Domino

Este trabalho apresenta uma forma lúdica de
propiciar uma aprendizagem coletiva. Para tanto,
utilizou-se um jogo de dominó diferente do tradicional.
Com ele é abordado o conteúdo de Matrizes e
Determinantes, buscando promover não apenas uma
revisão dos conteúdos, mas também uma expansão do
conhecimento matemático. Acredita-se que o principal
problema em relação a tal conteúdo se deve ao
desinteresse por parte dos alunos, possivelmente devido
à monotonia com que este tema é tratado. Objetivouse,
com esta atividade, propiciar, de maneira atrativa,
uma melhor forma de se obter o conhecimento sobre
Matrizes e Determinantes, visando ainda buscar uma
aprendizagem coletiva e eficaz. Desta forma, o projeto
busca trazer os educandos para um cenário lúdico, a fim
de que, ao longo da aplicação da atividade, possa-se
despertar o interesse deste estudante não apenas por
Matrizes e Determinantes, mas por vários temas que se
relacionam diretamente com a Matemática.

Abstract The present report intends to highlight the main lines of our investigation on a series of modular domino reactions focusing on a multi-task reagent, namely Pb(OAc)4 in conjunction with an olefin as a source of complexity. It covers the design, development, and mechanistic aspects of a domino methodology discovered in our laboratory, which presents numerous challenges, including issues of chemo-, regio-, and diastereoselectivities. The principal characteristic of the chemistry presented is the potential of creating cyclic arrays that can be suitably functionalized for subsequent conversion into various complex systems. The effects of systematic variation of domino promoter, substitution pattern, solvent, temperature, and microwave activation on the outcome of the domino reaction are presented. In general terms, the domino chemistry reported here could be conveniently divided into two categories, dealing with first and second generation domino probes based on the nature of the angular substituent, each of which will be addressed in turn. This review is not intended to give an extensive coverage of the various uses of Pb(OAc)4 in synthesis reported in the literature, but will expose relevant reactions where appropriate focusing exclusively on multi-stage transformations initiated by the reagent.

italianoL’A. esamina due frammenti - Ner. D.19.1.31.2 e Ulp. D.6.2.9.4 - nei quali si affronta il problema dell’individuazione del compratore da tutelare, con prevalenza sull’altro, fra coloro che hanno comprato dal medesimo venditore o da due venditori non proprietari. Si sofferma, in particolare, sul caso della compera da due venditori, perche con riferimento ad esso emerge l’esistenza di una diversita di opinioni tra i giuristi, variamente spiegata dagli studiosi. L’A. offre un contributo volto a chiarire, ancor di piu di quanto si e fatto, i termini reali di questa diversita di opinioni. EnglishTwo fragments - Ner. D.19.1.31.2 e Ulp. D.6.2.9.4 - deal with the problem which one between two buyers deserves protection. In one case, the two have bought from the same seller; in the other one from two non domini-sellers. In his general treatment the author examines in particular the latter case because with regard to this fragment there are different opinions among the jurists differe...

A series of spirooxindolopyrrolidine fused -styrylpiperidone heterocyclic hybrids has been synthesized in excellent yield via a domino multicomponent protocol that involves one-pot three component 1,3-dipolar cycloaddition and concomitant enamine reactions performed in an inexpensive ionic liquid, namely 1-butyl-3-methylimidazolium bromide ([bmim]Br). Compounds thus synthesized were evaluated for their cytotoxicity against U-937 tumor cells. Interestingly; compounds and exhibited a better cytotoxicity than the anticancer drug bleomycin. In addition; the effect of the synthesized compounds on the nuclear morphology of U937 FaDu cells revealed that treatment with compounds ⁻ led to their apoptotic cell death.