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Biomedicines
Special Issues
Neuropeptides, Dopamine and Their Interactions in Neuroscience (2nd Edition)
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Neuropeptides, Dopamine and Their Interactions in Neuroscience (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 5853

Special Issue Editor

Dr. László Péczely

E-Mail Website
Guest Editor
Medical School, Institute of Physiology, University of Pécs, 7624 Pécs, Hungary
Interests: oxytocin; autism; valproate; amygdala; anxiety; rat; elevated plus maze
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dopamine, as a neurotransmitter and neuromodulator, plays a crucial role in many functions within the central nervous system, such as motor behavior, motivation, reinforcement, learning and memory processes, influencing multiple neural pathways, and modulating synaptic plasticity. A dysfunction of mesencephalic dopaminergic systems, in addition to normal functions, can be observed in several neurological and psychiatric disorders. Moreover, dozens of neuropeptides are found in the central nervous system, such as substance P, neurotensin, oxytocin, and enkephalin. An accumulating body of evidence demonstrates their involvement in similar brain processes, such as dopamine. This raises the question of why such apparent redundancy is found in the brain. The answer may be found in the complex interaction between the neuropeptide and dopamine systems. In this Special Issue, we strive to unravel how dopamine and neuropeptides influence each other on various levels in the brain, mainly within the basal ganglia and the related areas, resulting in behavioral changes.

Dr. László Péczely
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dopamine
  • neuropeptides
  • psychiatric disorders
  • neurologic disorders
  • basal ganglia
  • behavior
  • learning and memory

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Related Special Issue

Published Papers (2 papers)

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Research

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17 pages, 9561 KiB  
Article
Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption
by Christina A. Nelson, James N. Brundage, Benjamin M. Williams, Jared K. Baldridge, Alyssa L. Stockard, Charlton H. Bassett, Brandon J. Burger, Bridger T. Gunter, Andrew J. Payne, Jordan T. Yorgason, Scott C. Steffensen and Kyle B. Bills
Biomedicines 2024, 12(7), 1593; https://doi.org/10.3390/biomedicines12071593 - 17 Jul 2024
Viewed by 965
Abstract
Exercise has increasingly been recognized as an adjunctive therapy for alcohol-use disorder (AUD), yet our understanding of its underlying neurological mechanisms remains limited. This knowledge gap impedes the development of evidence-based exercise guidelines for AUD treatment. Chronic ethanol (EtOH) exposure has been shown [...] Read more.
Exercise has increasingly been recognized as an adjunctive therapy for alcohol-use disorder (AUD), yet our understanding of its underlying neurological mechanisms remains limited. This knowledge gap impedes the development of evidence-based exercise guidelines for AUD treatment. Chronic ethanol (EtOH) exposure has been shown to upregulate and sensitize kappa opioid receptors (KORs) in the nucleus accumbens (NAc), which is innervated by dopamine (DA) neurons in the midbrain ventral tegmental area (VTA), which may contribute to AUD-related behaviors. In this study, we investigated the impact of voluntary exercise in EtOH-dependent mice on EtOH consumption, KOR and delta opioid receptor (DOR) expression in the NAc and VTA, and functional effects on EtOH-induced alterations in DA release in the NAc. Our findings reveal that voluntary exercise reduces EtOH consumption, reduces KOR and enhances DOR expression in the NAc, and modifies EtOH-induced adaptations in DA release, suggesting a competitive interaction between exercise-induced and EtOH-induced alterations in KOR expression. We also found changes to DOR expression in the NAc and VTA with voluntary exercise but no significant changes to DA release. These findings elucidate the complex interplay of AUD-related neurobiological processes, highlighting the potential for exercise as a therapeutic intervention for AUD. Full article
(This article belongs to the Special Issue Neuropeptides, Dopamine and Their Interactions in Neuroscience (2nd Edition))
►▼ Show Figures

