Human resource SGLT1-MAP17 complex
Zhu D, Cao W, Li J, Wu C, Cao D, Zhang X
Sci Adv (2024) 10 pp. eadn0092-eadn0092 [ Pubmed: 39058771 DOI: doi:10.1126/sciadv.adn0092 ]
- Sglt1-map17 (Complex from santria sp sf9)
The structure of the human cardiac F-actin mutant A331P
Resolution: 3.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 9b3q
Q-score: 0.513
Doran MH, Rynkiewicz MJ, Sousa D, Cammarato A, Lehman W
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin, alpha cardiac muscle 1 (42 kDa, Protein from Homo sapiens)
- Human cardiac f-actin with mutation a331p (420 kDa, Complex from Spodoptera frugiperda)
- Magnesium ion (24 Da, Ligand)
The structure of human cardiac F-actin
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 9b3r
Q-score: 0.501
Doran MH, Rynkiewicz MJ, Sousa D, Cammarato A, Lehman W
To Be Published
- Human cardiac f-actin (420 kDa, Complex from Spodoptera frugiperda)
- Actin, alpha cardiac muscle 1 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
cryo-EM structure complex of Frizzled-7 and Clostridioides difficile toxin B
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8qeo
Q-score: 0.416
Kinsolving J, Bous J, Kozielewicz P, Kosenina S, Shekhani R, Gratz L, Masuyer G, Wang Y, Stenmark P, Dong M, Schulte G
Cell Rep (2024) 43 pp. 113727-113727 [ Pubmed: 38308843 DOI: doi:10.1016/j.celrep.2024.113727 ]
- Masked region-fzd7 crd and leg of tcdb (Cellular component from Priestia megaterium DSM 319)
- Frizzled-7 (67 kDa, Protein from Homo sapiens)
- Toxin b (273 kDa, Protein from Clostridioides difficile)
- Zinc ion (65 Da, Ligand)
- Masked region--crop domain (Cellular component from Priestia megaterium DSM 319)
- Complex of frizzled-7 and clostridioides difficile toxin b (Complex from Spodoptera frugiperda)
- Masked region-core domain (Cellular component from Priestia megaterium DSM 319)
GR89,696 bound Kappa Opioid Receptor in complex with gustducin
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
Cryo-EM structures of peptide free and Gs-coupled GCGR
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8wg8
Q-score: 0.498
Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW
Cell Discov (2024) 10 pp. 18-18 [ DOI: doi:10.1038/s41421-024-00649-0 Pubmed: 38346960 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Pro-pro-pro-pro-phe-ser-asn-leu-val-met-asp-asp-leu-lys-asn-lys-lys (1 kDa, Protein from Spodoptera frugiperda)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Glucagon receptor (46 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucagon like peptide 1 receptor in complex with tirzepatide and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
cryo-EM Structure of Craf:14-3-3:Mek1
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8chf
Q-score: 0.18
Dedden D, Nitsche J, Schneider EV, Thomsen M, Schwarz D, Leuthner B, Gradler U
J Mol Biol (2024) 436 pp. 168483-168483 [ Pubmed: 38331211 DOI: doi:10.1016/j.jmb.2024.168483 ]
- Raf proto-oncogene serine/threonine-protein kinase (73 kDa, Protein from Homo sapiens)
- Dual specificity mitogen-activated protein kinase kinase 1 (43 kDa, Protein from Homo sapiens)
- 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol (334 Da, Ligand)
- 14-3-3 protein zeta isoform x1 (28 kDa, Protein from Spodoptera frugiperda)
- Complex of dimer phosphorylated c-raf kinase domain with 14-3-3 dimer and 2 subunits of mek1 containing ligand gdc-0623 (Complex from Homo sapiens)
Cryo-EM structure of CRaf dimer with 14:3:3
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8cpd
Q-score: 0.399
Dedden D, Nitsche J, Schneider EV, Thomsen M, Schwarz D, Leuthner B, Gradler U
J Mol Biol (2024) 436 pp. 168483-168483 [ Pubmed: 38331211 DOI: doi:10.1016/j.jmb.2024.168483 ]
Cryo-EM structure of an orphan GPCR-Gi protein signaling complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8g05
Q-score: 0.524
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C
Nat Commun (2023) 14 pp. 5706-5706 [ Pubmed: 37709767 DOI: doi:10.1038/s41467-023-41201-0 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 84 (48 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 6oau_gpr84_dngi_scfv16 (Complex from Spodoptera frugiperda)
- 6-(octylamino)pyrimidine-2,4(3h,5h)-dione (239 Da, Ligand)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)