Flutamide
0 Followers
Recent papers in Flutamide
In the present work the absorption of flutamide from suppositories containing hydrophilic tamarind alginate microparticles after rectal administration in rats was investigated with the purpose of enhancing bioavailability and to avoid... more
To compare the effectiveness of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism (IH). ... Social Security Agency, Aegean Obstetrics and Gynecology Teaching Hospital, Department of Reproductive... more
Androgens oppose the actions of estrogen on a number of neuroendocrine functions in the rat including prolactin and gonadotropin secretion and the activation of the female pattern of sex behavior. Although in nonneural tissues... more
PURPOSE The objective of this work was to determine the pharmacokinetics of flutamide (FLT) and its active metabolite, 2-hydroxy-flutamide (FLT-2-OH) in rats, following formulation in hydroxypropyl-Beta-cyclodextrin (FLT-HPBetaCyD).... more
To compare the efficacy of bicalutamide monotherapy to maximal androgen blockade in advanced prostatic cancer. Previously untreated patients with histologically proven stage C or D (American Urological Association Staging System) disease... more
This study was designed to differentiate the contributions of hyperandrogenism, insulin resistance (IR) and body weight to the development of endothelial dysfunction in polycystic ovary syndrome (PCOS) and determine the effectiveness of... more
The NRG/RTOG 9413 study showed that whole pelvic radiotherapy (WPRT) plus neoadjuvant hormonal therapy (NHT) improved progression-free survival in patients with intermediate-risk or high-risk localised prostate cancer compared with... more
To assess whether androgen excess per se might impair insulin action, insulin sensitivity was measured by a two-step (20 and 80 mU/m2. min) hyperinsulinemic euglycemic clamp combined with indirect calorimetry and tracer glucose infusion... more
Males have higher prevalence of hypertension and renal injury than females, which may be attributed in part to androgen-mediated effects on renal hemodynamics. Tubuloglomerular feedback (TGF) is an important mechanism in control of renal... more
Androgens are essential for testicular descent in eutherian mammals, but little is known about its hormonal control in marsupials. This study reports the effects of daily treatment with the anti-androgen flutamide (10 mg kg(-1)) from day... more
Although previous studies have shown that flutamide improves cardiovascular function after trauma-hemorrhage, the mechanisms responsible for the salutary effect remain unknown. We hypothesized that flutamide mediates its beneficial... more
The NRG/RTOG 9413 study showed that whole pelvic radiotherapy (WPRT) plus neoadjuvant hormonal therapy (NHT) improved progression-free survival in patients with intermediate-risk or high-risk localised prostate cancer compared with... more
Trial RTOG 9202 was a phase 3 randomized trial designed to determine the optimal duration of androgen deprivation therapy (ADT) when combined with definitive radiation therapy (RT) in the treatment of locally advanced nonmetastatic... more
The aromatase inhibitor 1,4,6-androstatriene- 3,17-dione (ATD), a nonsteroidal antiandrogen (flutamide), testosterone and estradiol were administered by Silastic capsule or injection to ovariectomized female and castrate and intact male... more
To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism. Twenty women with idiopathic hirsutism were randomized to receive either flutamide or spironolactone. Twenty hirsute women were... more
Background: This study was designed to investigate the effect of metformin and flutamide alone or in combination with anthropometric indices and laboratory tests of obese/overweight PCOS women under hypocaloric diet. Methods: This single... more
To compare the effectiveness of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism (IH). ... Social Security Agency, Aegean Obstetrics and Gynecology Teaching Hospital, Department of Reproductive... more
This is the peer-reviewed, manuscript version of the following article: DelBarco-Trillo, J and Greene, L K and Goncalves, I B and Fenkes, M and Wisse, J H and Drewe, J A and Manser, M B and Clutton-Brock, T and Drea, C M (2016) Beyond... more