Figure 1

Figure 1
<p>24 h 2 bottle choice. Exercise Prevents Increased EtOH Consumption in EtOH-dependent Mice: (<b>A</b>) Illustration showing two bottle choice (TBC) drinking before and after two weeks of twice-daily injections of EtOH. (<b>B</b>) Chronic EtOH injections increased EtOH consumption in the TBC procedure. (<b>C</b>) Exercise reduced EtOH consumption increase in the TBC procedure post chronic EtOH injections, measured as the percent change in ratio of consumption of EtOH:water after mice had received chronic EtOH for two weeks with or without exercise. Asterisks ** indicates <span class="html-italic">p</span> &lt; 0.01.</p> Full article ">Figure 2
<p>KOR FSCV. Voluntary Exercise Reduced KOR Expression in the NAc and VTA: KOR expression was evaluated immunohistochemically in four groups of mice: Sal NX, Sal EX, EtOH NX, and EtOH EX. (<b>A</b>–<b>D</b>) Example images of KOR Expression in the NAc and VTA following EtOH dependency protocol in mice with or without access to an exercise wheel for voluntary exercise (<b>A</b>–<b>D</b>). Quantification of mean fluorescence intensity of KOR fluorescence in the NAc (<b>E</b>) and VTA (<b>F</b>). Asterisks #, ## indicates <span class="html-italic">p</span> &lt; 0.05, <span class="html-italic">p</span> &lt; 0.01 respectively.</p> Full article ">Figure 3
<p>KOR IHC. Voluntary Exercise Alters KOR Sensitivity of Dopamine Release in the NAc: KOR sensitivity of DA release was evaluated with voltammetry in four groups of mice: Sal NX, Sal EX, EtOH NX, and EtOH EX. Example traces of evoked DA release following administration of 1 μM U-50488, a KOR agonist (<b>A</b>–<b>D</b>). Change in evoked DA release normalized to baseline following administration of 1 μM U50488 (<b>E</b>). Conditions indicate EtOH dependence protocol or saline protocol while being with or without access to an exercise wheel for voluntary exercise. Symbols *, ***, #, ## indicate <span class="html-italic">p</span> &lt; 0.05, <span class="html-italic">p</span> &lt; 0.001, <span class="html-italic">p</span> &lt; 0.05, <span class="html-italic">p</span> &lt; 0.01 respectively.</p> Full article ">Figure 4
<p>DOR FSCV. Voluntary Exercise impacted DOR Expression in the NAc and VTA: DOR expression was evaluated immunohistochemically in four groups of mice: Sal NX, Sal EX, EtOH NX, and EtOH EX. (<b>A</b>–<b>D</b>) Example images of DOR Expression in the NAc and VTA following EtOH dependency protocol in mice with or without access to an exercise wheel for voluntary exercise (<b>A</b>–<b>D</b>). Quantification of mean fluorescence intensity of DOR fluorescence in the NAc (<b>E</b>) and VTA (<b>F</b>). Asterisk *, # indicates <span class="html-italic">p</span> &lt; 0.05.</p> Full article ">Figure 5
<p>DOR IHC. Voluntary Exercise Does Not Significantly Alter DOR Sensitivity of Dopamine Release in the NAc: DOR sensitivity of DA release was evaluated with voltammetry in four groups of mice: Sal NX, Sal EX, EtOH NX, and EtOH EX. Example traces of evoked DA release following administration of 1 μM DPDPE, a DOR agonist (<b>A</b>–<b>D</b>). Change in evoked DA release normalized to baseline following administration 1 μM DPDPE, a selective DOR agonist compared between conditions (<b>E</b>) and against baseline. Conditions indicate EtOH dependence protocol or saline protocol while being with or without access to an exercise wheel for voluntary exercise. Asterisks *, *** indicates <span class="html-italic">p</span> &lt; 0.05, <span class="html-italic">p</span> &lt; 0.0001 respectively.</p> Full article ">

Review

Jump to: Research

19 pages, 369 KiB  
Review
Interactions of Oxytocin and Dopamine—Effects on Behavior in Health and Disease
by Maria Petersson and Kerstin Uvnäs-Moberg
Biomedicines 2024, 12(11), 2440; https://doi.org/10.3390/biomedicines12112440 - 24 Oct 2024
Viewed by 4260
Abstract
The hypothalamic neuropeptide and hormone oxytocin are of fundamental importance for maternal, social, and sexual behavior. Deviations in oxytocin levels have also been associated with anxiety, autism spectrum disorders (ASD), depression, ADHD (attention deficit hyperactivity disorder), and schizophrenia. Both oxytocin and dopamine are [...] Read more.
The hypothalamic neuropeptide and hormone oxytocin are of fundamental importance for maternal, social, and sexual behavior. Deviations in oxytocin levels have also been associated with anxiety, autism spectrum disorders (ASD), depression, ADHD (attention deficit hyperactivity disorder), and schizophrenia. Both oxytocin and dopamine are often considered reward- and feel-good hormones, and dopamine is associated with the above-mentioned behaviors and, and dopamine is also associated with the above-mentioned behaviors and disorders. Although being structurally totally different, oxytocin, a peptide, and dopamine, a monoamine, they have a number of similar effects. They are synthesized both in the brain and in the periphery, and they affect each other’s release and receptors. In addition, oxytocin and dopamine are released in response to, for example, social interaction, sex, feeding, and massage. This review discusses interactions between oxytocin and dopamine with a specific focus on behavioral effects and possible roles of oxytocin and dopamine in various mental disorders and functional diversities. Full article
(This article belongs to the Special Issue Neuropeptides, Dopamine and Their Interactions in Neuroscience (2nd Edition))
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