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Biomedicines
Special Issues
Molecular Mechanisms and Novel Therapies for Brain Injury: 2nd Edition
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Molecular Mechanisms and Novel Therapies for Brain Injury: 2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1825

Special Issue Editor

Dr. Arjun Sapkota

E-Mail Website
Guest Editor
Neuroscience Lab, San Diego Biomedical Research Institute, San Diego, CA, 92121, USA
Interests: ischemic stroke; multiple sclerosis; vascular dementia; neuroinflammation; hypoxia; vascular remodeling; drug discovery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Brain injury—whether that be stroke, spinal cord injury, traumatic brain injury, seizure, brain tumors—is the leading cause of death and disability globally. To date, numerous efforts have been made to develop new therapeutics that modulate the pathogenesis of brain injury. Unfortunately, these studies have not led to the successful development and discovery of new drug targets, biomarkers, and therapeutics that tackle brain injury. Therefore, uncovering the molecular mechanisms of injury, recovery, and neuroprotection is important for the development of novel, effective therapies.

This Special Issue aims to collect up-to-date overviews of the current understandings of brain injury, molecular mechanisms, and novel therapies, as well as the possible clinical translations and therapeutic strategies to treat brain injury. We invite authors to submit of original research articles, reviews, and short notes focusing on molecular mechanisms and novel therapies. These should highlight, but are not limited to, molecular or genetic manipulation affecting protective or detrimental outcomes, the mechanisms of action of various pharmacological agents, innovative therapeutic strategies for treatment, and neuroinflammation.

Dr. Arjun Sapkota
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • spinal cord injury
  • traumatic brain injury
  • seizure
  • brain tumors
  • neurodegeneration
  • neuroinflammation
  • blood–brain barrier disruption
  • neuroprotection
  • drug discover
  • mechanism of action
  • target validation

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Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (1 paper)

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Review

19 pages, 1540 KiB  
Review
Targeting Mitochondria in Glioma: New Hopes for a Cure
by Lidia Gatto, Vincenzo Di Nunno, Anna Ghelardini, Alicia Tosoni, Stefania Bartolini, Sofia Asioli, Stefano Ratti, Anna Luisa Di Stefano and Enrico Franceschi
Biomedicines 2024, 12(12), 2730; https://doi.org/10.3390/biomedicines12122730 - 28 Nov 2024
Cited by 2 | Viewed by 1390
Abstract
Drugs targeting mitochondrial energy metabolism are emerging as promising antitumor therapeutics. Glioma treatment is extremely challenging due to the high complexity of the tumor and the high cellular heterogeneity. From a metabolic perspective, glioma cancer cells can be classified into the oxidative metabolic [...] Read more.
Drugs targeting mitochondrial energy metabolism are emerging as promising antitumor therapeutics. Glioma treatment is extremely challenging due to the high complexity of the tumor and the high cellular heterogeneity. From a metabolic perspective, glioma cancer cells can be classified into the oxidative metabolic phenotype (mainly depending on mitochondrial respiration for energy production) and glycolytic phenotype or “Warburg effect” (mainly depending on glycolysis). Herein, we reviewed the function of novel bio-active molecules targeting oxidative phosphorylation (OXPHOS), mitochondrial membrane potential and mitochondrial dynamics. These molecules exhibit intriguing preclinical and clinical results and have been proven to be promising candidates to be further developed for glioma therapy. However, despite these initial encouraging results, it is imperative to rigorously assess the side effects of these metabolic drugs, which have a non-negligible toxicity profile. Full article
(This article belongs to the Special Issue Molecular Mechanisms and Novel Therapies for Brain Injury: 2nd Edition)
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Figure 1

Figure 1
<p>Warburg effect.</p> Full article ">Figure 2
<p>Small molecule mitochondrial metabolism inhibitors in pre-clinical or clinical development for the treatment of cancer, targeting (<b>A</b>) internal membrane, (<b>B</b>) matrix and (<b>C</b>) external membrane.</p> Full article ">Figure 3
<p>The electron transport chain is a crucial process in cellular respiration that occurs within the mitochondria. It involves a series of protein complexes (I–V), where high-energy electrons (2e<sup>−</sup>) are shuttled along the complexes, generating an electrochemical gradient that releases energy and produces ATP. Several inhibitors are highlighted that target complex I (metformin and IACS-010759), predominantly complex II (gamitrinib) and several complexes (Gboxin, imipridones, CLPP activators).</p> Full article ">
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