Clofibric Acid

In this work, the distribution and the ecotoxicological risk of sixteen pharmaceutically active compounds belonging to seven different therapeutic groups (five anti-inflammatory drugs, two antibiotics, an anti-epileptic drug, a β-blocker, a nervous stimulant, four estrogens and two lipid regulators) have been studied in sewage sludge from wastewater treatment plants. Only three of the sixteen pharmaceutical compounds were never detected in sludge while eleven of the studied pharmaceuticals were still detected in compost. Mean concentration levels of the pharmaceutically active compounds ranged between 24.9 and 4105 μg/kg dm, 14.5-944 μg/kg dm, 3.29-636 μg/kg dm and 9.19-974 μg/kg dm in primary, secondary, digested sludge and compost, respectively. An increase in the concentration levels of most of the pharmaceuticals was observed from summer to winter (mean values in primary and secondary sludge were 304 and 85.1 μg/kg dm in summer and 435 and 175 μg/kg dm in winter, respectively) p...

Male F344 rats were fed a diet containing the peroxisome proliferators 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl- propionic acid (ciprofibrate (0.025%)) or (4-chloro-6-(2,3-xyli- dino)-2-pyrimidinylthio)acetic acid (Wy-14643 (0.1%)) for up to 14 months to determine whether hepatic peroxisome prolifera tion caused by these agents results in the induction of membrane lipid peroxidation in the liver. Peroxidative damage of membrane lipids from whole liver, postnuclear, heavy-particle, microsomal,

To isolate novel auxin-responsive mutants in Arabidopsis (Arabidopsis thaliana), we screened mutants for root growth resistance to a putative antiauxin, p-chlorophenoxyisobutyric acid (PCIB), which inhibits auxin action by interfering the upstream auxin- signaling events. Eleven PCIB-resistant mutants were obtained. Genetic mapping indicates that the mutations are located in at least five independent loci, including two known auxin-related loci, TRANSPORT INHIBITOR

The catalytic ozonation of fenofibric and clofibric acids and the herbicides atrazine and linuron was studied using titanium dioxide, alumina, and manganese oxide supported on activated alumina and on silica SBA-15. The organics studied did not adsorb significantly either in wastewater or in phosphate-buffered water. The catalysts did not modify the rate of the hydroxyl-mediated ozonation with respect to the homogeneous value. The mode of action of metal oxide catalysts would be an enhanced generation of oxidant species from the catalytic decomposition of ozone. All catalysts increased the efficiency in the production of hydroxyl radicals from ozone.