transmission strategy is proposed in this article to maintain target levels of information availability for devices targeted by adversarial interference. In the proposed strategy, select IoT devices leverage a cooperative transmission approach to mitigate the IoT signal outages under active interference attacks. Second, we consider the case of information confidentiality for IoT devices as they communicate over wireless channels with possible eavesdroppers. In this case, we propose a collaborative transmission strategy where IoT devices create a signal outage for the eavesdropper, preventing it from decoding the signal of the targeted devices. The analytical and numerical results of this article illustrate the effectiveness of the proposed transmission strategy in achieving desired IoT security levels with respect to availability and confidentiality for both use cases. Full article
(This article belongs to the Topic Cyber-Physical Security for IoT Systems)
23 pages, 5398 KiB  
Article
An Efficient Trajectory Planning Method for High-Speed Interception of Invasive Drones
by Yue Zhang, Jian’an Zong, Xianzhong Gao and Zhongxi Hou
Appl. Sci. 2024, 14(16), 7030; https://doi.org/10.3390/app14167030 (registering DOI) - 10 Aug 2024
Viewed by 243
Abstract
This article introduces a rapid interception trajectory generation algorithm tailored for the mitigation of malicious drone activities and other high-speed airborne threats. The proposed method facilitates a high degree of flexibility in defining the terminal state parameters, including position, velocity, and acceleration, as [...] Read more.
This article introduces a rapid interception trajectory generation algorithm tailored for the mitigation of malicious drone activities and other high-speed airborne threats. The proposed method facilitates a high degree of flexibility in defining the terminal state parameters, including position, velocity, and acceleration, as well as the anticipated duration of drone maneuvers, thereby enabling the fulfillment of a variety of mission objectives. The approach employed in this study linearizes the aerodynamic resistance model and computes an efficient closed-form solution for the optimal trajectory motion primitive by applying Pontryagin’s Maximum Principle. Concurrently, it minimizes the cost function associated with the aggression of control inputs. The motion primitive is defined by the combination of the initial and terminal states of the drone, as well as the expected movement time. An efficient input feasibility verification method has been designed for the optimal trajectory. This algorithm can serve as a low-level trajectory generator for advanced task planning methods. After compilation, it can evaluate and compare thousands of motion primitives per second on a personal portable computer, thereby achieving certain advanced goals. The reliability of the algorithm is verified by setting up a multi-objective approach task in a physical simulation environment. Full article
Show Figures

Figure 1

Figure 1
<p>Quadrotor dynamics model.</p>
Full article ">Figure 2
<p>Diagram of the interception process of invading drones, where blue represents the interceptor, red represents the intruder, and arrows represent the vector of velocity.</p>
Full article ">Figure 3
<p>Linearization approximation of air resistance for quadcopter drones.</p>
Full article ">Figure 4
<p>Optimal control input trajectory corresponding to different rotor resistance parameters.</p>
Full article ">Figure 5
<p>Optimal control input trajectories corresponding to different body resistance parameters.</p>
Full article ">Figure 6
<p>Flowchart for efficient recursive testing of trajectory feasibility.</p>
Full article ">Figure 7
<p>Simulation results of comparison methods under low-speed conditions. The calculation takes 0.003 s.</p>
Full article ">Figure 8
<p>Simulation results of our method under low-speed conditions. The calculation takes 0.004 s.</p>
Full article ">Figure 9
<p>Simulation results of comparison methods under high-speed conditions. The calculation takes 0.003 s.</p>
Full article ">Figure 10
<p>Simulation results of our method under high-speed conditions. The calculation takes 0.004 s.</p>
Full article ">Figure 11
<p>Simulation results of the approach task for five targets (comparative method). The task took 23.29 s.</p>
Full article ">Figure 12
<p>The relative distance and speed of the target in the comparison method.</p>
Full article ">Figure 13
<p>Display of simulation results using comparative methods in 3D views.</p>
Full article ">Figure 14
<p>Simulation results of the approach task for five targets (our method). The task took 36.45 s.</p>
Full article ">Figure 15
<p>The relative distance and speed of our method’s target.</p>
Full article ">Figure 16
<p>The presentation of our method simulation results in a 3D view.</p>
Full article ">
12 pages, 567 KiB  
Conference Report
Conference Report: LPMHealthcare Emerging Viruses 2023 (EVOX23): Pandemics—Learning from the Past and Present to Prepare for the Future
by Fern Jenkins, Tobias Mapulanga, Gauri Thapa, Kelly A. S. da Costa and Nigel J. Temperton
Pathogens 2024, 13(8), 679; https://doi.org/10.3390/pathogens13080679 (registering DOI) - 10 Aug 2024
Viewed by 157
Abstract
The emergence of SARS-CoV-2 has meant that pandemic preparedness has become a major focus of the global scientific community. Gathered in the historic St Edmund Hall college in Oxford, the one-day LPMHealthcare conference on emerging viruses (6 September 2023) sought to review and [...] Read more.
The emergence of SARS-CoV-2 has meant that pandemic preparedness has become a major focus of the global scientific community. Gathered in the historic St Edmund Hall college in Oxford, the one-day LPMHealthcare conference on emerging viruses (6 September 2023) sought to review and learn from past pandemics—the current SARS-CoV-2 pandemic and the Mpox outbreak—and then look towards potential future pandemics. This includes an emphasis on monitoring the “traditional” reservoirs of viruses with zoonotic potential, as well as possible new sources of spillover events, e.g., bats, which we are coming into closer contact with due to climate change and the impacts of human activities on habitats. Continued vigilance and investment into creative scientific solutions is required for issues including the long-term physical and psychological effects of COVID-19, i.e., long COVID. The evaluation of current systems, including environmental monitoring, communication (with the public, regulatory authorities, and governments), and training; assessment of the effectiveness of the technologies/assays we have in place currently; and lobbying of the government and the public to work with scientists are all required in order to build trust moving forward. Overall, the SARS-CoV-2 pandemic has shown how many sectors can work together to achieve a global impact in times of crisis. Full article
(This article belongs to the Section Emerging Pathogens)
Show Figures

Figure 1

Figure 1
<p>Schematic showing latest emerging virus R&amp;D which builds successively on previous epidemics and pandemics. Figure generated using BioRender.</p>
Full article ">
10 pages, 224 KiB  
Article
Prevalence and Predictors of Soft Drink Consumption among Adolescents in the Gulf Countries: Findings from National Surveys
by Abdulmohsen H. Al-Zalabani
Nutrients 2024, 16(16), 2637; https://doi.org/10.3390/nu16162637 (registering DOI) - 10 Aug 2024
Viewed by 282
Abstract
Background and Objectives: This study aimed to investigate the prevalence and predictors of soft drink consumption among adolescents in the Gulf Cooperation Council (GCC) countries using nationally representative data from the Global School-based Student Health Survey (GSHS). Materials and Methods: Cross-sectional data were [...] Read more.
Background and Objectives: This study aimed to investigate the prevalence and predictors of soft drink consumption among adolescents in the Gulf Cooperation Council (GCC) countries using nationally representative data from the Global School-based Student Health Survey (GSHS). Materials and Methods: Cross-sectional data were collected using a self-administered questionnaire in a school survey and included 22,116 adolescents aged 12–18 years from Bahrain, Kuwait, Oman, Qatar, and the United Arab Emirates. Data were collected and analyzed using complex survey methods. The GSHS was not available for Saudi Arabia. Soft drink consumption was the main outcome variable. Multivariable logistic regression was used to examine its associations with sociodemographic characteristics, dietary behaviors, parental factors, and health-related behaviors. Results: The prevalence of soft drink consumption three or more times per day ranged from 10.6% to 26.8% across the countries, with the highest being in Qatar. Adjusted analyses showed that girls had lower odds of SD consumption compared to boys (OR = 0.66; 95% CI: 0.57–0.77). Food insecurity, a proxy for low socioeconomic status, was associated with twice the odds of frequent consumption (OR = 2.06; 95% CI: 1.75–2.43). Parental smoking and low physical activity levels were also associated with higher soft drink intake (OR = 1.46, 95% CI: 1.13–1.88 and OR = 1.18, 95% CI: 1.08–1.28, respectively), while obesity showed a weak positive association. Conclusions: Daily soft drink consumption was highly prevalent among adolescents in the GCC countries. Sociodemographic, behavioral, and health-related factors were significantly associated with frequent intake. These findings highlight the need for comprehensive, multi-sectoral interventions to reduce soft drink consumption in the region. Full article
(This article belongs to the Special Issue Dietary Patterns, Dietary Intake, Dietary Behaviours and Health)
Back to TopTop