[go: up one dir, main page]
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.0
Journals
JCM
Special Issues
Clinical Perspectives in Trauma and Orthopedic Surgery
share announcement

Clinical Perspectives in Trauma and Orthopedic Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 25 January 2025 | Viewed by 1762

Special Issue Editor

Dr. Francesca Veronesi

E-Mail Website
Guest Editor
Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano 1/10, 40136 Bologna, Italy
Interests: biocompatibility and therapeutic efficacy of biomaterials; tissue engineering techniques for the regeneration of bone, cartilage, and tendon tissues of scientific–industrial interest
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Trauma and orthopedic surgery techniques are rapidly evolving. This Special Issue provides a comprehensive overview of the latest research advancements in the field of trauma and orthopedic surgery techniques, especially regarding the knee, ankle, and hip. It focuses on cutting-edge techniques, innovative treatment approaches, and emerging trends in managing traumatic injuries and orthopedic conditions. The Special Issue includes contributions from leading experts who share their insights on surgical strategies, rehabilitation protocols, and the integration of new technologies (such as biologics and minimally invasive procedures). This collection of preclinical and clinical articles aims to enhance clinical practices, improve patient outcomes, and foster a deeper understanding of the complexities involved in trauma and orthopedic surgery. In this Special Issue, we welcome authors to submit papers on clinical advances in terms of both diagnosis and treatment.

Dr. Francesca Veronesi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • trauma
  • sports
  • ankle
  • knee
  • hip
  • cartilage regeneration
  • bone regeneration
  • orthopedic surgery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 4236 KiB  
Article
Regeneration of Osteochondral Lesion of the Talus with Retrograde Drilling Technique: An In Vitro Pilot Study
by Francesca Veronesi, Melania Maglio, Silvia Brogini, Antonio Mazzotti, Elena Artioli, Simone Ottavio Zielli, Cesare Faldini and Gianluca Giavaresi
J. Clin. Med. 2024, 13(14), 4138; https://doi.org/10.3390/jcm13144138 - 16 Jul 2024
Viewed by 765
Abstract
Background: Retrograde Drilling (RD) is a surgical technique employed for osteochondral lesions of the talus (OCLTs) to reach the subchondral bone lesion from behind, thus preserving cartilage integrity. The aim of the present pilot study was to set up an in vitro model [...] Read more.
Background: Retrograde Drilling (RD) is a surgical technique employed for osteochondral lesions of the talus (OCLTs) to reach the subchondral bone lesion from behind, thus preserving cartilage integrity. The aim of the present pilot study was to set up an in vitro model of OCLTs to evaluate the regenerative potential of biological approaches that could be associated with the RD technique. Methods: For this purpose, an OCLT was created in human osteochondral specimens, to try to mimic the RD technique, and to compare the regenerative potential of two biological treatments. For this purpose, three groups of treatments were performed in vitro: (1) no treatment (empty defect); (2) autologous bone graft (ABG); (3) hyaluronic membrane enriched with autologous bone marrow cells. Tissue viability; production of Collagen I and II, Vascular Endothelial Growth Factor, and Aggrecan; and histological and microCT evaluations were performed after 30 days of culture in normal culture conditions. Results: It was observed that Group 3 showed the highest viability, and Group 2 showed the highest protein production. From a histological and microtomographic point of view, it was possible to appreciate the structure of the morcellized bone with which the defect of Group 2 was filled, while it was not yet possible to observe the deposition of mineralized tissue in Group 3. Conclusions: To conclude, this pilot study shows the feasibility of an alternative in vitro model to evaluate and compare the regenerative potential of two biological scaffolds, trying to mimic the RD technique as much as possible. The tissues remained vital for up to 4 weeks and both ABG and hyaluronic acid-based scaffolds stimulated the release of proteins linked to regenerative processes in comparison to the empty defect group. Full article
(This article belongs to the Special Issue Clinical Perspectives in Trauma and Orthopedic Surgery)
►▼ Show Figures

