Akkermansia muciniphila as a Potential Guardian against Oral Health Diseases: A Narrative Review
"> Figure 1
<p>Oral Bacterial Imbalance, Inflammation, and the Protective Role of <span class="html-italic">Akkermansia muciniphila</span>. Imbalance in oral bacteria leads to inflammation, which contributes to periodontal diseases and can impact systemic health. <span class="html-italic">Akkermansia muciniphila</span>, a gut bacterium with anti-inflammatory properties, can help alleviate these conditions by reducing inflammation and promoting oral and overall health. Red arrows indicate the potentiation or worsening of diseases due to inflammation, while green arrows signify the inhibition or alleviation of diseases by decreasing inflammation.</p> "> Figure 2
<p><span class="html-italic">Akkermansia. muciniphila</span> and inflammation. <span class="html-italic">A. muciniphila</span> by increasing acetate and propionate levels reduces pro-inflammatory cytokines (TNF-α, IL-6, IL-1α, IL-12) while simultaneously increasing the anti-inflammatory cytokine IL-10. These findings highlight the crucial role of <span class="html-italic">A. muciniphila</span> in mitigating inflammation and highlight its potential as a therapeutic agent. Symbol ↑ indicates upregulation/increase and symbol ↓ indicates downregulation/decrease.</p> "> Figure 3
<p><span class="html-italic">A. muciniphila</span> and Oral Health-induced inflammation and bone loss. <span class="html-italic">Porphyromonas gingivalis</span> (<span class="html-italic">P. gingivalis</span>) and <span class="html-italic">Fusobacterium nucleatum</span> (<span class="html-italic">F. nucleatum</span>) have detrimental effects on periodontal diseases (PD) by triggering inflammatory responses and bone destruction. <span class="html-italic">Akkermansia muciniphila</span> has been shown to reduce inflammation, mitigate bone destruction, and enhance anti-inflammatory responses in models of PD. These findings highlight the potential of <span class="html-italic">A. muciniphila</span> as a therapeutic agent in the management of PD-associated inflammation and bone loss. Red arrows indicate the potentiation or worsening of diseases due to inflammation and bone loss, while green arrows signify the inhibition or alleviation of diseases by decreasing inflammation and bone destruction. Symbol ↑ indicates increase.</p> "> Figure 4
<p><span class="html-italic">Akkermansia muciniphila</span> and Other Systemic Diseases Related to Oral Health. <span class="html-italic">Akkermansia muciniphila</span> (<span class="html-italic">A. muciniphila</span>) has emerged as a notable player in managing systemic conditions linked to inflammation, including periodontal disease (PD), obesity, type 2 diabetes (T2D), and hypertension (HTN). <span class="html-italic">A. muciniphila</span>’s influence on inflammatory pathways and metabolic parameters highlights its potential as a therapeutic agent for chronic diseases and emphasizes the importance of the gut microbiome in overall health. Green arrows signify the inhibition or alleviation of diseases by decreasing inflammation.</p> "> Figure 5
<p>Impact of Specific Foods on Metabolic Diseases-induced periodontal diseases and <span class="html-italic">A. muciniphila</span> Abundance. Certain foods that help manage metabolic diseases like hyperlipidemia, diabetes, and hypertension also improve oral health. These foods increase the abundance of <span class="html-italic">Akkermansia muciniphila</span> (<span class="html-italic">A. muciniphila</span>), which may enhance their positive effects on systemic diseases and oral health. This suggests that dietary strategies could effectively address chronic conditions by leveraging <span class="html-italic">A. muciniphila</span>’s role in the gut microbiome to improve overall health.</p> ">
Abstract
:1. Oral Health and Inflammation
2. Akkermansia muciniphila and Inflammation
3. Akkermansia muciniphila and Oral Health
4. Akkermansia muciniphila and Other Systemic Diseases Related to Oral Health
5. Clinical Implications
6. Study Limitations
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
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Anderson, M.H.; Ait-Aissa, K.; Sahyoun, A.M.; Abidi, A.H.; Kassan, M. Akkermansia muciniphila as a Potential Guardian against Oral Health Diseases: A Narrative Review. Nutrients 2024, 16, 3075. https://doi.org/10.3390/nu16183075
Anderson MH, Ait-Aissa K, Sahyoun AM, Abidi AH, Kassan M. Akkermansia muciniphila as a Potential Guardian against Oral Health Diseases: A Narrative Review. Nutrients. 2024; 16(18):3075. https://doi.org/10.3390/nu16183075
Chicago/Turabian StyleAnderson, Molly H., Karima Ait-Aissa, Amal M. Sahyoun, Ammaar H. Abidi, and Modar Kassan. 2024. "Akkermansia muciniphila as a Potential Guardian against Oral Health Diseases: A Narrative Review" Nutrients 16, no. 18: 3075. https://doi.org/10.3390/nu16183075