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Advancements in Brain Diagnosis and Treatment: From Insights to Innovations

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1285

Special Issue Editors


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Guest Editor
Department of Anatomy, Histology and Neurosciences, Universidad Autónoma de Madrid, 28029 Madrid, Spain
Interests: brain disorders; neuroscience; neurology

Special Issue Information

Dear Colleagues,

The Special Issue titled "Advancements in Brain Diagnosis and Treatment: From Insights to Innovations" provides a comprehensive exploration of the latest developments and breakthroughs in the field of brain-related disorders. This collection of articles aims to bridge the gap between research discoveries, accurate diagnosis, and innovative treatment strategies for various neurological conditions.

The issue begins by highlighting the significance of research in unraveling the complexities of the brain and understanding the underlying mechanisms of neurological disorders. It emphasizes the need for multidisciplinary collaborations, bringing together experts from neuroscience, neurology, genetics, and other related fields. The articles delve into cutting-edge studies and findings, shedding light on the etiology, pathophysiology, and genetic factors associated with different brain disorders.

Furthermore, the Special Issue emphasizes the importance of accurate diagnosis in guiding effective treatment interventions for brain-related conditions. It explores state-of-the-art diagnostic techniques and technologies, including neuroimaging methods, biomarker analysis, and cognitive assessments. The articles discuss the challenges in early detection and differential diagnosis of brain disorders, providing insights into improving diagnostic accuracy and personalized patient care.

In the realm of treatment, the Special Issue covers a wide range of innovative approaches for brain disorders. It explores both established and emerging therapeutic modalities, including pharmacological interventions, neurostimulation techniques, and regenerative medicine. The articles highlight evidence-based practices, clinical trials, and individualized treatment strategies aimed at improving patient outcomes and quality of life.

Overall, the Special Issue "Advancements in Brain Diagnosis and Treatment: From Insights to Innovations" brings together the latest research advancements, diagnostic breakthroughs, and treatment innovations, fostering a deeper understanding of brain disorders and paving the way for improved diagnosis and care for patients in this rapidly evolving field.

Dr. Irene Chaves-Coira
Dr. Brandon Lucke-Wold
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain diagnosis and treatment
  • underlying mechanisms
  • individualized treatment

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Published Papers (1 paper)

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Review

22 pages, 1014 KiB  
Review
Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges
by Ahmed D. Alatawi, Krishnaraju Venkatesan, Khalid Asseri, Premalatha Paulsamy, Saleh F. Alqifari, Rehab Ahmed, Mathar Mohideen Nagoor Thangam, Nizar Sirag, Absar A. Qureshi, Hala Ahmed Elsayes, Zeinab Faried Bahgat, Nesren S. M. Bahnsawy, Kousalya Prabahar and Basma Mahmoud Abd Elhamid Dawood
Biomedicines 2025, 13(2), 265; https://doi.org/10.3390/biomedicines13020265 - 22 Jan 2025
Viewed by 986
Abstract
Ferroptosis, characterized by iron dependency and lipid peroxidation, has emerged as a key mechanism underlying neurodegeneration in rare neurological disorders. These conditions, often marked by significant therapeutic gaps and high unmet medical needs, present unique challenges for intervention development. This review examines the [...] Read more.
Ferroptosis, characterized by iron dependency and lipid peroxidation, has emerged as a key mechanism underlying neurodegeneration in rare neurological disorders. These conditions, often marked by significant therapeutic gaps and high unmet medical needs, present unique challenges for intervention development. This review examines the involvement of ferroptosis in rare neurological disease pathogenesis, focusing on its role in oxidative damage and neuronal dysfunction. We explore recent pharmacological advancements, including iron chelators, lipid peroxidation blockers, and antioxidant-based strategies, designed to target ferroptosis. While these approaches show promise, challenges such as disease heterogeneity, limited diagnostic tools, and small patient cohorts hinder progress. Furthermore, we discuss the translational and regulatory barriers to implementing ferroptosis-based therapies in clinical practice. By addressing these obstacles and fostering innovative solutions, this review underscores the potential of ferroptosis-targeting strategies to revolutionize treatment paradigms for rare neurological disorders. Full article
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<p>Ferroptosis in various diseases.</p>
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<p>Discovery of Ferroptosis.</p>
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<p>Mechanistic insights of ferroptosis.</p>
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