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Textile and clothing recycling and reuse is an under researched field, but there is a growing body of literature driven by government concerns and policies about waste management. Studies (ERM, 2007) have noted that the environmental impacts arising ...

The difficulty of developing an efficient malaria vaccine along with increasing spread of multidrug resistant strain of to the available antimalarial drugs poses the need to discover safe and efficacious antimalarial drugs to control malaria. An alternative strategy is to synthesize compounds possessing structures similar to the active natural products or marketed drugs. Several biologically active natural products and drugs contain β-carboline moiety. In the present study, few selected β-carboline derivatives have been synthesized and tested for their in vitro and in vivo antiplasmodial activity against the rodent malaria parasite (NK-65). The designed analogs exhibited considerable in vitro antimalarial activity. Two compounds (1,3)-methyl 1-(benzo[][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1-pyrido[3,4-]indole-3-carboxylate () and (1,3)-methyl 1-(pyridin-3-yl)-2,3,4,9-tetrahydro-1-pyrido[3,4-]indole-3-carboxylate () were further selected for in vivo studies. Both the lead compounds ( ...

Freeman Dyson has questioned whether any conceivable experiment in the real universe can detect a single graviton. If not, is it meaningful to talk about gravitons as physical entities? We attempt to answer Dyson's question and find it is possible concoct an idealized thought experiment capable of detecting one graviton; however, when anything remotely resembling realistic physics is taken into account, detection becomes impossible, indicating that Dyson's conjecture is very likely true. We also point out several mistakes in the literature dealing with graviton detection and production.