Figure 1

Figure 1
<p>Identification of the VOI for the morphometric microCT analysis: (<b>a</b>) complete 3D rendering of a representative sample from Group 2, with the volume corresponding to the defect highlighted in red; (<b>b</b>) subtraction of the measured VOI from the 3D rendering of the sample; (<b>c</b>) 3D rendering of the VOI corresponding to the defect.</p> Full article ">Figure 2
<p>Histograms of osteochondral defect culture viability of Groups 1, 2, and 3. T2: ** Group 2 vs. Group 1 (<span class="html-italic">p</span> = 0.004); ** Group 3 vs. Group 1 (<span class="html-italic">p</span> = 0.006); * Group 3 vs. Group 2 (<span class="html-italic">p</span> = 0.01). T4: *** Group 2 and Group 3 vs. Group 1 (<span class="html-italic">p</span> &lt; 0.001); * Group 3 vs. Group 2 (<span class="html-italic">p</span> = 0.01). c T2 vs. T0 and T4 vs. T2 (<span class="html-italic">p</span> &lt; 0.001).</p> Full article ">Figure 3
<p>Histograms of COLL I (<b>A</b>), VEGF (<b>B</b>), Aggrecan (<b>C</b>), and COLL II (<b>D</b>) of Groups 1, 2, and 3. COLL I, VEGF, Aggrecan: ***, Group 2 and Group 3 vs. Group 1 (<span class="html-italic">p</span> &lt; 0.001); Group 2 vs. Group 1 (<span class="html-italic">p</span> &lt; 0.001). COLL II: ***, Group 2 vs. Group 1 and Group 3 (<span class="html-italic">p</span> &lt; 0.001).</p> Full article ">Figure 4
<p>Representative 3D rendering of samples from Group 1 (<b>a</b>), Group 2 (<b>b</b>), and Group 3 (<b>c</b>).</p> Full article ">Figure 5
<p>Histograms of microtomographic parameters BV/TV (<b>A</b>), Tb.Th (<b>B</b>), and Tb.Sp (<b>C</b>) of Groups 1, 2, and 3 (n = 3 replicates). BV/TV: *, Group 3 vs. Group 1 (<span class="html-italic">p</span> = 0.03); **, Group 2 vs. Group 1 (<span class="html-italic">p</span> = 0.002); **, Group 2 vs. Group 3 (<span class="html-italic">p</span> = 0.003). Tb.Th: ***, Group 2 vs. Group 1 and Group 3 (<span class="html-italic">p</span> &lt; 0.001). Tb.Sp: ***, Group 3 vs. Group 2 (<span class="html-italic">p</span> &lt; 0.001).</p> Full article ">Figure 6
<p>Histological overview of Group 1 (<b>a</b>), Group 2 (<b>c</b>), and Group 3 (<b>e</b>). Magnification 2×. Safranin O/Fast Green staining. Details of interface between articular cartilage, surrounding bone, and defect of Group 1 (<b>b</b>) and Group 3 (<b>f</b>) and of defect filled with ABG in Group 2 (<b>d</b>). Magnification 20×. Safranin O/Fast Green staining.</p> Full article ">
15 pages, 5069 KiB  
Article
Clinical Workflow Algorithm for Preoperative Planning, Reduction and Stabilization of Complex Acetabular Fractures with the Support of Three-Dimensional Technologies
by Arpad Solyom, Flaviu Moldovan, Liviu Moldovan, Gabriela Strnad and Pal Fodor
J. Clin. Med. 2024, 13(13), 3891; https://doi.org/10.3390/jcm13133891 - 2 Jul 2024
Cited by 2 | Viewed by 724
Abstract
Background: Treatment of pelvic injuries poses serious problems for surgeons due to the difficulties of the associated injuries. The objective of this research is to create a clinical workflow that integrates three-dimensional technologies in preoperative planning and performing surgery for the reduction and [...] Read more.
Background: Treatment of pelvic injuries poses serious problems for surgeons due to the difficulties of the associated injuries. The objective of this research is to create a clinical workflow that integrates three-dimensional technologies in preoperative planning and performing surgery for the reduction and stabilization of associated acetabular fractures. Methods: The research methodology consisted of integrating the stages of virtual preoperative planning, physical preoperative planning, and performing the surgical intervention in a newly developed clinical workflow. The proposed model was validated in practice in a pilot surgical intervention. Results: On a complex pelvic injury case of a patient with an associated both-column acetabular fracture (AO/OTA-62C1g), we presented the results obtained in the six stages of the clinical workflow: acquisition of three-dimensional (3D) images, creation of the virtual model of the pelvis, creation of the physical model of the pelvis, preoperative physical simulation, orthopedic surgery, and imaging validation of the intervention. The life-size 3D model was fabricated based on computed tomography imagistics. To create the virtual model, the images were imported into Invesalius (version 3.1.1, CTI, Brazil), after which they were processed with MeshLab (version 2023.12, ISTI—CNR, Italy) and FreeCAD (version 0.21.2, LGPL, FSF, Boston, MA, USA). The physical model was printed in 21 h and 37 min using Ultimaker Cura software (version 5.7.2), on an Ultimaker 2+ printing machine through a Fused Deposition Modeling process. Using the physical model, osteosynthesis plate dimensions and fixation screw trajectories were tested to reduce the risk of neurovascular injury, after which they were adjusted and resterilized, which enhanced preoperative decision-making. Conclusions: The life-size physical model improved anatomical appreciation and preoperative planning, enabling accurate surgical simulation. The tools created demonstrated remarkable accuracy and cost-effectiveness that support the advancement and efficiency of clinical practice. Full article
(This article belongs to the Special Issue Clinical Perspectives in Trauma and Orthopedic Surgery)
►▼ Show Figures

Figure 1

Figure 1
<p>Clinical workflow integrating 3D printing technologies in preoperative planning and performing surgery for the reduction and stabilization of pelvic fractures: (1)–(4) are preoperative processes; (5) is an intraoperative process; (6) is a postoperative process.</p> Full article ">Figure 2
<p>Three-dimensional reconstruction of preoperative CT imaging in RadiAnt DICOM (Digital Imaging and Communications in Medicine) for the patient included in this study: (<b>a</b>) anterior view; (<b>b</b>) postero-lateral view.</p> Full article ">Figure 3
<p>The virtual model of the acetabulum fracture: (<b>a</b>) volume rendering; (<b>b</b>) crop volume.</p> Full article ">Figure 3 Cont.
<p>The virtual model of the acetabulum fracture: (<b>a</b>) volume rendering; (<b>b</b>) crop volume.</p> Full article ">Figure 4
<p>The virtual model of the acetabular fracture—editorial segment.</p> Full article ">Figure 5
<p>Three-dimensional printing of the acetabular fracture physical model: (<b>a</b>) preparation for printing in Ultimaker Cura software; (<b>b</b>) the actual print sustained by cork supports and platform.</p> Full article ">Figure 6
<p>Preoperative physical simulation (image of the 3D-printed model and the plates mounted on it—before being inserted into the patient): (<b>a</b>) anterior plate view; (<b>b</b>) posterior plate view.</p> Full article ">Figure 7
<p>Imaging validation of the intervention—3D reconstruction of postoperative CT imaging in RadiAnt DICOM (Digital Imaging and Communications in Medicine) for the patient included in this study: (<b>a</b>) anterior view; (<b>b</b>) postero-lateral view.</p> Full article ">
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop