<p>Representative non-contrast CT (NCCT) and CT perfusion (CTP) images of our clinical AIS protocol with corresponding segmentation in 2D.</p> Full article ">Figure 2
<p>The computation of (<b>a</b>) standard and (<b>b</b>) dynamic perviousness. Region of interests (ROIs) covering the entire thrombus on a 2D transversal slice were manually drawn in 3D Slicer (<a href="http://www.slicer.org" target="_blank">www.slicer.org</a>, accessed on 1 August 2024) [<a href="#B30-sci-06-00064" class="html-bibr">30</a>] by considering the hyperdense artery sign. The time-resolved contrast agent uptake (CAU) curve in (<b>b</b>) was determined by computing the mean thrombus density within the ROI for each imaging time point of the CTP time series.</p> Full article ">Figure 3
<p>Statistical analysis of standard perviousness (<b>a</b>) and dynamic perviousness (<b>b</b>–<b>d</b>). (<b>a</b>) Standard perviousness, using only two imaging time points (CTA and NCCT), showed no significant association with the clinical outcome. (<b>b</b>) Thrombi with good outcomes after reperfusion therapy showed a tendency for higher contrast agent uptake than thrombi with poor outcomes (<span class="html-italic">p</span> = 0.07). (<b>c</b>,<b>d</b>) CAU in thrombi with good clinical outcomes was approximately 20% faster (<span class="html-italic">p</span> = 0.04) than in thrombi with poor clinical outcomes (<b>c</b>), while the corresponding attenuation increase rate per second (<b>d</b>) was approximately 36% higher (<span class="html-italic">p</span> = 0.02). <span class="html-italic">p</span>-values were computed with the two-sided Wilcoxon–Mann–Whitney test in Matlab.</p> Full article ">Figure 4
<p>Statistical analysis of the group mean time windows for the CAU peak value concentration and their associations with the clinical outcome. (<b>a</b>) Group mean CAU curve and corresponding tW<sub>10</sub> (red dots), tW<sub>20</sub> (blue dots), and tW<sub>30</sub> (yellow dots) for mRs ≤ 2, mRs ≥ 3 and mean (including all patients), respectively. The group mean times were 9 ± 3 s, 12 ± 4 s, and 14 ± 3 s for tW<sub>10</sub>, tW<sub>20</sub>, and tW<sub>30</sub>, respectively. Thrombi with good clinical outcomes had significantly narrower time windows with the CAU peak than thrombi with poor outcomes (tW<sub>10</sub>: 7 ± 2 s vs. 10 ± 4 s, <span class="html-italic">p</span> = 0.004, tW<sub>20</sub>: 11 ± 4 s vs. 13 ± 4 s, <span class="html-italic">p</span> = 0.02, tW<sub>30</sub>: 12 ± 2 s vs. 16 ± 4 s, <span class="html-italic">p</span> = 0.004, <b>b</b>, <b>c</b>, <b>d</b>, respectively). <span class="html-italic">p</span>-values between mRS ≤ 2 and mRS ≤ 3 were computed with the two-sided Wilcoxon–Mann–Whitney test in Matlab.</p> Full article ">